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Safety of acupotomy in a real-world setting:A prospective pilot and feasibility study

Journal of Integrative Medicine 2022年第6期20卷 514-523页

作者： sang-hoon yoon Chan-Young Kwon Hee-Geun Jo Jae-Uk Sul Hyangsook Lee Jiyoon Won Su Jin Jeong Jun-Hwan Lee Jungtae Leem Chung-Yeon Korean Medicine Clinic Gangnam-guSeoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusanjin-guBusan 47340Republic of Korea Department of Herbal Pharmacology College of Korean MedicineGachon University1342 Seongnamdae-roSujeong-guSeongnam 13120Republic of Korea Department of Korean Rehabilitation Medicine Dongshin University Korean Medicine HospitalGwangju 61619Republic of Korea Acupuncture and Meridian Science Research Center Kyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea Department of Science in Korean Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Statistics Support Medical Science Research InstituteKyung Hee University Medical CenterDongdaemun-guSeoul 02447Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea Korean Medicine Life Science University of Science&Technology(UST)Campus of Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea College of Korean Medicine Wonkwang UniversityIksanJeollabuk-do54538Republic of Korea

Objective:Acupotomy is a modern acupuncture method that includes modern surgical *** acupotomy is relatively more invasive than filiform acupuncture treatment,it is important to establish the safety profile of this *** justify further large-scale prospective observational studies,this preliminary study was performed to assess the feasibility of the approach and investigate the safety profile and factors potentially associated with adverse events(AEs).Methods:This was a prospective pilot study that assessed the feasibility of a large-scale forthcoming safety study on acupotomy treatment in a real-world *** feasibility(call response rate,dropout rate,response rate for each variable and recruitment per month)and safety profile(incidence,type,severity and causality of AEs,and factors potentially associated with AEs)were ***:A total of 28 participants joined the study from January to May 2018.A follow-up assessment was achieved in 258(1185 treatment points)out of 261 sessions(1214 treatment points).The response rate via telephone on the day after treatment was 87.3%.There were 8 systemic AEs in all the sessions(8/258;3.11%)and 27 local AEs on the total points treated(27/1185;2.28%).Severe AEs did not *** AE and local AE occurrence were associated with blade width and the number of needle stimulations per treatment ***:The findings suggest that it could be feasible to analyze the safety of acupotomy in a realworld ***,the primary data on some relevant AEs could be *** are planning large-scale prospective studies based on these *** registration:Clinical Research Information Service(CRIS)KCT0002849(https://***/cris/search/***/11487).

关键词： Acupotomy Acupuncture Safety Adverse effects Observational study Traditional Chinese medicine

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Current Usage of Terminologies Related to Acupotomy: A Literature Research and Standardization Suggestion

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Chinese Journal of Integrative Medicine 2019年第2期25卷 147-150页

作者： sang-hoon yoon yoon-Sik Kim Hee-Guen Jo Chan-Young Kwon Chung-Yeon Medical Institute Department of Clinical Korean Medicine Graduate SchoolKyung Hee University Yanggu Public Health Center

Objective: To investigate the current usage of terminologies related to acupotomy through systematic search and analyze the pros and cons of each for proposing a standard terminology. Methods: Seven medical journal databases were searched including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Oriental Medicine Advanced Searching Integrated System, KoreaMed, and Korean studies Information Service System using 10 candidate terminologies as searching terms. All studies published from their inception to July 26, 2017 were collected. Articles were included if the title stated one of the 10 candidate terminologies consistent with the definition of acupotomy. Priorly established frequency and consistency of each candidate terminology from medical databases were calculated and evaluated. Moreover, the pros and cons of each were analyzed to propose a standard terminology. Results: A total of 112 studies in English databases, 1,129 studies in Chinese database, and 44 studies in Korean databases were included. The most frequently used terminologies were needle knife(35.71%), acupotomy(48.54%) and acupotomy(90.90%) in English, Chinese and Korean database, respectively. Overall, acupotomy and needle knife were the most frequently used. Others like acupotomology, needle scalpel, miniscalpel acupuncture and miniscalpel needle were used within 10% of the total searched literature. Acupotome, stiletto needle, sword like needle, and Xiaozhendao were rarely used. Acupotomy had the advantages of high frequency and consistency but lacked representativeness. Needle knife also showed a high frequency, but the consistency was poor. Though miniscalpel acupuncture and miniscule needle were used less frequently, they had advantages of inclusiveness and clarity. Conclusions: A debate for standardization of the terminology is necessary. This preliminary research can provide a basic outline for the standardization consensus process, and

