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Crushed Gold Shell Nanoparticles Labeled with Radioactive Iodine as a Theranostic Nanoplatform for Macrophage-Mediated Photothermal Therapy

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Nano-Micro Letters 2019年第2期11卷 244-257页

作者： sang Bong lee Jae-Eon lee Sung Jin Cho Jungwook Chin sang Kyoon Kim In-Kyu lee sang-woo lee Jaetae lee Yong Hyun Jeon New Drug Development Center Daegu-Gyeongbuk Medical Innovation FoundationDaeguSouth Korea Department of Biomaterials Science College of Natural Resources and Life Science/Life and Industry Convergence Research InstitutePusan National UniversityPusanSouth Korea Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease Kyungpook National University HospitalDaegu 702-210South Korea Department of Nuclear Medicine Kyungpook National University HospitalDaegu 702-210South Korea Department of Internal Medicine Kyungpook National University School of MedicineDaegu 700-721South Korea Daegu-Gyeongbuk Medical Innovation Foundation Daegu 360-4South Korea [Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation FoundationDaegu 360-4South Korea

Plasmonic nanostructure-mediated photothermal therapy(PTT) has proven to be a promising approach for cancer treatment,and new approaches for its effective delivery to tumor lesions are currently being *** study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells(124I-Au@AuCBs) as a theranostic nanoplatform.124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without *** the administration of 124I-Au@AuCB-labeled macrophages to colon tumors,intensive signals were observed at tumor lesions,and subsequent in vivo PTT with laser irradiation yielded potent antitumor *** results indicate the considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases.

关键词： Photothermal therapy Radionuclide crushed gold shell nanoballs Macrophage-mediated delivery

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Intermediate-scale Analysis of Landscape Characteristics Affecting Edge Formation in Burned Forests in Samcheok,Korea

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Journal of Mountain Science 2014年第2期11卷 384-397页

作者： sang-woo lee Myoung-Soo WON Joo-Mee lee Hai-Gyoung KIM Department of Design Konkuk University Kwangjin-Gu Hwayang-DongSeoul 143-701 South Korea Division of Forest Disaster and Fire prevention Korea Forest Research Institute Graduate Program Department of Landscape Architecture & Urban Planning Texas A&M University College Station Yirakjae Landscape Studio Songdong-Gu Hongik-Dong 210Seoul 133-880 South Korea

Compared to burn interiors, edges exhibit distinct biotic and abiotic conditions that include microclimate, wind speed, sunlight levels, soil composition, moisture content, nutrient availability, population density, and species diversity. This study characterized the landscapes in which burned forest edges formed in Samcheok, Korea. Over the study area, 500-m2 grid cells were generated to capture landscape characteristics. Grid cells intersecting burn boundary lines were designated as edge, while cells without these lines were classified as the interior of burned areas. Topographic variables including slope, elevation, topographic wetness index, solar radiation index, and proportions of fuel and land use types within grid cells were computed in a geographical information system(GIS). Correlation analysis with modified t-test and regression tree analysis were performed to explore the influences of landscape variables on edge formation with avoiding spatial autocorrelation problems. The results indicated that edges formed at low elevations with mild slopes, high topographic wetness, and low solar radiation. Edges were unlikely to form in areas dominated by Japanese red pines at low elevations. Moreover, heterogeneous land use/cover types contributed significantly to edge formation. Different forest management strategies for different landscape conditions can be more effective for enhancing resilience of forests to fire. Reducing susceptible fuel types might be effective at low elevations, while enhancing forest heterogeneity might be more effective at high elevations.

关键词： Forest fire Modified t-test, Edge formation Fuel type Topographic characteristics

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Another new variant of Bouveret's syndrome

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World Journal of Gastroenterology 2009年第3期15卷 378-379页

作者： Seong-Heum Park sang-woo lee Tae-Jin Song Department of Surgery Korea UniversityAnsan Hospital516Gojan-dongDanwon-guAnsanGyeonggi-do 425-707South Korea Department of Gastroenterology Korea UniversityAnsan Hospital516Gojan-dongDanwon-guAnsanGyeonggi-do 425-707South Korea

Although Bouveret's syndrome,*** outlet obstruction by a large gallstone impacted in the proximal duodenum secondary to a cholecystoduodenal fistula,is rare,its pathogenesis and clinical features are well ***,existence of variant forms of the syndrome are not well known,and as far as we know,only two cases of variant Bouveret's syndrome have been described in the English-language *** present a case of another new variant of Bouveret's syndrome in a 54-year-old Korean woman.

