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Spontaneous rupture of adrenal myelolipoma as a cause of acute flank pain:A case report

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World Journal of Clinical Cases 2021年第22期9卷 6552-6556页

作者： Dong soo Kim jeong Woo Lee sang Hyub Lee Department of Urology School of MedicineKyung Hee UniversitySeoul 02447South Korea

BACKGROUND Adrenal myelolipoma is a rare,benign,non-functioning mass that occurs in the adrenal *** is composed of an admixture of hematopoietic elements and mature adipose tissue,similar to bone *** at large sizes,adrenal myelolipomas are usually asymptomatic and often incidentally found by ultrasonography or computed tomography(CT)*** paper describes an unusual case of adrenal myelolipoma presenting as flank *** SUMMARY A 50-year-old male with severe right flank pain underwent a CT scan revealing a huge mass extending into the suprarenal *** mass showed a fat component with retroperitoneal *** tumor was treated laparoscopically,and pathologic examination revealed features of myelolipoma originating from the adrenal *** Adrenal myelolipomas are generally asymptomatic and can be treated ***,rupture and hemorrhage of the tumor can cause symptoms requiring surgical removal.

关键词： Adrenal neoplasms Myelolipoma Adrenal glands Case report

Long-term antibiotic use and risk of hepatocellular carcinoma later in life: a nationwide cohort study of 9.8 million participants

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Cancer Communications 2023年第10期43卷 1174-1177页

作者： Seogsong jeong Sun Jae Park Minseo Kim Young Jun Park Seulggie Choi Jooyoung Chang Ji soo Kim Yun Hwan Oh Ahryoung Ko sang Min Park Department of Biomedical Sciences Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Biomedical Informatics CHA University School of MedicineSeongnamSouth Korea Department of Medicine College of MedicineJeonbuk National UniversityJeonjuSouth Korea Medical Research Center Genomic Medicine InstituteSeoul National UniversitySeoulSouth Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea International Healthcare Center Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Family Medicine Chung-Ang University Gwangmyeong HospitalChung-Ang University College of MedicineGwangmyeongSouth Korea Department of Family Medicine Seoul National University HospitalSeoulSouth Korea

Dear Editor,Antibiotics are considered indispensable in numerous treatments against infectious ***,their over-prescription and widespread use are emerging as important global issues,as they lead to resistant bacteria,reducing the efficacy of antibiotics[1].The defined daily doses per 1,000 habitants per day for antibiotics in South Korea is 28,which is much higher than the average of Organization for Economic Co-operation and Development countries[1].In animal studies,antibiotic tigecycline was found to inhibit the proliferation and induce apoptosis of hepatocellular carcinoma(HCC)cells[2].In addition,isoprenoid antibiotic was found to suppress the growth and invasion of HCC by targeting the signal transducer and activator of the transcription 3 signaling cascade[3].Despite evidence of the beneficial effects of antibiotics against HCC,evidence regarding their effects on the longterm development of HCC is *** regarding the incidence of HCC is provided in the Supplementary file.

关键词： doses invasion nationwide

Critical factors to inhibit water-splitting side reaction in carbon-based electrode materials for zinc metal anodes

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Carbon Energy 2022年第6期4卷 1080-1092页

作者： Dong Hyuk Kang Eunji Lee Beom Sik Youn Son Ha Jong Chan Hyun Juhee Yoon Dawon Jang Kyoung Sun Kim Hyungsub Kim sang Moon Lee Sungho Lee Hyoung-Joon Jin Hyung-Kyu Lim Young soo Yun KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSeongbuk-guSouth Korea Division of Chemical Engineering and Bioengineering Kangwon National UniversityChuncheonGangwon-doSouth Korea Department of Eco-Polymer Science and Engineering Inha UniversityIncheonMichuhol-guSouth Korea Carbon Composite Materials Research Center Institute of Advanced Composite MaterialsKorea Institute of Science and Technology(KIST)Jeollabuk-doSouth Korea Department of Chemical and Biological Engineering Korea UniversitySeoulSeongbuk-guSouth Korea Neutron Science Division Korea Atomic Energy Research Institute(KAERI)DaejeonYuseong-guSouth Korea Research Center for Materials Analysis Korea Basic Science Institute(KBSI)DaejeonYuseong-guSouth Korea Department of Integrative Energy Engineering Korea UniversitySeoulSeongbuk-guSouth Korea

Zinc metal anodes(ZMA)have high theoretical capacities(820 mAh g−1 and 5855 mAh cm−3)and redox potential(−0.76 V *** hydrogen electrode),similar to the electrochemical voltage window of the hydrogen evolution reaction(HER)in a mild acidic electrolyte system,facilitating aqueous zinc batteries competitive in next-generation energy storage ***,the HER and byproduct formation effectuated by water-splitting deteriorate the electrochemical performance of ZMA,limiting their *** this study,a key factor in promoting the HER in carbon-based electrode materials(CEMs),which can provide a larger active surface area and guide uniform zinc metal deposition,was investigated using a series of threedimensional structured templating carbon electrodes(3D-TCEs)with different local graphitic orderings,pore structures,and surface *** ultramicropores of CEMs are the determining critical factors in initiating HER and clogging active surfaces by Zn(OH)2 byproduct formation,through a systematic comparative study based on the 3D-TCE series *** the 3D-TCEs had a proper graphitic structure with few ultramicropores,they showed highly stable cycling performances over 2000 cycles with average Coulombic efficiencies of≥99%.These results suggest that a well-designed CEM can lead to high-performance ZMA in aqueous zinc batteries.

