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基于深度学习重建和传统TSE序列在直肠癌磁共振检查的对比研究

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磁共振成像 2024年

作者：胡思洁范文文滕泽刘侃童晓婉江岳娈刘鹏郎宇 nickel Marcel Dominik 张红梅国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院影像诊断科西门子医疗系统有限公司北京分公司西门子医疗系统有限公司

目的评估深度学习重建（deep learning reconstruction, DL Recon）技术在提高直肠MRI快速自旋回波序列（turbo spin-echo, TSE）图像质量的价值。材料与方法前瞻性纳入2023年9月至2024年1月中国医学科学院肿瘤医院病理诊断为直肠癌... 详细信息

目的评估深度学习重建（deep learning reconstruction, DL Recon）技术在提高直肠MRI快速自旋回波序列（turbo spin-echo, TSE）图像质量的价值。材料与方法前瞻性纳入2023年9月至2024年1月中国医学科学院肿瘤医院病理诊断为直肠癌的初诊患者60例，对每位患者进行临床传统TSE序列及应用DL Recon技术的TSE序列（deep learning reconstruction-TSE,DL-TSE）扫描，并记录扫描时间，由两名影像科医师分别对两组图像（传统TSE、DL-TSE）的图像质量进行主观评价，采用“五分法”分别对病灶轮廓清晰度，图像伪影，病灶结构清晰度以及诊断信心进行评分；由两名影像科技师进行客观评价，分别计算DL-TSE和传统TSE图像的病灶信噪比（signal-to-noiseratio,SNR）以及病灶区域与周边组织的对比噪声比（contrast-to-noise ratio, CNR），采用配对样本t检验或配对样本非参数检验（Wilcoxon符号轶检验）进行统计学分析。结果图像主观评价显示DL-TSE序列的病灶轮廓清晰度、图像伪影、病灶结构清晰度以及诊断信心的主观评分得分均优于传统TSE序列，且差异具有统计学意义（P<0.001）。图像客观评价显示DL-TSE序列和传统TSE序列的SNR分别为24.26(15.95, 42.79)、11.84(7.63, 18.88)，差异有统计学意义（Z=-14.276,P<0.001）;DL-TSE序列和传统TSE序列CNR分别为10.75(7.19, 15.63),5.47(3.72, 8.86)，且差异有统计学意义（Z=-14.271,P<0.001）。DL-TSE序列的SNR及CNR相较于传统TSE序列均有明显提升。结论 DL-TSE序列通过采用原始K空间数据DL Recon算法，在保证图像质量和病变可检测性的情况下，可提升直肠癌患者序列图像SNR及CNR，并且可缩短36.6%扫描时间。

关键词：直肠癌信噪比对比噪声比深度学习重建磁共振成像

Energy Absorption in Functionally Graded Concrete Bioinspired by Sea Urchin Spines

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Journal of Bionic Engineering 2017年第2期14卷 369-378页

作者： Nicu Toader Werner Sobek Klaus G nickel Institute for Lightweight Structures and Conceptual Design (ILEK) Stuttgart Universitat 70569 Stuttgart Germany Institute for Geoscience (IFG) Applied Mineralogy Eberhard-Karls-Universitat Tubingen 72074 Tubingen Germany

Functionally Graded Concrete （FGC） is fabricated at the Institute for Lightweight Structures and Conceptual Design （ILEK） by using a layer-by-layer technique with two different technological procedures： casting and dry spraying. Functional gradations are developed from two reference mixtures with diametrically opposed characteristics in terms of density, porosity, compression strength and elasticity modulus. In this study the first mixture consists of Normal Density Concrete （NDC）, with density about 2160 kg·m^-3 while the second mixture helps to obtain a very lightweight concrete, with density about 830 kg·m^-3. The FGC specimens have layers with different alternating porosities and provide superior deformability capacity under bulk compression compared to NDC specimens. In addition, the FGC specimens experienced a graceful failure behaviour, absorbing high amounts of energy during extended compression paths. The porosity variation inside the layout of tested specimens is inspired by the internal structure of sea urchin spines of heterocentrotus mammillatus, a promising role model for energy absorption in biomimetic engineering.

