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利用神经网络模型预测球团矿的冷压强度(英文)

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世界钢铁 2012年第4期12卷 7-16页

作者： T Umadevi Naveen F Lobo sangamesh desai Manjunath Prabhu 黄可为金达尔钢公司宝钢研究院

建立了一个神经网络模型来预测球团矿的冷压强度,该网络模型采用三层前向BP神经网络,网络结构为12-12-1,12个输入变量分别为给料率、料层高度、焙烧温度、干透点温度、COREX煤气单耗、膨润土的添加量、生球水分、生球碳含量以及成品球的... 详细信息

建立了一个神经网络模型来预测球团矿的冷压强度,该网络模型采用三层前向BP神经网络,网络结构为12-12-1,12个输入变量分别为给料率、料层高度、焙烧温度、干透点温度、COREX煤气单耗、膨润土的添加量、生球水分、生球碳含量以及成品球的FeO、MgO、Al2O3含量和碱度;隐层含有12个神经元;输出为成品球团冷压强度;神经元激活函数选择双曲正切函数;神经网络学习算法使用的是带惯量项的误差反向传播学习算法(BP学习算法)。选取353组数据来训练和测试神经网络,其中247组数据用于训练网络,其余数据用于测试网络。测试结果表明,该网络的预测结果与实际结果的误差在3%以内,同时通过敏感性分析得出以下结论:①膨润土添加量、生球碳含量以及成品球的FeO、MgO、Al2O3含量和碱度对球团矿的冷压强度有重要影响;②增加膨润土添加量、成品球碱度、MgO含量、焙烧温度、干透点温度、COREX煤气单耗有助于改善球团矿的冷压强度;③增加FeO含量、生球碳含量、Al2O3含量、料层高度、给料率将使球团矿的冷压强度迅速下降;④增加生球水分会降低冷压强度;⑤提高球团矿冷压强度的参数设置(膨润土的添加量:0.86%～0.92%;wFeO<0.5%;生球碳含量:1.00%～1.10%;MgO含量:0.39%～0.44%);⑥在0.3～0.7范围内增加碱度不能显著改善球团矿的冷压强度。

关键词：神经网络 CCS 制粒固结生球球团质量

Performance study of jute-epoxy composites/sandwiches under normal ballistic impact

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Defence Technology（防务技术） 2020年第4期16卷 947-955页

作者： sangamesh Rajole K.S.Ravishankar S.M.Kulkarni Department of Mechanical Engineering National Institute of Technology KarnatakaSurathkalMangalore 575025India Department of Metallurgical and Materials Engineering National Institute of Technology KarnatakaSurathkalMangalore 575025India

This study is undertaken to explore the use of natural fiber Jute-epoxy(JE),Jute-epoxy-rubber(JRE)sandwich composite for ballistic energy *** absorbed and residual velocities for these composites are evaluated analytically and through Finite Element Analysis(FEA).FE analysis of JE plates is carried out for different thicknesses(3,5,10 and 15 mm).JE plates and JRE sandwiches having the same thickness(15 mm) are fabricated and tested to measure residual velocity and energy *** analytical results are found to agree well with the results of FE analysis with a maximum error of 9%.The study on JE composite plate reveals that thickness influences the energy *** and FE analysis study showed that JRE sandwiches have better energy absorption than JE *** absorption of a JRE sandwich is about 71% greater than JE *** obtained from FEA and testing are in good agreement,SEM analysis confirms composites failed by fiber rupture and fragmentation.

