检索结果-南通市图书馆

Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

引用

World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta trinks María F Mascardi Adrián Gadano Sebastián Marciano Instituto de Medicina traslacional e Ingeniería Biomédica-Consejo nacional de Investigaciones Científicas y técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo nacional de Investigaciones Científicas y técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MASLD)risk *** ability to identify patients with MASLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of MASLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MASLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MASLD biomarker research.

关键词： Metabolic dysfunction-associated steatotic liver disease non-alcoholic steatohepatitis Biomarker Risk stratification Omics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unsupervised intrusion detection system for in-vehicle communication networks

引用

Journal of Safety Science and Resilience 2024年第2期5卷 119-129页

作者： Kabilan n Vinayakumar Ravi V Sowmya Center for Computational Engineering and networking(CEn) Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia Center for Artificial Intlligence Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In-vehicle communication has been optimized day to day to keep updated of the *** area network(CAn)is used as a standard communication method because of its efficient and reliable ***,CAn is prone to several network level attacks because of its lack in security *** methods have been introduced to incorporate this in *** proposed an unsupervised method of intrusion detection for in-vehicle communication networks by combining the optimal feature extracting ability of autoencoders and more precise clustering using fuzzy C-means(FCM).the proposed method is light weight and requires less computation *** performed an extensive experiment and achieved an accuracy of 75.51%with the ML35o in-vehicle intrusion *** experimental result,the proposed method also works better for other intrusion detection problems like wireless intrusion detection datasets such as WnS-DS with accuracy of 84.05%and network intrusion detection datasets such as KDDCup with accuracy 60.63%,UnSW_nB15 with accuracy 73.62%and Information Security Center of Excellence(Iscx)with accuracy 74.83%.Overall,the proposed method outperforms the existing methods and avoids labeled datasets when training an in-vehicle intrusion detection *** results of the experiment of our proposed method performed on various intru-sion detection datasets indicate that the proposed approach is generalized and robust in detecting intrusions and can be effectively deployed in real time to monitor CAn traffic in vehicles and proactively alert during attacks.

关键词： Controlarea network Intrusiondetection Unsupervised learning Autoencoders Fuzzy C-means

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polyelectrolyte Complexes between Hyperbranched and Linear Polysaccharides: Fucoidan/Chitosan

引用

Chinese Journal of Polymer Science 2024年第4期42卷 468-479页

作者： Ekaterina R.Gasilova Daria n.Poshina Aleksandra O.Sitnikova natalia n.Saprykina Yury A.Skorik Institute of Macromolecular Compounds of the Russian Academy of Sciences Bolshoi VO 31St.Petersburg199004Russian Federation

Polyelectrolyte complexes(PECs)of hyperbranched(HB)and linear polysaccharides are promising as more effective encapsulation agents compared to PECs formed by linear *** investigated the PECs between the HB anionic polysaccharide fucoidan(FUC)and the cationic linear polysaccharide chitosan(CS).the FUC had a molecular weight(MW)of 30×*** PECs were prepared in three solvents(water,0.01 and 0.1 mol/L acetic acid)with CS of MW of 15,110 and 170 kDa,and deacetylation degrees(DDA)of 70%and 97%.the structures of the PECs and the initial FUC were investigated by multi-angle static and dynamic light *** the FUC contained 18 wt%of—OSO3 groups and 5 wt%of uronic acid units,it was a“strong-weak”copolyanion,so the HB macromolecules of the FUC formed nanogel particles in 0.1 mol/L AcOH and open branched structures in water,as confirmed by the Kratky *** mixing the solutions of original components,the PEC structures underwent an equilibration period,the duration of which increased with the MW of *** the charge stoichiometry was approached,the PECs shrank;the fractal dimension approached unity,indicating the side-by-side packing of adjacent FUC branches with the help of *** aggregation in the vicinity of the charge compensation was hardly observed,as it occurred in a very narrow *** PEC content at theζ-potential inversion depended on solvents’pH and the DDA of *** the extreme case of core-shell PECs in 0.1 mol/L AcOH,obtained by mixing FUC nanogels with the solutions of high MW CS of 97%DDA,the protruding tails of CS formed a positively charged shell in the whole range of FUC content(10 wt%t%).Scanning electron microscopy and atomic force microscopy images of dried samples were discussed in relation to the light scattering results.

