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Main outcomes from in situ thermo-hydro-mechanical experiments programme to demonstrate feasibility of radioactive high-level waste disposal in the Callovo-Oxfordian claystone

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第3期9卷 33-45页

作者： G. Armand f. Bumbieler N. Conil R. de la Vaissière J.-M. Bosgiraud M.-N. Vu Meuse/Haute Marne Underground Research laboratory Andra Bure 55290 France Andra Chatenay-Malabry 92298 France

In the context of radioactive waste disposal,an underground research laboratory(URL)is a facility in which experiments are conducted to demonstrate the feasibility of constructing and operating a radioactive waste disposal facility within a geological *** Meuse/Haute-Marne URL is a sitespecific facility planned to study the feasibility of a radioactive waste disposal in the Callovo-Oxfordian(COx)*** thermo-hydro-mechanical(THM)behaviour of the host rock is significant for the design of the underground nuclear waste disposal facility and for its long-term *** french National Radioactive Waste Management Agency(Andra)has begun a research programme aiming to demonstrate the relevancy of the french high-level waste(HLW)*** paper presents the programme implemented from small-scale(small diameter)boreholes to full-scale demonstration experiments to study the THM effects of the thermal transient on the COx claystone and the strategy implemented in this new programme to demonstrate and optimise current disposal facility components for *** shows that the french high-level waste concept is feasible and working in the COx *** also exhibits that,as for other plastic clay or claystone,heating-induced pore pressure increases and that the THM behaviour is anisotropic.

关键词： In situ experiments Claystone Thermo-hydro-mechanical(THM) behaviour Research programme Radioactive high-level waste(HLW) disposal

Crohn's disease-related'gastrocnemius myalgia syndrome'successfully treated with infliximab:A case report

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World Journal of Gastroenterology 2022年第7期28卷 755-762页

作者： Julien Catherine Hazim Kadhim frédéric lambot Claire Liefferinckx Virginie Meurant Lukas Otero sanchez Institute for Medical Immunology UniversitéLibre de BruxellesGosselies 6041Belgium department of Internal Medicine C.U.B.Hôpital ErasmeBrussels 1070Belgium NeuroMyopathology Unit(Anatomic Pathology Service)and Reference Center for Neuromuscular Pathology CHU BrugmannUniversitéLibre de BruxellesBrussels 1020Belgium department of Internal Medicine Centre Hospitalier Universitaire TivoliLa Louvière 7100Belgium department of Gastroenterology Hepatopancreatology and Digestive OncologyC.U.B.Hôpital ErasmeBrussels 1070Belgium laboratory of Experimental Gastroenterology UniversitéLibre de BruxellesBrussels 1070Belgium department of Emergency Medicine Centre Hospitalier Universitaire TivoliLa Louvière 7100Belgium

BACKGROUND Extra-intestinal manifestations in inflammatory bowel diseases(IBD)are frequent and involve virtually all ***,the clinical characteristics and course of inflammatory myopathies in IBD remain poorly described and mostly related to orbital ***,alternative therapeutic strategies in non-responder patients to corticosteroid therapy must still be *** SUMMARY A 33-year-old woman with a history of unclassified colitis presented with acute bilateral calf *** admission,her clinical and biological examinations were ***,magnetic resonance imaging showed bilateral inflammatory changes in gastrocnemius muscles suggestive of *** biopsy confirmed the diagnosis of myositis and demonstrated an inflammatory infiltrate mainly located in the perimysial compartment including lympho-plasmocytic cells with the formation of several granulomatous structures while the endomysium was relatively *** combined clinical,biological and histomyopathological findings were concordant with the diagnosis of‘gastrocnemius myalgia syndrome’(GMS),a rare disorder associated with Crohn’s disease(CD).Ileocolonoscopy confirmed CD diagnosis and systemic corticosteroids(CS)therapy was started,resulting in a rapid clinical *** CS tapering,however,she experienced a relapse of GMS together with a severe active *** was started and allowed a sustained remission of both conditions at the latest follow-up(20 mo).CONCLUSION The GMS represent a rare CD-associated inflammatory myopathy for which anti-tumour necrosis factor-αtherapy might be considered as an effective therapeutic option.

关键词： Crohn’s disease Extra-intestinal manifestation Gastrocnemius myalgia syndrome Granulomatous myositis Anti-tumour necrosis factor-αtherapy Case report

Comments on "Non-existence of Shilnikov chaos in continuous-time systems"

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Applied Mathematics and Mechanics(English Edition) 2013年第9期34卷 1175-1176页

作者： A.ALGABA f.fERNANdeZ-sanchez M.MERINO A.J.RODRIGUEZ-LUIS departamento de Matematicas Centro de Investigacion de Fisica Teorica y Matematica FIMATUniversity of Huelva departamento de Matematica Aplicada II E.S.IngenierosUniversity of Sevilla Camino de los Descubrimientos s/n

A paper, ＂Non-existence of Shilnikov chaos in continuous-time systems＂ was published in the journal Applied Mathematics and Mechanics （English Edition）. The authors gave sufficient conditions for the non-existence of homoclinic and heteroclinic orbits in an nth-order autonomous system. Unfortunately, we show in this comment that the proof presented is erroneous and the result is invalid. We also provide two counterexamples of the wrong criterion stated by the authors.

