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Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress

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Animal Nutrition 2022年第4期11卷 87-101页

作者： Jun Sik Eom Da Som Park sang Jin lee Bon-Hee Gu Shin Ja lee sang-Suk lee Seon-Ho Kim Byeong-woo Kim Sung Sill lee Myunghoo Kim Institute of Agriculture and Life Science Gyeongsang National UniversityJinju52828Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang50463Republic of Korea Life and Industry Convergence Research Institute Pusan National UniversityMiryang50463Republic of Korea University-Centered Labs Gyeongsang National UniversityJinju52828Republic of Korea Ruminant Nutrition and Anaerobe Laboratory Department of Animal Science and TechnologySunchon National UniversitySuncheon57922Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju52828Republic of Korea

Heat stress(HS)damages livestock by adversely affecting physiological and immunological ***,fundamental understanding of the metabolic and immunological mechanisms in animals under HS remains elusive,particularly in *** understand the changes on metabolic and immune responses in steers under HS condition,we performed RNA-sequencing and proton nuclear magnetic resonance spectroscopy-based metabolomics on HS-free(temperature humidity index[THI]value:64.92±0.56)and HS-exposed(THI value:79.13±0.56)Jersey steer(n=8,body weight:559.67±32.72 kg).This study clarifies the metabolic changes in 3 biofluids(rumen fluid,serum,and urine)and the immune responses observed in the peripheral blood mononuclear cells of HS-exposed *** integrated approach allowed the discovery of HS-sensitive metabolic and immunological *** metabolomic analysis indicated that HS-exposed steers showed potential HS biomarkers such as isocitrate,formate,creatine,and riboflavin(P<0.05).Among them,there were several integrative metabolic pathways between rumen fluid and ***,HS altered mRNA expression and immune-related signaling pathways.A meta-analysis revealed that HS decreased riboflavin metabolism and the expression of glyoxylate and dicarboxylate metabolism-related ***,metabolic pathways,such as the hypoxia-inducible factor-1 signaling pathway,were downregulated in immune cells by HS(P<0.05).These findings,along with the datasets of pathways and phenotypic differences as potential biomarkers in steers,can support more in-depth research to elucidate the interrelated metabolic and immunological *** would help suggest new strategies to ameliorate the effects of HS,including disease susceptibility and metabolic disorders,in Jersey steers.

关键词： Heat stress Jersey steer Metabolome Transcriptome Immunity Metabolism

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Enrichment by air classification of indium components from In-containing scrap powders scraped by sand-blasting chamber shields of sputter coaters

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Rare Metals 2010年第1期29卷 1-8页

作者： Sungkyu lee Soo-Bok Jeong Hang-Chul Jung Hyun Seon Hong Yongseung Yun sang Mo woo Plant Engineering Center Institute for Advanced Engineering633-2 Goan-ri Baegam-myeon Cheoin-gu Yongin-si Gyeonggi-do 449-863 Korea Division of Chemical and Materials Engineering Ajou University 5 Wonchon Youngtong Suwon Gyeonggi-do 443-749 Korea Minerals and Materials Processing Division Korea Institute of Geo-science and Mineral Resources (KIGAM) 30 Gajeong-dong Yuseong-gu Daejeon 305-350 Korea Plant Engineering Center Institute for Advanced Engineering633-2 Goan-ri Baegam-myeon Cheoin-gu Yongin-siGyeonggi-do 449-863 Korea 9 Digit Co. Ltd. 20BL-10L Namdong Industrial Complex428-9 Nonhyeon-dong Namdong-gu Incheon 405-848 Korea