关键词： Duodenal obstruction Biliary fistula Gallstones

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Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery

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World Journal of Gastroenterology 2017年第35期23卷 6474-6481页

作者： Dong-won lee Ja Seol Koo Jung Wan Choe sang Jun Suh Seung Young Kim Jong Jin Hyun Sung woo Jung Young Kul Jung Hyung Joon Yim sang woo lee Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan Hospital

AIM To investigate the factors affecting diagnostic delay and outcomes of diagnostic delay in inflammatory bowel disease(IBD) METHODS We retrospectively studied 165 patients with Crohn's disease(CD) and 130 patients with ulcerative colitis(UC) who were diagnosed and had follow up durations > 6 mo at Korea University Ansan Hospital from January 2000 to December 2015. A diagnostic delay was defined as the time interval between the first symptom onset and IBD diagnosis in which the 76^(th) to 100^(th) percentiles of patients were *** The median diagnostic time interval was 6.2 and 2.4 mo in the patients with CD and UC, respectively. Among the initial symptoms, perianal discomfort before diagnosis(OR = 10.2, 95%CI: 1.93-54.3, P = 0.006) was associated with diagnostic delays in patients with CD; however, no clinical factor was associated with diagnostic delays in patients with UC. Diagnostic delays, stricturing type, and penetrating type were associated with increased intestinal surgery risks in CD(OR = 2.54, 95%CI: 1.06-6.09; OR = 4.44, 95%CI: 1.67-11.8; OR = 3.79, 95%CI: 1.14-12.6, respectively). In UC, a diagnostic delay was the only factor associated increased intestinal surgery risks(OR = 6.81, 95%CI: 1.12-41.4).CONCLUSION A diagnostic delay was associated with poor outcomes, such as increased intestinal surgery risks in patients with CD and UC.

关键词： Diagnostic delay Intestinal surgery Inflammatory bowel disease Crohn’s disease Ulcerative colitis

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Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics

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Nano Research 2017年第3期10卷 767-775页

作者： Geonwook Yoo Heekyeong Park Minjung Kim Won Geun Song Seokhwan Jeong Min Hyung Kim Hyungbeen lee sang woo lee Young KiHong Min Goo lee Sungho lee Sunkook Kim School of Electronic Engineering Soongsil University Seou106978 Republic of Korea Multi-Functional Nano/Bio Electronics Lab. Kyung Hee University Gyeonggi 17104 Republic of Korea Department of Biomedical Engineering Yonsei University Wonju 26493 Republic of Korea Korea Electronics Technology Institute Gyeonggi 13488 Republic of Korea

Various approaches have been proposed for point-of-care diagnostics, and in particular, optical detection is preferred because it is relatively simple and fast. At the same time, field-effect transistor （FET）-based biosensors have attracted great attention because they can provide highly sensitive and label-free detection. In this work we present highly sensitive, epidermal skin-type point-of-care devices with system-level integration of flexible MOS2 FET biosensors, read-out circuits, and light-emitting diode （LEDs） that enable real-time detection of prostate cancer antigens （PSA）. Regardless of the physical forms or mechanical stress conditions, our proposed high-performance MoS2 biosensors can detect a PSA concentration of 1 ***-1 without specific surface treatment for anti-PSA immobilization on the MoS2 surface on which we characterize and confirm physisorption of anti-PSA using Kelvin probe force microscopy （KPFM） and tapping-mode atomic force microscopy （tm-AFM）. Furthermore, current modulation induced by the binding process was stably maintained for longer than 2-3 min. The results indicate that flexible MoS2-based FET biosensors have great potential for point-of-care diagnostics for prostate cancer as well as other biomarkers.