关键词： Polyelectrolyte complexes Chitosan Hyperbranched fucoidan Light scattering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Long-term monitoring reveals the effect of precipitation and silviculture on nothofagus regeneration in northern Patagonia mixed forests

引用

Ecological Processes 2024年第02期13卷 103-117页

作者： Georgina Sola Camila Mateo Alejandro Dezzotti Paula Marchelli Hernán Attis Beltrán Renato Sbrancia Luis Chauchard Marcelo González Pe?alba Martín Lara Verónica El Mujtar Consejo nacional de Investigaciones Científicas y técnicas (COnICEt ) Asentamiento Universitario San Martín de los Andes (AUSMA-UnCo) Instituto de Investigaciones Forestales y Agropecuarias Bariloche (IFAB) Instituto Nacional de Tecnología Agropecuaria (INTA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Departamento de Conservación y Manejo Parque Nacional Lanín- Administración de Parques Nacionales (PNL-APN)

Background tree regeneration is a key component of resilience because it promotes post-disturbance recovery of forests. northwestern Patagonia from Argentina is occupied by nothofagus alpina（na）, n. obliqua（no）, and n. dombeyi（nd） forests that grow along an intense precipitation gradient, managed throughout shelterwood silvicultural system by technicians of the Lanin natural Reserve. the objective of this study was to evaluate the influence of seeding cuttings over the dynamics of nothofagus mixed forests across landscape（precipitation gradient） based mainly on the composition and abundance of tree regeneration, permanent sampling plots and generalized linear mixed models. In particular, we analysed:（i） the structure of sexual and asexual regeneration during nd > 20 years after harvest（the dynamics of managed forests）, and（ii） the structure of sexual regeneration in primary and managed forests after > 20 years of harvest（the effect of silviculture）.Results nd was the most abundant species in the regeneration of managed forests during all periods in both sites despite its lower contribution to the adult cohort. During the 10–20 years period after harvest, the humid site exhibited higher regeneration density than the mesic site(120,000 and 6000 ind ha-1, respectively), and it decreased afterwards. the number of established regeneration（> 2 m height） was lower for na in the mesic site and for no in the humid site(0 and 57 ind ha-1, respectively). However, in comparison to no, na showed a higher number of sprouted stumps and sprouts per stump, and a higher sprout height in the mesic site. no exhibited higher sprout mortality in the humid site. Finally, the regeneration of primary forests showed lower density and height, and a more balanced composition than that of managed *** the silvicultural effects on the mixed forest regeneration dynamics was strongly influenced by the condition of sites. therefore, management prescriptions should be adj

关键词： nothofagus alpina nothofagus obliqua nothofagus dombeyi Basal sprouting Shelterwood silvicultural system Ecological resilience

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Effects of synthesis parameters on the performance of crosslinked Co-polymers with clays for conformance control

引用

Petroleum Research 2024年第1期9卷 98-108页

作者： A.A.Roslan n.A.A.Aziz n.F.A.Deraman I.Dzulkarnain Petroleum Engineering Department Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia Chemical Engineering Department Centre of Research Enhanced Oil Recovery(COREOR)Universiti Teknologi PETRONASSeri IskandarPerakMalaysia

Conformance control or water shut-off is a technique used to improve oil *** conformance control,polymers block high permeability water areas and redistribute water drive toward unswept oil *** this study,co-polymers(denoted AtP-PGV/AM-co-AMPS)were synthesized using acrylamide(AM)and 2-acrylamide-2-methylpropane sulfonic acid(AMPS)as the monomers,polyethylene glycol(PEG)-200 and methylenebisacrylamide(MBA)as the crosslinkers,attapulgite(AtP)and bentonite(PGV)as the clay types,and ammonium persulfate(APS)as the initiator,in addition to paraffin oil and *** were synthesized using inverse emulsion polymerization with different concentrations of monomers,crosslinkers,and clays,and they were characterized using Fourier-transform infrared(FtIR)spectroscopy and scanning electron microscopy(SEM)with energy dispersive X-ray spectroscopy(EDX).FtIR spectra of the samples confirmed the existence of sulfonate and hydroxyl groups,which are important for polymer ***-EDX images indicated that the morphology and elemental composition were different before and after swelling,confirming the occurrence of ***,samples were placed in sodium chloride solution(20,000 ppm)for 7 days to evaluate swelling at both room temperature and 90°*** analysis(tGA)and differential scanning calorimetry(DSC)were used to determine the thermal characteristics of the ***,rheological measurements were used to assess the deformation and rheological behavior of the *** results showed that after 1 day,good swelling without loss of mechanical strength was achieved with the composite synthesized using 10%AM,15%AMPS,6%PGV,and 10%AtP.