关键词： acupuncture Chinese medicine acupotomy terminology

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Clinical Efficacy and Safety of Miniscalpel-Needle Treatment for Tension-Type Headache:A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2020年第9期26卷 713-720页

作者： Chan-Young Kwon sang-hoon yoon Sun-Yong Chung Jong Woo Kim Department of Clinical Korean Medicine Graduate SchoolKyung Hee U niversitySeoul(02447)Republic of Korea Chung-Yeon Central Institute Gwang-juRepublic of Korea Department of Oriental Neuropsychiatry Kyung Hee University Hospital at GangdongSeoul(02447)Republic of Korea

Objective:To investigate the clinical efficacy and safety of miniscalpel-needle(MSN)treatment for tension-type headache(TTH).Method:Seven medical databases were searched to identify randomized controlled trials(RCTs)evaluating the effect and safety of MSN *** articles published up to November 15,2018 were retrieved.A meta-analysis was conducted for the included studies,and the risk of bias was *** outcomes were visual analogue scale(VAS)or numeric rating scale(NRS)*** outcomes were clinical effective rates including total effective rate(TER),markedly effective rate(MER),and totally cured rate(TCR)determined by improvement in clinical symptoms or VAS scores,the frequency of adverse events(AEs)that occurred during the study,and participant quality of life(QOL).Results:Seven RCTs involving 724 participants were *** treatment showed significantly higher MER and TCR[relative risk(RR)1.27,95%confidence interval(Cl)1.01 to 1.61;RR 1.31,95%Cl 1.09 to 1.57,respectively],but not TER(RR 1.03,95%Cl 0.96 to 1.10)compared to *** treatment plus conventional treatment showed significant lower VAS and higher TER,MER,and TCR(mean difference-3.54,95%Cl-3.80 to-3.28;RR 1.14,95%Cl 1.06 to 1.23;RR 2.31,95%Cl 1.50 to 3.58;RR 3.01,95%Cl 2.25 to 4.02,respectively)compared to conventional ***:According to current evidence,MSN treatment as a monotherapy or as an adjunctive treatment to other existing treatments might have benefits on treating ***,since the number and the sample size of studies included were both small and the methodological quality was poor,the findings of this review should be interpreted with great caution,and our confidence in the results is low.A high quality RCT using objective outcomes should be performed on this topic.

关键词： acupuncture acupotomy tension-type headache systematic review meta-analysis

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Sc掺杂对PDP中MgO薄膜外逸电子发射性能的影响

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真空科学与技术学报 2011年第5期31卷 521-525页

作者：况亚伟 sang-hoon yoon Yong-SeogKim 李青朱笛张雄东南大学电子科学与工程学院显示技术研究中心南京210096 韩国弘益大学材料科学与工程学院

研究了等离子显示器中Sc掺杂对MgO介质保护薄膜外逸电子发射性能的影响。测试出无掺杂和Sc掺杂MgO薄膜在不同温度条件下的外逸电子发射电流,并基于理论模型模拟计算外逸电子发射电流对比实验结果。结果表明Sc掺杂加深了MgO禁带中的电子... 详细信息