关键词： biomimetic engineering energy absorption sea urchin spine functionally graded concrete graceful failure behaviour

Robotic pancreaticoduodenectomy after the learning curve-a new hope

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 489-491页

作者： Philip C.Müller Beat P.Müller-Stich Thilo Hackert Felix nickel Swiss HPB and Transplantation Center Department of Surgery and TransplantationUniversity Hospital ZurichZurichSwitzerland Department of General Visceral and Transplantation SurgeryHeidelberg University HospitalHeidelbergGermany

First,we would like to congratulate Liu et *** their successful multicenter study including 1,032 patients undergoing robotic pancreaticoduodenectomy(RPD)and 1,154 open pancreaticoduodenectomy(OPD)in seven high volume centers in China over an 8 year period(1).To ensure the best possible outcomes of both techniques,RPD was performed by five surgeons from three centers after overcoming the individual learning curve that was defined as having performed>40 *** the other hand,OPD was performed by 9 surgeons from 6 centers after reaching the individual learning curve,defined as an experience of>60 OPD.

关键词： centers learning after

Addition of heparin binding sites strongly increases the bone forming capabilities of BMP9 in vivo

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Bioactive Materials 2023年第11期29卷 241-250页

作者： Claudia Siverino Shorouk Fahmy-Garcia Viktoria Niklaus Nicole Kops Laura Dolcini Massimiliano Maraglino Misciagna Yanto Ridwan Eric Farrell Gerjo JVMvan Osch Joachim nickel Department of Tissue Engineering and Regenerative Medicine University Hospital WuerzburgWuerzburgGermany Department of Orthopaedics and Sports Medicine Erasmus MCUniversity Medical CenterRotterdamthe Netherlands Department of Internal Medicine Erasmus MCUniversity Medical CenterRotterdamthe Netherlands Department of Oral and Maxillofacial Surgery Erasmus MCUniversity Medical CenterRotterdamthe Netherlands Fin-Ceramica Faenza SpA Via Granarolo 177/348018FaenzaItaly AMIE Core Facility Erasmus University Medical CenterRotterdamthe Netherlands Department of Otorhinolaryngology Head and Neck SurgeryErasmus MCUniversity Medical CenterRotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritime and Materials EngineeringDelft University of TechnologyDelftthe Netherlands Fraunhofer ISC Translational Center RTWuerzburgGermany

Bone Morphogenetic proteins(BMPs)like BMP2 and BMP7 have shown great potential in the treatment of severe bone *** recent in vitro studies,BMP9 revealed the highest osteogenic potential compared to other BMPs,possibly due to its unique signaling pathways that differs from other osteogenic ***,in vivo the bone forming capacity of BMP9-adsorbed scaffolds is not superior to BMP2 or *** silico analysis of the BMP9 protein sequence revealed that BMP9,in contrast to other osteogenic BMPs such as BMP2,completely lacks so-called heparin binding motifs that enable extracellular matrix(ECM)interactions which in general might be essential for the BMPs’osteogenic ***,we genetically engineered a new BMP9 variant by adding BMP2-derived heparin binding motifs to the N-terminal segment of BMP9′s mature *** resulting protein(BMP9 HB)showed higher heparin binding affinity than BMP2,similar osteogenic activity in vitro and comparable binding affinities to BMPR-II and ALK1 compared to ***,remarkable differences were observed when BMP9 HB was adsorbed to collagen scaffolds and implanted subcutaneously in the dorsum of rats,showing a consistent and significant increase in bone volume and density compared to BMP2 and *** at 10-fold lower BMP9 HB doses bone tissue formation was *** innovative approach of significantly enhancing the osteogenic properties of BMP9 simply by addition of ECM binding motifs,could constitute a valuable replacement to the commonly used *** possibility to use lower protein doses demonstrates BMP9 HB’s high translational potential.

