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Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis

World Journal of Gastroenterology 2013年第16期19卷 2543-2549页

作者： sang jung park Jin Dong Kim Yeon Seok Seo Beom Jin park Min Ju Kim Soon Ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong jung Bora Keum Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho sang Ryu Department of Internal Medicine College of Medicine Korea University Department of Internal Medicine Cheju Halla General Hospital Department of Radiology College of Medicine Korea University Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Christian Hospital

AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis.

关键词： Acute hepatitis Cholestasis Computed tomography Prognosis Gallbladder

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The H∞ Robust Stability and Performance Conditions for Uncertain Robot Manipulators

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 270-272页

作者： Geun Il Song Hae Yeon park jung Hoon Kim the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Institute for Convergence Research and Education in Advanced Technology Yonsei University

Dear Editor,H∞This letter develops a new framework for the robust stability and performance conditions as well as the relevant controller synthesis with respect to uncertain robot *** often exist model uncertainties between the nominal model and the real robot manipulator and disturbances. Hence, dealing with their effects plays a crucial role in leading to high tracking performances, as discussed in [1]–[5].

关键词： Robot applications

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Gut–brain axis and environmental factors in parkinson's disease:bidirectional link between disease onset and progression

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Neural Regeneration Research 2025年第12期20卷 3416-3429页

作者： Soo jung park Kyung Won Kim Eun Jeong Lee Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Life Science and Multidisciplinary Genome Institute Hallym UniversityChuncheonSouth Korea

parkinson's disease has long been considered a disorder that primarily affects the brain,as it is defined by the dopaminergic neurodegeneration in the substantia nigra and the brain accumulation of Lewy bodies containingα-synuclein *** recent decades,however,accumulating research has revealed that parkinson's disease also involves the gut and uncovered an intimate and important bidirectional link between the brain and the gut,called the“gut–brain axis.”Numerous clinical studies demonstrate that gut dysfunction frequently precedes motor symptoms in parkinson's disease patients,with findings including impaired intestinal permeability,heightened inflammation,and distinct gut microbiome profiles and ***,α-synuclein deposition has been consistently observed in the gut of parkinson's disease patients,suggesting a potential role in disease ***,individuals with vagotomy have a reduced parkinson's disease *** these observations,researchers have hypothesized thatα-synuclein accumulation may initiate in the gut and subsequently propagate to the central dopaminergic neurons through the gut–brain axis,leading to parkinson's *** review comprehensively examines the gut's involvement in parkinson's disease,focusing on the concept of a gut-origin for the *** also examine the interplay between altered gut-related factors and the accumulation of pathologicalα-synuclein in the gut of parkinson's disease *** the accessibility of the gut to both dietary and pharmacological interventions,targeting gut-localizedα-synuclein represents a promising avenue for developing effective parkinson's disease therapies.

关键词： gut inflammation gut microbiome gut-brain axis micro/nano-plastics parkinson’s disease α-synuclein

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Conversion of N-doped biochar from carotenoid-extracted Tetraselmis suecica and its application to produce supercapacitors

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Journal of Environmental Sciences 2025年第5期151卷 410-423页

作者： Se Hun Lee Kang Hyun Lee sang-hwa Lee Soo Kweon Lee Ok Sung Jeon Young Pyo Jeon Dongpyo Hong Young Joon Yoo sang Yoon park Hah Young Yoo Advanced Institute of Convergence Technology(AICT) Seoul National UniversitySuwon 16229Republic of Korea Department of Biotechnology Sangmyung University20 Hongjimun 2-GilJongno-GuSeoul 03016Republic of Korea Department of Bio-Convergence Engineering Dongyang Mirae University445-8Gyeongin-roGuro-guSeoul 08221Republic of Korea Fermentation team Lotte R&D Center210 Magokjungang-RoGangseo-GuSeoul 07594Republic of Korea School of Electronic Engineering Kyonggi UniversityGyeonggi-do 16227Republic of Korea

Microalgae are one of the promising feedstocks for biorefinery,contributing significantly to net-zero emissions through carbon capture and ***,the disposal of microalgal byproducts from the manufacturing process causes additional environmental pollution,thus,a new application strategy is *** this study,the Tetraselmis suecica byproduct from the carotenoid extraction process was carbonized and converted into *** converted biochar was proved to be nitrogen-doped biochar(NDB),up to 4.69%,with a specific surface area of 206.59m^(2)/g andwas used as an electrode for a *** NDB electrode(NDB-E)in half-cell showed a maximum specific capacitance of 191 F/*** a full-cell test,the NDB-E exhibited a high energy density of 7.396 Wh/kg and a high-power density of 18,100 W/kg,and maintained specific capacity of 95.5%after charge and discharge of 10,000 *** conclusion,our study demonstrated that the carotenoid-extracted microalgal byproducts are a useful resource for the supercapacitor *** approach is the first to convert *** into active materials for supercapacitors.

