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npj Computational Materials 2022年第1期8卷 2076-2083页

作者： Annick De Backer sandra Van Aert Christel Faes Ece Arslan Irmak Peter DNellist Lewys Jones EMAT University of AntwerpGroenenborgerlaan 1712020AntwerpBelgium NANOlab Center of Excellence University of AntwerpGroenenborgerlaan 1712020AntwerpBelgium I-BioStat Data Science InstituteHasselt UniversityHasseltBelgium Department of Materials University of OxfordParks RoadOX13PHOxfordUK Advanced Microscopy Laboratory Centre for Research on Adaptive Nanostructures and Nanodevices(CRANN)Dublin 2Ireland School of Physics Trinity College DublinThe University of DublinDublin 2Ireland

We introduce a Bayesian genetic algorithm for reconstructing atomic models of monotype crystalline nanoparticles from a single projection using Z-contrast *** number of atoms in a projected atomic column obtained from annular dark field scanning transmission electron microscopy images serves as an input for the initial three-dimensional *** algorithm minimizes the energy of the structure while utilizing a priori information about the finite precision of the atom-counting results and neighbor-mass *** results show promising prospects for obtaining reliable reconstructions of beam-sensitive nanoparticles during dynamical processes from images acquired with sufficiently low incident electron doses.

关键词： algorithm atomic utilizing

Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease

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Neural Regeneration Research 2022年第8期17卷 1666-1674页

作者： Alejandro R.Roda Gabriel Serra-Mir Laia Montoliu-Gaya Lidia Tiessler sandra Villegas Protein Design and Immunotherapy Group Departament de Bioquímica i Biologia MolecularFacultat de BiociènciesUniversitat Autònoma de BarcelonaBellaterraBarcelonaSpain Department of Psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska AcademyUniversity of GothenburgSweden

Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018.A large amount of evidence supports the amyloid cascade hypothesis,which states that amyloid-beta accumulation triggers tau hyperphosphorylation and aggregation in form of neurofibrillary tangles,and these aggregates lead to inflammation,synaptic impairment,neuronal loss,and thus to cognitive decline and behavioral *** poor correlation found between cognitive decline and amyloid plaques,have led the scientific community to question whether amyloid-beta accumulation is actually triggering neurodegeneration in Alzheimer’s *** occurrence of tau neurofibrillary tangles better correlates to neuronal loss and clinical symptoms and,although amyloid-beta may initiate the cascade of events,tau impairment is likely the effector molecule of ***,it has been shown that amyloid-beta and tau cooperatively work to impair transcription of genes involved in synaptic function and,more importantly,that downregulation of tau partially reverses transcriptional *** mounting evidence points to an interplay between amyloid-beta and tau,some factors could independently affect both ***,the dual pathway hypothesis,which states that there are common upstream triggers causing both amyloid-beta and tau abnormalities has been *** others,the immune system seems to be strongly involved in amyloid-beta and tau *** factors,as the apolipoprotein Eε4 isoform has been suggested to act as a link between amyloid-beta and tau ***,amyloid-beta-immunotherapy reduces not only amyloid-beta but also tau levels in animal models and in clinical ***,it has been shown that tau-immunotherapy also reduces amyloid-beta ***,even though amyloid-beta immunotherapy is more advanced than tau-immunotherapy,combined amyloid-beta and tau-directed therapie

关键词： aggregation Alzheimer amyloid-beta dementia immunotherapy inflammation neurodegeneration tau

Advances in diagnosis of chronic liver diseases in pediatric patients

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World Journal of Pediatrics 2018年第6期14卷 541-547页

作者： Lucija Ruzman Ivana Mikolasevic Kristina Baraba Dekanic sandra Milic Goran Palcevski Pediatric Clinic UHC RijekaIstarska 4351000 RijekaCroatia Department of Gastroenterology UHC RijekaRijekaCroatia Pediatric Clinic Department of GastroenterologyUHC RijekaRijekaCroatia

Background Chronic liver diseases (CLD) present important clinical problem in children with various age-dependent causes. Nonalcoholic fatty liver disease (NAFLD) with its increasing prevalence is a major problem with regard to its timely recog-nition and the need for long-term disease monitoring. At present, a perfect non-invasive method for the evaluation of liver fibrosis is not available. Methods A non-systematic literature search was performed to summarize the current knowledge about transient elastog-raphy (TE) with controlled attenuation parameter (CAP) in children with CLD. Ovid MEDLINE, Ovid EMBASE, Google scholar, and The Cochrane Library databases were searched for relevant articles evaluating TE in the pediatric population. Results Normal values of liver stiffness measurements (LSM) according to the age are given, as well as the advantages and disadvantages of the method. The utility of TE in specific liver disease in pediatric population is summarized. Conclusions TE with CAP is a valuable non-invasive method for the liver-damage assessment. Clinical interpretation of TE results should be made in parallel with the assessment of the patient's demographics, disease etiology, and essential laboratory parameters.