研究了等离子显示器中Sc掺杂对MgO介质保护薄膜外逸电子发射性能的影响。测试出无掺杂和Sc掺杂MgO薄膜在不同温度条件下的外逸电子发射电流,并基于理论模型模拟计算外逸电子发射电流对比实验结果。结果表明Sc掺杂加深了MgO禁带中的电子陷阱深度,延长了MgO薄膜的外逸电子发射的衰减时间。Sc掺杂MgO薄膜具备了持续发射外逸电子的能力,能够实现等离子显示器放电单元稳定快速的寻址。

关键词：等离子体显示器 MgO薄膜 Sc掺杂外逸电子

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Gender differences in adult traumatic brain injury according to the Glasgow coma scale:A multicenter descriptive study

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Chinese Journal of Traumatology 2021年第6期24卷 333-343页

作者： Ki Seong Eom Jang Hun Kim sang hoon yoon Seong-jong Lee Kyung-Jae Park Sung-Kon Ha Jin-gyu Choi Kwang-Wook Jo JongYeon Kim Suk Hyung Kang Jong-Hyun Kim Department of Neurosurgery Institute of Wonkwang Medical ScienceWonkwang University School of MedicineIksanSouth Korea Department of Neurosurgery Armed Forces Capital HospitalSeongnamSouth Korea Department of Neurosurgery Armed Force HospitalYangjuSouth Korea Department of Neurosurgery Korea University Anam HospitalSeoulSouth Korea Department of Neurosurgery Korea University Ansan HospitalAnsanSouth Korea Department of Neurosurgery Yeouido St.Mary's HospitalCatholic UniversitySeoulSouth Korea Department of Neurosurgery Catholic University St.Mary's HospitalBucheonSouth Korea Department of Neurosurgery Wonju Severance Christian HospitalWonjuSouth Korea Department of Neurosurgery Hallym University Sacred Heart HospitalChuncheonSouth Korea Department of Neurosurgery Korea University Guro HospitalSeoulSouth Korea

Purpose:Patients’gender,which can be one of the most important determinants of traumatic brain injury(TBI)outcomes,is also likely to interact with many other outcome variables of *** multicenter descriptive study investigated gender differences in epidemiological,clinical,treatment,mortality,and variable characteristics in adult TBI ***:The selection criteria were defined as patients who had been diagnosed with TBI and were admitted to the hospital between January 1,2016 and December 31,2018.A total of 4468 adult TBI patients were enrolled at eight University *** on the list of enrolled patients,the medical records of the patients were reviewed and they were registered online at each *** registered patients were classified into three groups according to the Glasgow coma scale(GCS)score:mild(13-15),moderate(9-12),and severe(3-8),and the differences between men and women in each group were *** risk factors of moderated and severe TBI compared to mild TBI were also ***:The study included 3075 men and 1393 women and the proportion of total males was 68.8%.Among all the TBI patients,there were significant differences between men and women in age,past history,and GCS *** the mild and severe TBI groups showed significant differences in age,past history,and clinical symptoms,the moderate TBI group showed significant differences in age,past history,cause of justice,and ***:To the best of our knowledge,this multicenter study is the first to focus on gender differences of adult patients with TBI in *** study shows significant differences between men and women in many aspects of adult ***,gender differences should be strongly considered in TBI studies.

关键词： Traumatic brain injuries Gender Epidemiology Glasgow coma scale

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Vomiting-induced pharyngeal perforation during bowel preparation for colonoscopy:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3615-3621页

作者： Geonhee Kim Won Hyuk Lee Seokin Kang Jung Rock Moon yoon Suk Lee Jun Hyuk Son Nam-hoon Kim Jong Wook Kim Department of Internal Medicine Ilsan Paik HospitalInje University College of MedicineGoyang 10380South Korea

