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Structural modeling of a typical gas turbine system

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Frontiers in Energy 2012年第1期6卷 57-79页

作者： Naresh YADAV Irshad Ahmad KHAN sandeep grover Mechanical Engineering Department Jamia Millia IslamiaNew Delhi 110025India Mechanical Engineering Department YMCA University of Science and TechnologyFaridabad 121006India

This paper presents an approach for the structural modeling and analysis of a typical gas turbine system. This approach has been applied to the systems and subsystems, which are integral parts of a typical gas turbine system. Since a gas turbine system performance is measured in terms of fluid flow ene：rgy transformations across its various assemblies and subassemblies, the performance of such subsystems affects the overall performance of the gas turbine system. An attempt has been made to correlate the associativity of such subsystems contributing to overall gas turbine system functional evaluation using graph theoretic approach. The characteristic equations at the system level as well as subsystem level have been developed on the basi.s of associativity of various factors affecting their performance. A permanent function has been proposed for the functional model of a gas turbine system, which further leads to selection, identification and optimal evaluation of gas turbine systems.

关键词： system modeling gas turbine system evaluation graph theoretic approach

Inhibition of proliferation of retinal vascular endothelial cells more effectively than choroidal vascular endothelial cell proliferation by bevacizumab

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 15-22页

作者： Bharani Krishna Mynampati Kumar Sambhav sandeep grover Kakarla V.Chalam Department of Ophthalmology University of FloridaCollegeof MedicineJacksonvilleFL 32209USA

AIM： To evaluate the differential inhibitory effects of bevacizumab on cell proliferation of vascular endothelial growth factor （VEGF）-stimulated choroidal vascular endothelial cells （CVECs） and retinal vascular endothelial cells （RVECs） in ***： VEGF （400 ng/mL） enriched CVECs and RVECs were treated with escalating doses of bevacizumab （0.1, 0.5, 1, 1.5 and 2 mg/mL）. Cell proliferation changes were analyzed with WST-1 assay and trypan blue exclusion assay at 48, 72h and 1wk. Morphological changes were recorded with bright field ***： VEGF enriched RVECs showed significantly more decline of cell viability than CVECs after bevacizumab treatment. One week after treatment, RVEC cell proliferation decreased by 29.7%, 37.5%, 52.8%, 35.9% and 45.6% at 0.1, 0.5, 1.0, 1.5 and 2 mg/mL bevacizumab respectively compared to CVEC proliferation decrease of 4.1%, 7.7%, 2.4%, 4.1% and 17.7% （P〈0.05） by WST-1 assay. Trypan blue exclusion assay also revealed similar decrease in RVEC proliferation of 20%, 60%, 73.3%, 80% and 93.3% compared to CVEC proliferation decrease of 4%, 12%, 22.9%, 16.7% and 22.2% respectively （P〈0.05）. The maximum differential effect between the two cell types was observed at bevacizumab doses of 1.0 and 1.5 mg/mL at all time points. RVECs were 22 fold more sensitive （P〈0.01） compared to CVECs （52.8% vs 2.4%） at concentration of 1.0 mg/mL, and 8.7 fold more at 1.5 mg/mL （35.9% vs 4.1%） 1wk after treatment （P〈0.05 respectively）.CONCLUSION： VEGF-enriched RVECs are more susceptible to bevacizumab inhibition than CVECs at clinically used dosage of 1.25 mg and this differential sensitivity between two cell types should be taken into consideration in dosage selection.

关键词： bevacizumab retinal vascular endothelialcells choroidal vascular endothelial cells

Assessment scales for delirium: A review

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World Journal of Psychiatry 2012年第4期2卷 58-70页

作者： sandeep grover Natasha Kate Department of Psychiatry Postgraduate Institute of Medical Education and Research Chandigarh 160012 India