关键词： Child Liver disease Liver stiffness Pediatric Transient elastography

MYC inhibitors in multiple myeloma

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Cancer Drug Resistance 2021年第4期4卷 842-865页

作者： sandra Martínez-Martín Laura Soucek Preclinical&Translational Research Program Vall d’Hebron Institute of Oncology(VHIO)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Peptomyc S.L. Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Department of Biochemistry and Molecular Biology Universitat Autònoma de BarcelonaBellaterra 08193Spain InstitucióCatalana de Recerca i Estudis Avançats(ICREA) Barcelona 08010Spain

The importance of MYC function in cancer was discovered in the late 1970s when the sequence of the avian retrovirus that causes myelocytic leukemia was *** then,over 40 years of unceasing research have highlighted the significance of this protein in malignant transformation,especially in hematologic ***,some of the earliest connections among the higher expression of proto-oncogenes(such as MYC),genetic rearrangements and their relation to cancer development were made in Burkitt lymphoma,chronic myeloid leukemia and mouse *** myeloma(MM),in particular,is a plasma cell malignancy strictly associated with MYC deregulation,suggesting that therapeutic strategies against it would be beneficial in treating this ***,targeting MYC was-and,somehow,still is-challenging due to its unique properties:lack of defined three-dimensional structure,nuclear localization and absence of a targetable enzymatic *** these difficulties,however,many studies have shown the potential therapeutic impact of direct or indirect MYC *** molecules have been tested,in fact,in the context of *** this review,we summarize the current status of the different compounds,including the results of their clinical testing,and propose to continue with the efforts to identify,repurpose,redesign or improve drug candidates to combine them with standard of care therapies to overcome resistance and enable better management of myeloma treatment.

关键词： MYC inhibition multiple myeloma undruggable target targeted therapies transcription factor epigenetics MYC downregulation

BDNF methylation and mRNA expression in brain and blood of completed suicides in Slovenia

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World Journal of Psychiatry 2021年第12期11卷 1301-1313页

作者： sandra Ropret Katarina Kouter TomažZupanc Alja Videtic Paska Institute of Biochemistry and Molecular Genetics Faculty of MedicineUniversity of LjubljanaLjubljana SI-1000Slovenia Institute of Forensic Medicine Faculty of MedicineUniversity of LjubljanaLjubljana SI-1000Slovenia

BACKGROUND Suicide is a major public health ***,around 800000 people die by suicide every *** is a multifactorial disorder,with numerous environmental and genetic risk factors *** the candidate genes,changes in the BDNF locus at the gene,epigenetic,mRNA,and protein expression levels have been implicated in psychiatric disorders,including suicidal behavior and completed *** To investigate changes in BDNF methylation and expression of four alternative BDNF transcripts for association with completed *** This case-control study included 42 unrelated male Caucasian subjects,where 20 were control subjects who died following acute cardiac arrest,and 22 were suicide victims who died by *** and RNA were extracted from brain tissue(Brodmann area 9 and hippocampus)and from *** methylation and mRNA expression levels were determined by targeted bisulfite next-generation sequencing and reverse-transcription quantitative *** analysis was done by use of two-tailed Student’s t tests for two independent samples,and the Benjamini-Hochberg procedure was implemented for correction for multiple *** In DNA from brain tissue,there were no significant differences in BDNF methylation between the study ***,data showed significantly reduced DNA methylation of the BDNF region upstream of exon I in blood samples of suicide victims compared to the controls(5.67±0.57 vs 6.83±0.64,P_(corr)=0.01).In Brodmann area 9 of the brain of the suicide victims but not in their hippocampus,there was higher expression of BDNF transcript I-IX(NM_170731.4)compared to the controls(0.077±0.024 vs 0.05±0.013,P=0.042).In blood,expression analysis for the BDNF transcripts was not feasible due to extensive RNA *** Despite the limitations of the study,the obtained data further support a role for BDNF in ***,it should be noted that suicidal behavior is a multifactorial disorder wi

关键词： Suicidal behavior Epigenetics Next-generation sequencing Brain Blood Caucasian

Preparation and characterization of phosphate-modified mesoporous TiO2 incorporated in a silica matrix and their photocatalytic properties in the photodegradation of Congo red

