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Dynamic changes of protein corona compositions on the surface of zinc oxide nanoparticle in cell culture media

Frontiers of Chemical Science and Engineering 2019年第1期13卷 90-97页

作者： Vo-Van Giau Yoon-Hee Park Kyu-Hwan Shim sang-wook son Seong-Soo A. An Department of Bionanotechnology and Gachon Medical Research Institute Gachon University and Gachon Medical Research Institute Seongnam Korea Laboratory of Cell Signaling and Nanomedicine Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science Korea University College of Medicine Seoul Korea

The potential applications of nanomaterials used in nanomedicine as ingredients in drug delivery systems and in other products continue to expand. When nanomaterials are introduced into physiological environments and driven by energetics, they readily associate proteins forming a protein corona (PC) on their surface. This PC could result in an alteration of the nanomatcrial's surface characteristics, affecting their interaction with cells due to conformational changes in adsorbed protein molecules. However, our current understanding of nanobiological interactions is still very limited. Utilizing a liquid chromatography-mass spectroscopy/mass spectroscopy technology and a Cytoscape plugin (ClueGO) approach, we examined the composition of the PC for a set of zinc oxide nanoparticles (ZnONP) from cell culture media typically and further analyzed the biological interaction of identified proteins, respectively. In total, 36 and 33 common proteins were investigated as being bound to ZnONP at 5 min and 60 min, respectively. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Proteins bound to the surface of nanoparticles that may modify the structure, therefore the function of the adsorbed protein could be consequently affect the complicated biological processes.

关键词： ZnONPs nanoparticles protein corona ClueGO

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Vomiting-induced pharyngeal perforation during bowel preparation for colonoscopy:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3615-3621页

作者： Geonhee Kim Won Hyuk Lee Seokin Kang Jung Rock Moon Yoon Suk Lee Jun Hyuk son Nam-Hoon Kim Jong wook Kim Department of Internal Medicine Ilsan Paik HospitalInje University College of MedicineGoyang 10380South Korea

BACKGROUND Effective bowel cleansing is essential for a successful ***,such as polyethylene glycol,are commonly used for bowel *** is a frequent complication during bowel preparation,and forceful vomiting can potentially lead to esophageal perforation,as reported in several previous ***,pharyngeal perforation during bowel preparation has not been previously ***,we present a case of pharyngeal perforation induced by forceful vomiting during bowel *** SUMMARY A 38-year-old man with a history of hypertension,dyslipidemia,diabetes mellitus,and end-stage renal disease on hemodialysis was admitted for evaluation of recurrent abdominal *** patient complained of sudden pain in the neck,throat,and anterior chest following forceful vomiting during bowel *** examination revealed crepitus under the skin of the neck and anterior chest on palpation,and upper gastrointestinal endoscopy revealed pharyngeal *** perforation site was located above the upper esophageal sphincter,which distinguished it from Boerhaave’s *** medical management was chosen after consultation with a thoracic surgeon and an otolaryngologist,considering the patient's mild symptoms,stable vital signs,and the small size of the lesion;the perforation resolved without endoscopic or surgical *** patient was discharged from hospital two weeks after the *** Despite its rarity,pharyngeal perforation should be considered a potential complication of bowel preparation for colonoscopy.

关键词： Colonoscopy Pharynx Polyethylene glycols Spontaneous perforation Case report

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Exercise-induced muscle fatigue in the unaffected knee joint and its influence on postural control and lower limb kinematics in stroke patients

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Neural Regeneration Research 2017年第5期12卷 765-769页

作者： Sun wook Park Sung Min son Na Kyung Lee Department of Physical Therapy Faculty of Health Science Eulji University Department of Physical Therapy College of Health Science Cheongju University Department of Physical Therapy College of Rehabilitation Science Daegu University

This study aimed to investigate the effects of exercise-induced muscle fatigue in the unaffected knee joint on postural control and kinematic changes in stroke patients. Forty participants（20 stroke patients, 20 age-matched healthy participants） were recruited. To induce fatigue, maximum voluntary isometric contractions were performed in the unaffected knee joint in a Leg Extension Rehab exercise machine using the pneumatic resistance. We measured static and dynamic balance and lower-limb kinematics during gait. Changes in postural control parameters anteroposterior sway speed and total center of pressure distance differed significantly between the stroke and control groups. In addition, changes in gait kinematic parameters knee and ankle angles of initial contact differed significantly between stroke（paretic and non-paretic） and control groups. Muscle fatigue in the unaffected knee and ankle impaired postural control and debilitates kinematic movement of ipsilateral and contralateral lower limbs, and may place the fatigued stroke patients at greater risk for falls.