关键词： Bone morphogenetic protein 9(BMP9) Heparin binding sites Bone regeneration Subcutaneous animal model

Artificial intelligence in pancreatic surgery:current applications

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Journal of Pancreatology 2023年第2期6卷 74-81页

作者： Christoph Kuemmerli Fabian Rössler Caroline Berchtold Michael C.Frey Alexander Studier-Fischer Amila Cizmic Jan Philipp Jonas Thilo Hackert Felix nickel Philip C.Müller Department of Surgery Clarunis-University Centre for Gastrointestinal and Liver DiseasesBaselSwitzerland Swiss HPB and Transplantation Center Department of Surgery and TransplantationUniversity Hospital ZurichZurichSwitzerland Department for General Visceral and Vascular SurgeryKantonsspital BadenBadenSwitzerland Department of General Visceral and Transplantation SurgeryHeidelberg University HospitalHeidelbergGermany Department of General Visceral and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfHamburgGermany

Surgery plays a central role in the treatment of benign and malignant pancreatic *** intelligence(AI)is an important upcoming technology to support surgeons in pre-,intra-,and postoperative diagnosis,decision-making and training toward an optimized patient *** AI applications show a promising role in the evaluation of preoperative images for prediction of malignancy and resectability,intraoperative decision support,surgical training as well as a postoperative risk stratification to per-sonalize the management of *** scoping review summarizes the most up to date developments of AI in pancreatic surgery with the highest available level of evidence.

关键词： Artificial intelligence Image-guidance Machine learning Pancreas neoplasms Pancreatic ductal carcinoma Personalized medicine Surgery

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对肝硬化病人应用压缩感知和同时应用超快速并行采集技术行肝胆期成像

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国际医学放射学杂志 2024年第3期 377-377页

作者： S.Yoon Y.S.Shim S.H.Park J.Sung M.D.nickel Y.J.Kim 余翔玲

摘要目的旨在比较肝硬化病人用压缩感知（CS）和同时应用超快速并行采集技术（CAPIRINHA）的肝胆期（HBP）成像的影像质量和局灶病变检测能力。方法回顾性纳入

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Learning robotic distal pancreatectomy: the force awakens

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胰腺病学杂志(英文) 2022年第3期05卷 132-133页

作者： Müller Philip C. Müller-Stich Beat P. Hackert Thilo nickel Felix Swiss HPB and Transplantation Center Department of Surgery and Transplantation 3. University Hospital Zurich 4. Zurich 5. Switzerland Department of General Visceral and Transplantation Surgery 8. Heidelberg University Hospital 9. Heidelberg 10. Germany

Arduino的崛起——David Cuartielles访谈

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单片机与嵌入式系统应用 2022年第8期22卷 1-3页

作者： Jens nickel 透镜(译) Elektor

谈到Arduino的历史以及21世纪的电子世界,David Cuartielles认为Arduino影响巨大。在电子工作区、创客空间、高科技贸易展或大学EE/ECE实验室,Arduino随处可见。Arduino项目源于大约15年前,最初主要面向艺术家和其他非程序员,后来Arduin... 详细信息

谈到Arduino的历史以及21世纪的电子世界,David Cuartielles认为Arduino影响巨大。在电子工作区、创客空间、高科技贸易展或大学EE/ECE实验室,Arduino随处可见。Arduino项目源于大约15年前,最初主要面向艺术家和其他非程序员,后来Arduino在制造商和专业人士中也深受欢迎。我最近有机会采访了David Cuartielles(他与Massimo Banzi和其他一些微控制器爱好者共同创立了Arduino),探讨了Arduino的过去、现在和未来。

关键词：创客空间微控制器贸易展程序员实验室专业人士

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Not yet IDEAL?-evidence and learning curves of minimally invasive pancreaticoduodenectomy

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 812-814页

作者： Felix nickel Caelán Max Haney Beat-Peter Müller-Stich Thilo Hackert Department of General Visceraland Transplantation SurgeryHeidelberg UniversityHospital HeidelbergHeidelbergGermany

In response to“What’s the next step in evaluating laparoscopic pancreaticoduodenectomy?”(http://***/article/view/29682/25710)by Fernando Burdío,Luís Grand and Ignasi *** and foremost,we would like to express our sincere condolences on the passing of Professor Ignasi *** were deeply saddened to hear of this and wish his family,friends and colleagues strength in these difficult times of grieving.

关键词： IDEAL learning Grand