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Frontiers of Materials Science 2017年第3期11卷 250-261页

作者： Alberto ESTRELLA GONZALEZ Maximiliano ASOMOZA Ulises ARELLANO sandra CIPAGAUTA DiAZ Silvia SOLíS Department of Chemistry Metropolitan Autonomous University-lztapalapa P.O. Box 55-532 C.P. 09340 México City México

This study describes the development of mesostructured TiO2 photo- catalysts modified with PO4^3- to improve its specific surface area and reduce the recombination rate of the electron-hole pairs. The mesoporous photocatalyst was successfully incorporated into a high specific surface area silica matrix by the hydrolysis reaction of tetraethyl orthosilicate （TEOS）. Pluronic 123 and phosphoric acid were used as the directing agent for the structure of the mesoporous TiO2 and as a source of phosphorus, respectively, TiO2, P/TiO2, TiO2-SiO2 and P/TiO2-SiO2 materials were characterized by BET, XRD, TEM-EDS, FTIR and UV-vis DRS measurements. The photoactivity of TiO2-SiO2 nanocomposites containing 15 wt.% photocatalystJsilica was evaluated in the degradation reaction of anionic dyes with UV radiation. The proposed nanomaterials showed high potential for applications in the remediation of wastewater, being able to reuse in several cycles of reaction, maintaining its photoactivity and stability. The separation and recovery time of the material is reduced between cycles since no centrifugation or filtration processes are required after the photooxidation reaction.

关键词： photocatalysis phosphated TiO2 TiO2-SiO2 Congo red dye

Prevalence of factor V Leiden and prothrombin G20210A in patients with gastric cancer

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World Journal of Gastroenterology 2006年第26期12卷 4179-4180页

作者： sandra Battistelli Massimo Stefanoni Alberto Genovese Aurelio Vittoria Roberto Cappelli Franco Roviello Dipartimento di Chirurgia e Specialità Chimrgiche Policlinico Le Scotte Viale Bracci53100 SienaItaly Dipartimento di Medicina Clinica e Scienze Immunologiche Policlinico Le Scotte Viale Bracci53100 SienaItaly Dipartimento di Medicina Interna Cardiovascolare e Geriatrica Policlinico Le ScotteViale Bracci53100 SienaItaly Dipartimento di Patologia Umana ed Oncologia Policlinico Le Scotte Viale Bracci53100 SienaItaly

AIM： To analyze the prevalence of the two commonest thrombophilic mutations, factor V Leiden and prothrombin G20210A, in patients with gastric cancer. METHODS： One hundred and twenty-one patients with primary gastric carcinoma and 130 healthy subjects, comparable for age and sex, were investigated. Factor V Leiden was detected by using polymerase chain reaction and restriction enzyme digestion, and prothrombin G20210A gene mutation by allele-specific PCR. RESULTS： Among the 121 cancer patients, factor V Leiden was found in 4 cases （GA genotype： 3.3%） and prothrombin G20210A in 10 cases （GA genotype： 8.3%）. Of the 130 control subjects, factor V Leiden was detected in 6 cases （GA genotype： 4.6%） and prothrombin G20210A in 8 cases （GA genotype： 6.1%）. No double heterozygous carriers of both mutations were found in either group. The prevalence of both factor V Leiden and prothrombin G20210A variant was not statistically different between the cancer patients and the healthy subjects. CONCLUSION： Our study suggests that, in gastric cancer, the risk factors of thrombophilic cancer state are on acquired rather than on a genetic basis and that prothrombin G20210A does not seem to be a cofactor in gastric cancer pathogenesis.

关键词： Gastric cancer Genetic polymorphism Factor V Leiden Prothrombin G20210A

Tree mortality and biomass loss in drought-aff ected forests of East Texas,USA

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Journal of Forestry Research 2021年第1期32卷 67-80页

作者： Mukti Ram Subedi Weimin Xi Christopher B.Edgar sandra Rideout-Hanzak Ming Yan Department of Biological and Health Sciences Texas A&M University-KingsvilleKingsvilleTX 78363USA Department of Forest Resources University of MinnesotaSt.PaulMN 55108USA Department of Rangeland and Wildlife Sciences and Caesar Kleberg Wildlife Research Institute Texas A&M University-KingsvilleKingsvilleTX 78363USA School of Life Sciences Shanxi Normal UniversityLinfen 041004People’s Republic of China