关键词： homoclinic chaos heteroclinic chaos non-existence of Shilnikov chaos

Amplified spontaneous emission at the band edges of Ag-coated Al nanocone array

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Photonics Research 2023年第12期11卷 2202-2209页

作者： YE XIANG YONGPING ZHAI JIAZHI YUAN KE REN XUCHAO ZHAO DONGDA WU JUNQIAO la YI WANG WENXIN WANG College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China College of Physics and Optoelectronic Engineering Harbin Engineering UniversityHarbin 150001China Qingdao Innovation and development Center of Harbin Engineering University Harbin Engineering UniversityQingdao 266500China

Surface lattice resonances(SLRs)with ultra-narrow linewidth(high quality factor)can enhance light–matter interactions at the nanoscale and modulate the propagating light from the emission wavelength direction to efficiency by photonic band ***,SLRs can serve as an excited candidate to enhance and,more importantly,modulate amplified spontaneous emission(ASE)with more optical ***,this work presents a system of two-dimensional Ag-coated Al nanocone array(Ag-NCA)packaged with Nile red,and a normal ASE with 15-fold enhancement is observed under external driving *** enhancement fades away,obviously,in the case of the off-normal condition,as the optical feedback evolves from the band edge steady state to the propagating *** ASE of this hybrid plasmonic system expands the possibilities of interaction between light and matter and has great promise for applications in nanolasing,super-resolution imaging,and photonic integration circuits.

关键词： band lasing driving

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基于语义增强的藏医药命名实体识别研究

中国数字医学 2024年第5期19卷 53-58页

作者：才让加措拥措拉毛东只张英周青西藏大学信息科学技术学院西藏自治区藏文信息技术人工智能重点实验室藏文信息技术教育部工程研究中心拉萨850000

针对通用藏文预训练语言模型在处理藏医数据时无法适应且存在词信息损失的问题,提出了一种融合藏医词汇特征与通用藏文预训练模型字特征的方法,以改善对藏医学专有名词的识别,并增强模型对藏医领域的理解能力。该方法通过构建藏医领域... 详细信息

针对通用藏文预训练语言模型在处理藏医数据时无法适应且存在词信息损失的问题,提出了一种融合藏医词汇特征与通用藏文预训练模型字特征的方法,以改善对藏医学专有名词的识别,并增强模型对藏医领域的理解能力。该方法通过构建藏医领域的特征词典,并利用词典来获取训练数据中每个字潜在的匹配词集,接着将词集特征嵌入字符表示中来增强藏医字符的表征能力。经实验表明,仅使用通用藏文预训练模型会降低对藏医实体识别的性能。融合词集特征后,f1值明显提高了17.19%,验证了此方法不仅能补充预训练模型缺乏的词汇信息,还可以有效缓解模型与藏医数据不匹配的问题。

关键词：命名实体识别藏医学语义增强预训练语言模型

The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： fabiola Mavillard Javier Perez-florido francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan f.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain departamento de Neurología Hospital Virgen de las NievesGranadaSpain departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia

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Bone Research 2022年第1期10卷 137-149页

作者： Ludovic Martin Nabil Kaci Catherine Benoist-lasselin Marine Mondoloni Suzanne decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine flipo Benoît demuynck Maria de la Luz Cádiz-Gurrea florent Barbault Salvador fernández-Arroyo laurent Schibler Antonio Segura-Carretero Emilie Dambroise laurence Legeai-Mallet Universitéde Paris Imagine InstituteLaboratory of Molecular and Physiopathological Bases of OsteochondrodysplasiaINSERM UMR 1163F‑75015ParisFrance Inovarion ParisFrance department of Analytical Chemistry University of GranadaGranadaSpain Research and development of functional food Centre(CIDAf) GranadaSpain Universitéde Paris ITODYSCNRSUMR 708615 rue J-A de BaïfParisFrance Biomedical Research Unit Medicine and Surgery DepartmentRovira i Virgili UniversityTarragonaSpain ALLICE Maison Nationale des EleveursParisFrance

A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(fGfR3)results in achondroplasia(ACH),the most frequent form of *** activation of fGfR3 impairs bone formation and elongation and many signal transduction *** of new and relevant compounds targeting the fGfR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate ***,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited fGfR3’s downstream signaling *** analysis in an fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related *** femurs isolated from a mouse model(fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo *** vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in *** modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone *** results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH.

