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Altered gut microbiota patterns in COVID-19:Markers for inflammation and disease severity

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World Journal of Gastroenterology 2022年第25期28卷 2802-2822页

作者： Chiranjib Chakraborty Ashish Ranjan Sharma Manojit Bhattacharya Kuldeep Dhama sang-soo lee School of Life Science and Biotechnology Adamas UniversityKolkata 700126India Institute for Skeletal Aging&Orthopaedic Surgery Hallym UniversityChuncheon-si 24252South Korea Department of Zoology Fakir Mohan UniversityBalasore 756020India Division of Pathology Indian Council of Agricultural Research(ICAR)-Indian Veterinary Research Institute(IVRI)Bareilly 243122Uttar PradeshIndia Institute for Skeletal Aging&Orthopedic Surgery Hallym UniversityChuncheon-si 24252South Korea

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection leads to a severe respiratory illness and alters the gut microbiota,which dynamically interacts with the human immune *** alterations include decreased levels of beneficial bacteria and augmentation of opportunistic ***,we describe critical factors affecting the microbiota in coronavirus disease 2019(COVID-19)*** include,such as gut microbiota imbalance and gastrointestinal symptoms,the pattern of altered gut microbiota composition in COVID-19 patients,and crosstalk between the microbiome and the gut-lung axis/gut-brain-lung ***,we have illustrated the hypoxia state in COVID-19 associated gut microbiota *** role of ACE2 in the digestive system,and control of its expression using the gut microbiota is discussed,highlighting the interactions between the lungs,the gut,and the brain during COVID-19 ***,we address the gut microbiota in elderly or co-morbid patients as well as gut microbiota dysbiosis of in severe *** clinical trials to understand the role of probiotics in COVID-19 patients are listed in this *** inflammation is one of the major driving forces for COVID-19 symptoms and gut microbiome disruption and is associated with disease ***,understanding the role of the gut microbiota in immune modulation during SARS-CoV-2 infection may help improve therapeutic strategies for COVID-19 treatment.

关键词： COVID-19 Inflammation Gut microbiota Therapeutic

PPARγLBD and its ligand specificity reveal a selection of potential partial agonist:Molecular dynamics based T2D drug discovery initiative

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BIOCELL 2021年第4期45卷 953-961页

作者： BIDYUT MALLICK ASHISH RANJAN SHARMA MANOJIT BHATTACHARYA sang-soo lee CHIRANJIB CHAKRABORTY Department of Applied Science Galgotias College of Engineering and TechnologyKnowledge Park-IIGreater Noida201306India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Korea Department of Zoology Fakir Mohan UniversityVyasa ViharBalasore756020India Department of Biotechnology School of Life Science and BiotechnologyAdamas UniversityKolkata700126India

PPARγis a peroxisome proliferator-activated receptor(PPAR)family protein and is a target for type 2 diabetes(T2D).In this paper,we have performed a molecular docking analysis between ligand molecules(CID9816265,CID11608015,CID20251380,CID20251343,CID20556263,CID624491,CID42609928,and CID86287562)and PPARγto determine the ligand *** also helps to understand the ligand-binding domain(LBD)activity of PPARγduring the binding of the ***,a molecular dynamics simulation study was performed to determine the ligand biding stability in the PPARγ*** ligand specificity informed us about the potentiality of selecting a partial *** study also shows the binding conformation of Ceramicine B having hydrogen bonding affinity with a tricyclic polar head and stabilized theβ-sheet *** the other hand,the tricyclic polar head of nimbolide also formed hydrogen bonding(Ser342),but it shows a lesser degree of stabilization in theβ-sheet *** shows the binding conformation of partial agonist(PPARγ)in the Pocket-II of PPARγLBD,which has a significant role in stabilizing theβ-sheet *** might help to regulate ERK/Cdk5 mediated phosphorylation of *** study helps us understand the valid pose of a set of ligands confirmation and target protein conformation using docking and molecular dynamics *** in silico study will also help to initiate a drug discovery process of T2D.

