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Petrogenesis of Granites from the Ediacaran Socorro Batholith,SE Brazil:Constraints from Zircon Dating,Geochemistry and Sr-Nd-Hf Isotopes

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Journal of Earth Science 2021年第6期32卷 1397-1414页

作者： Bárbara Bueno Toledo Valdecir de Assis Janasi Instituto de Geociências USPCEP 05508-900S∼ao PauloSPBrazil

Whole rock elemental and Sr-Nd isotope geochemistry and in situ zircon Hf isotope geochemistry were used to identify the sources of the Neoproterozoic granites from the Socorro batholith,Socorro-GuaxupéNappe(SGN),South Brasilia Orogen,*** trace elements and Hf isotope geochemistry provided information about sources and crystallization(T,f_(O2))*** main types of granites built the bulk of the batholiths,beginning with probably pre-collisional~640–630 Ma charnockites,and ending with~610 Ma voluminous post-collisional high-K calc-alkaline(HKCA)Ⅰ-type granites(Bragan?a Paulista-type).Several types of leucogranites were generated from 625 to 610 Ma,spanning the interval from collisional to post-collisional *** charnockite bodies occur in the study area:the~640 Ma Socorro charnockite has remarkable chemical similarities with Braganca Paulista-type granites,but higherε_(Nd)(t)=-6.1 and average zirconε_(Hf)(t)=-9.1 and lower^(86)Sr/^(87)Sr_(t)(0.7093)values,indicative of more juvenile and water-poor ***~633 Ma Atibaia charnockite has distinct geochemical signature(lower Mg^(#)and Sr content;higher Zr),more negativeε_(Nd)(t)=-14.1,similar average zirconε_(Hf)(t)=-8.9,and much higher^(86)Sr/^(87)Sr_(t)=0.7197,probably reflecting a larger component from old *** predominant~610 Ma Bragan?a Paulista-type granites were emplaced in a post-collisional setting,and correspond to porphyritic biotite-hornblende monzogranites of high-K calc-alkaline character with 61 wt.%–67 wt.%SiO_(2),high Mg^(#)(39–42),Sr/Y(19–40),la/Yb(12–69),highly negativeε_(Nd)(t)(-12.3 to-12.9)and zirconε_(Hf)(t)(-12 to-17)and^(87)Sr/^(86)Sr_(t)=0.7119–*** features are interpreted as indicative of magma generation in a thickened crust,where melts from enriched mantle sources emplaced in the lowermost crust,heated host old continental crust rocks(gneisses and granulites)and partially mixed with their melting *** plutons(SiO_(2)>72 wt.%)occur

关键词： U-Pb dating Socorro-GuaxupéNappe high-K calc-alkaline granites

Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia

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Bone Research 2022年第1期10卷 137-149页

作者： Ludovic Martin Nabil Kaci Catherine Benoist-lasselin Marine Mondoloni Suzanne decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine flipo Benoît demuynck Maria de la Luz Cádiz-Gurrea florent Barbault Salvador fernández-Arroyo laurent Schibler Antonio Segura-Carretero Emilie Dambroise laurence Legeai-Mallet Universitéde Paris Imagine InstituteLaboratory of Molecular and Physiopathological Bases of OsteochondrodysplasiaINSERM UMR 1163F‑75015ParisFrance Inovarion ParisFrance department of Analytical Chemistry University of GranadaGranadaSpain Research and development of functional food Centre(CIDAf) GranadaSpain Universitéde Paris ITODYSCNRSUMR 708615 rue J-A de BaïfParisFrance Biomedical Research Unit Medicine and Surgery DepartmentRovira i Virgili UniversityTarragonaSpain ALLICE Maison Nationale des EleveursParisFrance

A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(fGfR3)results in achondroplasia(ACH),the most frequent form of *** activation of fGfR3 impairs bone formation and elongation and many signal transduction *** of new and relevant compounds targeting the fGfR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate ***,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited fGfR3’s downstream signaling *** analysis in an fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related *** femurs isolated from a mouse model(fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo *** vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in *** modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone *** results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH.