关键词： inhibited arrangement eliminated

Magnetocaloric effect in ErNi2 melt-spun ribbons

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Journal of Rare Earths 2020年第6期38卷 612-616页

作者： J.L.sanchez Llamazares P.Ibarra-Gaytan C.f.sanchez-Valdes D.Rlos-Jara P.Alvarez-Alonso Instituto Potosino de Investigacion Ciendfica y Tecnoldgica A.C. Camino a la Presa San Jose 2055Col.Lomas 4San Luis Potosi.S.LP.78216Mexico CPM-TIP University Pavol Jozef SafarikPark Angelinum 9.04154 KosiceSlovakia Division Multidisciplinaria Ciudad UniversitariaUniversidad Aurdnoma de Ciudad Juarez(UACJ)Calle Jose de Jesus Macias Delgado#18100Ciudad Juarez 32579Chihuahua.Mexico departamento de fisica Universidad de OviedoCalvo Sotelo s/n33007 OviedoSpain

ErNi2 ribbons were produced by rapid solidification using the melt spinning *** structural,magnetic and magnetocaloric properties in the as-solidified state were studied by X-ray diffraction,scanning electron microscopy,magnetization and specific heat *** are single phase with the MgCu2-type crystal structure,a Curie temperature TC of 6.8 K and a saturation magnetization at2 K and 5 T of 124.0 A·m2/*** a magnetic field change μ0△H of 5 T(2 T) ribbons show a maximum magnetic entropy change |△SMpeak| of 24.1(16.9) J/(kg·K),and an adiabatic temperature change △Tadmax of8.1(4.4) K;this is similar to the previously reported literature for bulk alloys that were processed through conventional melting techniques followed by prolonged thermal *** addition,the samples also show slightly wider △SM(T) curves with respect to bulk alloys leading to a larger refrigerant capacity.

关键词： ErNi2 laves phase Melt-spun ribbons Magnetic entropy change Adiabatic temperature change Rare Earths

苜蓿皂苷提取物对断奶湖羊免疫、抗氧化能力和瘤胃微生物区系的影响

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中国畜牧兽医 2024年第7期51卷 2799-2809页

作者：张艳马森栗守仁皇甫卫康腊邵凯马季祥王志昌史莹华河南农业大学动物科技学院郑州450002 河南省草地资源创新与利用重点实验室郑州450002 河南省牧草工程技术研究中心郑州450002

【目的】苜蓿皂苷作为一类天然生物活性物质,具有提高畜禽机体免疫力、促生长及调节胃肠道功能等多方面效用。试验旨在探究苜蓿皂苷提取物对断奶湖羊生长性能、免疫功能、抗氧化能力和瘤胃微生物区系的影响。【方法】选取45日龄、体重相... 详细信息

【目的】苜蓿皂苷作为一类天然生物活性物质,具有提高畜禽机体免疫力、促生长及调节胃肠道功能等多方面效用。试验旨在探究苜蓿皂苷提取物对断奶湖羊生长性能、免疫功能、抗氧化能力和瘤胃微生物区系的影响。【方法】选取45日龄、体重相近(15.67 kg±1.18 kg)的断奶湖羊32只,随机分为2组,每组4个重复,每个重复4只羊。对照组(CON)湖羊饲喂基础饲粮,皂苷组(AS)湖羊在基础饲粮中添加2 g/kg(饲粮干物质基础)苜蓿皂苷提取物,预试期7 d,正试期60 d。试验结束后收集断奶湖羊瘤胃液测定微生物组成,采集颈静脉血用于测定血清免疫和抗氧化性能相关指标。【结果】(1)两组湖羊平均日增重(ADG)和料重比(f/G)均无显著差异(P>0.05)。(2)与对照组相比,皂苷组湖羊血清中免疫球蛋白(IgA、IgM)、抗炎因子白介素-10(IL-10)、CD4^(+)T细胞和CD4/CD8水平极显著或显著升高(Pf-α)、IL-6含量均极显著降低(PfA)浓度均无显著差异(P>0.05)。(5)两组间湖羊Shannon指数、Simpson指数和主坐标分析(PCoA)均无明显差异;在属水平上,皂苷组湖羊瘤胃液中硫酸盐还原菌脱硫弧菌属(desulfovibrio)和有益菌罗氏菌属(Roseburia)、凸腹真杆菌群(Eubacterium_ventriosum_group)等的相对丰度均显著高于对照组(P<0.05)。【结论】饲粮中添加苜蓿皂苷提取物可以影响断奶湖羊瘤胃微生物的组成,提高机体免疫和抗氧化能力,且一定程度上有利于机体健康。

关键词：断奶湖羊苜蓿皂苷提取物免疫功能抗氧化能力瘤胃微生物