Raw scrap powders containing 10 wt.% In were recovered by sand-blasting chamber shields of sputter coaters and used as a sole source of indium components for both sieving and air-classification. Sieving was performed first as a feasibility test, and enrichment of indium component was possible up to 19 wt.% with a mesh size of 635. With this experimental basis, the raw scrap powders were air-classified into 12 lots according to the revolution per minute （r/min） of a single horizontally arranged classifying wheel： 4000, 6000, 8000, 10000, 12000, and 14000 r/rain. The particle cut size varied from 56 to 5 μm with turbo wheel speeds corresponding to 4000 to 14000 r/min, respectively, and enrichment of indium component was possible in fine overflow fractions at all turbo wheel speeds while the indium components were not concentrated in all of the coarse underflow fractions. The grade of the indium components became higher with decreasing particle size of the air-classified scrap powders, with the highest grade obtained in the fine overflow fraction with a turbo wheel speed of 14000 r/min. The amount of indium in the fine overflow fractions varied between 15.9 wt.% and 31.5 wt.%. All in all, the grade or purity of the indium component improved rather significantly from 15.9 wt.% to 31.5 wt.% by air-classification, but this also resulted in overall decrease in recovery rate from 99.33% to 49.64%. Therefore, enrichment and separation of indium should be optimized for maximum recovery and grade of the indium components, which can be used as raw materials in the subsequent electro-refining processes.

关键词： indium air-classification recycling indium tin oxide gas-cyclone dry dispersion

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Effect of atractylenolide Ⅲ on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2081-2092页

作者： Na Yeon Kim Myoung Ok Kim sangsu Shin woo‑Sung Kwon Bomi Kim Joon Yeop lee sang In lee Department of Animal Science and Biotechnology Kyungpook National UniversitySangjuGyeong‑sangbuk‑do37224Republic of Korea Research Institute for Innovative Animal Science Kyungpook National UniversitySangjuGyeongsangbuk‑do 37224Republic of Korea National Institute for Korean Medicine Development Gyeongsan 38540Republic of Korea

Background The intestinal epithelium performs essential physiological functions,such as nutrient absorption,and acts as a barrier to prevent the entry of harmful *** are prevalent contaminants found in ani-mal feed that exert harmful effects on the health of ***(ZEA)is produced by the Fusarium genus and induces gastrointestinal dysfunction and disrupts the health and immune system of ***,we evaluated the molecular mechanisms that regulate the effects of ZEA on the porcine intestinal *** Treatment of IPEC-J2 cells with ZEA decreased the expression of E-cadherin and increased the expression of Snai1 and Vimentin,which induced Snail1-mediated epithelial-to-mesenchymal transition(EMT).In addition,ZEA induces Snail-mediated EMT through the activation of TGF-β*** treatment of IPEC-J2 cells with atractyle-nolideⅢ,which were exposed to ZEA,alleviated *** Our findings provide insights into the molecular mechanisms of ZEA toxicity in porcine intestinal epi-thelial cells and ways to mitigate it.

关键词： Atractylenolide III Epithelial–mesenchymal transition IPEC-J2 cells Snail TGF-beta signaling Zearalenone

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Surgical outcome of pancreatic cancer using radical antegrade modular pancreatosplenectomy procedure

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World Journal of Gastroenterology 2012年第39期18卷 5595-5600页

作者： Ye Rim Chang Sung-Sik Han sang-Jae Park Seung Duk lee Tae Suk Yoo Young-Kyu Kim Tae Hyun Kim sang Myung woo woo Jin lee Eun Kyung Hong Department of Surgery Seoul National University HospitalSeoul 110-744South Korea Center for Liver Cancer National Cancer CenterGyeonggido 411-764South Korea

AIM:To evaluate the surgical outcomes following radical antegrade modular pancreatosplenectomy (RAMPS) for pancreatic cancer. METHODS:Twenty-four patients underwent RAMPS with curative intent between January 2005 and June 2009 at the National Cancer Center, South Korea. Clinicopathologic data, including age, sex, operative findings, pathologic results, adjuvant therapy, postop-erative clinical course and follow-up data were retro-spectively collected and analyzed for this study. RESULTS:Twenty-one patients (87.5%) underwent distal pancreatectomy and 3 patients (12.5%) underwent total pancreatectomy using RAMPS. Nine patients (37.5%) underwent combined vessel resection, including 8 superior mesenteric-portal vein resections and 1 celiac axis resection. Two patients (8.3%) underwent combined resection of other organs, including the colon, stomach or duodenum. Negative tangential margins were achieved in 22 patients (91.7%). The mean tumor diameter for all patients was 4.09 ± 2.15 cm. The 2 patients with positive margins had a mean diameter of 7.25 cm. The mean number of retrieved lymph nodes was 20.92 ± 11.24 and the node positivity rate was 70.8%. The median survival of the 24 patients was 18.23 ± 6.02 mo. Patients with negative margins had a median survival of 21.80 ± 5.30 mo and those with positive margins had a median survival of 6.47 mo (P = 0.021). Nine patients (37.5%) had postoperative complications, but there were no postoperative mortalities. Pancreatic fistula occurred in 4 patients (16.7%):2 patients had a grade A fistula and 2 had a grade B fistula. On univariate analysis, histologic grade, positive tangential margin, pancreatic fistula and adjuvant therapy were significant prognostic factors for survival. CONCLUSION:RAMPS is a feasible procedure for achieving negative tangential margins in patients with carcinoma of the body and tail of the pancreas.