关键词： Polymer Clay Water shut-off Conformance Swelling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Early Phases of Star Formation: testing Chemical tools

引用

Research in Astronomy and Astrophysics 2024年第1期24卷 96-118页

作者： n.C.Martinez S.Paron COnICEt-Universidad de Buenos Aires.Instituto de Astronomía y Física del Espacio Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

Star-forming processes strongly influence the ISM ***,many high-quality databases are available at millimeter *** them,it is possible to carry out studies that review and deepen previous *** these studies involve large samples of sources,it is preferred to use direct tools to study the molecular *** the aim of testing these tools such as the use of the HCn/HnC ratio as a thermometer,and the use of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H as "chemical clocks," we present a molecular line study toward 55 sources representing massive young stellar objects at different evolutionary stages:infrared dark clouds(IRDCs),highmass protostellar objects(HMPOs),hot molecular cores(HMCs) and ultracompact H II *** found that the use of the HCn/HnC ratio as a universal thermometer in the ISM should be taken with care because the HCn optical depth is a big issue that can affect the ***,this tool should be utilized only after a careful analysis of the HCn spectrum,checking that no line,neither the main nor the hyperfine ones,presents absorption *** point out that the analysis of the emission of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H could be useful to trace and distinguish regions among IRDCs,HMPOs and *** molecular line widths of these four species increase from the IRDC to the HMC stage,which can be a consequence of the gas dynamics related to the starforming processes taking place in the molecular *** results not only contribute with more statistics,acting as a probe of such chemical tools,useful to obtain information in large samples of sources,but also complement previous works through the analysis of other types of sources.

关键词： stars:formation ISM:molecules ISM:clouds

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Psychological consequences of a diagnosis of infertility in men:a systematic analysis

引用

Asian Journal of Andrology 2024年第1期26卷 10-19页

作者： Sarah n Biggs Jane Halliday Karin Hammarberg Reproductive Epidemiology Murdoch Children's Research InstituteMelbourne 3052Australia Department of Paediatrics University of MelbourneMelbourne 3052Australia Public Health and Preventative Medicine Monash UniversityMelbourne 3004Australia Victorian Assisted Reproductive treatment Authority Melbourne 3000Australia

Almost half of infertility cases involve male *** the consequence of a diagnosis of male infertility,as a sole or partial contributor to the couples'infertility,to the mental health of men is required to ensure clinical care meets their psychological *** aim of this systematic analysis was to synthesize the evidence regarding whether men diagnosed with male factor infertility experience greater psychological distress than(1)men described as fertile and(2)men in couples with other infertility *** databases were searched using a combination of Medical Subject Headings(MeSH)headings and keywords relating to male infertility and psychological *** search yielded 1016 unique publications,of which 23 were included:8 case-control,14 prospective cohort,and 1 data linkage *** aspects of psychological distress were identified depression,anxiety,self-esteem,quality of life,fertility-related stress,general psychological stress or well-being,and psychiatric ***-control studies reported that men with male factor infertility have more symptoms of depression,anxiety and general psychological distress,worse quality of some aspects of life,and lower self-esteem than *** men with male factor infertility were compared to men in couples with other causes of infertility,there were few differences in the assessed aspects of psychological *** methodological limitations within the studies,this systematic analysis suggests that the experience of infertility,irrespective of its cause,negatively affects men's mental health and demonstrates the need for assisted reproduction technology(ARt)providers to consider men undergoing assisted reproduction as individuals with their own unique support needs.