关键词： PPARγ Partial agonist Molecular simulation T2D Drug discovery

The 2019 novel coronavirus disease(COVID-19) pandemic: A zoonotic prospective

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Asian Pacific Journal of Tropical Medicine 2020年第6期13卷 242-246页

作者： Chiranjib Chakraborty Ashish Ranjan Sharma Manojit Bhattacharya Garima Sharma sang-soo lee Department of Biotechnology School of Life Science and BiotechnologyAdamas UniversityBarasat-Barrackpore RdKolkataWest Bengal 700126India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Gangwon-doRepublic of Korea Neuropsychopharmacology and Toxicology Program College of PharmacyKangwon National UniversityRepublic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),a novel coronavirus(CoV),has recently emerged as a significant pathogen for humans and the cause for the recent outbreak of the 2019 novel coronavirus disease(COVID-19)throughout the *** developing any preventive measure,an understanding of the zoonotic pattern for this virus is a *** should have a clear knowledge of its reservoir host,its distribution pattern and spreading *** about zoonotic reservoirs and its transmission among them can help to understand the COVID-19 *** this article,we discuss about the bats as the zoonotic reservoir of several CoV strains,co-existence of bats and CoV/viruses,the sequence similarity of SARS-CoV-2 with bat SARS-like CoV,the probable source of the origin of SARS-CoV-2 strain and COVID-19 outbreak,intermediate host of CoVs and SARS-CoV-2,human to human transmission and the possibility to maintain the zoonotic *** knowledge about the zoonotic reservoir of SARS-CoV-2 and its transmission ability may help develop the preventive measures and control for the future outbreak of CoV.

关键词： SARS-CoV-2 COVID-19 Coronavirus Zoonotic reservoir

Anti-inflammatory effects of traditional mixed extract of medicinal herbs(MEMH)on monosodium urate crystal-induced gouty arthritis

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Chinese Journal of Natural Medicines 2017年第8期15卷 561-575页

作者： Ju-Suk Nam Supriya Jagga Ashish Ranjan Sharma Joon-Hee lee Jong Bong Park Jun-Sub Jung sang-soo lee Institute For Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheonGangwon-do24252Republic of Korea Institute of Natural Medicine College of MedicineHallym UniversityChucheonGangwon-do 24252Republic of Korea Hana Oriental Clinic ChucnheonGangwon-do 24433Republic of Korea

Korean oriental medicine prescription is widely used for the treatment of gouty diseases. In the present study, we investigated anti-inflammatory effects of modified Korean herbal formulation, mixed extract of medicinal herbs(MEMH), and its modulatory effects on inflammatory mediators associated with gouty arthritis. Both in vitro and in vivo studies were carried out to assess the anti-inflammatory efficacy of MEMH on monosodium urate(MSU) crystals-induced gouty inflammation. MSU crystals stimulated human chondrosarcoma cell line, SW1353, and human primary chondrocytes were treated with MEMH in vitro. The expression levels of pro-inflammatory mediators and metalloproteases were analyzed. The effect of MEMH on NFκB signaling pathway in SW1353 cells was examined. Effect of MEMH on the mR NA expression level of pro-inflammatory mediators and chemotactic factor from human monocytic cell line, THP-1, was also analyzed. The probable role of MEMH in the differentiation process of osteoblast like cells, SaO S-2, after MSU treatment was also observed. To investigate the effects of MEMH in vivo, MSU crystals-induced ankle arthritic model was established. Histopathological changes in affected joints and plasma levels of pro-inflammatory mediators(IL-1β and TNFα) were recorded. MEMH inhibited NFκB signaling pathway and COX-2 protein expression in chondrocytes. MSU-induced mR NA expressions of pro-inflammatory mediators and chemotactic cytokines were suppressed by MEMH. In MSU crystals-induced ankle arthritic mouse model, administration of MEMH relieved inflammatory symptoms and decreased the plasma levels of IL-1β and TNFα. The results indicated that MEMH can effectively inhibit the expression of inflammatory mediators in gouty arthritis, demonstrating its potential for treating gouty arthritis.