BACKGROUND Effective bowel cleansing is essential for a successful ***,such as polyethylene glycol,are commonly used for bowel *** is a frequent complication during bowel preparation,and forceful vomiting can potentially lead to esophageal perforation,as reported in several previous ***,pharyngeal perforation during bowel preparation has not been previously ***,we present a case of pharyngeal perforation induced by forceful vomiting during bowel *** SUMMARY A 38-year-old man with a history of hypertension,dyslipidemia,diabetes mellitus,and end-stage renal disease on hemodialysis was admitted for evaluation of recurrent abdominal *** patient complained of sudden pain in the neck,throat,and anterior chest following forceful vomiting during bowel *** examination revealed crepitus under the skin of the neck and anterior chest on palpation,and upper gastrointestinal endoscopy revealed pharyngeal *** perforation site was located above the upper esophageal sphincter,which distinguished it from Boerhaave’s *** medical management was chosen after consultation with a thoracic surgeon and an otolaryngologist,considering the patient's mild symptoms,stable vital signs,and the small size of the lesion;the perforation resolved without endoscopic or surgical *** patient was discharged from hospital two weeks after the *** Despite its rarity,pharyngeal perforation should be considered a potential complication of bowel preparation for colonoscopy.

关键词： Colonoscopy Pharynx Polyethylene glycols Spontaneous perforation Case report

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Inverse design of a Si-based high-performance vertical-emitting meta-grating coupler on a220 nm silicon-on-insulator platform

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Photonics Research 2023年第6期11卷 897-905页

作者： JINHYEONG yoon JAE-YONG KIM JUNHYEONG KIM HYEONHO yoon BERKAY NESELI HYO-hoon PARK HAMZA KURT School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea

Efficient extraction of light from a high refractive index silicon waveguide out of a chip is difficult to *** inverse design approach was employed using the particle swarm optimization method to attain a vertical emitting meta-grating coupler with high coupling efficiency in a 220-nm-thick silicon-on-insulator *** carefully selecting the figure of merit and appropriately defining parameter space,unique L-shape and U-shape grating elements that boosted the out-of-plane radiation of light were *** addition,a 65.7%(-1.82 dB)outcoupling efficiency and a 60.2%(-2.2 dB)fiber-to-chip vertical coupling efficiency with an 88 nm 3 dB bandwidth were demonstrated by numerical *** fabrication constraints,the optimized complex meta-grating coupler was modified to correspond to two etching steps and was then fabricated with a complementary metal-oxide-semiconductor-compatible *** modified meta-grating coupler exhibited a simulated coupling efficiency of 57.5%(-2.4 d B)with a 74 nm 3-dB bandwidth in the C-band and an experimentally measured coupling efficiency of 38%(-4.2 dB).

关键词： waveguide coupling insulator

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Real-time porosity reduction during metal directed energy deposition using a pulse laser

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Journal of Materials Science & Technology 2022年第21期116卷 214-223页

作者： hoon Sohn Peipei Liu Hansol yoon Kiyoon Yi Liu Yang sangjun Kim Department of Civil and Environmental Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Center for 3D Printing Nondestructive Testing Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Global R&D Center SQ EngineeringSeoul 05818Republic of Korea Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Porosity is a challenging issue in additive manufacturing and is detrimental to the quality of the additively manufactured *** this study,a real-time porosity reduction technique was developed by incorporating a pulse laser into a laser metal powder directed energy deposition(DED)*** incorporated pulse laser can accelerate fluid flow within the melt pool and facilitate the escape of pores before complete *** achieves this real-time porosity reduction by inducing accelerated and turbulent Marangoni flow,ultrasonic waves,and shock waves into the melt *** uniqueness and advantages of the proposed technique include the following:(1)For a laser metal powder DED process,this study proposed a noncontact,nondestructive,and real-time porosity reduction technique at the melt pool level.(2)It was experimentally and numerically validated that the developed technique did not alter the geometry and the grain structure of the manufactured Ti-6Al-4V samples.(3)Because the porosity reduction is accomplished at the melt pool level,its application is not limited by the size,shape,or complexity of the printing target.(4)The developed technique can be readily incorporated into the existing DED systems without any modification of the original tool-path *** experimental results showed that the pore volume fraction decreased from 0.132%to 0.005%,no pores larger than 6×10^(4)μm^(3) were observed,and a 91%reduction in the total pore number was achieved when the pulse laser energy reached 11.5 mJ.

