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Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus

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CCS Chemistry 2024年第2期6卷 487-496页

作者： Ke Sun Zhe Ding Xiaoying Jia Haonan Cheng Yingwen Li Yan Wu Zhuoyu Li Xiaohua Huang Fangxu Pu Entao Li Guiyou Wang Wei Wang Yun Ding Gary Wong sandra Chiu Jiaming Lan Aiguo Hu Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 CAS Key Laboratory of Molecular Virology&Immunology Chinese Academy of SciencesShanghai 200031 University of the Chinese Academy of Sciences Beijing 100049 State Key Laboratory of Virology Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071 Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230027 Department of Clinical Laboratory The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001

The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses ***,state-of-the-art treatments still lag behind the continual emergence of new *** to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural ***,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)*** core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the *** EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”

关键词： enediyne broad spectrum antiviral protein disintegration coronavirus polyanions

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诗意的日光

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世界建筑 2024年第1期 30-33页

作者：无 Louise Gronlund sandra Gonon(摄影) 孙斯坦(译) 丹麦皇家建筑艺术学院建筑与设计研究所 Claus Pryds建筑事务所不详

“诗意的日光”展馆展现了日光的空间品质,人们可以在一系列空间中体验日光的感性、美学以及其诗性的潜力。日光让我们了解自己在世界上的位置,以及我们每天所处的空间。建筑物的整体氛围很大程度上取决于日光。我们很愉快地看到日光从... 详细信息

“诗意的日光”展馆展现了日光的空间品质,人们可以在一系列空间中体验日光的感性、美学以及其诗性的潜力。日光让我们了解自己在世界上的位置,以及我们每天所处的空间。建筑物的整体氛围很大程度上取决于日光。我们很愉快地看到日光从早到晚的变化,并且体验到光明和黑暗如何塑造着我们周围的空间。

关键词：空间品质日光整体氛围诗意体验

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Dosage Formula in Anesthesia for Manual Intrauterine Aspiration Post-Abortion in Resource-Limited Settings

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Pharmacology & Pharmacy 2024年第4期15卷 71-80页

作者： Serge Ibula Rivain Iteke Berthe Barhayiga Doddie Tsansya Roger Cishugi Jean Jacques Kalongo sandra Sagboze Jean Paul Cikwanine Dieudonné Sengeyi ISTM/Bukavu Anesthesia-Resuscitation Section CIMAC Hospital Center in Goma Goma The Democratic Republic of the Congo Department of Anesthesia-Resuscitation University of Lubumbashi Lubumbashi The Democratic Republic of the Congo Department of Anesthesia-Resuscitation University of Kinshasa Kinshasa The Democratic Republic of the Congo Department of Gyneco-Obstetrics University of Kinshasa Kinshasa The Democratic Republic of the Congo Anesthesia-Resuscitation Department Panzi Hospital Bukavu The Democratic Republic of the Congo

Setting: Provincial General Reference Hospital of Bukavu, General Reference Hospital of Panzi, General Reference Hospital of Ciriri, General Reference Hospital of Nyatende and Biopharm Hospital Center. Objective: Contribute to the improvement of the anesthetic ECP of patients benefiting from MVA for incomplete abortion, Describe the methodology used for adoption of the dosage formula in Anesthesia for MVA, present the mathematical demonstration leading to the dosage formula in anesthesia for MVA. Materials and Methods: Our study was descriptive by mathematical demonstration of obtaining the equilibrium constant of the dosage formula of bipuvacaine 0.1% and Fentanyl 50 µg% adapted to the weight and specific size of patients treated anesthetically in MVA cases for incomplete abortion. We also carried out an operational research by first determining the interval where our equilibrium constant is included and secondly by means of the ends of the intervals found correlated to the ends of intervals of possible weights and sizes in the being normal human female of childbearing age to arrive at the real numerical value of the equilibrium constant of the BUKAVU Dosage Formula in the case of anesthesia for MVA during the management of incomplete abortions. Results: TWO-STAGE OPERATIONAL RESEARCH: • Determination of the interval where the equilibrium constant x = −0.95 x x by crossing the means between the extremes of volumes of anesthetic drugs giving a satisfactory sensory block without hemodynamic disturbance and the extremes of normal weight and height for women of childbearing age. We ended up with X = 0.37. Conclusion: At the end of our study which had the general objectives of contributing to the improvement of the anesthetic PEC of patients receiving MVA for incomplete abortion and specific objectives of describing the methodology used for adoption of the dosage formula in Anesthesia for MVA and present the mathematical demonstration which resulted in the dosage formul

