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Therapeutic potential of Gastrodia elata Blume for the treatment of Alzheimer's disease

Neural Regeneration Research 2013年第12期8卷 1061-1070页

作者： Guang-Biao Huang Tong Zhao Sushma Shrestha Muna Hong-Mei Jin Jong-Il Park Kyu-Sik Jo Bo-Hee Lee Soo-Wan Chae Sun-Young kim Soo-Hyun Park Eun-ock Park Eun-Kyung Choi Young-Chul Chung Department of Psychiatry Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea Muju Chunma Native Local Industrial Center Muju 568-844 Republic of Korea Clinical Trial Center for Functional Foods Chonbuk National University HospitalJeonju 561-756 Republic of Korea Department of Pharmacology Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea

Several studies have demonstrated that the Chinese herb Gastrodia elata Blume can protect against amyloid beta-peptide （Ap）-induced cell death. To investigate the possible therapeutic effects of Gastrodia elata Blume on Alzheimer＇s disease, we established a rat model of AIzheimer＇s disease by injecting A325-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg Gastrodia elata Blume per day for 52 consecutive days. Morris water maze tests showed that Gastrodia elata Blume treatment significantly improved the spatial memory of Alzheimer＇s disease rats. Congo red staining revealed that Gastrodia elata Blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of Gastrodia elata Blume, while EIIman method showed significant decrease in the activity of acetylcholinesterase in all three regions （prefrontal cortex, medial septum and hippocampus）. These findings suggest that long-term administration of Gastrodia elata Blume has therapeutic potential for Alzheimer＇s disease.

关键词： neural regeneration neuroprotective effect Traditional Chinese medicine Gastrodia elata Blume Alzheimer's disease Morris water maze test choline acetyltransferase acetylcholinesterase grants-supported paper neuroregeneration

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1-Chloromethyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-sulfonic acid amide, a derivative of tetrahydroisoquinoline, induces granulocytic differentiation of the human leukemic HL-60 cells via G0/G1 phase arrest

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Health 2013年第5期5卷 1-7页

作者： Sung-Min Ju Hyun-ock Pae Won-Sin kim Chai-Ho Lee Byung-Hun Jeon Department of Biological Science College of Natural Sciences Wonkwang University Iksan South Korea Department of Bionanochemistry School of Natural Sciences Wonkwang University Iksan South Korea Department of Microbiology and Immunology Wonkwang University School of Medicine Iksan South Korea Department of Pathology College of Korean Medicine Wonkwang University Iksan South Korea

Tetrahydroisoquinolines are known to have various biological effects, including antitumor activity. This study investigated the effect of 1-chloromethyl-6, 7-dimethoxy-3, 4-dihydro-1H-isoquinoline-2-sulfonic acid amide (CDST), a newly synthesized anticancer agent, on cellular differentiation and proliferation in HL-60 cells. Differentiation and proliferation of HL-60 cells were determined through expression of CD11b and CD14 surface antigens using flow cytometry and nitroblue tetrazolium (NBT) assay, and through analysis of cell cycle using propidium iodide staining, western blot analysis and immunoprecipitation, respectively. CDST induced the differentiation of HL-60, as shown by increased expression of differentiation surface antigen CD11b (but no significant change in CD14 expression) and increased NBT-reducing functional activity. DNA flow cytometry analysis indicated that CDST markedly induced a G0/G1 phase arrest of HL-60 cells. Subsequently, we examined the expre-ssion of G0/G1 phase cell cycle-related proteins, including cyclin-dependent kinases (CDKs), cyclins and cyclin dependent kinase inhibitors (CKIs), during the differentiation of HL-60. The levels of CDK2, CDK6, cyclin E and cyclin A were decreased, whereas steady-state levels of CDK4 and cyclin D1 were unaffected. The expression of the p27Kip1 was markedly increased by CDST, but not p21WAF1/Cip1. Moreover, CDST markedly enhanced the binding of p27Kip1 with CDK2 and CDK6, resulting in the reduced activity of both kinases. Taken together, these results demonstrate that CDST is capable of inducing cellular differentiation and growth inhibition through p27Kip1 protein-related G0/G1 phase arrest in HL-60 cells.

关键词： Differentiation G0/G1 Phase Arrest HL-60 Cells Tetrahydroisoquinolines P27Kip1

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情境教学法在对外汉语近义词教学中的运用研究

情境教学法在对外汉语近义词教学中的运用研究

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作者：金炅玉（kim Gyong ock）苏州大学

学位级别：硕士

为了通过一种语言进行沟通,掌握词汇的意义和用法很重要。在对外汉语词汇教学中,经过运用基础的词汇的零起点阶段后,达到一定的水平,掌握近义词,正确地运用近义词是必须的。但是,汉语的近义词特别多,近义词之间有微细意义的差异、不同... 详细信息

