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Pregnancy outcomes following supplementation of single dose GnRH agonist to sustain the luteal phase in antagonist fresh embryo transfer cycles:A multicentric prospective cohort study

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Asian pacific Journal of Reproduction 2023年第4期12卷 162-169页

作者： Tatapudi S V Parvathi Devi Alka Gahlot sangita sharma Manisha Choudhary Ravikant Soni Meeta sharma Department of Reproductive Medicine&Surgery Mahatma Gandhi Medical College&HospitalJaipurIndia Department of Biochemistry Senior EmbryologistMahatma Gandhi Medical College&HospitalJaipurIndia Department of Reproductive Medicine&Surgery Senior EmbryologistMahatma Gandhi Medical College&HospitalJaipurIndia

Objective:To determine whether a single dose of gonadotropin-releasing hormone(GnRH)agonist administered subcutaneously in addition to the regular progesterone supplementation could provide a better luteal support in antagonist protocol fresh embryo transfer ***:This prospective,multicentric,cohort study included total 140 women,70 in each *** ovarian stimulation was carried out as per fixed GnRH antagonist *** trigger was given with *** vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)was performed and day-3 embryos were *** were divided into groups 1 and 2 based on computer generated randomization *** days following oocyte retrieval,group 1 received 0.2 mg decapeptyl subcutaneously in addition to regular progesterone support while group 2 received progesterone *** support was given for 14 days to both groups;if pregnancy was confirmed luteal support was continued till 12 weeks of *** clinical pregnancy rate was the primary *** implantation rate,miscarriage rate,live birth delivery rate,and multiple pregnancy rates were the secondary ***:A total of 140 patients were analysed,70 in each *** pregnancy rates(47.1%vs.35.7%;P=0.17),implantation rates(23.4%vs.18.1%,P=0.24),live birth delivery rates(41.4%vs.27.1%,P=0.08),and multiple pregnancy rates(21.2%vs.16.0%,P=0.74)were higher in group 1 than in group *** 1 had a lower miscarriage rate than group 2(5.7%vs.8.6%;P=0.75).However,these differences were not statistically significant between the two ***:Administration of a single dose of GnRH agonist in addition to regular natural micronized vaginal progesterone as luteal support in GnRH antagonist protocol cycles marginally improves implantation rates,clinical pregnancy rates,and live birth delivery ***,more studies with higher sample sizes are needed before any conclusive statements about GnRH agonist as luteal phase suppo

关键词： GnRH agonist Triptorelin IVF Ovum pick up Luteal phase support Antagonist protocol Cleavage stage Fresh embryo transfer Live birth delivery rate

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