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Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第26期18卷 3426-3434页

作者： Yang Hyun Baek Kyoung Tae Kim Sung Wook Lee Jin Sook Jeong Byeong Ho Park Kyung Jin Nam Jin han Cho young Hoon Kim young Hoon Roh Hyung Sik Lee young Min Choi sang young han Department of Internal Medicine Dong-A University College of MedicineBusan 602-103South Korea Department of Pathology Dong-A University College of MedicineBusan 602-103South Korea Department of Radiology Dong-A University College of MedicineBusan 602-103South Korea Department of Surgery Dong-A University College of MedicineBusan 602-103South Korea Department of Radiation Oncology Dong-A University College of MedicineBusan 602-103South Korea

AIM:To investigate the efficacy of hepatic arterial infusion chemotherapy(HAIC) using floxuridine(FUDR) in patients with advanced hepatocellular carcinoma(HCC) confined to the ***:Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at ourhospital between March 2005 and May *** the 34 patients,9 patients were classified as Child class C,and 18 patients had portal vein tumor thrombus(PVTT).One course of chemotherapy consisted of continuous infusion of FUDR(0.3 mg/kg during day 1-14) and dexamethasone(10 mg on day 1,4,7 and 11),and this treatment was repeated every 28 ***:Two patients(5.9%) displayed a complete response,and 12 patients(35.3%) had a partial *** tumor control rate was 61.8%.The median overall survival times were 15.3 mo,12.4 mo and 4.3 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0392).The progression-free survival was 12.9 mo,7.7 mo and 2.6 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0443).The cumulative survival differed significantly according to the Child-Pugh classification and the presence of *** addition to hepatic reserve capacity and PVTT,the extent of HCC was an independent factor in determining a poor *** most common adverse reactions to HAIC were mucositis,diarrhea and peptic ulcer disease,but most of these complications were improved by medical treatment and/or a delay of ***:The present study demonstrates that intra-arterial FUDR chemotherapy is a safe and effective treatment for advanced HCC that is recalcitrant to other therapeutic modalities,even in patients with advanced cirrhosis.

关键词： Hepatic arterial infusion chemotherapy Floxuridine Advanced hepatocellular carcinoma Child-Pugh classification Portal vein tumor thrombus

Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction

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World Journal of Gastroenterology 2006年第1期12卷 146-149页

作者： Ki-Jae Park Hong-Jo Choi Sung-Heun Kim sang-young han Sook-Hee Hong Jin-han Cho Hyung-Ho Kim Department of Surgery Dong-A University College of MedicinePusanSouth Korea Department of Internal Medicine Dong-A University College of Medicine.PusanSouth Korea Department of Pathology Dong-A University College of MedicinePusanSouth Korea Department of Radiology Dong-A University College of MedicinePusanSouth Korea Department of Surgery Seoul National University Bundang HospitalBundangKyunggi-DoSouth Korea

We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp. The patient was a 56-year-old man who suffered from rectal bleeding for one day. He initially visited his general practitioner and was diagnosed as having an intraluminal mass of 15 cm from the anal verge. Several hours after admission to our coloproctology clinic, he suddenly presented with lower abdominal cramping pain with rectal bleeding during his bowel preparation using polyethylene glycol electrolyte solution. An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum. Gastrograffin enema showed that the invaginated bowel segment was 3 cm from the anal verge. CT scan showed the typical finding of intussusception. We performed laparoscopic anterior resection and anastomosis after the sponge-on-the-stickassisted manual reduction. The permanent pathologic finding showed villotubular adenoma of the sigmoid colon.

关键词： Sigmoidorectal intussusception Adenomatouspolyp Laparoscopic resection

A Cu-Pd alloy catalyst with partial phase separation for the electrochemical CO_(2) reduction reaction

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Journal of Energy Chemistry 2024年第6期93卷 8-15,I0001页

作者： Gyeong Ho han Jung Yong Seo Minji Kang Myung-gi Seo youngheon Choi Soo young Kim sang Hyun Ahn School of Chemical Engineering and Material Science Chung-Ang UniversitySeoul 06974Republic of Korea Lotte Chemical Institute of Technology Daejeon 34110Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Cu catalysts can convert CO_(2) through an electrochemical reduction reaction into a variety of useful carbon-based ***,this capability provides an obstacle to increasing the selectivity for a single ***,we report a simple fabrication method for a Cu-Pd alloy catalyst for use in a membrane electrode assembly(MEA)-based CO_(2) electrolyzer for the electrochemical CO_(2) reduction reaction(ECRR)with high selectivity for CO *** the composition of the Cu-Pd alloy catalyst was fabricated at 6:4,the selectivity for CO increased and the production of multi-carbon compounds and hydrogen is *** a Cu-Pd alloy catalyst with 6:4 ratio as the cathode of the MEAbased CO_(2) electrolyzer showed a CO faradaic efficiency of 92.8%at 2.4 V_(cell).We assumed that these results contributed from the crystal planes on the surface of the Cu-Pd *** phases of the Cu-Pd alloy catalyst were partially separated through annealing to fabricate a catalyst with high selectivity for CO at low voltage and C_(2)H_4 at high *** results of CO-stripping testing confirmed that when Cu partially separates from the lattice of the Cu-Pd alloy,the desorption of~*CO is suppressed,suggesting that C-C coupling reaction is favored.