关键词： Carcinoma Pancreas Surgical resection Sur-vival Radical antegrade modular pancreatosplenectomy

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Role of oregano and Citrus species-based essential oil preparation for the control of coccidiosis in broiler chickens

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1089-1097页

作者： Francisco Xavier Gordillo Jaramillo Da-Hye Kim sang Hyeok lee Sun-Kwan Kwon Rajesh Jha Kyung-woo lee Department of Animal Science and Technology Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Republic of Korea Harim Bio Research Center Jeilfeed Co.LTD136 Techno2-roYuseong-guDeajeon-si 34025Republic of Korea Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agricultural and Human ResourcesUniversity of Hawaii at ManoaHonoluluHI 96822USA

Background:Due to presence of drug-resistant Eimeria strains and raised public health safety concerns about drug residues in the meat,there is renewed interest in the search for natural alternatives to the coccidiosis control *** study was conducted to test the anticoccidial efficacy of oregano and Citrus spp.-based essential oils for ***:A total of 2807-day-old broiler chicks were fed a control diet or diets with salinomycin or essential oils for up to 35 d of *** d 14,half of the control groups and the treated groups were orally challenged with a coccidiosis vaccine at 25 times higher than the recommended vaccine *** diet-fed chickens that were gavaged with phosphate-buffered saline were considered non-challenged control ***:Eimeria challenge or dietary additives failed to affect growth performance during the 7 to 20 d growth period although essential oil-fed chickens exhibited the lowest body wight gain(P=0.332)and the highest feed conversion ratio(P=0.062).Oocysts in the litter were detected in the challenged control diet group and the challenged/essential oil-fed groups at 21 and 35 d,*** dismutase activity in the serum was elevated(P=0.059)in the salinomycin-fed chickens compared to the challenged ***-1-acid glycoprotein was decreased by 28.7%in the salinomycin-fed chickens but increased by 38.1%in the essential oil group compared with the challenged control *** control group exhibited a significantly higher cooking loss of the thigh meat,compared to the non-challenged control diet group,which was marginally mitigated by dietary supplementation with essential *** fed essential oil-added diet had the highest branched-chain fatty acids contents in the ***:In conclusion,this study shows that oregano and Citrus-based essential oil preparation did not affect growth performance in broiler chickens challenged with the coccidiosis vaccine nor did Eimeria-spec

关键词： Broiler chickens Coccidiosis Essential oils Growth performance Salinomycin

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Development of a variable rate applicator for uniform fertilizer spreading

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International Journal of Agricultural and Biological Engineering 2019年第2期12卷 82-89页

作者： Cheol-woo Han sang-yoon lee Young-ki Hong Gi-young Kweon Department of Bio-Industrial Machinery Engineering(Institute of Agriculture and Life Science) Gyeongsang National UniversityJinju 52828Korea Department of Agriculture Engineering National Academy of Agricultural ScienceRDAJeonju 54875Korea