关键词： inhibited arrangement eliminated

Association between cardiorespiratory fitness level and insulin resistance in adolescents with various obesity categories

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World Journal of Diabetes 2023年第7期14卷 1126-1136页

作者： lavinia la Grasta Sabolic Marija Pozgaj Sepec Bernardica Valent Moric Maja Cigrovski Berkovic department of Pediatric Endocrinology and Diabetology University Hospital Centre Sestre milosrdniceZagreb 10000Croatia School of Medicine Catholic UniversityZagreb 10000Croatia department for Sport and Exercise Medicine Faculty of Kinesiology University of ZagrebZagreb 10000Croatia

BACKGROUND An association between cardiorespiratory fitness(CRf)and insulin resistance in obese adolescents,especially in those with various obesity categories,has not been systematically *** is a lack of knowledge about the effects of CRf on insulin resistance in severely obese adolescents,despite their continuous *** To investigate the association between CRf and insulin resistance in obese adolescents,with special emphasis on severely obese *** We performed a prospective,cross-sectional study that included 200 pubertal adolescents,10 years to 18 years of age,who were referred to a tertiary care center due to *** to body mass index(BMI),adolescents were classified as mildly obese(BMI 100% to 120% of the 95^(th)percentile for age and sex)or severely obese(BMI≥120% of the 95^(th)percentile for age and sex or≥35 kg/m^(2),whichever was lower).Participant body composition was assessed by bioelectrical impedance analysis.A homeostatic model assessment of insulin resistance(HOMA-IR)was *** oxygen uptake(VO_(2)max)was determined from submaximal treadmill exercise *** was expressed as VO_(2)max scaled by total body weight(TBW)(mL/min/kg TBW)or by fat free mass(ffM)(mL/min/kg ffM),and then categorized as poor,intermediate,or good,according to VO_(2)max *** were analyzed by statistical software package SPSS(IBM SPSS Statistics for Windows,Version 24.0).Pdered statistically *** A weak negative correlation between CRf and HOMA-IR was found[Spearman’s rank correlation coefficient(rs)=-0.28,Pfor CRf_(TBW);(r_(s))=-0.21,Pfor CRf_(ffM)].One-way analysis of variance(ANOVA)revealed a significant main effect of CRf on HOMA-IR[f(2200)=6.840,P=0.001 for CRf_(TBW);f_((2200))=3.883,P=0.022 for CRf_(ffM)].Subsequent analyses showed that obese adolescents with poor CRf had higher HOMA-IR than obese adolescents with good CRf(P=0.001 for CRf_(TBW);P=0.018 for CRf_(ffM)).Two-w

关键词： Cardiorespiratory fitness Insulin resistance Obese adolescents Severe obesity Obesity category

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中国南方古生代的一些海相新藻类(英文)

微体古生物学报 2011年第1期28卷 127-136页

作者： B. MAMET Universite libre de Bruxelles Departement des Sciences de la Terre et de l'Environnement CP160/02 Av. F.D. Roosevelt 50 B-1050 Bruxelles Belgique

本文报道中国南方广西、贵州晚泥盆世-早石炭世的钙质微体古生物,描述红藻新属Yishanella及其二个新种(Yishanelle ***.,***.),一个绿藻新种(***.)和一种分类位置未定化石(Menselina ***.)。该微体植物群繁衍于透光带中。识别出三个组合... 详细信息

本文报道中国南方广西、贵州晚泥盆世-早石炭世的钙质微体古生物,描述红藻新属Yishanella及其二个新种(Yishanelle ***.,***.),一个绿藻新种(***.)和一种分类位置未定化石(Menselina ***.)。该微体植物群繁衍于透光带中。识别出三个组合,分别代表清洁水体的Girvanella,泥质的Issinella和介于二者之间的Menselina环境。

关键词：藻类新属种海相古生代广西贵州

Anthocyanin profi les and color properties of red wines made from Vitis davidii and Vitis vinifera grapes

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food Science and Human Wellness 2021年第3期10卷 335-344页

作者： Yanlun Ju la Yang Xiaofeng Yue Yunkui Li Rui He Shenglin deng Xin Yang Yulin fang College of Enology Northwest A&F UniversityYangling 712100China Shaanxi Engineering Research Center for Viti-Viniculture Yangling 712100China

Spine grape(Vitis davidii foex.)is an important wild grape species native to *** red spine grape clones and three red Vitis vinifera grape varieties were used to evaluate the differences in the anthocyanin profiles and color properties of wines made from *** and *** *** spine wines,‘Junzi#2’wine had the highest total phenolic and total anthocyanin,‘Xiangzhenzhu’wine had the highest total flavonoids,and‘Junzi#1’wine had the highest total *** anthocyanin compositions of all of the spine wines were dominated by Mv-3,*** total individual anthocyanin contents in spine wines,except‘Gaoshan#5’,‘Junzi#5055’,‘Junzi#5061’,and‘Junzi#5044’,were signifi cantly higher than in *** *** of the spine wines had a stronger red intensity and a brighter chroma with a bluer hue than *** *** analysis revealed that the color properties were closely related to the anthocyanin *** results suggest that wines made from spine grapes may be useful for the wine industry for their color properties and high individual anthocyanin contents.