Over the years many scales have been designed for screening, diagnosis and assessing the severity of delirium. In this paper we review the various instruments available to screen the patients for delirium, instruments available to diagnose delirium, assess the severity, cognitive functions, motoric subtypes, etiology and associated distress. Among the various screening instruments, NEECHAM confusion scale and delirium observation scale appear to be most suitable screening instrument for patients' in general medical and surgical wards, depending on the type of rater(physician or nurse). In general, the instruments which are used for diagnosis [i.e., confusion assessment method(CAM), CAM for intensive care unit(CAM-ICU), Delirium Rating Scale-revised version(DRS-R-98), memorial selirium assessment scale, etc. ] are based on various Diagnostic and Statistical Manual criteria and have good to excellent reliability and fair to good validity. Among the various diagnostic instruments, CAM is considered to be most useful instrument because of its accuracy, brevity, and ease of use by clinicians and lay interviewers. In contrast, DRS-R-98 appears to be a comprehensive instrument useful for diagnosis, severity rating and is sensitive to change and hence can be used for monitoring patients over a period. In the ICU setting, evidence suggests that CAM-ICU and Nursing Delirium Screening Scale had comparable sensitivities, but CAM-ICU has higher specificity. With regard to assessment of delirium in pediatric age group, certain instruments like Pediatric Anesthesia Emergence Delirium scale and pediatric CAM-ICU has been designed and have been found to be useful.

关键词： Delirium Screening Diagnosis Cognition

Gender differences in caregiving among family- caregivers of people with mental illnesses

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World Journal of Psychiatry 2016年第1期6卷 7-17页

作者： Nidhi Sharma Subho Chakrabarti sandeep grover Depart-ment of Psychiatry Postgraduate Institute of Medical Education and Research

All over the world women are the predominant providers of informal care for family members with chronic medical conditions or disabilities, including the elderly and adults with mental illnesses. It has been suggested that there are several societal and cultural demands on women to adopt the role of a family-caregiver. Stress-coping theories propose that women are more likely to be exposed to caregiving stressors, and are likely to perceive, report and cope with these stressors differently from men. Many studies, which have examined gender differences among family-caregivers of people with mental illnesses, have concluded that women spend more time in providing care and carry out personal-care tasks more often than men. These studies have also found that women experience greater mental and physical strain, greater caregiver-burden, and higher levels of psychological distress while providing care. However, almost an equal number of studies have not found any differences between men and women on these aspects. This has led to the view that though there may be certain differences between male and female caregivers, most of these are small in magnitude and of doubtful clinical significance. Accordingly, caregivergender is thought to explain only a minor proportion of the variance in negative caregiving outcomes. A similar inconsistency characterizes the explanations provided for gender differences in caregiving such as role expectations, differences in stress, coping and social support, and response biases in reporting distress. Apart from the equivocal and inconsistent evidence, there are other problems in the literature on gender differences in caregiving. Most of the evidence has been derived from studies on caregivers of elderly people who either suffer from dementia or other physical conditions. Similar research on other mental illnesses such as schizophrenia or mood disorders is relatively scarce. With changing demographics and social norms men are increasingly as

关键词： Gender Family-caregiving Schizophrenia Elderly Dementia Mood disorders

Prevalence of internet addiction among college students in the Indian setting:a systematic review and meta-analysis

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General Psychiatry 2021年第4期34卷 1-12,I0001-I0009页

作者： Jaison Joseph Abin Varghese Vijay VR Manju Dhandapani sandeep grover Suresh Sharma Deepika Khakha Sucheta Mann Biji P Varkey College of Nursing Department of Psychiatric NursingPandit Bhagwat Dayal Sharma University of Health SciencesRohtakHaryanaIndia College of Nursing Bhopal Memorial Hospital and Research CentreBhopalIndia College of Nursing All India Institute of Medical SciencesBhubaneswarOrissaIndia National Institute of Nursing Education Post Graduate Institute of Medical Education and ResearchChandigarhIndia Department of Psychiatry Post Graduate Institute of Medical Education and ResearchChandigarhIndia College of Nursing All India Institute of Medical SciencesJodhpurRajasthanIndia College of Nursing AIl India Institute of Medical SciencesNew DelhiIndia Post Graduate Institute of Medical Sciences Pandit Bhagwat Dayal Sharma University of Health SciencesRohtakHaryanaIndia