Environmental impact and economic concerns have driven a variable rate technology(VRT).Spinner spreaders were mainly used for granular fertilizer application since they are simple in design,inexpensive,and can cover large ***,the spreader was not adequate for VRT because uniformity changes drastically while varying application ***,the purpose of this study was to develop a variable rate applicator with uniform spreading patterns.A commercial spreader was modified with a controller and electric actuators for controlling fertilizer discharge directions and *** was established to determine the optimum discharge direction according to the fertilizer application *** uniformity of spreading patterns in accordance with the spread amount per set unit area was evaluated by the statistical coefficient of variation(CV)lower than 15%is assumed to prevent damage to the *** results showed that CVs were 8%,9%,and 8%,respectively,for a tractor in race track mode(adjacent passes in same direction of travel)at 200 kg/hm^(2),300 kg/hm^(2),and 400 kg/hm^(2).This indicates that the fertilizer was spread uniformly,while the coefficient of variation was 12%at 200 kg/hm^(2) in back and forth mode(adjacent passes in the opposite direction of travel).Overall,the results suggest that the race track mode is suitable for operation of a tractor to ensure uniform spreading of fertilizer when applying at variable *** future goal is to establish a system for automatic variable rate application according to location in connection with soil analysis and geographic information systems.

关键词： variable rate technology fertilizer application uniform spreading spinner granular applicator fertilizer amount control

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Characterization and sensor application of cellulose electro-active paper (EAPap)

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Chinese Science Bulletin 2009年第15期54卷 2703-2707页

作者： lee sang-woo KIM Joo-Hyung KIM Jaehwan KIM Heung Soo Creative Research Center for EAPap Actuator Mechanical Engineering Department Inha University School of Mechanical and Automotive Engineering Catholic University of Daegu

As a novel piezoelectric material, the mechanical and piezoelectric properties of cellulose electro-active paper (EAPap) were studied. Young's modulus of piezoelectric EAPap was dependant on the material orientation as compared with other EAP materials. The highest Young's modulus was obtained at 0° direction, while the highest direct piezoelectric charge constant was achieved at 45°. By measuring the induced output voltage from the thin piezoelectric cellulose film under the applied impact force, we demonstrate that piezoelectric EAPap film has a potential for sensor applications.

关键词：传感器应用纤维素膜压电材料表征杨氏模量压电性能电子机械输出电压

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Mononeuropathy multiplex associated with systemic vasculitis:A case report

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World Journal of Clinical Cases 2021年第7期9卷 1741-1747页

作者： Hyun Jun Chae Jung woo Kim Yae Lim lee Jeong Hwan Park sang Yoon lee Department of Rehabilitation Medicine Seoul National University College of MedicineSeoul National University HospitalSeoul 07061South Korea Department of Pathology Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061South Korea Department of Rehabilitation Medicine Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061South Korea

BACKGROUND Vasculitis,a systemic disorder with inflammation of blood vessel walls,can develop broad spectrum of signs and symptoms according to involvement of various organs,and therefore,early diagnosis of vasculitis is *** herein describe a patient who developed a special case of systemic vasculitis with mononeuropathy multiplex,rectal perforation and antiphospholipid syndrome(APS)presented with pulmonary *** SUMMARY A 61-year-old woman visited hospital with complaints of myalgia and occasional *** was initially diagnosed as proctitis and treated with antibiotics,however,there was no *** addition,she also complained right foot drop with hypesthesia,and left 2^(nd) and 3^(rd) finger tingling *** underwent nerve conduction study for evaluation,and it revealed sensorimotor polyneuropathy in the left arm and bilateral *** sural nerve biopsy strongly suggested vasculitic *** on nerve biopsy and clinical manifestation,she was diagnosed with vasculitis and treated with immunosuppressive *** treatment,sudden rectal perforation and pulmonary thromboembolism occurred,and further laboratory study suggested probable concomitant *** Hartmann operation was performed for rectal perforation,and anti-coagulation therapy was started for *** few cycles of immunosuppressive therapy,tingling sensation and weakness in her hand and foot had been partially recovered and vasculitis was considered to be *** Vasculitis can be presented with a variety of signs and symptoms,therefore,clinicians should always consider the possibility of diagnosis.

