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World Journal of Gastroenterology 2008年第11期14卷 1781-1784页

作者： Soon Woo Nam Si Hyun Bae Seung Woo Lee Yeon Soo Kim sang bum kang Jong Young Choi Se Hyun Cho Seung Kew Yoon Joon-Yeol Han Jin Mo Yang Young Suk Lee Division of Gastroenterology and Hepatology Department ofInternal medicineMedical College of the Catholic University ofKoreaDaejeon St.Mary's Hospital#62 Daeheung-dongChung-guDaejeonRepublic of Korea

AIM： To evaluate the efficacy of short-term overlap lamivudine therapy with adefovir in patients with lamivudine-resistant and naive chronic hepatitis B, we compared patients receiving overlap therapy with those receiving adefovir alone. METHODS： Eighty patients who had received lamivudine treatment for various periods and had a lamivudineo resistant liver function abnormality were enrolled. Forty of these patients received adefovir treatment combined with lamivudine treatment for ≥ 2 mo, while the other 40 received adefovir alone. We assessed the levels of hepatitis B virus （HBV） DNA at 0, 12 and 48 wk and serum alanine aminotransferase （ALT） levels after 0, 12, 24 and 48 wk of adefovir treatment in each group. RESULTS： We found serum ALT became normalized in 72 （87.5%） of the 80 patients, and HBV DNA decreased by ≥ 2 Ioglo copies/mL in 60 （75%） of the 80 patients at the end of a 48-wk treatment. HBV DNA levels were not significantly different between the groups. The improvements in serum ALT were also not significantly different between the two groups. CONCLUSION： These findings suggest short-term overlap lamivudine treatment results in no better virological and biological outcomes than non-overlap adefovir monotherapy.

关键词： Adefovir dipivoxil Chronic hepatitis B Hepatitis B virus DNA Overlap

A Review on Soft Ionic Touch Point Sensors

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Energy & Environmental Materials 2024年第6期7卷 193-208页

作者： Gibeom Lee Donghyun Lee Gwang-bum Im Younghoon Lee Department of Mechanical Engineering Gachon University1342 SeongnamdaeroSujeong-guSeongnam 13120South Korea Department of Surgery Harvard Medical SchoolBostonMassachusetts 02115USA

A touch sensor is an essential component in meeting the growing demand for human-machine *** sensors have been developed in wearable,attachable,and even implantable forms to acquire a wide range of information from *** be applied to the human body,sensors are required to be biocompatible and not restrict the natural movement of the *** materials are a promising candidate for soft touch sensors due to their outstanding properties,which include high stretchability,transparency,ionic conductivity,and ***,this review discusses the unique features of soft ionic touch point sensors,focusing on the ionic material and its key role in the *** touch sensing mechanisms include piezocapacitive,piezoresistive,surface capacitive,piezoelectric,and triboelectric and triboresistive *** review analyzes the implementation hurdles and future research directions of the soft ionic touch sensors for their transformative potential.

关键词： iontronics ionic materials soft materials touch sensors

Congestive ischemic colitis successfully treated with antiinflammatory therapy: A case report

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World Journal of Clinical Cases 2024年第1期12卷 142-147页

作者： Geon Woo Lee Su bum Park Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan 50612South Korea

BACKGROUND Congestive ischemic colitis is a rare subtype of ischemic colitis with an unknown *** conservative management,such as fasting,no established treatment exists;therefore,surgical intervention should be considered in some cases if symptoms *** literature suggests that anti-inflam-matory agents may effectively treat congestive ischemic *** SUMMARY We present the case of a 68-year-old female patient who underwent laparoscopic left hemicolectomy for transverse colon cancer 3 years ***,follow-up included an annual colonoscopy and abdominal computed tomography(CT)at a local ***,progressive erythema and edema of the sigmoid colon were observed 1 year *** admission to our hospital,she complained of abdominal pain and *** CT showed thickening of the sigmoid colon walls,and colonoscopy revealed erythema,edema,and multiple ulcers with exudate in the sigmoid *** angiography showed engorgement of the sigmoid vasa recta without any vascular *** diagnosis was congestive ischemic colitis,and we treated the patient with anti-inflammatory *** 2 mo of glucocorticoid therapy(20 mg once daily)and 7 mo of 5-aminosalicylate therapy(1 g twice daily),the ulcers completely *** has not experienced any recurrence for 2 *** Anti-inflammatory therapy,specifically glucocorticoids and 5-aminosalicylate,has demonstrated promising efficacy and introduces potential novel treatment options for congestive ischemic colitis.

