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High-resolution multi-scale air pollution system:Evaluation of modelling performance and emission control strategies

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Journal of Environmental Sciences 2024年第3期137卷 65-81页

作者： Diogo Lopes Joana Ferreira sandra rafael Ka In Hoi Xin Li Yuan Liu Ka-Veng Yuen Kai Meng Mok Ana Isabel Miranda Department of Environment and Planning&CESAM University of AveiroAveiroPortugal Department of Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric *** also allows furthering the design and assessment of air pollution control measures for a specific *** evaluate its performance and suitability,the system was applied to the Macao Special Administrative Region(SAR),China,one of the most densely populated areas on earth,during a winter period when this area is affected by high levels of Particulate Matter(PM).Although the developed system tends to underestimate the PM concentrations,it revealed a good performance in reproducing the temporal and spatial air pollution *** exceedances of the Chinese air quality standards were calculated and high population exposure to PM pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should focus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in Macao *** approach developed in this work can support policymakers in defining new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory Particulate matter Population exposure

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The importance of functional diversity in the stability of Mediterranean shrubland communities after the impact of extreme climatic events

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Journal of Plant Ecology 2017年第2期10卷 281-293页

作者： Enrique Gde la Riva Francisco Lloret Ignacio MPérez-Ramos Teodoro Marañón sandra Saura-Mas Ricardo Díaz-Delgado rafael Villar Area de Ecología Facultad de CienciasUniversidad de Cordoba.14071 CordobaSpain CREAF Cerdanyola del Vallés08193 BarcelonaSpain Unitat d’Ecologia Dept.Biologia AnimalBiologia Vegetal i EcologiaUniversitat Autònoma BarcelonaEdifici CCampus UAB08193Cerdanyola del VallèsBarcelonaSpain IRNAS CSICAv.Reina Mercedes 10PO Box 1052.41080 SevillaSpain Estación Biológica de Doñana CSIC.c/Americo Vespucios/nIsla de la Cartuja.41092 SevillaSpain

Aims Extreme climatic events may have important consequences for plant community structure and *** 2005,a severe drought together with a cold winter promoted extensive damage and mortal-ity in shrubland communities of southwest Spain(Doñana National Park).Here,we aim to identify the mechanisms underlying commu-nity stability(resistance and resilience)in response to this extreme climatic event,considering changes in the functional structure of these *** We used a trait-based approach,quantifying variations in 10 func-tional traits at the community level(community weighted means,CWM)and the functional diversity(functional richness,evenness and divergence)in 18 plots at three different times:predating the climatic event(estimated from the sum of the live and dead volume of each species in 2007),and 2 and 8 years after the 2005 *** also quantified the differences in functional traits and functional diversity between adult and recruit stages,which allowed us to bet-ter understand the contribution of the recruitment to the mainte-nance of the functional structure and diversity of the *** Findings Communities with higher functional divergence before the cli-matic event maintained nearly constant their levels of functional divergence 8 years after,but they were more prone to changes in species *** resistance in terms of vegeta-tion cover was positively correlated with root dry matter content,whereas community resilience was positively correlated with leaf chlorophyll(LChl).We also found that some values(weighted means)of functional community traits(such as root dry matter con-tent and LChl)had increased 2 years after the event,returning to the pre-event conditions after 8 *** addition,there was hardly any establishment of new species in the community and the recruits did not make substantial differences to the community functional *** seed mass differed significantly between the adult and se

关键词： climate change Doñana drought functional trait recruitment resilience resistance

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Perceptions of Climate Change in Puerto Rico before and after Hurricane Maria

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American Journal of Climate Change 2021年第2期10卷 153-166页

作者： Méndez-Tejeda rafael María Santos-Corrada Mena sandra Natural Science Department Atmospherical Science Laboratory University of Puerto Rico at Carolina Puerto Rico USA School of Business and Entrepreneurship University of Ana G. Méndez Gurabo Puerto Rico USA