关键词： aqueous batteries carbon electrode hydrogen evolution reaction multivalent ion zinc metal anode

Goniosynechialysis for secondary angle closure glaucoma in a pseudophakic patient after vitrectomy and silicone oil injection

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 914-916页

作者： Jonghoon Shin Hyeshin jeon Ik soo Byon Ji-Woong Lee Department of Ophthalmology Pusan National University School of Medicine Medical Research Institute Pusan National University Hospital Department of Ophthalmology Pusan National University Yangsan Hospital

Dear Sir,Iam Jonghoon Shin,from the Department of Ophthalmology of Pusan National University Hospital,Busan,Korea.I write to present a patient with secondary angle closure glaucoma(SACG)after vitrectomy and silicone o... 详细信息

关键词： SO IOP Goniosynechialysis for secondary angle closure glaucoma in a pseudophakic patient after vitrectomy and silicone oil injection UBM

Dynamic changes of protein corona compositions on the surface of zinc oxide nanoparticle in cell culture media

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 90-97页

作者： Vo-Van Giau Yoon-Hee Park Kyu-Hwan Shim sang-Wook Son Seong-soo A. An Department of Bionanotechnology and Gachon Medical Research Institute Gachon University and Gachon Medical Research Institute Seongnam Korea Laboratory of Cell Signaling and Nanomedicine Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science Korea University College of Medicine Seoul Korea

The potential applications of nanomaterials used in nanomedicine as ingredients in drug delivery systems and in other products continue to expand. When nanomaterials are introduced into physiological environments and driven by energetics, they readily associate proteins forming a protein corona (PC) on their surface. This PC could result in an alteration of the nanomatcrial's surface characteristics, affecting their interaction with cells due to conformational changes in adsorbed protein molecules. However, our current understanding of nanobiological interactions is still very limited. Utilizing a liquid chromatography-mass spectroscopy/mass spectroscopy technology and a Cytoscape plugin (ClueGO) approach, we examined the composition of the PC for a set of zinc oxide nanoparticles (ZnONP) from cell culture media typically and further analyzed the biological interaction of identified proteins, respectively. In total, 36 and 33 common proteins were investigated as being bound to ZnONP at 5 min and 60 min, respectively. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Proteins bound to the surface of nanoparticles that may modify the structure, therefore the function of the adsorbed protein could be consequently affect the complicated biological processes.

关键词： ZnONPs nanoparticles protein corona ClueGO

Development of 3D bicontinuous metal-intermetallic composites through subsequent alloying process after liquid metal dealloying

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Journal of Magnesium and Alloys 2023年第11期11卷 4274-4281页

作者： Jee Eun Jang Jihye Seong soo-Hyun Joo Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Dankook UniversityCheonan 31116Republic of Korea

This study presents a novel process for the fabrication of metal-intermetallic composites with a 3D bicontinuous structure, achieved through a combination of liquid metal dealloying(LMD) and subsequent alloying. Initially, porous Ti structures are produced using the LMD process, followed by immersion in a molten Mg-3Al(wt%) metal. Due to the higher thermodynamic miscibility of Al with Ti compared to Mg, the concentration of Al in the Ti matrix increases as the immersion time increases. This results in a sequential phase transition within the Ti matrix: α-Ti → Ti_(3)Al → Ti Al. The phase transition considerably affects the hardness and strength of the composite material,with the Mg-Ti_(3)Al-Ti Al composite exhibiting a maximum hardness nearly twice as high as that of the conventional Mg-Ti composite. This innovative process holds potential for the development of various bicontinuous metal-intermetallic composites.