关键词： Energy absorption Composites Polymer composites Ballistic impact High velocity impact

Nanocomposites and bone regeneration

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Frontiers of Materials Science 2011年第4期5卷 342-357页

作者： Roshan JAMES Meng DENG Cato T. LAURENCIN sangamesh G. KUMBAR Institute for Regenerative Engineering University of Connecticut Health Center Farmington CT 06030 USA New England Musculoskeletal Institute University of Connecticut Health Center Farmington CT 06030 USA Department of Orthopaedic Surgery University of Connecticut Health Center Farmington CT 06030 USA Department of Chemical Materials and Biomolecular Engineering University of Connecticut Storrs CT 06269 USA

This manuscript focuses on bone repair/regeneration using tissue engineering strategies, and highlights nanobiotechnology developments leading to novel nanocomposite systems. About 6.5 million fractures occur annually in USA, and about 550,000 of these individual cases required the application of a bone graft. Autogenous and allogenous bone have been most widely used for bone graft based therapies; however, there are significant problems such as donor shortage and risk of infection. Alternatives using synthetic and natural biomaterials have been developed, and some are commercially available for clinical applications requiring bone grafts. However, it remains a great challenge to design an ideal synthetic graft that very closely mimics the bone tissue structurally, and can modulate the desired function in osteoblast and progenitor cell populations. Nanobiomaterials, specifically nanocomposites composed of hydroxyapatite （HA） and/or collagen are extremely promising graft substitutes. The biocomposites can be fabricated to mimic the material composition of native bone tissue, and additionally, when using nano-HA （reduced grain size）, one mimics the structural arrangement of native bone. A good understanding of bone biology and structure is critical to development of bone mimicking graft substitutes. HA and collagen exhibit excellent osteoconductive properties which can further modulate the regenerative/ healing process following fracture injury. Combining with other polymeric biomaterials will reinforce the mechanical properties thus making the novel nano-HA based composites comparable to human bone. We report on recent studies using nanocomposites that have been fabricated as particles and nanofibers for regeneration of segmental bone defects. The research in nanocomposites, highlight a pivotal role in the future development of an ideal orthopaedic implant device, however further significant advancements are necessary to achieve clinical use.

关键词： bone graft substitute nanocomposite hydroxyapatite collagen nanofiber,biomimetic nanobiomaterial osteogenic segmental defect tibia defect

Amorphous silica fiber matrix biomaterials:An analysis of material synthesis and characterization for tissue engineering

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Bioactive Materials 2023年第1期19卷 155-166页

作者： Hyun S.Kim sangamesh G.Kumbar Syam P.Nukavarapu Department of Biomedical Engineering University of ConnecticutStorrsCTUSA Department of Material Science and Engineering University of ConnecticutStorrsCTUSA Department of Orthopaedic Surgery University of Connecticut HealthFarmingtonCTUSA

Silica biomaterials including Bioglass offer great biocompatibility and bioactivity but fail to provide pore and degradation features needed for tissue *** we report on the synthesis and characterization of novel amorphous silica fiber matrices to overcome these *** silica fibers were fused by sintering to produce porous *** effects of sacrificial polymer additives such as polyvinyl alcohol(PVA)and cellulose fibers(CF)on the sintering process were also *** resulting matrices formed between sintering temperatures of 1,350-1,550◦C retained their fiber *** matrices presented pores in the range of 50-200μm while higher sintering temperatures resulted in increased pore *** addition to silica significantly reduced the pore diameter and porosity compared with silica matrices with or without the addition of *** PVA additive morphologically appeared to fuse the silica fibers to a greater extent and resulted in significantly higher compressive modulus and strength than the rest of the matrices *** matrices lost roughly 30%of their original mass in an in vitro degradation study over 40 *** matrices absorbed 500 wt%of water and did not change in their overall morphology,size,or shape with *** fiber matrices supported human mesenchymal stem cell adhesion,proliferation,and mineralized matrix *** silica fiber biomaterials/matrices reported here are biodegradable and porous and closely resemble the native extracellular matrix structure and water absorption *** the methodology reported here to alter matrix properties may lead to a variety of tissue engineering,implant,and drug delivery applications.