关键词： Ischemic colitis Glucocorticoids 5-aminosalicylate Colon cancer

A case of ascending colon variceal bleeding treated with venous coil embolization

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World Journal of Gastroenterology 2013年第2期19卷 311-315页

作者： Bong Suk Ko Woo Tae Kim Su Sun Chang Eun Hye Kim Seung Woo Lee Won Seok Park Yeon Soo Kim Soon Woo Nam Dong Soo Lee Ji Chang Kim sang bum kang Department of Internal Medicine College of MedicineThe Catholic University of KoreaDaejeon St.Mary's HospitalDaejeon 301-723South Korea Department of Radiology College of MedicineThe Catholic University of KoreaDaejeon St.Mary's HospitalDaejeon 301-723South Korea

A 38-year-old female with a history of alcoholic liver cirrhosis visited our hospital with a massive *** esophagogastroduodenoscopy did not demonstrate any bleeding source,and a colonoscopy showed a massive hemorrhage in the ascending colon but without an obvious *** source of the bleeding could not be found with a mesenteric artery *** performed an enhanced abdominal computed tomography,which revealed a distal ascending colonic varix,and assumed that the varix was the source of the *** performed a venous coil embolization and histoacryl injection to obliterate the colon *** intervention appeared to be successful because the vital signs and hemoglobin laboratory data remained stable and because the hematochezia was no longer *** report here on a rare case of colonic variceal bleeding that was treated with venous coil embolization.

关键词： Colon ascending Varicose veins Liver cirrhosis Therapeutic embolization

Effect of Meteorological Data Assimilation on Regional Air Quality Forecasts over the Korean Peninsula

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Journal of Meteorological Research 2024年第2期38卷 262-284页

作者： Yunjae CHO Hyun Mee KIM Eun-Gyeong YANG Yonghee LEE Jae-bum LEE Soyoung HA Department of Atmospheric Sciences Yonsei UniversitySeoul 03722Republic of Korea Air Quality Forecasting Center National Institute of Environmental ResearchIncheon 22689Republic of Korea National Center for Atmospheric Research BoulderCO 80305USA University of Maryland Baltimore County BaltimoreMD 21250USA Global Modeling and Assimilation Office NASA Goddard Space Flight CenterGreenbeltMD 20771USA

The Weather Research and Forecasting model coupled with Chemistry(WRF-Chem),a type of online coupled chemistry-meteorology model(CCMM),considers the interaction between air quality and meteorology to improve air quality *** data assimilation(DA)can be used to reduce uncertainty in meteorological field,which is one factor causing prediction uncertainty in the *** this study,WRF-Chem and three-dimensional variational DA were used to examine the impact of meteorological DA on air quality and meteorological forecasts over the Korean *** nesting model domains were configured over East Asia(outer domain)and the Korean Peninsula(inner domain).Three experiments were conducted by using different DA domains to determine the optimal model domain for the meteorological *** the meteorological DA was performed in the outer domain or both the outer and inner domains,the root-mean-square error(RMSE),bias of the predicted particulate matter(PM)concentrations,and the RMSE of predicted meteorological variables against the observations were smaller than those in the experiment where the meteorological DA was performed only in the inner *** indicates that the improvement of the synoptic meteorological fields by DA in the outer domain enhanced the meteorological initial and boundary conditions for the inner domain,subsequently improving air quality and meteorological *** to the experiment without meteorological DA,the RMSE and bias of the meteorological and PM variables were smaller in the experiments with *** effect of meteorological DA on the improvement of PM predictions lasted for approximately 58-66 h,depending on the ***,the uncertainty reduction in the meteorological initial condition by the meteorological DA contributed to a reduction of the forecast errors of both meteorology and air quality.

