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Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan Kim Hyemi Eo sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Pull-out tests and slope stability analyses of nailing systems comprising single and multi rebars with grouted cement

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Journal of Central South University 2012年第1期19卷 262-272页

作者： sang-Soo jeon Construction Technology Research Center Department of Civil EngineeringInje UniversityObang-dong 607KimhaeKyungsangnam-Do #621-749Korea

The pull-out capacities for soil nailing systems comprising of one single 29 mm diameter(type A) and four 16 mm diameter(type B) rebars with grouted cement were examined.A field test and numerical analysis for the type A and type B systems were carried out to investigate the pull-out capacities and the slope stability reinforcement efficiency in soil and rock *** results of the pull-out tests show the mobilized shear force and load transfer characteristics with respect to soil *** load-displacement relationship was examined for both type A and type B *** stability analyses were carried out to study the relationships between soil and nail reinforcement and bending stiffness as well as combined axial tension and shear *** of safety were calculated in relation to the number of nails and their outside *** soil and rock slopes were included in this evaluation.

关键词： soil nailing bending resistance pull-out test finite difference method

Effect of geogrid reinforcement on soft and medium dense soils

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Journal of Central South University 2011年第5期18卷 1638-1645页

作者： jeon sang-Soo Department of Civil Engineering Construction Technology Research CenterINJE UniversityObang-dong 607KimhaeKyungsangnam-Do #621-749South Korea

The field tests were carried out to examine the reinforcement effect of a geogrid on various conditions of embankment height,the number of passages of vibratory roller,the number of reinforced layer of geogrid,and soil *** test results of the dynamic earth pressure indicate that the soil reinforced by geogrid is very effective to increase the stiffness of soil,especially in soft *** dynamic earth pressure ratio,which is defined as the ratio of dynamic earth pressure to self weight of soils,exponentially decreases as the embankment height *** dynamic earth pressure ratio increases up to 80% for soft soils reinforced by both one layer of geogrid in place of no reinforced soils and two layers in place of a single layer of geogrid.

关键词： dynamic earth pressure geogrid reinforced soils repetitive loading

Damage Pattern Recognition of Spatially Distributed Slope Damages and Rainfall Using Optimal GIS Mesh Dimensions

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Journal of Mountain Science 2014年第2期11卷 336-344页

作者： sang-Soo jeon Department of Civil & Urban Engineering Inje University

Damage assessment for slopes using geographical information system(GIS) has been actively carried out by researchers working on several government organizations and research institutes in Korea. In this study, 596 slope damages were examined to identify the types of damage associated with dip angles, dip directions, and heavy rainfall resulting from typhoons in South Korea. Heavy rainfall of 100 mm to 300 mm resulted in 80% at the investigated slope damages. A GIS database was developed for highways, rainfall, soil or rock geometry, and types of damage. A grid of rainfall intensity was generated from the records of maximum daily rainfall. Contours for slope damages and heavy rainfall using optimal GIS mesh dimensions were generated to visualize damage patterns and show substantially strong correlation of rainfall with slope damages. The combination of remote sensing with the GIS pattern recognition process described in this work are being expanded for a new generation of emergency response and rapid decision support systems.

关键词： Damage assessment Slope damages Rainfall GIS Typhoon

Roadbed behavior subjected to tilting-train loading at rail joint and continuous welded rail

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Journal of Central South University 2014年第7期21卷 2962-2969页

作者： jeon sang-Soo Department of Civil&Urban Engineering Inje University

The tilting-train is very attractive to the railroad users in the world due to the advantage of high speed in curved track using pre-existing infrastructure of ***-train has a unique allowable speed and mechanism especially in curved *** this work,when tilting-train is operated with the allowable speed,the behavior of roadbed is evaluated by examining its settlement and bearing ***,the stability of roadbed is estimated as the roadbed is in the condition of soft soil influenced by the weather effects and cyclic train *** results show that the roadbed settlement satisfies the allowable settlement when the elastic moduli of upper roadbed and in-situ soil are greater than 3800 and 4600 kN/m2 for rail joint and 2300 and 3300 kN/m2 for continuous welded rail(CWR).

关键词： railway roadbed tilting-train bearing capacity settlement

Areas vulnerable to natural disasters and damage estimation of infrastructure in Busan, Korea

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Journal of Central South University 2014年第4期21卷 1499-1507页

作者： jeon sang-Soo Department of Civil and Urban Engineering Inje University

Since the damages caused by disasters associated with climate anomalies and the diversification of the social structure increase every year, an efficient management system associated with a damage assessment of the areas vulnerable to disasters is demanded to prevent or mitigate the damages to infrastructure. The areas vulnerable to disasters in Busan, located at southeastern part of Korea, were estimated based on historical records of damages and a risk assessment of the infrastructure was performed to provide fundamental information prior to the establishment of the real-time monitoring system for infrastructure and establish disaster management system. The results are illustrated by using geographical information system(GIS) and provide the importance of the roadmap for comprehensive and specific strategy to manage natural disasters.

关键词： natural disaster damages risk assessment infrastructure disaster management system geographical information system

A speech enhancement algorithm to reduce noise and compensate for partial masking effect

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Journal of Central South University 2011年第4期18卷 1121-1127页

作者： jeon Yu-yong LEE sang-min Department of Electronic Engineering Inha University Institute for Information and Electronics Research Inha University

To enhance the speech quality that is degraded by environmental noise,an algorithm was proposed to reduce the noise and reinforce the *** minima controlled recursive averaging(MCRA) algorithm was used to estimate the noise spectrum and the partial masking effect which is one of the psychoacoustic properties was introduced to reinforce *** performance evaluation was performed by comparing the PESQ(perceptual evaluation of speech quality) and segSNR(segmental signal to noise ratio) by the proposed algorithm with the conventional *** a result,average PESQ by the proposed algorithm was higher than the average PESQ by the conventional noise reduction algorithm and segSNR was higher as much as 3.2 dB in average than that of the noise reduction algorithm.

关键词： speech enhancement noise reduction psychoacoustic property human hearing property

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra jeon Changmin Shin Sun-Young Kwon Sojin Shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Stochastic rules for predator and prey hunting and escape behavior in a lattice-based model

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International Journal of Biomathematics 2016年第6期9卷 181-190页

作者： Wonju jeon sang-Hee Lee Department of Mechanical Engineering Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea Division of Integrated Mathematics National Institute for Mathematical Sciences Daejeon 34047 Republic of Korea

Understanding of ecosystem resilience and stability requires comprehending predator- prey dynamics because ecosystems consist of dynamically interacting subsystems that include predator-prey relationships. This relationship is closely related to the hunting- escaping strategies employed by the predator and prey. Therefore, understanding the effects of hunting and escaping strategies on ecosystems will lead to a better under- standing of these systems. As an approach for describing the predator-prey interaction, lattice-based models have been adopted because this approach has strong advantages for simulating various dynamical processes of individual-individual interaction. In the models, each lattice cell is either considered as an attractive/repulsive cell, or an indi- vidual cell, or else it is empty. The attractive （or repulsive cell） can be interpreted as the prey （or predator） of the individual. These states allow us to incorporate the ecological processes of local antagonistic interactions, namely the spread of disturbances （by the predator） and regrowth or recovery （by the prey）. These processes are directly related to the strategic behavior of individuals, such as hunting and escaping. In this study, we suggest a simple and effective mapping formula as a stochastic rule to describe the hunt- ing and escaping behavior. This formula could be widely used not only in the behavior but also in competitive and cooperative relationships.

关键词： Hunting and escaping behavior strategic behavior predator-prey interaction individual-based model.