关键词： Microalgae Tetraselmis suecica Carbonization N-doped biochar Supercapacitor

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG park MINSUK KWON MINAE AN jung YONG HONG JOON OH park SUNG HEE LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

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Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential

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World Journal of Stem Cells 2025年第1期17卷 40-52页

作者： Seoung-Woo Lee Young-Ju Lim Hee-Yeon Kim Wansoo Kim Wook-Tae park Min-jung Ma Junho Lee Min-Soo Seo Young In Kim sangbum park Seong-Kyoon Choi Gun Woo Lee Core Protein Resources Center Daegu-Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaegu 42415South Korea Department of Veterinary Pathology College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea School of Life Science BK21 FOUR KNU Creative BioResearch GroupKyungpook National UniversityDaegu 41566South Korea Laboratory of Veterinary Tissue Engineering College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea College of Veterinary Medicine Kyungpook National UniversityDaegu 41566South Korea Department of Veterinary Tissue Engineering Kyungpook National UniversityDaegu 41566South Korea Cellexobio. Ltd.Daegu 42415South Korea Michigan State University Institute for Quantitative Health Science&EngineeringEast LansingMI 48824United States Department of Orthopedic Surgery Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Mesenchymal stem cells(MSCs)are promising candidates for regenerative therapy due to their self-renewal capability,multilineage differentiation potential,and immunomodulatory *** molecular characteristics of MSCs are influenced by their ***,epidural fat(EF)and EF-derived MSCs(EF-MSCs)have garnered attention due to their potential benefits to the spinal microenvironment and their high expression of neural SC ***,their clinical applications are limited due to cell senescence and limited accessibility of *** many studies have attempted to establish an immortalized,stable SC line,the characteristics of immortalized EF-MSCs remain to be *** To establish and analyze stable immortalized *** The phenotypes of EF-MSCs were analyzed using optical *** immortalization was performed using lentiviral *** biomolecular characteristics of the cells were analyzed by immunoblotting,quantitative PCR,and *** The immortalized EF-MSCs demonstrated a significantly extended lifespan compared to the control group,with well-preserved adipogenic potential and SC surface marker *** of human telomerase reverse transcriptase genes markedly increased the lifespan of *** analysis revealed substantial increase in the expression of DNA replication pathway components in immortalized *** Immortalized EF-MSCs exhibited significantly enhanced proliferative capacity,retained adipogenic potential,and upregulated the expression of DNA replication pathway components.

关键词： Immortalization Transfection Stem cell Epidural fat Proteomics

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Half-Covered'Glitter-Cake'AM@SE Composite:A Novel Electrode Design for High Energy Density All-Solid-State Batteries

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Nano-Micro Letters 2025年第5期17卷 463-478页

作者： Min Ji Kim Jin-Sung park Jin Woong Lee Sung Eun Wang Dowoong Yoon Jong Deok Lee jung Hyun Kim Taeseup Song Ju Li Yun Chan Kang Dae Soo jung Energy and Environmental Division Korea Institute of Ceramic Engineering and TechnologyJinjuGyeongnam 52851Republic of Korea Department of Materials Science and Engineering Korea UniversityAnam-DongSeongbuk-GuSeoul 136-713Republic of Korea Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 20139USA Department of Materials Science and Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea Department of Energy Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

All-solid-state batteries(ASSBs)are pursued due to their potential for better safety and high energy ***,the energy density of the cathode for ASSBs does not seem to be satisfactory due to the low utilization of active materials(AMs)at high *** small amount of solid electrolyte(SE)powder in the cathode,poor electrochemical performance is often observed due to contact loss and non-homogeneous distribution of AMs and SEs,leading to high tortuosity and limitation of lithium and electron transport ***,we propose a novel cathode design that can achieve high volumetric energy density of 1258 Wh L^(-1)at high AM content of 85 wt%by synergizing the merits of AM@SE core–shell composite particles with conformally coated thin SE shell prepared from mechanofusion process and small SE *** core–shell structure with an intimate and thin SE shell guarantees high ionic conduction pathway while unharming the electronic *** addition,small SE particles play the role of a filler that reduces the packing porosity in the cathode composite electrode as well as between the cathode and the SE separator *** systematic demonstration of the optimization process may provide understanding and guidance on the design of electrodes for ASSBs with high electrode density,capacity,and ultimately energy density.

关键词： All-solid-state batteries Cathodes Sulfide-based solid electrolytes Interfaces Mechanofusion

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Cellulose Elementary Fibrils as Deagglomerated Binder for High-Mass-Loading Lithium Battery Electrodes

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Nano-Micro Letters 2025年第5期17卷 281-296页

作者： Young-Kuk Hong jung-Hui Kim Nag-Young Kim Kyeong-Seok Oh Hong-I Kim Seokhyeon Ryu Yumi Ko Ji-Young Kim Kwon-Hyung Lee sang-Young Lee Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea Advanced Analysis and Data Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Ulsan Advanced Energy Technology R&D Center Korea Institute of Energy Research(KIER)Ulsan 44776Republic of Korea Department of Battery Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea

Amidst the ever-growing interest in high-mass-loading Li battery electrodes,a persistent challenge has been the insufficient continuity of their ion/electron conduction ***,we propose cellulose elementary fibrils(CEFs)as a class of deagglomerated binder for high-mass-loading *** from natural wood,CEF represents the most fundamental unit of cellulose with nanoscale *** preparation of the CEFs involves the modulation of intermolecular hydrogen bonding by the treatment with a proton acceptor and a hydrotropic *** elementary deagglomeration of the cellulose fibers increases surface area and anionic charge density,thus promoting uniform dispersion with carbon conductive additives and suppressing interfacial side reactions at ***,a homogeneous redox reaction is achieved throughout the *** resulting CEF-based cathode(overlithiated layered oxide(OLO)is chosen as a benchmark electrode active material)exhibits a high areal-mass-loading(50 mg cm^(-2),equivalent to an areal capacity of 12.5 mAh cm^(-2))and a high specific energy density(445.4 Wh kg–1)of a cell,which far exceeds those of previously reported OLO *** study highlights the viability of the deagglomerated binder in enabling sustainable high-mass-loading electrodes that are difficult to achieve with conventional synthetic polymer binders.

关键词： Cellulose elementary fibrils Deagglomeration Electrode binders Lithium batteries High-mass-loading

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Novel transparent high-entropy sesquioxide ceramics with high physicochemical plasma etching resistance

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JOURNAL OF ADVANCED CERAMICS 2025年第1期14卷 163-176页

作者： Shin, Yu-Bin Ham, Su Been Kim, Ha-Neul Kim, Mi-Ju Ko, Jae-Woong Lee, Jae-Wook park, Young-Jo Kim, jung-Hyung Lee, Hyo-Chang jung, Young Hwa Lee, jung Woo Ma, Ho Jin Korea Inst Mat Sci Nano Mat Res Div Chang Won 51508 Gyeongsangnam South Korea Pusan Natl Univ Dept Mat Sci & Engn Pusan 46241 South Korea Korea Res Inst Stand & Sci Semicond Integrated Metrol Team Daejeon 34113 South Korea Korea Aerosp Univ Dept Semicond Sci Engn & Technol Goyang 10540 South Korea Korea Aerosp Univ Sch Elect & Informat Engn Goyang 10540 South Korea Pohang Accelerator Lab PLS II Beamline Div Pohang 37673 South Korea

High-entropy ceramics exhibit novel intrinsic properties. Hence, they have been explored for a wide range of applications ranging from thermal insulation and energy storage to advanced optical components. Recently, the semiconductor industry has faced a demand for higher-performance chips, necessitating higher aspect ratios in wafer fabrication and further miniaturization of linewidths. Therefore, novel materials with high plasma etching resistance and minimal contaminant generation are needed. The plasma-etching resistance displayed by high-entropy ceramics can be an innovative solution to this emerging challenge. In this study, we successfully fabricated single-phase high-entropy sesquioxide ceramics with high optical transparency, dense microstructure, and minimal residual pores. A structural analysis of the fabricated samples revealed a single-phase structure with excellent phase homogeneity. An evaluation of the plasma-etching resistance of high-entropy ceramics revealed for the first time a low etching rate of 8 nm/h compared with that of conventional plasma-resistant materials. These comprehensive characterizations of high-entropy ceramics indicate that they are promising candidates for significantly improving the production yield of semiconductors and for a wide range of potential applications, such as next-generation active optical ceramics.

关键词： high-entropy ceramics plasma etching resistance transparent ceramics sintering semiconductor manufacturing

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Porous FeS nanofibers with numerous nanovoids obtained by Kirkendall diffusion effect for use as anode materials for sodium-ion batteries

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Nano Research 2017年第3期10卷 897-907页

作者： jung sang Cho Jin-Sung park Yun Chan Kang Department of Materials Science and Engineering Korea University Anam-Dong Seongbuk-Gu Seou1136-713 Republic of Korea Department of Engineering Chemistry Chungbuk National University Chungbuk 361-763 Republic of Korea

Porous FeS nanofibers with numerous nanovoids for use as anode materials for sodium-ion batteries were prepared by electrospinning and subsequent sulfidation. The post-treatment of the as-spun Fe（acac）3-polyacrylonitrile composite nanofibers in an air atmosphere yielded hollow Fe2O3 nanofibers due to Ostwald ripening. The ultrafine Fe2O3 nanocrystals formed at the center of the fiber diffused toward the outside of the fiber via Ostwald ripening. On sulfidation, the Fe2O3 hollow nanofibers were transformed into porous FeS nanofibers, which contained numerous nanovoids. The formation of porosity in the FeS nanofibers was driven by nanoscale Kirkendall diffusion. The porous FeS nanofibers were very structurally stable and had superior sodium-ion storage properties compared with the hollow Fe2O3 nanofibers. The discharge capacities of the porous FeS nanofibers for the Ist and 150th cycles at a current density of 500 mA.g-1 were 561 and 592 mA.h-g-1, respectively. The FeS nanofibers had final discharge capacities of 456, 437, 413, 394, 380, and 353 mA-h.g-1 at current densities of 0.2, 0.5, 1.0, 2.0, 3.0, and 5.0 A.g-1, respectively.

关键词： iron sulfide sodium-ion batteries Kirkendall effect nanofibers electrospinning

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