This article analyzes the perceptions of Puerto Rican citizens of global climate change (GCC) before and after an extreme weather event, specifically Hurricane Maria (HM). The purpose of the current article is to evaluate Puerto Ricans’ perceptions of the impact of extreme meteorological phenomena and of GCC before and after HM. This tropical cyclone entered the island as a category IV hurricane on September 17, 2017, causing enormous destruction, loss of life, and economic damage. In this study, two data samples were collected before and after HM struck Puerto Rico (PR) (the second sample was collected approximately six months after the hurricane). Surveyed citizens with general knowledge of GCC increased from 43% to 62%, which the researchers consider a small increase, considering the severe destruction caused by HM. This study also found that Puerto Ricans trust non-profit institutions and the scientific community more than state authorities. Furthermore, 85% of citizens believe that public policies on GCC should be directed by the state (federal, state, and municipal governments);this did not change after HM. In addition, this study found that the poor response of the federal and state governments to the destruction caused by HM increased citizens’ trust in the scientific community.

关键词： Puerto Rico Hurricane Maria Perception Climatechange

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Implications of Electrical Impedance-Based Microbiological Technology in Pork Meat Processing Industry for the Rapid Detection and Quantification of Salmonella Spp.

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Journal of Food Science and Engineering 2017年第1期7卷 1-16页

作者： Cristina Pablos Javier Marugan sandra Cristobal rafael van Grieken Department of Chemical and Environmental Technology University Rey Juan Carlos C/Tulipan s/n Mostoles (Madrid) 28933Spain

The absence of efficient tools for preventing bacterial contamination in the meat processing industry as well as for detecting Salmonella positive samples in real time is a matter of concern. Impedance technology has proved its effectiveness as a bacterial quantification tool for research purposes instead of laborious standard plate count, and as a detection tool to substitute tedious current horizontal method ISO 6579：2002. Calibration curves were carded out for S. enteritidis and S. typhimurium in raw pork matrix （R2 〉 0.90）. Calibrations of mixtures of both strains at different ratio were prepared, showing a high efficiency to differentiate bacterial metabolism. Impediometry was also validated against standard plate count in raw pork samples treated by UV-C illumination to inactivate Salmonella. Even, damaged but still viable bacteria were recorded. Detection of Salmonella by impediometry led to a decrease in false positives, obtaining results within 30 h compared to 72 h in case of conventional method.

关键词： Impediometry S. enteritidis S. typhimurium quantification detection pork meat.

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鳞状上皮细胞癌抗原水平新检测方法在宫颈癌、肺癌和头颈部癌鉴别诊断中的性能及临床表现

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中国肺癌杂志 2018年第7期21卷 J0001-J0012页

作者： Stefan HOLDENRIEDER rafael MOLINA Ling QIU Xiuyi ZHI sandra RUTZ Christine ENGEL Pia KASPER- SAUER Farshid DAYYANI Catharina Mkorse 波恩大学医院德国波恩巴塞罗那医院巴塞罗那大学西班牙巴塞罗那北京协和医院中国北京首都医科大学宣武医院中国北京罗氏诊断公司德国Penzberg 罗氏诊断公司德国Mannheim 罗氏诊断国际有限公司瑞士Rotkreuz 加利福尼亚大学美国Irvine CA 荷兰癌症研究院荷兰阿姆斯特丹

鳞状上皮细胞癌抗原水平在鳞状上皮细胞癌中通常升高。这项多中心研究评估了一种新的Elecsys?鳞状上皮细胞癌检测的检测性能,该检测方法是以等摩尔方式测量血清鳞状上皮细胞癌抗原1和2的水平,并研究了鳞状上皮细胞癌抗原用于宫颈癌、肺... 详细信息