Changes in tree mortality due to severe drought can alter forest structure,composition,dynamics,ecosystem services,carbon fl uxes,and energy interactions between the atmosphere and land *** utilized long-term(2000‒2017,3 full inventory cycles)Forest Inventory and Analysis(FIA)data to examine tree mortality and biomass loss in drought-aff ected forests for East Texas,*** that experienced six or more years of droughts during those censuses were selected based on 12-month moderate drought severity[Standardized Precipitation Evaporation Index(SPEI)-1.0].Plots that experienced other disturbances and inconsistent records were excluded from the *** total,222 plots were retained from nearly 4000 *** nonlinear mixed models(GNMMs)were used to examine the changes in tree mortality and recruitment rates for selected *** results showed that tree mortality rates and biomass loss to mortality increased overall,and across tree sizes,dominant genera,height classes,and *** average mortality rate of 5.89%year−1 during the study period could be incited by water stress created by the regional prolonged and episodic drought *** overall plot and species-group level recruitment rates decreased during the study *** mortality showed mixed results regarding basal area and forest density using all plots together and when analyzed the plots by stand origin and *** mortality rates of smaller trees were detected and were likely compounded by densitydependent *** analysis of drought-induced tree mortality using hydro-meteorological data along with drought severity and length gradient is suggested to better understand the eff ects of drought on tree mortality and biomass loss around and beyond East Texas in the southeastern United States.

关键词： Generalized nonlinear mixed model Endogenous factors Drought index Standardized precipitation evaporation index(SPEI) Above-ground biomass Competition index Biomass lost to mortality East Texas

The role of recrystallization and grain growth in optimizing the sheet texture of magnesium alloys with calcium addition during annealing

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Journal of Magnesium and Alloys 2020年第1期8卷 252-268页

作者： Fei Guo Risheng Pei Luyao Jiang Dingfei Zhang sandra Korte-Kerzel Talal Al-Samman College of Materials Science and Engineering Chongqing University of Technology400054 ChongqingChina Chongqing Key Laboratory of Mold Technology Chongqing University of Technology400054 ChongqingChina Institut für Metallkunde und Metallphysik RWTH Aachen University52056 AachenGermany College of Materials Science and Engineering Chongqing University400044 ChongqingChina

The contribution of recrystallization and grain growth to the texture evolution in AZ31 alloy and a modified version AZ31+0.5 wt.%Ca was investigated utilizing a multi-step annealing *** results showed that the addition of Ca triggered a considerable texture modification by increasing the texture spread and decreasing the overall texture *** effect was found to be temperature *** the annealing temperature remained lower than 450℃,a weak double peak texture with large basal pole tilt towards the RD was *** is correlated to microstructure observations of a large number of Ca-containing nano-sized particles that seemed to suppress grain growth below 450℃,which stabilized the weak recrystallization *** favorable texture was lost upon annealing at higher *** AZ31,recrystallization nuclei were found to preserve the orientation of their deformed parents,which offered limited potential to optimize the texture via annealing *** growth of recrystallized grains resulted in a distinct sheet texture transition from a double-peak to a single-peak basal *** of grain boundary energy and grain topology are discussed to explain the growth advantage of the sharp basal component over other orientations.

关键词： Magnesium alloys Microstructure Texture Recrystallization Grain growth

NIR-plasmon-enhanced Systems for Energy Conversion and Environmental Remediation

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Chemical Research in Chinese Universities 2020年第6期36卷 1000-1005页

作者： WANG Wenke sandra Elizabeth SAJI Siva KARUTURI ZHENG Hong MENG Guodong CHENG Yonghong YIN Zongyou Center of Nanomaterials for Renewable Energy(CNRE) State Key Laboratory of Electrical Insulation and Power EquipmentSchool of Electrical EngineeringXi'an Jiaotong UniversityXi'an 710049P.R.China Research School of Chemistry Australian National UniversityACT 2601Australia Research School of Physics and Research School of Electrical Energy and Materials EngineeringAustralian National UniversityCanberraATC 2601Australia

The introduction of plasmons is an important method to solve the insufficient utilization of the full spectrum of solar energy by semiconductor ***,semiconductor catalysts combined with traditional noble metal plasmons(Au,Ag)can only extend the absorption spectrum to partially visible *** order to further improve the photoenergy absorption efficiency of catalysts,they need to be able to effectively utilize near-infrared light,which has become a new research *** studies have shown that traditional noble metal plasmons can absorb a part of NIR through special morphology,size control and material *** the same time,gratifying achievements have been made in the application of plasmonic semiconductors with broad spectrum absorption in *** article reviews the principles of generating and regulating plasmonic effects in different catalytic *** applications of plasmon absorption of near-infrared light in energy conversion and environmental remediation have also been presented.

关键词： Near-infrared Plasmon Energy conversion Environmental remediation