关键词： Silica biomaterial Porous matrix ECM-Like fibrous structure Biodegradable Water absorption

Stimuli-responsive peptide assemblies:Design,self-assembly,modulation,and biomedical applications

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Bioactive Materials 2024年第5期35卷 181-207页

作者： Rongqiu Mu Danzhu Zhu Sama Abdulmalik Suranji Wijekoon Gang Wei sangamesh G.Kumbar College of Chemistry and Chemical Engineering Qingdao University266071QingdaoChina Department of Biomedical Engineering&Department of Materials Science and Engineering University of ConnecticutStorrs06269USA Department of Orthopaedic Surgery University of Connecticut HealthFarmington06030USA

Peptide molecules have design flexibility,self-assembly ability,high biocompatibility,good biodegradability,and easy functionalization,which promote their applications as versatile biomaterials for tissue engineering and *** addition,the functionalization of self-assembled peptide nanomaterials with other additive components enhances their stimuli-responsive functions,promoting function-specific applications that induced by both internal and external *** this review,we demonstrate recent advance in the peptide molecular design,self-assembly,functional tailoring,and biomedical applications of peptide-based *** strategies on the design and synthesis of single,dual,and multiple stimuli-responsive peptide-based nanomaterials with various dimensions are analyzed,and the functional regulation of peptide nanomaterials with active components such as metal/metal oxide,DNA/RNA,polysaccharides,photosensitizers,2D materials,and others are *** addition,the designed peptide-based nanomaterials with temperature-,pH-,ion-,light-,enzyme-,and ROS-responsive abilities for drug delivery,bioimaging,cancer therapy,gene therapy,antibacterial,as well as wound healing and dressing applications are presented and *** comprehensive review provides detailed methodologies and advanced techniques on the synthesis of peptide nanomaterials from molecular biology,materials science,and nanotechnology,which will guide and inspire the molecular level design of peptides with specific and multiple functions for function-specific applications.

关键词： Peptide assemblies Molecular design Functional modulation Stimuli-responsive nanomaterials Biomedical applications

Review: Bioengineering approach for the repair and regeneration of peripheral nerve

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Bioactive Materials 2019年第1期4卷 107-113页

作者： Joshua Moskow Bryan Ferrigno Nikhil Mistry Devina Jaiswal Ketan Bulsara Swetha Rudraiah sangamesh G.Kumbar epartment of Orthopaedic Surgery University of Connecticut Health263Farmington Ave.FarmingtonCT 06030USA Department of Biomedical Engineering University of Connecticut260Glenbrook RoadUnit 3247StorrsCT 06269USA Department of Surgery University of Connecticut Health263 Farmington Ave.FarmingtonCT 06030USA Department of Pharmaceutical Sciences School of PharmacyUniversity of Saint Joseph229 Trumbull St.Hartford CT 06103USA

Complex craniofacial surgeries of damaged tissues have several limitations,which present complications and challenges when trying to replicate facial function and *** treatment techniques have shown suitable nerve function regeneration with various *** technology continues to advance,new methods have been explored in order to regenerate damaged nerves in an effort to more efficiently and effectively regain original function and *** article will summarize recent bioengineering strategies involving biodegradable composite scaffolds,bioactive factors,and external stimuli alone or in combination to support peripheral nerve *** emphasis is made on the contributions of growth factors and electrical stimulation on the regenerative process.

关键词： Peripheral nerve regeneration Composite materials Growth factor Electrical stimulation

Decellularized extracellular matrix biomaterials for regenerative therapies:Advances,challenges and clinical prospects

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Bioactive Materials 2024年第2期32卷 98-123页

作者： Aleksandra A.Golebiowska Jonathon T.Intravaia Vinayak M.Sathe sangamesh G.Kumbar Syam P.Nukavarapu Department of Biomedical Engineering University of ConnecticutStorrsCT06269USA Department of Materials Science&Engineering University of ConnecticutStorrsCT06269USA Department of Orthopaedic Surgery University of Connecticut HealthFarmingtonCT06032USA

Tissue engineering and regenerative medicine have shown potential in the repair and regeneration of tissues and organs via the use of engineered biomaterials and ***,current constructs face limitations in replicating the intricate native microenvironment and achieving optimal regenerative capacity and functional *** address these challenges,the utilization of decellularized tissues and cell-derived extracellular matrix(ECM)has emerged as a promising *** biocompatible and bioactive biomaterials can be engineered into porous scaffolds and grafts that mimic the structural and compositional aspects of the native tissue or organ microenvironment,both in vitro and in *** dECM materials provide a unique tissue-specific microenvironment that can regulate and guide cellular processes,thereby enhancing regenerative *** this review,we explore the emerging frontiers of decellularized tissue-derived and cell-derived biomaterials and bio-inks in the field of tissue engineering and regenerative *** discuss the need for further improvements in decellularization methods and techniques to retain structural,biological,and physicochemical characteristics of the dECM products in a way to mimic native tissues and *** article underscores the potential of dECM biomaterials to stimulate in situ tissue repair through chemotactic effects for the development of growth factor and cell-free tissue engineering *** article also identifies the challenges and opportunities in developing sterilization and preservation methods applicable for decellularized biomaterials and grafts and their translation into clinical products.

关键词： Non-immune biomaterials and grafts Native micro-environment Bio-chemical cues Chemotactic ability Tissue-inks Clinical therapies

Bioactive polymeric scaffolds for tissue engineering

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Bioactive Materials 2016年第2期1卷 93-108页

作者： Scott Stratton Namdev B.Shelke Kazunori Hoshino Swetha Rudraiah sangamesh G.Kumbar Department of Orthopaedic Surgery UConn HealthFarmingtonCTUSA Institute for Regenerative Engineering UConn HealthFarmingtonCTUSA Department of Biomedical Engineering University of ConnecticutStorrsCTUSA Department of Pharmaceutical Sciences School of PharmacyUniversity of Saint JosephHartfordCT06103USA

A variety of engineered scaffolds have been created for tissue engineering using polymers,ceramics and their *** has been adopted for majority of the three-dimensional(3D)scaffold design both in terms of physicochemical properties,as well as bioactivity for superior tissue *** fabricated via salt leaching,particle sintering,hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in *** systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and *** scaffold fabrication techniques often failed to create intricate structures with greater resolution,not reproducible and involved multiple *** 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug *** review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores,bioactivity and degradation rate to enable tissue *** highlights few examples of bioactive scaffold mediated nerve,muscle,tendon/ligament and bone *** of the efforts required for optimization,a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined.

关键词： Bioactive Biomaterials Scaffold Porosity Biodegradable Tissue regeneration

Studies of Anomalies in Mixed Conduction of Na₂O and V₂O₅ Doped Boro-Phosphate Glasses

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New Journal of Glass and Ceramics 2022年第1期12卷 1-18页

作者： sangamesh Jakhati Nagaraja Nadavalumane JalandharRao Sonkamble Ashwajeet Department of Physics VTU-Research Centre Rao Bahadur Y Mahabaleswarappa Engineering College Ballari India Department of Physics Davangere University Davanagere India

A set of borophosphate glasses doped with alkali and transition metal (TM) ions have been synthesized. The glasses were carried through;annealing, XRD, density, DC conductivity studies. Molar volume and density varied nonlinearly. High temperature activation energy is analysed taking into consideration of Mott’s SPH model. The low temperature electrical conductivity was analysed by Mott and Greaves VRH. Several polaron hopping related parameters at high temperature region and density of states at low temperature region were computed. The high temperature DC activation energy measured by conductivity, calculated numerous pertained parameters varied nonlinearly with mole fraction of vanadium content. The Study exhibits DC electrical conduction is due to both alkali and transition metal ions and thus confirms the mixed conductivity. A crossover conduction mechanism from the ionic dominant region to polaronic predominant region has been also observed. Studies revealed the single transition effect at 0.4 mol fraction of V2O5 content.

关键词： Borophosphate Glasses Sodium Vanadium Single Alkali Effect (SAE) Single Transition Effect (STE)