关键词： nerve regeneration knee muscle fatigue stroke postural control gait kinemetics neural regeneration

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Optimization of thermoelectric properties of n-type Bi_2(Te,Se)_3 with optimizing ball milling time

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Rare Metals 2018年第4期37卷 351-359页

作者： Ji-Hee son Min-wook Oh Bong-Seo Kim Su-Dong Park Thermoelectric Conversion Research Center Korea Electrotechnology Research Institute Department of Materials Science and Engineering Hanbat National University

The thermoelectric properties at elevated temperature were investigated for n-type Bi2（Te,Se）3 which is obtained from ball milling processed powder with various milling times. Electrical properties such as electrical resistivity and Seebeck coefficient are clearly dependent on milling time, in which the carrier concentration is attributed to the change of the electrical properties. The concentrations of the defects are also varied with the ball milling time, which is the origin of the carrier concentration variation. Even though finer grain sizes are obtained after the long ball milling time, the temperature dependence of the thermal conductivity is not solely understood with the grain size, whereas the electrical contribution to the thermal conductivity should be also considered. The highest figure of merit value of ZT = 0.83 is achieved at 373 K for the optimized samples, in which ball milling time is 10 h. The obtained ZT value is 48% improvement over that of the 0.5-h sample at 373 K.

关键词： Thermoelectric properties Ball milling Bi2Te3 Seebeck coefficient Grain size Thermalconductivity

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Stomach cancer screening and preventive behaviors in relatives of gastric cancer patients

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World Journal of Gastroenterology 2011年第30期17卷 3518-3525页

作者： Jung Min Kang Dong wook Shin Young Min Kwon sang Min Park Min Sun Park Jin Ho Park Ki Young son Be Long Cho Department of Family Medicine Seoul National University Hospital101 DaehangnoJongno-Gu110-744 SeoulSouth Korea

AIM:To investigate gastric cancer screening and preventive behaviors among the relatives of patients with gastric cancer[i.e.,gastric cancer relatives(GCRs)].METHODS:We examined the Korean National Health and Nutrition Examination Survey 2005(KNHANESⅢ) database and compared the gastric cancer screening and preventive behaviors of GCRs(n=261)with those of non-GCRs(n=454)and controls without a family history of cancer(n=2842).RESULTS:The GCRs were more likely to undergo gastric cancer screening compared with the control group(39.2%vs 32.3%,adjusted odds ratio:1.43,CI:1.05-1.95),although the absolute screening rate was *** patterns and smoking rates did not differ significantly between the groups,and a high proportion of GCRs reported inappropriate dietary habits(i.e.,approximately 95%consumed excessive sodium,30% were deficient in vitamin C,and 85%were deficient in dietary fiber).CONCLUSION:The gastric cancer screening and preventive behaviors of GCRs have yet to be *** increase awareness among GCRs,systematic family education programs should be implemented.

关键词： Family history of cancer Cancer relatives Gastric cancer screening Preventive behaviors Cancerprevention

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CNN Accelerator Using Proposed Diagonal Cyclic Array for Minimizing Memory Accesses

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Computers, Materials & Continua 2023年第8期76卷 1665-1687页

作者： Hyun-wook son Ali AAl-Hamid Yong-Seok Na Dong-Yeong Lee Hyung-Won Kim Department of Electronics College of Electrical and Computer EngineeringChungbuk National UniversityCheongju28644Korea Department of Electrical Engineering College of EngineeringAl-Azhar UniversityCairo11651Egypt

This paper presents the architecture of a Convolution Neural Network(CNN)accelerator based on a newprocessing element(PE)array called a diagonal cyclic array(DCA).As demonstrated,it can significantly reduce the burden of repeated memory accesses for feature data and weight parameters of the CNN models,which maximizes the data reuse rate and improve the computation ***,an integrated computation architecture has been implemented for the activation function,max-pooling,and activation function after convolution calculation,reducing the hardware *** evaluate the effectiveness of the proposed architecture,a CNN accelerator has been implemented for You Only Look Once version 2(YOLOv2)-Tiny consisting of 9 ***,the methodology to optimize the local buffer size with little sacrifice of inference speed is presented in this *** implemented the proposed CNN accelerator using a Xilinx Zynq ZCU102 Ultrascale+Field Programmable Gate Array(FPGA)and ISE Design *** FPGA implementation uses 34,336 Look Up Tables(LUTs),576 Digital Signal Processing(DSP)blocks,and an on-chip memory of only 58 KB,and it could achieve accuracies of 57.92% and 56.42% mean Average Precession@0.5 thresholds for intersection over union(mAP@0.5)using quantized 16-bit and 8-bit full integer data manipulation with only 0.68% as a loss for 8-bit version and computation time of 137.9 and 69 ms for each input image respectively using a clock speed of 200 *** speeds are expected to be doubled five times using a clock speed of 1GHz if implemented in a silicon System on Chip(SoC)using a sub-micron process.