关键词： meteorological data assimilation regional air quality forecast particulate matter concentration optimal model domain forecast error WRF-Chem

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi sangmi Jun bum-Tae Kim Jong-Won Oh Aleem Siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

Gelfoam embolization for distal, medium vessel injury during mechanical thrombectomy in acute stroke: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5668-5674页

作者： Ji Yun kang Kyung Sik Yi sang-Hoon Cha Chi-Hoon Choi Yook Kim Jisun Lee bum sang Cho Department of Radiology Chungbuk National University HospitalCheongju 28644South Korea College of Medicine and Medical Research Institute Chungbuk National UniversityCheongju 28644South Korea

BACKGROUND Arterial perforation has inevitably increased as endovascular treatments have become more common for intracranial large vessel occlusions,and even distal,medium vessel occlusions.A distal,medium vessel has a tortuous course and thinner wall compared to large arteries,making it more susceptible to ***,we review the treatment strategies for arterial perforation during mechanical thrombectomy,and we report the case of a patient treated with gelfoam *** SUMMARY A 63-year-old woman presented to the emergency department with sudden neurologic symptoms of right hemiparesis and global *** initial National Institutes of Health Stroke Scale score was *** tomography(CT)and CT angiography revealed hyperacute infarction and emergent arterial occlusion of the left middle cerebral artery M2-3 *** endovascular mechanical thrombectomy,arterial rupture *** patient’s vital signs were stable,but delayed angiography showed persistent active ***,selective embolization of the injured artery was performed using *** left vertebral and internal carotid angiography was performed to confirm hemostasis.A localized subarachnoid hemorrhage(SAH)was confirmed on a follow-up CT scan.A repeated CT scan after 12 d showed resolution of the SAH,and rebleeding did not *** Rescue embolization with gelfoam could be considered an additional option in distal,medium vessel perforation.

关键词： Gelfoam Embolization Acute ischemic stroke Mechanical thrombectomy Arterial perforation Case report

Bidirectional WDM Self-Healing Ring Network for Hub/Remote Nodes

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光学学报 2003年第S1期23卷 715-716页

作者： Sung-bum Park Seung Goo kang sang Bae Lee Chang-Hee Lee KAIST Dept. of Electrical Engineering and Computer Science 373-1 Kusong-dong Yusong-gu Daejeon 305-701 KoreaCurrent affiliation: Samsung Electronics Co. Ltd. Suwon KoreaXL Photonics Inc.Daejeon KoreaKIST Seoul KoreaKAIST Dept. of Electrical Engineering and Computer Science 373-1 Kusong-dong Yusong-gu Daejeon 305-701 Korea

We demonstrate a bidirectional WDM self-healing ring network for hub/remote nodes with one fiber. In this network, self-healing can be achieved within 8 ms. The transmission capacity can be doubled in the operating st... 详细信息

关键词： WDM on in Bidirectional WDM Self-Healing Ring Network for Hub/Remote Nodes for dBm

Concurrent hepatocellular carcinoma metastasis to stomach,colon,and brain:A case report

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World Journal of Clinical Cases 2020年第16期8卷 3534-3541页

作者： Ryounggo Kim Jooyweon Song sang bum Kim Department of Surgery Dongnam Institute of Radiological&Medical SciencesBusan 46033South Korea Department of Pathology Dongnam Institute of Radiological&Medical SciencesBusan 46033South Korea Department of Surgery Korea Cancer Center HospitalKorea Institute of Radiological&Medical SciencesSeoul 01812South Korea

BACKGROUND Extrahepatic metastasis(EHM)from hepatocellular carcinoma(HCC)occurs in 10%–15%of cases following initial *** most frequent sites of EHM are the lung,lymph nodes,and *** or brain metastasis from HCC is rarely ***,we report a rare case of concurrent HCC metastases to the stomach,colon,and *** SUMMARY A 72-year-old male with a history of alcohol induced HCC presented with multiple intrahepatic recurrences and tumorous lesions in the stomach and ascending *** years earlier,he underwent right hemihepatectomy,and 1 year ago,he had a video-assisted thoracoscopic wedge resection for pulmonary metastasis of *** decided on surgical resection of the new metastases because of massive gastric bleeding and concern for possible colonic *** patient underwent gastric wedge resection and right *** weeks later,the patient developed dysarthria and mild cognitive *** resonance imaging of the brain revealed a left frontal lobe lesion,and he underwent resection of a metastatic brain ***,he died 6 weeks after the last surgery due to hepatorenal *** Decision of surgery was carefully recommended in this case and may extend survival in other metastatic HCC patients with well-preserved hepatic function.

关键词： Hepatocellular carcinoma Extrahepatic metastasis Stomach Colon Brain Case report