关键词： Spine grape Vitis vinifera L. Wine analysis Wine color Anthocyanin

苜蓿皂苷提取物对断奶湖羊免疫、抗氧化能力和瘤胃微生物区系的影响

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中国畜牧兽医 2024年第7期51卷 2799-2809页

作者：张艳马森栗守仁皇甫卫康腊邵凯马季祥王志昌史莹华河南农业大学动物科技学院郑州450002 河南省草地资源创新与利用重点实验室郑州450002 河南省牧草工程技术研究中心郑州450002

【目的】苜蓿皂苷作为一类天然生物活性物质,具有提高畜禽机体免疫力、促生长及调节胃肠道功能等多方面效用。试验旨在探究苜蓿皂苷提取物对断奶湖羊生长性能、免疫功能、抗氧化能力和瘤胃微生物区系的影响。【方法】选取45日龄、体重相... 详细信息

【目的】苜蓿皂苷作为一类天然生物活性物质,具有提高畜禽机体免疫力、促生长及调节胃肠道功能等多方面效用。试验旨在探究苜蓿皂苷提取物对断奶湖羊生长性能、免疫功能、抗氧化能力和瘤胃微生物区系的影响。【方法】选取45日龄、体重相近(15.67 kg±1.18 kg)的断奶湖羊32只,随机分为2组,每组4个重复,每个重复4只羊。对照组(CON)湖羊饲喂基础饲粮,皂苷组(AS)湖羊在基础饲粮中添加2 g/kg(饲粮干物质基础)苜蓿皂苷提取物,预试期7 d,正试期60 d。试验结束后收集断奶湖羊瘤胃液测定微生物组成,采集颈静脉血用于测定血清免疫和抗氧化性能相关指标。【结果】(1)两组湖羊平均日增重(ADG)和料重比(f/G)均无显著差异(P>0.05)。(2)与对照组相比,皂苷组湖羊血清中免疫球蛋白(IgA、IgM)、抗炎因子白介素-10(IL-10)、CD4^(+)T细胞和CD4/CD8水平极显著或显著升高(Pf-α)、IL-6含量均极显著降低(PfA)浓度均无显著差异(P>0.05)。(5)两组间湖羊Shannon指数、Simpson指数和主坐标分析(PCoA)均无明显差异;在属水平上,皂苷组湖羊瘤胃液中硫酸盐还原菌脱硫弧菌属(desulfovibrio)和有益菌罗氏菌属(Roseburia)、凸腹真杆菌群(Eubacterium_ventriosum_group)等的相对丰度均显著高于对照组(P<0.05)。【结论】饲粮中添加苜蓿皂苷提取物可以影响断奶湖羊瘤胃微生物的组成,提高机体免疫和抗氧化能力,且一定程度上有利于机体健康。

关键词：断奶湖羊苜蓿皂苷提取物免疫功能抗氧化能力瘤胃微生物

Severe Allergic Reaction following Administration of Antivenom Serum for Snakebite: A Case Report from Togo

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Case Reports in Clinical Medicine 2024年第8期13卷 297-303页

作者： Awèréou Kotosso Lidaw deassoua Bawe Akouda Akessiwe Patassi lampouguini Nebona Cici Amouzou Esso-Essinam félix Pissang Bawoubadi Abaltou Gnimdou Tchamdja Magnoudewa Poko Hassimou Bramah Majesté Ihou Wateba facult des Sciences de la Sant Universit de Lom Lom Togo department of Infectious Diseases Centre Hospitalier Rgional Lom-Commune Lom Togo department of Infectious Diseases and Tropical Medicine Centre Hospitalier Universitaire Sylvanus Olympio Lom Togo department of General Medicine Centre Mdical des Armes de Sokod Lom Togo