关键词： Dosage Anesthesia Intrauterine Aspiration DR Congo

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Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala Sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

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Gut microbiota in preterm infants receiving breast milk or mixed feeding

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World Journal of Clinical Pediatrics 2024年第2期13卷 135-145页

作者： sandra Gabriela Sánchez-González Bárbara Gabriela Cárdenas-del-Castillo Elvira Garza-González Gerardo R Padilla-Rivas Isaías Rodríguez-Balderrama Consuelo Treviño-Garza Fernando Félix Montes-Tapia Gerardo C Palacios-Saucedo Anthony Gutiérrez-Rodríguez Manuel Enrique de-la-O-Cavazos Department of Pediatrics Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Departamento de Bioquímica y Medicina Molecular Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Biochemistry and Molecular Medicine Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMéxico Department of Pediatric Surgery Hospital Universitario"Dr.JoséEleuterio González"Monterrey 64460Nuevo LeónMéxico

BACKGROUND Preterm birth is the leading cause of mortality in newborns,with very-low-birthweight infants usually experiencing several *** milk is considered the gold standard of nutrition,especially for preterm infants with delayed gut colonization,because it contains beneficial microorganisms,such as Lactobacilli and *** To analyze the gut microbiota of breastfed preterm infants with a birth weight of 1500 g or *** An observational study was performed on preterm infants with up to 36.6 wk of gestation and a birth weight of 1500 g or less,born at the University Hospital ***éEleuterio González at Monterrey,Mexico.A total of 40 preterm neonates were classified into breast milk feeding(BM)and mixed feeding(MF)groups(21 in the BM group and 19 in the MF group),from October 2017 to June *** samples were collected before they were introduced to any feeding *** full enteral feeding was achieved,the composition of the gut microbiota was analyzed using 16S rRNA gene *** variables were compared using Student’s t-test or using the Mann–Whitney U test for nonparametric ***,evenness,equitability,Margalef’s index,Fisher’s alpha,Chao-1 index,and Shannon’s diversity index were also *** No significant differences were observed at the genus level between the *** comparison indicated higher counts of Alphaproteobacteria and Betaproteobacteria in the initial compared to the final sample of the BM group(P<0.011).In addition,higher counts of Gammaproteobacteria were detected in the final than in the initial sample(P=0.040).According to the Margalef index,Fisher’s alpha,and Chao-1 index,a decrease in species richness from the initial to the final sample,regardless of the feeding type,was observed(P<0.050).The four predominant phyla were Bacteroidetes,Actinobacteria,Firmicutes,and Proteobacteria,with Proteobacteria being the most ***,no significant differences were

关键词： Gut microbiota Human milk Preterm infant Proteobacteria Very low birth weight 16S rRNA

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Measurements of Laminar Burning Velocities of Alternative Fuels:Application in Transport and Aerospace

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Journal of Thermal Science 2023年第2期32卷 503-512页

作者： RICHTER sandra BRAUN-UNKHOFF Marina NAUMANN Clemens German Aerospace Center(DLR) Institute of Combustion TechnologyDepartment of Chemical Kinetics and AnalyticsStuttgart 70569Germany

The laminar burning velocity belongs to the fundamental combustion properties of fuels being a measure for their heat release,flame length,as well as reactivity and combustion stability,and thus,may impact the design of burners and combustion ***,these experimental data are needed for the validation and optimization within the construction and development of detailed chemical kinetic reaction *** this study,an overview of the different applications of fuel characterization regarding the specific area of interest(road transport,aviation,and aerospace)will be *** on the application,effects of different molecular characteristics on the laminar burning velocity are evaluated:the presence of oxygen atoms and the grade of branching in a specific fuel molecule as well as the difference in the type of a chemical bond,here,single and double *** of alternative fuels being discussed in the present study are:(Ⅰ)oxymethylene ether(OMEn)in the field of road transport;(Ⅱ)a paraffinic Alcohol-to-Jet fuel as sustainable aviation fuel;and(Ⅲ)mixtures of ethane or ethene with nitrous oxide as green propellants for rocket propulsion applications.

关键词： laminar burning velocity alternative sustainable fuels road transport aviation fuels green propellants

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CD5:from antiquated T cell marker to immunotherapy’s new hope

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2442-2444页

作者： sandra Schwarz Michael Linnebacher Molecular Oncology and Immunotherapy Clinic of General SurgeryRostock University Medical Center18057RostockGermany

In a recent study published in Science,He et *** the role of CD5 on dendritic cells(DCs)in priming effector T cells.^(1)By proving the importance of CD5 in engaging effective antitumor immune responses,they highlighte... 详细信息

关键词： immunotherapy al. CD5

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Greasy hair against obesity

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Signal Transduction and Targeted Therapy 2022年第1期7卷 11-12页

作者： sandra Nickel Bruno Christ Department of General Visceral and Vascular SurgeryJena University Hospital07740 JenaGermany Cell Transplantation/Molecular Hepatology Lab Department of VisceralTransplantThoracic and Vascular SurgeryUniversity of Leipzig Medical Center04103 LeipzigGermany

In their article,Choa et *** the perspective to loose fat by in creasing seboge *** a T cell-depe ndent mechanism,they suggest that stimulation of sebum production by thymic stromal lymphopeietin(TSLP)"pulls"lipids out of the adipose tissue.^(1) The World Population Review(***/)ranks obesity rates to one third of the global *** co-morbidities comprise diabetes type 2,ischemic stroke and cardiovascular complications render this epidemic disease the number 1 cause of deaths worldwide(***/).

关键词： obesity al stimulation

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Atomic Crosschain Transactions for Ethereum Private Sidechains

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Blockchain(Research and Applications) 2022年第1期3卷 23-39页

作者： Peter Robinson Raghavendra Ramesh sandra Johnson ConsenSys Software R&D Brisbane4520Australia School of Information Technology and Electrical Engineering The University of QueenslandQueensland 4072Australia ARC Centre of Excellence for Mathematical and Statistical Frontiers(ACEMS) Queensland University of TechnologyQueensland 4001Australia

The Atomic Crosschain Transaction for Ethereum Private Sidechains protocol allows composable programming across permissioned Ethereum *** allows for inter-contract and inter-blockchain function calls that are both synchronous and atomic:if one part fails,the whole call tree of function calls is *** protocol is not based on existing techniques such as Hash Time Locked Contracts,relay chains,block header transfer,or trusted *** uses(a)threshold signatures to prove values across blockchains,(b)coordination contracts to manage the state of crosschain transactions,and(c)a function call tree commitment scheme to allow users to commit to a call tree and then later check that the correct function calls have been *** paper analyses the processing overhead of using this technique compared to using multiple standard non-atomic single blockchain *** additional processing is analysed for four scenarios involving multiple blockchains:a Trade–Finance system,the Hotel–Train problem,a Supply Chain with Provenance,and an *** protocol is shown to have both safety and liveness properties.

关键词： Crosschain Blockchain Transaction Atomic Ethereum

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Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5129-5131页

作者： Ruben A.Ferrer Marta Torregrossa sandra Franz Department of Dermatology Allergology and VenerologyUniversity LeipzigLeipzigGermany

Skin injury releases damage-associated molecular patterns(DAMPs)represented by tissue-components and intracellular contents as well as changes in the levels of certain molecules and metabolites that signal the“non-homeostatic”state of the *** addition,microorganisms entering a wound release molecules,which are sensed as“non-self”(pathogen-associated molecular patterns,PAMPs).Together,DAMPs and PAMPs initiate a complex and coordinated repair process aimed at restoring *** exciting work from Liu et *** of an additional novel mechanism by which a“non-homeostatic”state in murine cutaneous wounds elicits a response through IL-24 to mediate repair(Fig.1).

关键词： wound homeostasis release

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