关键词： Gout Monosodium urate crystals Inflammation Chondrocyte Oriental medicine

A pilot proof-of-concept study of a modified device for one-step endoscopic ultrasound-guided biliary drainage in a new experimental biliary dilatation animal model

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World Journal of Gastroenterology 2014年第19期20卷 5859-5866页

作者： Tae Hoon lee Jun Hyuck Choi sang soo lee Hyun Deuk Cho Dong Wan Seo sang-Heum Park Sung Koo lee Myung-Hwan Kim Do Hyun Park Division of Gastroenterology Department of Internal MedicineSoonchunhyang University School of MedicineCheonan HospitalChungcheongnamdo 330-721South Korea Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineSeoul 138-736South Korea Department of Pathology Soonchunhyang University School of MedicineCheonan HospitalChungcheongnam-do 330-721South Korea

AIM: To evaluate the technical feasibility of a modified tapered metal tip and low profile introducer for one-step endoscopic ultrasound (EUS)-guided biliary drainage (EUS-BD) in a new experimental biliary dilatation ... 详细信息

关键词： Endoscopic ultrasound Biliary drainage Biliary dilation Feasibility Complications

Field Trial of 40 Gbit/s ETDM Prototype System over 219 km of Installed Single Mode Fiber

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光学学报 2003年第S1期23卷 659-660页

作者： sang soo lee Hyun Woo Cho sang Kyu Lim Ki Ho Han Jin soo Han Moo Jung Chu Je soo Ko Kyeong-Mo Yoon Yong-Gi lee Optical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Communication Department Electronics and Telecommunications Research Institute Deajeon KoreaOptical Transmission Research Team Technical Laboratory KT Deajeon KoreaOptical Transmission Research Team Technical Laboratory KT Deajeon Korea

Transmission of 40Gbit/s NRZ signal was successfully demonstrated over 219km of installed SMF in KT's Daejeon area network. After transmission, the measured power penalty was 0.5dB for all the tributary channels.

关键词： of ET be over Field Trial of 40 Gbit/s ETDM Prototype System over 219 km of Installed Single Mode Fiber

Modeling the impacts of temperature and precipitation changes on soil CO_2 fluxes from a Switchgrass stand recently converted from cropland

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Journal of Environmental Sciences 2016年第5期28卷 15-25页

作者： Liming Lai Sandeep Kumar Rajesh Chintala Vance N. Owens David Clay Joseph Schumacher Abdul-Sattar Nizami sang soo lee Rashad Rafique Department of Plant Science South Dakota State University Brookings South Dakota 57007 USA. North Central Sun Grant Center South Dakota State University Brookings South Dakota 57007 USA Center of Excellence in Environmental Studies (CEES) King Abdulaziz University Abdullah Sulayman Jeddah 22254 Saudi Arabia kangwon National University Chuncheon 200-701 South Korea Joint global Change Research Institute Pacific Northwest National Lab College Park Maryland 20740 USA

Switchgrass（Panicum virgatum L.） is a perennial C_4 grass native to North America and successfully adapted to diverse environmental conditions. It offers the potential to reduce soil surface carbon dioxide（CO_2） fluxes and mitigate climate change. However, information on how these CO_2 fluxes respond to changing climate is still lacking. In this study, CO_2 fluxes were monitored continuously from 2011 through 2014 using high frequency measurements from Switchgrass land seeded in 2008 on an experimental site that has been previously used for soybean（Glycine max L.） in South Dakota, USA. DAYCENT, a process-based model, was used to simulate CO_2 fluxes. An improved methodology CPTE[Combining Parameter estimation（PEST） with ＂Trial and Error＂ method] was used to calibrate DAYCENT. The calibrated DAYCENT model was used for simulating future CO_2 emissions based on different climate change scenarios. This study showed that：（i） the measured soil CO_2 fluxes from Switchgrass land were higher for 2012 which was a drought year, and these fluxes when simulated using DAYCENT for long-term（2015–2070） provided a pattern of polynomial curve;（ii） the simulated CO_2 fluxes provided different patterns with temperature and precipitation changes in a long-term,（iii） the future CO_2 fluxes from Switchgrass land under different changing climate scenarios were not significantly different, therefore, it can be concluded that Switchgrass grown for longer durations could reduce changes in CO_2 fluxes from soil as a result of temperature and precipitation changes to some extent.