关键词： epidermal skin biomarker MoS2 biosensor real-time point-of-care diagnostics

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Development of enterohepatic fistula after embolization in ileal gastrointestinal stromal tumor: A case report

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World Journal of Gastroenterology 2013年第43期19卷 7816-7819页

作者： Yun Ho lee Ja Seol Koo Chang Ho Jung sang Yoon Chung Jae Joong lee Seung Young Kim Jong Jin Hyun Sung woo Jung Rok Seon Choung sang woo lee Jai Hyun Choi Division of Gastroenterology Department of Internal MedicineKorea University Ansan Hospital516 Gojan-dongDanwon-guAnsan-siGyeonggi-do 425-707South Korea

Gastrointestinal stromal tumor(GIST)is a rare mesenchymal tumor of the gastrointestinal tract that has been associated with the formation of fistulas to adjacent organs in few case ***,GIST with enterohepatic fistula has not been *** we report the case of an enterohepatic fistula that occurred after embolization of a liver mass originating in the distal *** 87-year-old woman was hospitalized for *** initial conventional endoscopy,a bleeding focus in the gastrointestinal tract was not *** of massive hematochezia,enteroscopy was performed through the anus.A protruding,ulcerative mass was found in the distal ileum that was suspected to be the source of the bleeding;a biopsy sample was *** was not successful in controlling the bleeding;therefore,embolization was *** embolization,the patient developed a high fever and severe abdominal tenderness with rebound ***-up abdominopelvic computed tomography revealed an enterohepatic fistula between the liver and distal *** fistula was treated surgically by segmental resection of the distal ileum and unlooping of the liver mass.

关键词： Gastrointestinal stromal tumor Enterohepatic fistula Therapeutic embolization Bleeding Ileal gastrointestinal stromal tumor

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Does Environmental Risk Affect Human Migration Behavior?

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Journal of Geographic Information System 2017年第4期9卷 493-504页

作者： Seong Nam Hwang sang-woo lee Environmental Science Program Department of Biology Southeast Missouri State University Cape Girardeau USA Department of Forestry and Landscape Architecture Konkuk University Seoul Korea

This study tests the influence of environmental risks associated with floods, hurricanes, and hazardous material releases on human migration behavior. With close attention to a function of environmental risk factors, socio-demographic attributes, hazard risk and locational attributes were measured and correlated to the standardized number of recent arrivals and long term residents at the census tract level. Two groups (i.e., recent arrivals and long-term residents) were created to compare their moving behavior. The results indicate that flood risk showed little relationship to either recent arrivals or long-term residents. These results are consistent with past research which suggests that people tend to ignore their vulnerability to natural hazards. However, both groups had negative relationships to the risk from hurricanes and hazardous material releases. This counter-intuitive result suggests that other factors, such as proximity to employment opportunities or property tax advantages, need to be examined. In particular, the recent arrivals were negatively related to chemical risk while long-term residents were positively related to chemical risks, indicating that people that just arrived and old residents are somewhat different in perceiving environmental risks. In addition, the results of this study suggest that people are objective about environmental risks in selecting their habitat. However, once the habitat is settled, people’s perception of the risks may be interfered or reduced by other factors.

关键词： GIS Environmental Hazards Emergency Management Moving Behavior Environmental Risk

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How good is cola for dissolution of gastric phytobezoars?

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World Journal of Gastroenterology 2009年第18期15卷 2265-2269页

作者： Beom Jae lee Jong-Jae Park Hoon Jai Chun Ji Hoon Kim Jong Eun Yeon Yoon Tae Jeen Jae Seon Kim Kwan Soo Byun sang woo lee Jae Hyun Choi Chang Duck Kim Ho sang Ryu Young-Tae Bak Division of Gastroenterology Department of Internal MedicineKorea University College of MedicineSeoul 152-703South Korea

AIM:To evaluate the efficacy of cola treatment for gastric phytobezoars,including ***:A total of 17 patients(range:48 to 78 years) with symptomatic gastric phytobezoars treated with cola and adjuvant endoscopic therapy were *** liters of cola lavage(10 cases) or drink(7 cases) were initially used,and then endoscopic fragmentation was done for the remnant bezoars by using a lithotripsy basket or a polypectomy *** overall success of dissolving a gastric phytobezoars with using three liters of cola and the clinical and endoscopic findings were compared retrospectively between four cases of complete dissolution by using only cola and 13 cases of partial dissolution with ***:After 3 L of cola lavage or drinking,a complete dissolution of bezoars was achieved in four patients(23.5%),while 13 cases(76.5%) were only partially ***(4 of 6 cases) were observed more frequently than diospyrobezoars(0 of 11) in the group that underwent complete dissolution(P = 0.006).Gender,symptom duration,size of bezoar and method of cola administration were not significantly different between the two *** of 13 patients with residual bezoars were completely treated with a combination of cola and endoscopic ***:The rate of complete dissolution with three liters of cola was 23.5%,but no case of diospyrobezoar was completely dissolved using this ***,pretreatment with cola may be helpful and facilitate endoscopic fragmentation of gastric phytobezoars.