鳞状上皮细胞癌抗原水平在鳞状上皮细胞癌中通常升高。这项多中心研究评估了一种新的Elecsys?鳞状上皮细胞癌检测的检测性能,该检测方法是以等摩尔方式测量血清鳞状上皮细胞癌抗原1和2的水平,并研究了鳞状上皮细胞癌抗原用于宫颈癌、肺癌和头颈部鳞状上皮细胞癌鉴别诊断的潜能。在欧洲三个研究中心进行了精确度和方法学比较实验。健康人群的参考区间使用来自欧洲和中国人群的样本确定的。鉴别诊断试验确定了鳞状上皮细胞癌抗原水平能否将宫颈癌、肺癌或头颈癌与表观健康的、良性的或其他恶性群组区分开来。根据95%特异性下的鳞状上皮细胞癌抗原水平计算出鳞状上皮细胞癌抗原医学截断值。9个分析浓度的重复性变异系数<5.3%,中间精密变异系数<0.3%。方法学比较显示,与Architect和Kryptor系统具有很好的相关性(斜率分别为1.1和1.5)。表观健康人群的第95百分位数的参考区间为2.3 ng/m L(95%置信区间:1.9-3.8;欧洲队列,n=153)和2.7 ng/m L(95%置信区间:2.2-3.3;中国队列,n=146)。最佳的鉴别诊断结果见于宫颈鳞状上皮细胞癌:受试者工作特征曲线分析显示鳞状上皮细胞癌抗原水平(2.9 ng/m L的医学截断值)鉴别宫颈鳞状上皮细胞癌(n=127)与表观健康女性(n=286;曲线下面积:86.2%;95%置信区间:81.8-90.6;灵敏度:61.4%;特异性:95.6%),良性疾病(n=187;曲线下面积:86.3%;95%置信区间:81.2-91.3;灵敏度:61.4%;特异性:95.0%)和其他宫颈癌(n=157;曲线下面积:78.9%;95%置信区间:70.8-87.1;灵敏度:61.4%;特异性:86.7%)。鳞状上皮细胞癌还可帮助鉴别诊断肺癌。Elecsys鳞状上皮细胞癌检测技术在宫颈鳞状上皮细胞癌的临床实践中表现出了良好的性能,适合用于鉴别诊断。

关键词：鳞状上皮细胞癌免疫检测颈部肺部头部颈部

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New environmental factors related to diabetes risk in humans:Emerging bisphenols used in synthesis of plastics

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World Journal of Diabetes 2023年第8期14卷 1301-1313页

作者： rafael Moreno-Gómez-Toledano María Delgado-Marín Alberto Cook-Calvete Claudia González-Cucharero Nunzio Alcharani Beatriz Jiménez-Guirado Ignacio Hernandez rafael Ramirez-Carracedo Laura Tesoro Laura Botana sandra Sánchez-Esteban Javier Diez-Mata Jose Luis Zamorano Ricardo J.Bosch Carlos Zaragoza Marta Saura Universidad de Alcalá Department of Biological Systems/PhysiologyAlcaláde Henares 28871Spain Cardiology Department University Hospital Ramón y CajalMadrid 28034Spain Laboratory of Cardiovascular Pathophysiology Joint Translational Research UnitUniversity Francisco de Vitoria School of MedicineMadrid 28034Spain Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS Madrid 28034Spain

BACKGROUND Diabetes mellitus(DM)is one of the largest global health emergencies of the 21st *** recent years,its connection with environmental pollutants,such as bisphenol A(BPA),has been demonstrated;consequently,new structurally similar molecules are used to replace BPA in the plastics industry(BPS,BPF and BPAF).AIM To carry out a systematic review to allow coherent evaluation of the state of the ***,a meta-analysis was performed to unify the existing quantitative *** Firstly,a systematic review was carried out,using the terms“(bisphenol)AND(Diabetes OR Hyperglycemia)”,to maximize the number of ***,three authors analyzed the set of ***,a meta-analysis was performed for each BP,using RevMan *** addition,funnel plots were developed to study publication *** The systematic analysis of the literature revealed 13 recent articles(2017–2023)related to the study *** qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry:BPS,BPF and ***,the meta-analysis determined a positive relationship with BPS,BPF and BPAF,which was only statistically significant with *** There is a need to apply the precautionary principle,regulating the use of new ***,replacing BPA with BPS,BPF or BPAF is unlikely to protect the population from potential health risks,such as DM.

关键词： Bisphenol S Bisphenol F Bisphenol AF Diabetes mellitus Systematic review Meta-analysis

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Thalidomide induces mucosal healing in Crohn's disease: Case report

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World Journal of Gastroenterology 2011年第45期17卷 5028-5031页

作者： Márcio Rios Leite sandra Sousa Santos André Castro Lyra Jaciane Mota Genoile Oliveira Santana Department of Gastroenterology Prof. Edgard Santos University Hospital Federal University of Bahia Salvador Department of Gastrohepatology So Rafael Hospital Monte Tabor Foundation So Marcos Avenue

Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract that is defi ned by relapsing and remitting episodes. Tumor necrosis factor alpha (TNF-α) appears to play a central role in the pathophysiology of the disease. Standard therapies for inflammatory bowel disease fail to induce remission in about 30% of patients. Biological therapies have been associated with an increased incidence of infections, especially infection by Mycobacterium tuberculosis (Mtb). Thalidomide is an oral immunomodulatory agent with anti-TNF-α properties. Recent studies have suggested that thalidomide is effective in refractory luminal and fistulizing Crohn's disease. Thalidomide costimulates T lymphocytes, with greater effect on CD8+ than on CD4+ T cells, which contributes to the protective immune response to Mtb infection. We present a case of Crohn's disease with gastric, ileal, colon and rectum involvement as well as steroid dependency, which progressed with loss of response to infliximabafter three years of therapy. The thorax computed tomography scan demonstrated a pulmonary nodule suspected to be Mtb infection. The patient was started on thalidomide therapy and exhibited an excellent response.

关键词： Anti-tumor necrosis factor alpha Crohn’s disease Mucosal healing Mycobacterium tuberculosis Thalidomide

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Antagonistic Effect of Bacteria Isolated from the Digestive Tract of Lutzomyia evansi against Promastigotes of Leishmania infantum, Antimicrobial Activities and Susceptibility to Antibiotics

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Advances in Microbiology 2016年第10期6卷 760-775页

作者： rafael J. Vivero Gómez Gloria E. Cadavid Restrepo Claudia X. Moreno Herrera Victoria Ospina sandra I. Uribe Sara M. Robledo PECET-Medical Research Institute University of Antioquia Medellin Colombia Molecular Systematics Group National University of Colombia Medellin Colombia Microbiodiversity and Bioprospection Research Group Cellular and Molecular Biology Laboratory National University of Colombia Medellin Colombia

Lutzomyia evansi is a phlebotomine insect endemic to Colombia’s Caribbean coast and is considered the main vector of visceral and cutaneous leishmaniasis in the region. Specific studies of the direct effects generated by bacteria in the digestive tract of the insect vectors, under Leishmania infantum using in vitro models, represent a novel alternative as a control strategy for the transmission of leishmaniasis and also provide the opportunity to detect natural products or antimicrobial peptides with different biological activities. In this study, we evaluate the leishmanicidal and antimicrobial activities of Pantoea ananatis, Ochrobactrum anthropi and Enterobacter cloacae, isolated from the digestive tract of Lutzomyia evansi and the susceptibility of these bacteria to commonly used antibiotics. The antagonistic effect of Pantoea ananatis, Ochrobactrum anthropi and Enterobacter cloacae was evaluated against six species of human pathogenic bacteria and against stationary (Metacyclic-like) and exponential promastigotes (Procyclic-like) of Leishmania infantum (BCN-GFP strain) by co-culture assays for 24 hours. The activity of the bacterial isolates on Leishmania infantum promastigotes was quantified by flow cytometry. The susceptibility of the bacterial strains to clinically used antibiotics was analyzed by antibiogram. The highest percentage of inhibition was observed against exponential promastigotes with bacterial concentrations of 108 CFU/ml of Enterobacter cloacae (77.29% ± 0.6%) and Pantoea ananatis (70.17% ± 1.1%). The extracts produced by three bacterial isolates showed similar biological activity (13 mm - 22 mm inhibition halos) against all tested bacteria;however, significant differences were observed with respect to gram-positive bacteria (P < 0.003557). The most active antibacterial activity was displayed against the pathogenic bacteria Bacillus cereus. Ochrobactrum anthropi was the isolate with the highest number of antibiotic resistance patter