关键词： Cu-Pd catalyst Electrodeposition Electrochemical carbon dioxide reduction Partial phase separation Membrane electrode assembly-based electrolyzer

Gastric ischemia after epinephrine injection in a patient with liver cirrhosis

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World Journal of Gastroenterology 2013年第3期19卷 411-414页

作者： Su young Kim Seung-Hee han Kyung han Kim sang Ock Kim sang-young han Sung-Wook Lee Yang Hyun Baek Department of Internal Medicine Dong-A University College of MedicineBusan 602-715South Korea

Endoscopic epinephrine injection is relatively easy,quick and ***,it has a low rate of com-plications,and it is widely used for the management of nonvariceal upper gastrointestinal *** have been several case reports of gastric ischemia after en-doscopic injection *** intra-arterial in-jection may result in either spasm or thrombosis,leading to subsequent tissue ischemia or necrosis,although the stomach has a rich vascular supply and the vascular reserve of the intramural *** addition to endoscopic injection therapy,smoking,hypertension and atherosclerosis are risk factors of gastric ischemia. We report a case of gastric ischemia after submucosal epinephrine injection in a 51-year-old woman with hy-pertension and liver cirrhosis.

关键词： Hematemesis Epinephrine Gastric ischemia Liver cirrhosis Hypertension

Importance of dietary supplementation of soluble and insoluble fibers to sows subjected to high ambient temperatures during late gestation and effects on lactation performance

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Animal Nutrition 2024年第1期16卷 73-83页

作者： Seung Min Oh Abdolreza Hosseindoust sang Hun Ha Jun young Mun Joseph Moturi Habeeb Tajudeen Yo han Choi Su Hyup Lee Jin Soo Kim Gyeongbuk Livestock Research Institute Yeongju 63052 Republic of Korea Department of Animal Industry Convergence Kangwon National University Chuncheon 24341 Republic of Korea Swine Division National Institute of Animal Science Rural Development Administration Cheonan 31000 Republic of Korea Department of Swine Science Korea National University of Agriculture and Fisheries Jeonju 54874 Republic of Korea

Heat stress adversely affects sows' performance, which can be improved by applying proper nutritional strategies. This study was conducted to investigate the interactive effects of dietary fiber levels and sources on sows' reproductive performance, metabolic response during gestation, and the carry-over influence on litter performance in the lactation period during heat stress (average room temperature of 27.1 °C). Fifty-four multiparous sows (Landrace × Yorkshire; initial body weight of 236.3 ± 16 kg; 2, 3 and 4 parities) at d 90 of gestation were assigned to a 2 × 3 factorial arrangement (9 sows/treatment), involving 2 dietary fiber levels (4.5% and 6% crude fiber) and 3 dietary fiber sources (wheat bran [WB], palm kernel meal [PK], and beet pulp [BP]). Sows fed the BP diet had highest ( P < 0.01) feed intake and constipation index and lowest ( P < 0.01) farrowing duration. Piglet weight ( P = 0.041) and litter weight ( P < 0.01) at weaning were higher in sows in the BP treatment compared to PK treatment. Sows in the BP treatment showed the greatest ( P < 0.01) digestibility of crude protein and neutral detergent fiber. The fecal concentration of acetate was the lowest ( P < 0.01) in the PK treatment. Total short-chain fatty acid production was increased in the WB and BP treatments compared with the PK. Sows in the BP treatment showed the lowest ( P = 0.036) hair cortisol. The blood insulin concentration of sows was higher ( P = 0.026) in the high fiber (6%) treatment compared with the low fiber (4.5%) treatment at 90 min and 120 min after the meal. The concentration of phthalic acid, succinic acid, phenylethylamine, hydrocinnamic acid, iron, linoleic acid, glycerol, ketone, and formamide were increased ( P < 0.05) in the BP treatment compared with the WB. The BP treatment with high soluble fiber content improved the constipation index, farrowing duration, and litter performance, while high insoluble fibers increased sows comfort and reduced stress factor

关键词： Soluble fiber Insoluble fiber Beet pulp Wheat bran Palm kernel Metabolites

Rapidly aggravated skeletal muscle metastases from an intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2015年第6期21卷 1989-1993页

作者： Jiyoung Lee Sung Wook Lee sang young han Yang Hyun Baek Su young Kim Hyo In Rhyou Department of internal medicine Dong-A University College of Medicine

We present a rare case of intrahepatic cholangiocarcinoma(ICC)with multiple skeletal muscle *** patient was a 55-year-old Asian woman presenting with abdominal pain;abdominal and pelvic computed tomography and magnetic resonance cholangiopancreatography revealed an unresectable ICC with hepatic metastasis and metastastatic lymphadenopathy in the porto-caval *** 3 mo of treatment with palliativeradiotherapy and chemotherapy,magnetic resonance imaging of the thoracolumbar spine detected right psoas muscle and paraspinous muscle *** performed an ultrasound-guided percutaneous fineneedle biopsy that confirmed a similar pattern of poorly differentiated *** patient treated with palliative chemotherapy and achieved 10 mo of *** we report the first case quickly spread to multiple sites of muscle even though the three-month treatment,compare to the other cases reported muscle metastases at diagnosis.