关键词： Systemic Vasculitis Peripheral nervous system diseases Mononeuropathies Antiphospholipid syndrome Pulmonary embolism Case report

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Endoscopic management of occluded metal biliary stents:Metal versus 10F plastic stents

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World Journal of Gastroenterology 2010年第42期16卷 5347-5352页

作者： Won Jae Yoon Ji Kon Ryu Jung Won lee Dong-Won Ahn Yong-Tae Kim Yong Bum Yoon sang Myung woo woo Jin lee Division of Gastroenterology Department of Internal MedicineSeoul National University College of Medicine101 Daehang-roJongno-guSeoul110-744South Korea Center for Liver Cancer National Cancer Center323 Ilsan-roIlsandong-guGoyang-siGyeonggi-do410-769South Korea

AIM:To compare the efficacy of self-expandable metal stents(SEMSs) with 10F plastic stents(PSs) in the endoscopic management of occluded ***:We retrospectively reviewed the medical records of 56 patients who underwent SEMS insertion for palliation of unresectable malignant biliary obstruction between 2000 and 2007 and subsequent endoscopic retrograde biliary drainage(ERBD) with SEMS or PS for initial SEMS occlusion between 2000 and ***:Subsequent ERBD with SEMS was performed in 29 patients and with PS in *** median time to stent occlusion after subsequent ERBD was 186 d in the SEMS group and 101 d in the PS group(P= 0.118).Overall median stent patency was 79 d for the SEMS group and 66 d for the PS group(P = 0.379).The mean number of additional biliary drainage procedures after subsequent ERBD in patients that died(n = 50) during the study period was 2.54 ± 4.12 for the SEMS group and 1.85 ± 1.95 for the PS group(P = 0.457).The mean total cost of additional biliary drainage procedures after the occlusion of subsequent SEMS or PS was $410.04 ± 692.60 for the SEMS group and $630.16 ± 671.63 for the PS group(P = 0.260).Tumor ingrowth as the cause of initial SEMS occlusion was the only factor associated with a shorter time to subsequent stent occlusion(101 d for patients with tumor ingrowth vs 268 d for patients without tumor ingrowth,P = 0.008).CONCLUSION:Subsequent ERBD with PSs offered similar patency and number of additional biliary drainage procedures compared to SEMSs in the management of occluded SEMS.

关键词： Stents Biliary tract neoplasms Obstructive jaundice Endoscopy Endoscopic retrograde cholangiopancreatography

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High morbidity in myocardial infarction and heart failure patients after gastric cancer surgery

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World Journal of Gastroenterology 2015年第21期21卷 6631-6638页

作者： sang-Ho Jeong Young-woo Kim Wansik Yu sang Ho lee Young Kyu Park Seong-Heum Park In Ho Jeong sang Eok lee Yongwhi Park Young-Joon lee Department of Surgery Gyengsang National University Department of Surgery Gastric Cancer BranchNational Cancer Center Department of Surgery Kyungpook National University Hospital Deparment of Surgery Kosin University College of Medicine Department of Surgery Chonnam National University Hwasun Hospital Department of Surgery South Korea University College of Medicine South Korea University Ansan hospital Department of Surgery Cheju National University Department of Surgery Konyang University Hospital Department of Cardilolgy Gyengsang National University

AIM:To evaluate to morbidity and mortality differences between 4 underlying heart diseases,myocardial infarction(MI),angina pectoris(Angina),heart failure(HF),and atrial fibrillation(AF),after radical surgery for gastric ***:We retrospectively collected data from 221 patients of a total of 15167 patients who underwent radical gastrectomy and were preoperatively diagnosed with a history of Angina,MI,HF,or AF in 8 ***:We find that the total morbidity rate is significantly higher in the MI group(44%) than the Angina(15.7%),AF(18.8%),and HF(23.1%) groups(P < 0.01).Moreover,we note that the risk for postoperative cardiac problems is higher in patients with a history of HF(23.1%) than patients with a historyof Angina(2.2%),AF(4.3%),or MI(6%; P = 0.01).The HF and MI groups each have 1 case of cardiogenic ***:We conclude that MI patients have a higher risk of morbidity,and HF patients have a higher risk of postoperative cardiac problems than Angina or AF.

关键词： Stomach neoplasm Comorbidity Morbidity Heart disease Heart failure

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