关键词： Intestinal Microbiota Leishmanicidal Activity Antimicrobial Activity Antibiotic Susceptibility

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Upper limb embolism as the first manifestation of atrial fibrillation

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Chinese Medical Journal 2014年第8期127卷 1599-1599页

作者： Gabriel Pérez Baztarrica Flavio Salvaggio sandra Zamar rafael Porcile Department of Cardiology and Physiology Universitary Hospital Universidad Abierta Interamericana Faculty of Medicine Buenos Aires Argentine

To the editor： We present a male patient, 75 years old, admitted to our emergency room with right ann pain for about an hour. The patient had only a history of arterial hypertension. On his physical examination, she had an irregular pulse. The right arm showed hypothermic with cyanotic hand. The right upper limb pulses were not palpable. Her initial electrocardiogram revealed atrial fibrillation with a fast ventricular response.

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Effect of music therapy on short-term psychological and physiological outcomes in mechanically ventilated patients:A randomized clinical pilot study

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Journal of Intensive Medicine 2024年第4期4卷 515-525页

作者： Mark Ettenberger Rosangela Casanova-Libreros Josefina Chávez-Chávez Jose Gabriel Cordoba-Silva William Betancourt-Zapata rafael Maya Lizeth Alexa Fandino-Vergara Mario Valderrama Ingrid Silva-Fajardo sandra Milena Hernández-Zambrano SONO-Centro de Musicoterapia BogotáColombia Vice-Rectorate for Research Fundación Universitaria de Ciencias de la SaludBogotáColombia Department of Biomedical Engineering University of Los AndesBogotáColombia Department of Rehabilitation Sociedad de Cirugía de Bogotá Hospital de San JoséBogotáColombia Faculty of Nursing Fundación Universitaria de Ciencias de la SaludBogotáColombia

Background:Elevated anxiety levels are common in patients on mechanical ventilation(MV)and may challenge *** suggests music-based interventions may reduce anxiety during ***,studies inves-tigating specific music therapy techniques,addressing psychological and physiological well-being in patients on MV,are ***:This three-arm randomized clinical pilot study was conducted with MV patients admitted to the intensive care unit(ICU)of Hospital San Joséin Bogotá,Colombia between March 7,2022,and July 11,*** were divided into three groups:intervention group 1(IG1),music-assisted relaxation;intervention group 2(IG2),patient-preferred therapeutic music listening;and control group(CG),standard *** main outcome measure was the 6-item State-Anxiety *** outcomes were:pain(measured with a visual analog scale),resilience(measured with the Brief Resilience Scale),agitation/sedation(measured with the Richmond Agitation-Sedation Scale),vital signs(including heart rate,blood pressure,oxygen saturation,and respiratory rate),days of MV,extubation success,and days in the ***,three patients underwent electroencephalography during the ***:Data from 23 patients were analyzed in this *** age range of the patients was 24.0-84.0 years,with a median age of 66.0 years(interquartile range:57.0-74.0).Of the 23 patients,19 were female(82.6%).No statistically significant differences between the groups were observed for anxiety(P=0.330),pain(P=0.624),resilience(P=0.916),agitation/sedation(P=0.273),length of ICU stay(P=0.785),or vital signs.A statistically significant difference between the groups was found for days of MV(P=0.019).Electroencephalography mea-surements showed a trend toward delta and theta band power decrease for two patients and a power increase on both beta frequencies(slow and fast)in the frontal areas of the brain for one ***:In this pilot study,music therapy did not sig

关键词： Music therapy Mechanical ventilation Intensive care unit Anxiety Pain

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