关键词： Liquid metal dealloying Subsequent alloying Metal–intermetallic composite 3D bicontinuous structure Hardness

Emerging role of ^(18)F-fluorodeoxyglucose positron emission tomography for guiding management of hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第11期25卷 1289-1306页

作者： sang Mi Lee Hong soo Kim sangheun Lee jeong Won Lee Department of Nuclear Medicine Soonchunhyang University Cheonan Hospital Department of Internal Medicine Soonchunhyang University Cheonan Hospital Division of Hepatology Department of Internal medicineCatholic Kwandong University College of MedicineInternational St.Mary’s Hospital Institute for Health and Life Science Catholic Kwandong University College of MedicineInternational St.Mary’s Hospital Department of Nuclear Medicine Catholic Kwandong University College of MedicineInternational St.Mary’s Hospital

Hepatocellular carcinoma(HCC) is one of major causes of cancer mortality worldwide. For decades, ^(18)F-fluorodeoxyglucose(FDG) positron emission tomography(PET) has been widely used for staging, predicting prognosis, and detecting cancer recurrence in various types of malignant diseases. Due to low sensitivity of FDG PET for detecting intrahepatic HCC lesions, the clinical value of FDG PET in HCC patients has been limited. However, recent studies with diverse analytic methods have shown that FDG PET has promising role in aiding management of HCC patients. In this review, we will discuss the clinical role of FDG PET for staging, predicting prognosis, and evaluating treatment response in HCC. Further, we will focus on recent clinical studies regarding implication of volumetric FDG PET parameters, the significance of FDG uptake in HCC for selecting treatment and predicting treatment response, and the use of radiomics of FDG PET in HCC.

关键词： Hepatocellular carcinoma Fluorodeoxyglucose F18 Positron emission tomography Staging Prognosis

Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

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World Journal of Gastroenterology 2016年第42期22卷 9427-9436页

作者： Junhyeon Cho sang soo Lee Yun Suk Choi Yejoo jeon Jung Wha Chung Joo Yeong Baeg Won Keun Si Eun Sun Jang Jin-Wook Kim sook-Hyang jeong Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Internal Medicine Gyeongsang National University Changwon Hospital Gyeongsang National University College of Medicine

AIM To clarify the prevalence of occult hepatitis B virus(HBV) infection(OBI) and the association between OBI and liver disease progression, defined as development of liver cirrhosis or hepatocellular carcinoma(HCC), worsening of Child-Pugh class, or mortality in cases of chronic hepatitis C virus(HCV) infection. METHODS This prospective cohort study enrolled 174 patients with chronic HCV infection(chronic hepatitis, n = 83; cirrhosis, n = 47; HCC, n = 44), and evaluated disease progression during a mean follow-up of 38.7 mo. OBI was defined as HBV DNA positivity in 2 or moredifferent viral genomic regions by nested polymerase chain reaction using 4 sets of primers in the S, C, P and X open reading frame of the HBV genome. RESULTS The overall OBI prevalence in chronic HCV patients at enrollment was 18.4%, with 16.9%, 25.5% and 13.6% in the chronic hepatitis C, liver cirrhosis and HCC groups, respectively(P = 0.845). During follow-up, 52 patients showed disease progression, which was independently associated with aspartate aminotransferase > 40 IU/L, Child-Pugh score and sustained virologic response(SVR), but not with OBI positivity. In 136 patients who were not in the SVR state during the study period, OBI positivity was associated with neither disease progression, nor HCC development. CONCLUSION The prevalence of OBI in chronic HCV patients was 18.4%, and OBI was not associated with disease progression in South Koreans.

关键词：肝炎 B 病毒丙肝病毒疾病控制 Oncogenesis

Protective effect of sulfated polysaccharides from a Celluclast-assisted extract of Hizikia fusiforme against ultraviolet B-induced photoaging in vitro in human keratinocytes and in vivo in zebrafish

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Marine Life Science & Technology 2019年第1期1卷 104-111页

作者： Lei Wang Jae Young Oh Hye-Won Yan Hyun soo Kim You-Jin jeon Department of Marine Life Sciences Jeju National UniversityJeju CityJeju Self-Governing Province 63243Republic of Korea Marine Science Institute Jeju National UniversityJeju CityJeju Self-Governing Province 63333Republic of Korea

Our previous study evaluated the in vitro and in vivo antioxidant activities of sulfated polysaccharides from a Celluclastassistedextract of Hizikia fusiforme (HFPS). The results indicate that HFPS possesses potent antioxidant activity and suggestthe potential use of HFPS to combat photoaging. In this study, we investigated the ultraviolet (UV) protective effect of HFPSin vitro in keratinocytes (HaCaT cells) and in vivo in zebrafish. The results indicate that HFPS significantly reduced thelevel of intracellular reactive oxygen species (ROS) and improved the viability of UVB-irradiated HaCaT cells. In addition,HFPS remarkably decreased apoptosis formation in UVB-irradiated HaCaT cells in a dose-dependent manner. The in vivotest results also demonstrate that HFPS significantly reduced intracellular ROS levels, cell death, NO production, and lipidperoxidation levels in UVB-irradiated zebrafish in a dose-dependent manner. These results suggest that HFPS possessesstrong in vitro and in vivo UV-protective effects, making it a potential ingredient in the cosmeceutical industry.

关键词： Hizikia fusiforme Sulfated polysaccharides Ultraviolet B