Background The internet is an integral part of everyone’s *** going adolescents are highly vulnerable to the misuse of the *** To estimate the pooled prevalence of internet addiction(IA)among college students in *** Literature databases(PubMed,Web of Science,Scopus,EMBASE,PsycINFO and Google Scholar)were searched for studies assessing IA using the Young Internet Addiction Test(Y-IAT)among adolescents from India,published in the English language up to December *** included studies from 2010 to 2020 as this is the marked era of momentum in wireless internet connectivity in *** methodological quality of each study was scored,and data were extracted from the published *** prevalence was estimated using the fixed-effects *** bias was evaluated using Egger’s test and visual inspection of the symmetry in funnel *** Fifty studies conducted in 19 states of India estimated the prevalence of IA and the overall prevalence of IA as 19.9%(95%CI:19.3%to 20.5%)and 40.7%(95%CI:38.7%to 42.8%)based on the Y-IAT cut-off scores of 50 and 40,*** estimated prevalence of severe IA was significantly higher in the Y-IAT cut-off points of 70 than 80(12.7%(95%CI:11.2%to 14.3%)vs 4.6%(95%CI:4.1%to 5.2%)).The sampling method and quality of included studies had a significant effect on the estimation of prevalence in which studies using non-probability sampling and low risk of bias(total quality score≥7)reported lower *** overall quality of evidence was rated as‘moderate’based on the Grading of Recommendations Assessment,Development and Evaluation *** Our nationally representative data suggest that about 20%to 40%of college students in India are at risk for *** is a need for further research in the reconsideration of Y-IAT cut-off points among Indian college students.

关键词： internet Google everyone

Health-care needs of remitted patients with bipolar disorder: A comparison with schizophrenia

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World Journal of Psychiatry 2016年第4期6卷 431-441页

作者： Rajarshi Neogi Subho Chakrabarti sandeep grover Department of Psychiatry Postgraduate Institute of Medical Education and Research (PGIMER)

AIM To investigate health-care needs and their correlates among patients with remitted bipolar disorder(BD) compared to patients with remitted schizophrenia. METHODS Outpatients with BD(n = 150) and schizophrenia(n = 75) meeting clearly defined remission criteria were included in the study along with their relatives. Diagnostic ascertainment was carried out using the Mini International Neuropsychiatric Interview. Demographic and clinical details were recorded using structured formats. Residual symptoms were assessed using standardized scales. Health-care needs were assessed on two separate scales. The principal instrument employed to assess health-care needs was the Camberwell Assessment of Need-Research version(CAN-R). To further evaluate health-care needs we felt that an additional instrument, which was more relevant for Indian patients and treatment-settings and designed to cover those areas of needs not specifically covered by the CAN-R was required. This instrument with a structure and scoring pattern similar to the CAN-R was used for additional evaluation of needs. Patients' level offunctioning was assessed using the Global Assessment of Functioning Scale and their quality of life(QOL) using the World Health Organization Quality Of Life-BREF version in *** An average of 6-7 needs was reported by patients with BD as well as their relatives. Commonly reported needs were in the areas of economic and welfare needs, informational needs, social needs and the need for treatment. According to the CAN-R, both patients and relatives reported that more than 60% of the total needs were being met. However, over 90% of the needs covered by the additional evaluation were unmet according to patients and relatives. Needs in the areas of economic and welfare-benefits, information, company, daytime activities and physical health-care were largely unmet according to patients and relatives. Total, met and unmet needs were significantly higher for schizophrenia, but the m

关键词： Health-care needs Bipolar disorder Schizophrenia Remission Patients Relatives

Positive aspects of caregiving in schizophrenia: A review

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World Journal of Psychiatry 2012年第3期2卷 43-48页

作者： Parmanand Kulhara Natasha Kate sandeep grover Ritu Nehra Department of Psychiatry Postgraduate Institute of Medical Education and ResearchChandigarh 160012 India

Schizophrenia is a severe mental illness which is associated with significant consequences for both the patients and their relatives. Due to chronicity of the illness, the relatives of patients of schizophrenia have to bear the main brunt of the illness. Studies across the world have evaluated various aspects of caregiving and caregivers such as burden, coping, quality of life, social support, expressed emotions, and psychological morbidity. In general the research has looked at caregiving as a negative phenomenon, however, now it is increasingly recognised that caregiving is not only associated with negative consequences only, also experience subjective gains and satisfaction. This review focus on the conceptual issues, instruments available to assess the positive aspects of caregiving and the various correlates of positive aspects of caregiving reported in relation to schizophrenia. The positive aspect of caregiving has been variously measured as positive caregiving experience, caregiving satisfaction, caregiving gains and finding meaning through caregiving scale and positive aspects of caregiving experience. Studies suggests that caregivers of patients with schizophrenia and psychotic disorders experience caregiving gains(in the form of becoming more sensitive to persons with disabilities, clarity about their priorities in life and a greater sense of inner strength), experience good aspects of relationship with the patient, do have personal positive experiences. Some of the studies suggest that those who experience greater negative caregiving experience also do experience positive caregiving experience.