关键词： Real-time porosity reduction Pulse laser Melt pool Directed energy deposition Ti-6Al-4V

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Highly Flexible Fabrics/Epoxy Composites with Hybrid Carbon Nanofillers for Absorption-Dominated Electromagnetic Interference Shielding

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Nano-Micro Letters 2022年第11期14卷 307-323页

作者： Jong-hoon Lee yoon-Sub Kim Hea-Jin Ru Seul-Yi Lee Soo-Jin Park Department of Chemistry Inha University100 InharoIncheon 22212Korea Korea Architecture Safety Testing and Research Institute(KASTI) 88 Gasan Digital 1-roSeoul 08590Korea

Epoxy-based nano-composites can be ideal electromagnetic interference(EMI)-shielding materials owing to their lightness,chemical inertness,and mechanical ***,poor conductivity and brittleness of the epoxy resin are challenges for fast-growing portable and flexible EMI-shielding applications,such as smart wristband,medical cloth,aerospace,and military *** this study,we explored hybrid nanofillers of single-walled carbon nanotubes(SWCNT)/reduced graphene oxide(rGO)as conductive inks and polyester fabrics(PFs)as a substrate for flexible EMI-shielding *** highest electrical conductivity and fracture toughness of the SWCNT/rGO/PF/epoxy composites were 30.2 S m^(−1)and 38.5 MPa m^(1/2),which are~270 and 65%enhancement over those of the composites without SWCNTs,*** mechanical durability was demonstrated by stable electrical conductivity retention during 1000 cycles of bending *** EMI-shielding effectiveness of~41 dB in the X-band frequency of 8.2-12.4 GHz with a thickness of 0.6 mm was obtained with an EM absorption-dominant behavior over a 0.7 absorption *** results are attributed to the hierarchical architecture of the macroscale PF skeleton and nanoscale SWCNT/rGO networks,leading to superior EMI-shielding *** believe that this approach provides highly flexible and robust EMI-shielding composites for next-generation wearable electronic devices.

关键词： Conductive polymer composites Fracture toughness Flexible composites Absorption-dominated electromagnetic interference shielding

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Complete response of metastatic BRAF V600-mutant anaplastic thyroid cancer following adjuvant dabrafenib and trametinib treatment:A case report

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世界临床病例杂志 2023年第27期11卷 6664-6669页

作者： sang Jae Lee Si-Youn Song Min Kyoung Kim Hyung Gyun Na Chang hoon Bae Yong-Dae Kim yoon Seok Choi Department of Otorhinolaryngology-Head and Neck Surgery College of MedicineYeungnam UniversityDaegu 42415South Korea Division of Hematology-Oncology Department of Internal MedicineCollege of MedicineYeungnam UniversityDaegu 42415South Korea Regional Center for Respiratory Diseases Yeungnam University Medical CenterDaegu 42415South Korea

BACKGROUND Anaplastic thyroid cancer(ATC)is a rare but aggressive type of thyroid *** V600E-mutation,which is found in 10%-50%of ATCs,is associated with poor prognosis.A recent clinical trial reported a substantial clinical benefit of concomitant treatment of dabrafenib(BRAF inhibitor)and trametinib(MEK inhibitor)for treating BRAF V600E-mutant ***,reports on patients with ATC treated with this regimen following surgery are *** SUMMARY We report the case of a 63-year-old female patient diagnosed with BRAF V600Emutant *** three surgeries—total thyroidectomy,total laryngectomy,and neck dissection—she was diagnosed with lung metastasis during *** metastatic ATC was successfully treated with dabrafenib and *** patient achieved a complete response at the 32-mo *** Adjuvant chemotherapy with dabrafenib plus trametinib is efficacious for treatment and prevention of recurrent ATC with BRAF mutation following surgery.

关键词： Thyroid carcinoma Anaplastic BRAF Dabrafenib Trametinib Chemotherapy Adjuvant Case report

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