关键词： CNN accelerator systolic array memory optimization YOLOv2-tiny mAP@0.5

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Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman:A rare cause of hemoperitoneum

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World Journal of Gastroenterology 2008年第1期14卷 136-139页

作者： Seong-Heum Park Jong-Han Kim Byung wook Min Tae Jin song Gil Soo son Seung Joo Kim sang Woo Lee Hwan-Hoon Chung Ju Han Lee Jun Won Um Department of Surgery Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Internal Medicine Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Radiology Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Pathology Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea

Inflammatory myofibroblastic tumor （INT） of the stomach in adults is extremely rare, with unpredictable prognosis. We present a 55-year-old woman with a gastric IMT. She experienced sudden abdominal pain 4 d previously. Physical examination showed mild abdominal tenderness in the hypogastrium, but no palpable abnormal abdominal mass. Abdominal CT showed a mass of approximately 8 cm in the gastrocolic ligament. On laparoscopic exploration, unexpected hemoperitoneum of approximately 1.5 L of blood was found, and an exophytic gastric mass of approximately 10 cm, appeared from the anterior wall of the gastric body along the greater curvature. Laparoscopy further showed that non- clotting blood in the abdominal cavity seemed to be from the gastric tumor. After conversion to open surgery for more precise evaluation of the cause of hemoperitoneum and the large friable tumor, gastric wedge resection, including the tumor, was conducted. The final diagnosis was consistent with IMT that originated from the gastric wall.

关键词： Stomach disease Stomach neoplasms Hemoperitoneum Myofibroma Granuloma Plasma cell Stomach surgery

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Asymmetrical response of summer rainfall in East Asia to CO_(2)forcing

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Science Bulletin 2022年第2期67卷 213-222,M0004页

作者： Se-Yong song sang-wook Yeh Soon-Il An Jong-Seong Kug Seung-Ki Min Seok-Woo son Jongsoo Shin Department of Marine Sciences and Convergence Technology Hanyang UniversityAnsan 15588South Korea Department of Atmospheric Sciences/Irreversible Climate Change Research Center Yonsei UniversitySeoul 03722South Korea Division of Environmental Science and Engineering Pohang University of Science and TechnologyPohang 37673South Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversityIncheon 21983South Korea School of Earth and Environmental Science Seoul National UniversitySeoul 08826South Korea

Understanding the regional hydrological response to varying CO_(2)concentration is critical for cost-benefit analysis of mitigation and adaptation polices in the near future. To characterize summer monsoon rainfall change in East Asia in a changing CO_(2)pathway, we used the Community Earth System Model(CESM) with28 ensemble members in which the CO_(2)concentration increases at a rate of 1% per year until its quadrupling peak, i.e., 1468 ppm(ramp-up period), followed by a decrease of 1% per year until the present-day climate conditions, i.e., 367 ppm(ramp-down period). Although the CO_(2)concentration change is symmetric in time, the amount of summer rainfall anomaly in East Asia is increased 42% during a rampdown period than that during a ramp-up period when the two periods of the same CO_(2)concentration are compared. This asymmetrical rainfall response is mainly due to an enhanced El Ni?o-like warming pattern as well as its associated increase in the sea surface temperature in the western North Pacific during a ramp-down period. These sea surface temperature patterns enhance the atmospheric teleconnections and the local meridional circulations around East Asia, resulting in more rainfall over East Asia during a ramp-down period. This result implies that the removal of CO_(2)does not guarantee the return of regional rainfall to the previous climate state with the same CO_(2)concentration.

关键词： CO_(2)concentration East Asian summer monsoon Asymmetric rainfall El Ni?o-like warming

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Mirizzi syndrome in an anomalous cystic duct:A case report

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World Journal of Gastroenterology 2007年第41期13卷 5527-5529页

作者： Cheol Woong Jung Byung wook Min Tae Jin song Gil Soo son Hong Sik Lee Seung Joo Kim Jun Won Um Department of Surgery Korea University College of Medicine126-15-Ga Anam-DongSungbuk-GuSeoul 136-705Korea Department of Internal Medicine Korea University College of Medicine126-15-Ga Anam-DongSungbuk-GuSeoul 136-705Korea

Mirizzi syndrome is a rare complication of gallstone disease,and results in partial obstruction of the common bile duct or a cholecystobiliary fistula. Moreover,congenital anatomical variants of the cystic duct are common,occurring in 18%-23% of cases,but Mirizzi syndrome underlying an anomalous cystic duct is an important clinical consideration. Here,we present an unusual case of typeⅠMirizzi syndrome with an uncommon anomalous cystic duct,namely,a low lateral insertion of the cystic duct with a common sheath of cystic duct and common bile duct.

关键词： Bile duct diseases and surgery Cholelithiasis Cholelithiasis and surgery, Cystic duct Cholangiography

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Perceived risk as a barrier to appropriate diagnosis of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第48期20卷 18360-18366页

作者： Eunmi Ahn Ki Young son Dong wook Shin Min Kyu Han Hyejin Lee Ah Reum An Eun Ho Kim Be Long Cho Department of Family Medicine Seoul National University Hospital Cancer Survivorship Clinic Seoul National University Cancer HospitalSeoul 110-744 South Korea

AIM: To evaluate perceived risk, diagnostic testing, and acceptance of a diagnosis of irritable bowel syndrome (IBS) among the Korean laypersons.

关键词： Diagnostic testing Patient attitude Positive diagnosis Functional gastrointestinal disease Irritable bowel syndrome

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