关键词： Carbon dioxide Switchgrass DAYCENT Climate change

Endoscopic gastrojejunostomy with a natural orifice transluminal endoscopic surgery technique

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World Journal of Gastroenterology 2013年第22期19卷 3447-3452页

作者： Tae Jun Song Dong Wan Seo Su Hui Kim Do Hyun Park sang soo lee Sung Koo lee Myung-Hwan Kim Department of Internal Medicine Inje University Ilsan Paik Hospital Koyang 411-706 South Korea Department of Internal Medicine University of Ulsan College of Medicine Asan Medical Center Seoul 138-736 South Korea Asan Institute for Life Science Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea

AIM: To determine the technical feasibility and safety of an endoscopic gastrojejunostomy with a pure natural orifice transluminal endoscopic surgery (NOTES) technique using a T-anchoring device in a porcine survival model. METHODS: An endoscopic gastrojejunostomy with a pure NOTES technique using a T-anchoring device was performed on 10 healthy female minipigs weighing approximately 40 kg each under general anesthesia. All procedures were performed with a transgastric approach using a 2-channel therapeutic endoscope. RESULTS: The transgastric gastrojejunostomy was technically successful in all cases. A total of four to sixstitched pairs of a T-anchoring device were used to secure the anastomosis. The median time required to enter the peritoneal cavity and pull the small bowel into the stomach was 34 min (range: 19-41 min); the median time required to suture the anastomosis was 67 min (range: 44-78 min). An obstruction of the efferent limb occurred in one case, and a rupture of the anastomosis site occurred in another case. As a result, the functional success rate was 80% (8/10). Small bowel adhesion to the stomach and liver occurred in one case, but the anastomosis was intact without leakage or obstruction. CONCLUSION: A transgastric gastrojejunostomy with a T-anchoring device may be safe and technically feasible. A T-anchoring device may provide a simple and effective endoscopic suturing method.

关键词： Natural orifice transluminal endoscopic surgery Endoscopy Pigs Aanastomosis

Diagnostic performance of the current risk-stratified approach with computed tomography for suspected choledocholithiasis and its options when negative finding

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 366-372页

作者： Hyun Woo lee Tae Jun Song Do Hyun Park sang soo lee Dong-Wan Seo Sung Koo lee Myung-Hwan Kim Jae Hyuck Jun Ji Eun Moon Yeon Han Song Digestive Disease Center and Research Institute Department of Internal MedicineSoonchunhyang University School of MedicineBucheonKorea Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineAsan Medical CenterSeoulKorea Division of Gastroenterology Department of Internal MedicineUniversity of Eulji College of MedicineEulji Medical CenterDaejeonKorea Department of Biostatistics Clinical trial centerSoonchunhyang University Bucheon HospitalBucheonKorea

Background:Several studies evaluated the current guideline of the American Society for Gastrointestinal Endoscopy(ASGE)and reported only suboptimal *** study evaluated the diagnostic performance of the ASGE guideline based on computed tomography(CT)and role of endoscopic ultrasonography(EUS)and magnetic resonance cholangiopancreatography(MRCP)in patients with suspected choledocholithiasis but negative CT ***:Patients with suspected choledocholithiasis undergoing ERCP between January 2016 and January 2017 were retrospectively *** patients underwent CT to detect *** or MRCP was performed when the CT scan showed negative *** were classified into the high and intermediate-risk groups,based on predictors from the ASGE ***:Of 583 patients with suspected choledocholithiasis,340(58.3%)had stones on ERCP(65.9%in the high-risk group and 40.6%in the intermediate-risk group).The accuracy of ASGE guideline for CT was 63.98%(79.12%sensitivity,42.80%specificity)and 36.02%(20.88%sensitivity,57.20%specificity)in the high-risk and intermediate-risk groups,*** 103 patients in the high-risk group underwent both CT and US,the accuracy of CT was higher than that of US for detecting choledocholithiasis(78.64%vs.53.40%),with a significant difference in area under the curve(AUC)(0.78 vs.0.59,P<0.001).Of 339 with negative CT finding,the accuracy of EUS was higher than that of MRCP(90.91%vs.82.76%),but with no significant difference in AUC(0.91 vs.0.83,P=0.347).Conclusions:CT-based ASGE guideline showed superior diagnostic performance than US for predicting *** diagnostic options,EUS or MRCP,with negative CT finding showed comparable ***,the diagnostic modality should be selected based on availability,experience,cost,and contraindications.

关键词： Choledocholithiasis ASGE guideline Accuracy Endoscopic ultrasound Magnetic resonance cholangiopancreatography