关键词： Gastric phytobezoars Diospyrobezoars Cola Dissolution Clinical efficacy

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Exophytic inflammatory myofibroblastic tumor of the stomach in an adult woman:A rare cause of hemoperitoneum

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World Journal of Gastroenterology 2008年第1期14卷 136-139页

作者： Seong-Heum Park Jong-Han Kim Byung wook Min Tae Jin Song Gil Soo Son Seung Joo Kim sang woo lee Hwan-Hoon Chung Ju Han lee Jun Won Um Department of Surgery Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Internal Medicine Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Radiology Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea Department of Pathology Korea University College of Medicine 126-1 5-Ga Anam-Dong Sungbuk-Gu Seoul 136-705 Korea

Inflammatory myofibroblastic tumor （INT） of the stomach in adults is extremely rare, with unpredictable prognosis. We present a 55-year-old woman with a gastric IMT. She experienced sudden abdominal pain 4 d previously. Physical examination showed mild abdominal tenderness in the hypogastrium, but no palpable abnormal abdominal mass. Abdominal CT showed a mass of approximately 8 cm in the gastrocolic ligament. On laparoscopic exploration, unexpected hemoperitoneum of approximately 1.5 L of blood was found, and an exophytic gastric mass of approximately 10 cm, appeared from the anterior wall of the gastric body along the greater curvature. Laparoscopy further showed that non- clotting blood in the abdominal cavity seemed to be from the gastric tumor. After conversion to open surgery for more precise evaluation of the cause of hemoperitoneum and the large friable tumor, gastric wedge resection, including the tumor, was conducted. The final diagnosis was consistent with IMT that originated from the gastric wall.

关键词： Stomach disease Stomach neoplasms Hemoperitoneum Myofibroma Granuloma Plasma cell Stomach surgery

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Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis

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World Journal of Gastroenterology 2022年第44期28卷 6294-6309页

作者： Kang Nyeong lee Oh Young lee Hoon Jai Chun Jin Il Kim Sung Kook Kim sang woo lee Kyung Sik Park Kook Lae lee Suck Chei Choi Jae-Young Jang Gwang Ha Kim In-kyung Sung Moo In Park Joong Goo Kwon Nayoung Kim Jae Jun Kim Soo Teik lee Hyun Soo Kim Ki Bae Kim Yong Chan lee Myung-Gyu Choi Joon Seong lee Hwoon-Yong Jung Kwang Jae lee Jie-Hyun Kim Hyunsoo Chung Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Korea University Anam HospitalSeoul 02841South Korea Department of Internal Medicine The Catholic University of KoreaYeouido ST.Mary’s HospitalSeoul 07260South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine Korea University Ansan HospitalAnsan-si 15355South Korea Department of Internal Medicine Keimyung University Dongsan HospitalDaegu 42601South Korea Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061South Korea Department of Internal Medicine Wonkwang University HospitalIksan 54538South Korea Department of Internal Medicine KyungHee University Medical CenterSeoul 02447South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 47241South Korea Department of Internal Medicine KKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Kosin University Gaspel HospitalBusan 49267South Korea Department of Internal Medicine Daegu Catholic University Medical CenterDaegu 42471South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam-si 13620Gyeonggi-doSouth Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju-si 54907South Korea Department of Internal Medicine Chonnam National University HospitalGwangju 61469South Korea Department of Internal medicine Chungbuk National University School of MedicineCheong Ju 28644South Korea Department of Internal Medicine Severance HospitalSeoul 03722South Korea Department of Internal Medicine The Catholic University of KoreaSeoul ST.Mary’s HospitalSeoul 06591South Korea Digestive Disease Center Soon

BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal ***’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent *** To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight *** primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week *** secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life *** profiles and serum gastrin levels were compared between the *** Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life ***,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the *** Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week *** suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE.

关键词： Gastroesophageal reflux Esophagitis Proton pump inhibitors Heartburn Quality of life

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