关键词： Intrahepatic cholangiocarcinoma Skeletal muscle me

Dual in-situ observation of tribochemical and morphological evolution of single-layer WS_(2)and multi-layer WS_(2)/C coatings

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Friction 2024年第7期12卷 1580-1598页

作者： Yuzhen LIU Jae-Ho han Shusheng XU young Chan JUNG Dae-Eun KIM State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Department of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264000China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264000China

The outstanding tribological performance of transition metal dichalcogenides(TMDs)is attributed to their unique sandwich microstructure and low interlayer shear *** advantageous structure allows TMDs to demonstrate exceptional friction reduction ***,the incorporation of TMDs and amorphous carbon(a-C)in multi-layer structures shows excellent potential for further enhancing tribological and anti-oxidation *** carbon,known for its high ductility,chemical inertness,and excellent wear resistance,significantly contributes to the overall performance of these multi-layer *** gain an in-depth understanding of the tribological mechanism and evolution of TMDs’multi-layer coatings,a dual in-situ analysis was carried out using a tribometer equipped with a 3D laser microscope and a Raman *** innovative approach allowed for a comprehensive evolution of the tribological,topographical,and tribochemical characteristics of both single-layer WS_(2)and multi-layer WS_(2)/C coatings in real *** findings from the dual in-situ tribotest revealed distinct failure characteristics between the single-layer WS_(2)coating and the multi-layer WS_(2)/C *** single-layer WS_(2)coating predominantly experienced failure due to mechanical removal,whereas a combination of mechanical removal and tribochemistry primarily influenced the failure of the multi-layer WS_(2)/C *** tribological evolution process of these two coatings can be classified into four stages on the basis of their tribological behavior:the running-in stage,stable friction stage,re-deposition stage,and lubrication failure *** stage represents a distinct phase in the tribological behavior of the coatings and contributes to our understanding of their behavior during sliding.

关键词： In-situ analysis multi-layer coating tribology tribochemistry

Nonconvulsive status epilepticus disguising as hepatic encephalopathy

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World Journal of Gastroenterology 2015年第16期21卷 5105-5109页

作者： Yong Min Jo Sung Wook Lee sang young han Yang Hyun Baek Ji Hye Ahn Won Jong Choi Ji young Lee sang Ho Kim Byeol A Yoon Department of Internal Medicine Dong-A University School of Medicine Department of Neurology Dong-A University School of Medicine

Nonconvulsive status epilepticus has become an important issue in modern neurology and *** is based on difficulty in definitively elucidating thecondition and its various clinical phenomena and on our inadequate insight into the intrinsic pathophysiological *** nonconvulsive status epilepticus being a situation that requires immediate treatment,this disorder may not be appreciated as the cause of mental status *** the pathophysiology of nonconvulsive status epilepticus remains unknown,this disorder is thought to lead to neuronal damage,so its identification and treatment are *** status epilepticus should be considered in the differential diagnosis of patients with liver cirrhosis presenting an altered mental *** report a case of a 52-year-old male with liver cirrhosis presenting an altered mental *** was initially diagnosed with hepatic encephalopathy but ultimately diagnosed with nonconvulsive status epilepticus by electroencephalogram.

关键词： Liver cirrhosis Hepatic encephalopathy Nonconvulsive status epilepticus Electroencephalogram

Retreatment with peginterferon and ribavirin in chronic hepatitis C

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World Journal of Gastroenterology 2015年第6期21卷 1994-1999页

作者： Yong Min Jo Sung Wook Lee sang young han Yang Hyun Baek Soo young Kim Woo Jae Kim Ji Hye Ahn Ji young Lee Department of Internal Medicine Dong-A University School of Medicine

The development of boceprevir and telaprevir was a major step forward in the treatment of chronic hepatitis *** addition,the treatment of these infections has been recently revolutionized by the approval of sofosbuvir and ***,there are several challenges associated with the application of noveldrugs,such as new and more frequent adverse events,new drug interactions,and excessively high treatment *** additional concern is viral *** considerations highlight the fact that direct-acting antiviral agents are not a panacea and may not be the best option for all patients who are in need of *** retrospective study revealed that the sustained virologic response was not significantly reduced following peginterferon and ribavirin retreatment compared with the new *** suggest that patients who experience relapse shortly after completing treatment with peginterferon and ribavirin have a reasonable chance of achieving a sustained virologic response when retreated with these drugs alone.

关键词： Chronic hepatitis C Direct-acting antiviral agents