关键词： Schizophrenia Caregiving Positive aspects

Comparative effectiveness of quetiapine and haloperidol in delirium:A single blind randomized controlled study

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World Journal of Psychiatry 2016年第3期6卷 365-371页

作者： sandeep grover Sudhir Mahajan Subho Chakrabarti Ajit Avasthi Department of Psychiatry Postgraduate Institute of Medical Education and Research

AIM To evaluate the effectiveness of quetiapine and haloperidol in patients of delirium referred to psychiatry consultation liaison *** The study followed a single blind randomised controlled trial ***-two patients in the haloperidol group and 31 patients in the quetiapine group were assessed at the baseline and 6 consecutive *** dosing regimen(haloperidol:0.25-1.25 mg;quetiapine 12.5-75 mg/d) was *** Rating Scale-Revised-98(DRS-R-98) and mini mental status examination(MMSE) were the primary and secondary efficacy measures *** Baseline DRS-R-98 severity score and MMSE scores did not differ between the 2 study *** baseline to day 6,there was significant reduction in the total DRS-R-98 scores,DRS-R-98 cognitive domain scores,DRS-R-98 non-cognitive domain scores and significant increase in the MMSE scores in both the *** the groups did not differ on any of the assessments in terms of DRS-R98 and MMSE *** effectiveness of both the medications was similar in adult and elderly(≥ 60 years) *** the end of the trial,68.75% and 67.74% of subjects in the haloperidol and quetiapine group respectively had mean DRS-R-98 scores below *** 6th day,12(37.5%) patients in haloperidol group and 9(29.03%) patients in the quetiapine group hadDRS-R98 score of "0" with no significant difference between the two groups(P = 0.47).CONCLUSION Quetiapine is as effective as haloperidol in the management of delirium.

关键词： Delirium Quetiapine Effectiveness Atypical antipsychotics

Aqueous Interleukin-6 (IL-6) Level Is a Marker for Treatment Resistance to Bevacizumab in Age-Related Macular Degeneration —Aqueous Cytokines after Bevacizumab

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Open Journal of Ophthalmology 2014年第1期4卷 24-30页

作者： Kakarla V. Chalam sandeep grover Sankarathi Balaiya Ravi K. Murthy Department of Ophthalmology University of Florida College of Medicine Jacksonville USA

Background: To prospectively evaluate the effect of intravitreal bevacizumab on aqueous levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in patients with exudative age-related macular degeneration (AMD) and to correlate clinical outcomes of patients and aqueous cytokine levels before and after injection. Methods: The study group consisted of 30 eyes from 30 patients with exudative AMD who underwent intravitreal injection of bevacizumab three times at monthly intervals. The aqueous samples prior to the 1st injection (baseline) and 3rd injection were analyzed for VEGF and IL-6 levels, evaluating the effect of 2 doses of intravitreal bevacizumab. Study patients were sub-grouped based upon change in central subfield (CSF) macular thickness on SD-OCT, at 8 weeks. Group 1 included patients (n = 14) with a decrease in CSF thickness greater than 10% from the baseline and were categorized to have “improved”. Group 2 included patients (n = 16) who had a decrease in CSF thickness 10% or less and were considered “treatment-resistant”. Results: There was no statistically significant change in aqueous VEGF and IL-6 levels after intravitreal bevacizumab. In sub-group analysis, in both Groups 1 and 2 patients, aqueous IL-6 levels showed a better correlation with CSF thickness on SD-OCT (r = 0.72 and 0.71, respectively). Conclusions: Data from our study suggest that aqueous IL-6 may be an important marker of treatment response or resistance. Future therapeutic strategies may include targeted treatment against both VEGF and IL-6, in patients who do not respond to anti-VEGF treatment alone.

关键词： VEGF Interleukin-6 AMD Bevacizumab Aqueous Bead Based Assay