关键词： anxiety depression infertility male mental health quality of life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Imprints of a gravitational wave through the weak field deflection of photons

引用

Chinese Physics C 2024年第8期48卷 240-245页

作者： Reggie C.Pantig Ali Övgün Physics Department Mapúa University658 Muralla St.IntramurosManila 1002Philippines Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkiye

In this study,we investigate the novel phenomenon of gravitational lensing experienced by gravitational waves traveling past a Schwarzschild black hole perturbed by a specific,first-order,polar gravitational *** apply the Gauss-Bonnet theorem,finding a topological contribution to the deflection of light rays passing near the black *** demonstrate that the deflection angle can be determined by analyzing a region entirely outside the path of the light ray,leading to a calculation based solely on the parameters of the perturbing wave(Legendre polynomial order,l;frequency,σ).this approach offers a unique perspective on gravitational lensing and expands our understanding of black hole interactions with gravitational waves.

关键词： supermassive black holes gravitational waves chaos weak deflection angle Gauss-Bonnet theorem

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Academic productivity correlates with industry earnings in foot and ankle fellowship programs in the United States:A retrospective analysis

引用

World Journal of Orthopedics 2024年第2期15卷 129-138页

作者： Albert t Anastasio Anthony n Baumann Kempland C Walley Kyle J Hitchman Conor O’neill Jonathan Kaplan Samuel B Adams Department of Orthopedic Surgery Duke University HospitalDurhamNC 27710United States College of Medicine Northeast Ohio Medical UniversityRootstownOH 44272United States Department of Orthopedic Surgery University of MichiganAnn ArborMI 48109United States School of Osteopathic Medicine Campbell UniversityLillingtonNC 27546United States

BACKGROUnD the study investigates the connection between academic productivity and industry earnings in foot and ankle orthopedic surgery *** metrics like the H-index and Open Payments Database(OPD)data,it addresses a gap in understanding the relationship between scholarly achievements and financial outcomes,providing a basis for further exploration in this specialized medical *** to elucidate the trends between academic productivity and industry earnings across foot and ankle orthopedic surgery fellowship programs in the United *** this study is a retrospective analysis of the relationship between academic productivity and industry earnings of foot and ankle orthopedic surgery fellowships at an individual faculty and fellowship *** productivity was defined via H-index and recorded from the Scopus *** earnings were recorded from the *** Forty-eight foot and ankle orthopedic surgery fellowships(100%of fellowships)in the United States with a combined total of 165 physicians(95.9%of physicians)were *** individual physician(n=165)total life-time earnings reported on the OPD website was United States Dollar(USD)451430.30±1851084.89(range:USD 25.16-21269249.85;median:USD 27839.80).Mean physician(n=165)H-index as reported on Scopus is 14.24±12.39(range:0-63;median:11).there was a significant but weak correlation between individual physician H-index and individual physician total life-time earnings(Pn’s rho=0.334)and a significant and moderate positive correlation between combined fellowship H-index and total life-time earnings per fellowship(P=0.004,Spearman’s rho=0.409).COnCLUSIOn there is a significant and positive correlation between academic productivity and industry earnings at foot and ankle orthopedic surgery fellowships in the United *** observation is true on an individual physician level as well as on a fellowship level.

关键词： Sunshine act Foot and ankle Orthopedic surgery Orthopedic fellowship Industry earnings

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Detection of 4p16.3 deletion and 11p15.5p15.4 gain in a boy by comparative genomic hybridization array:A case report

引用

World Journal of Clinical Cases 2024年第8期12卷 1517-1522页

作者： Işın Kaya Medical Genetics Bakırçay UniversityÇiğli Education ve Training Hospitalİzmir 35620Turkey

BACKGROUnD nonallelic homologous recombination(nAHR)of segmental duplications or low copy repeats(LCRs)result in DnA gain/loss and play an important role in the origin of genomic *** SUMMARY A 3-year-old boy was referred for genetic *** genomic hybrid-ization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal region and a gain of 3201 kb in the 11p15.5p15.4 chromosomal *** Genomic imbalances caused by nAHR in LCRs result in deletion and duplication syndromes.

关键词： Wolf-Hirschhorn syndrome Silver-Russell syndrome Recurrent rearrangements Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：