为了通过一种语言进行沟通,掌握词汇的意义和用法很重要。在对外汉语词汇教学中,经过运用基础的词汇的零起点阶段后,达到一定的水平,掌握近义词,正确地运用近义词是必须的。但是,汉语的近义词特别多,近义词之间有微细意义的差异、不同的用法等的原因,近义词教学一直被对外汉语界认为是重点和难点。为了开发有效的对外汉语近义词教学方法,本文采用当前在对外汉语教学热门的情境教学法。情境是培养留学生交际能力的重要辅助工具,情境教学法要有真实性或者要模拟真实的情境。教师创设的情境要生动、形象,这可以让学习者引起联想、想象,激发认知的兴趣,提高认知效率。本文例举了利用情境教学对《发展汉语》教材中的生词,特别是近义词教学设计的一些案例,希望提供行之有效的教学方法,促进对外汉语课堂教学整个水平的提升。本文共分为绪论、正文和结论三部分:绪论介绍了选题意义、研究现状与研究方法等。正文有三章。第一章为对外汉语近义词教学概述,介绍汉语近义词的特点,对外汉语近义词教学的重点与难点,对外汉语近义词教学中存在的问题。第二章为情境教学法在对外汉语近义词教学中运用设想。第三章为对外汉语近义词的情境教学建议与设计。最后为结语部分,强调将情境教学法应用到对外汉语近义词教学当中的重要性。

关键词：对外汉语教学近义词情境教学法教学案例

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A Study on the Pressure Values of Contrast Media Injecting for the Prevention of Extravasations used Extravasation Detector

A Study on the Pressure Values of Contrast Media Injecting f...

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2010中华医学会影像技术分会第十八次全国学术大会

作者： Youha Hwang Minsoo Lee Seungho ock Heejin Hwang Jongjin Ahn Ohsung Kwon Hyeong cheol kim Chunkyu Choi Department of Radiology Seoul National University HospitalSeoulKorea

Objective:Extravasation of contrast media has been seriously managed for the patients’safety and various studies are currently being performed on ***,it is very difficult to prevent the extravasations which caused by...

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Pemetrexed in Previously Treated Non-small Cell Lung Cancer Patients with Poor Performance Status

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中国肺癌杂志 2011年第1期14卷 33-38页

作者： Sun Young JUNG Su Jin YOO Ji Young SHIN Ji Won PARK Jeong Eun LEE Hee Sun PARK Ju ock kim Sun Young kim Department of Internal Medicine Chungnam National University Hospital

Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner(NSCLC) in progression after first-line *** evaluated the activity and feasibility of pemetrexed in previously treated *** Patients with histologically or cytologically confirmed NSCLC were evaluated from April 2007 to March *** patients had relapsed or progressed after prior chemotherapy ***(500 mg/m2) was administered intravenously once every 3 weeks after progression to prior *** tumor response was evaluated according to RECIST criteria by chest CT at every 2 cycles of *** A total 61 patients were eligible for *** status of them(100%) was over *** response rate and disease control rate were 14.7% and 37.7% ***-squamous cell carcinoma histology was significantly associated with a superior response rate(P=0.045) and disease control rate(P=0.008).The median survival time and the median progression free survival(PFS) time were 6.11 months and 2.17 months,*** the efficacy of pemetrexed in these two settings [second-line versus(12/61) more than third(49/61)],there was no significant difference in regard to median survival(11.18 months vs 11.46 months,P=0.922,5),but PFS was more longer in third-or further-line groups than second-line group(1.39 months vs 2.25 months,P=0.015,3).Conclusion Pemetrexed is a feasible regimen in previously treated NSCLC with poor performance status.

关键词：肺癌症状化学疗法临床治疗

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The effect of dimiristoylphosphatidylethanol on the rotational mobility of n-(9-Anthroyloxy) stearic acid in neuronal and model membranes

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Journal of Biophysical Chemistry 2010年第3期1卷 133-140页

作者： Young-Sik Park No-Soo Park Jun-Bong Seo Soo-Kyoung Bae You-Kwang kim Ki-Soo Seong Young-Jun kim Ju-Won Park Joung-Moung Shin Young-Chan Jeon In-Kyo Chung Moon-Kyoung Bae Hye-ock Jang Il Yun 不详

The aim of this study was to provide a basis for examining the molecular mechanism for the pharmacological action of ethanol. We studied di?myristoyl?phosphatidylethanol (DMPEt)’s effects on specific locations of n-(9-anthroyloxy) palmitic acid or stearic acid (n-AS) within phos?pholipids of synaptosomal plasma membrane vesicles isolated from bovine cerebral cortex (SPMV) and liposomes of total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from SPMV. DMPEt increased rotational mobility (increased disordering) of hydrocarbon interior, but it decreased mobility (increased ordering) of membrane interface, in native and model membranes. The degree of rotational mobility in accordance with the carbon atom numbers of phospholipids comprising neuronal membranes was in the order at the 16, 12, 9, 6 and 2 position of aliphatic chain present in phospholipids. The sensitivity of increasing or decreasing effect of rotational mobility of hydrocarbon interior or surface region by DMPEt differed depending on the neuronal and model membranes in the descending order of SPMV, SPMVPL and SPMVTL.

关键词： Ethanol Phosphatidylethanol Fluorescence Quenching Technique Rotational Mobility Hydrocarbon Interior Membranes lnterface

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The effect of dimiristoylphosphatidylethanol on the rotational mobility of n-(9-Anthroyloxy)stearic acid in neuronal and model membranes

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Journal of Biophysical Chemistry（生物物理化学） 2010年第3期

作者： Young-Sik Park No-Soo Park Jun-Bong Seo Soo-Kyoung Bae You-Kwang kim Ki-Soo Seong Young-Jun kim Ju-Won Park Joung-Moung Shin Young-Chan Jeon In-Kyo Chung Moon-Kyoung Bae Hye-ock Jang Il Yun

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