Background: Ophidian envenomation is common in Sub-Saharan Africa, and its management is hampered by the lack of access to healthcare services in rural areas, in particular the availability and appropriate use of antivenom. Rare cases of serious side effects following the administration of antivenom have been reported. This is the case for a young farmer from the central region of Togo, who experienced a second snake bite within four years, and in whom antivenom serotherapy led to severe allergic manifestations. Case presentation: This 24-year-old patient, with a history of antivenom and tetanus serotherapy, was admitted to the Centre Hospitalier Régional (CHR) of Sokodé for a snakebite that occurred 45 minutes earlier while working in the field. Clinical assessment on admission revealed grade 1 envenomation, characterized by local pain in the right upper limb, with no sign of complication. He received an intravenous infusion of antivenom serotherapy, which rapidly relieved the pain, allowing him to be discharged after 24 hours of hospital monitoring. However, he was readmitted five days later for a skin rash associated with generalized pruritus and edema of the face and the neck, which prompted his evacuation to the Sylvanus Olympio University Hospital. He was diagnosed with a hypersensitivity-type allergic reaction to antivenom serum. Symptomatic treatment with antihistamines resulted in a favourable outcome after five days in the hospital. Conclusion: This young farmer developed a severe allergic reaction following a second course of antivenom serotherapy for low-grade ophidian envenomation. Although the efficacy of antivenom serum is undeniable in the management of snakebites, its use should be guided by a sound clinical assessment and framed by rigorous monitoring, especially in people sensitized to antivenom or antitoxin serotherapy. This highlights the importance of training healthcare staff alongside the availability of anti-venomous sera at peripheral healt

关键词： Snakebite Antivenom Allergic Reaction Sub-Saharan Africa Togo

Traditional Chinese medicine wrist pulse-taking is associated with pulse waveform analysis and hemodynamics in hypertension

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Journal of Integrative Medicine 2016年第2期14卷 100-113页

作者： Nathalia Gomes Ribeiro de Moura Ivan Cordovil Arthur de Sa ferreira Postgraduate Program of Rehabilitation Science Augusto Motta University Center21041-010Rio de JaneiroR JBrazil Division of Arterial Hypertension National Institute of Cardiology22240-002Rio de JaneiroR JBrazil department of Physical Therapy Salgado de Oliveira University24030-060NiteroiR JBrazil

BACKGROUND： Pulse wave analysis（PWA） quantifies the phenomenon of pulse waveform propagation in patients with cardiovascular diseases, whereas pulse image analysis（PIA） is a subjective examination in traditional Chinese medicine. OBJECTIVE： This study evaluated the association of PIA with PWA and hemodynamics in patients with hypertension. deSIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This observational, cross-sectional study enrolled 45 patients（26 men,（55.2± 10.3） years, systolic blood pressure（155± 28） mm Hg, diastolic blood pressure（93± 17） mm Hg） for assessment of clinical and laboratorial data. MAIN OUTCOME MEASURES： Primary outcomes comprised： pattern differentiation based on an automated method; PIA at the radial artery using the ‘simultaneous pressing＇ method for identification of factors such as strength（strong/weak）, depth（superficial/deep）, and speed（fast/moderate/slow）; and PWA at the same artery using a noninvasive system. RESULTS： Significant multivariate main effects were observed for depth（l=0.648, f_（5,29）=3.149, P=0.022, h^2 =0.352）, strength（l=0.608, f_（5,29） =3.736, P=0.010, h^2 =0.392）, and speed（l=0.535, f_（5,29） =5.302, P=0.002, h^2 =0.465）. General effects comprised high values of PWA and blood pressure for superficial, strong, and fast pulse images. A strong pulse was found for pulse pressure ≥ 62.5 mm Hg and systolic blood pressure ≥ 149.5 mm Hg, whereas a superficial pulse was found for heart rate ≥ 58.25 beats/min; a fast pulse was found for heart rate ≥ 69.6 beats/min and pulse wave velocity ≥ 9.185 m/s. CONCLUSION： Associations were explained by la Place＇s law, arterial remodeling in hypertension, alongside the traditional criterion for classifying speed in pulse images. PIA is associated with PWA and hemodynamics in patients with hypertension. Systolic and pulse pressures, heart rate, and pulse wave velocity are quantitative variables that have information to describe the qualitative pulse images such as strength, depth and speed.

关键词： medicine Chinese traditional hypertension syndrome differentiation rehabilitation

The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： fabiola Mavillard Javier Perez-florido francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan f.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain departamento de Neurología Hospital Virgen de las NievesGranadaSpain departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive