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Immune cells in term and preterm labor

Cellular & Molecular Immunology 2014年第6期11卷 571-581页

作者： nardhy Gomez-Lopez Derek StLouis Marcus A Lehr Elly n sanchez-Rodriguez Marcia Arenas-Hernandez Department of Obstetrics & Gynecology and Immunology & Microbiology Wayne State University Detroit MI USA Perinatology Research Branch nICHD/nIH School of Medicine Wayne State University Detroit MI USA

Labor resembles an inflammatory response that includes secretion of cytokines/chemokines by resident and infiltrating immune cells into reproductive tissues and the maternal/fetal interface. Untimely activation of these inflammatory pathways leads to preterm labor, which can result in preterm birth. Preterm birth is a major determinant of neonatal mortality and morbidity; therefore, the elucidation of the process of labor at a cellular and molecular level is essential for understanding the pathophysiology of preterm labor. Here, we summarize the role of innate and adaptive immune cells in the physiological or pathological activation of labor. We review published literature regarding the role of innate and adaptive immune cells in the cervix, myometrium, fetal membranes, decidua and the fetus in late pregnancy and labor at term and preterm. Accumulating evidence suggests that innate immune cells （neutrophils, macrophages and mast cells） mediate the process of labor by releasing pro-inflammatory factors such as cytokines, chemokines and matrix metalloproteinases. Adaptive immune cells （T-cell subsets and B cells） participate in the maintenance of fetomaternal tolerance during pregnancy, and an alteration in their function or abundance may lead to labor at term or preterm. Also, immune cells that bridge the innate and adaptive immune systems （natural killer T （nKT） cells and dendritic cells （DCs）） seem to participate in the pathophysiology of preterm labor. In conclusion, a balance between innate and adaptive immune cells is required in order to sustain pregnancy; an alteration of this balance will lead to labor at term or preterm.

关键词： B cells cytotoxic T cells dendritic cells macrophages mast cells neutrophils nKT cells parturition preterm delivery regulatory T cells T cells

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Trombe walls with porous medium insertion and their influence on thermal comfort in flats in Cusco,Peru

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Energy and Built Environment 2024年第2期5卷 194-210页

作者： Patrick Facelli sanchez Lisset Mercado Hancco Department of Civil Engineering Faculty of Architecture and Civil EngineeringUniversidad Nacional de San Antonio Abad del Cusco08003 CuscoPeru

The Trombe wall is a passive indirect heating system which should be used in Cusco,Peru to improve thermal conditions against the typical frosts and low temperatures during winter in the high Andean *** to this problem,the use of a modified Trombe wall with insertion of porous medium is proposed to improve thermal comfort in flat buildings in *** research aims to analyse and compare the performance of dwellings without Trombe wall,with traditional Trombe wall,and with Trombe wall with glass and plastic pellets insertion in thermal comfort ***■CFD was used to simulate and analyse the *** simulation was performed with three prototype flats(55 m^(2),75 m^(2) and 95 m^(2))for six months of the *** the results obtained,the level of thermal comfort in the traditional scenarios is low with an average PMV of-1.86,in the scenarios with Trombe wall is good and in the scenarios with Trombe wall with insertion of porous medium is slightly better than the previous one,reaching an average PMV of+0.10 and a temperature of 21.90℃.The study carried out is important because it represents an efficient eco-sustainable heating alternative that improves the thermal comfort sensation in houses during the coldest months of the year.

关键词： Trombe wall thermal comfort porous medium residential buildings computational fluid dynamics

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Avian responses to an extreme weather event:The case of the‘Filomena’snowstorm in Madrid(central Spain)

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Avian Research 2024年第2期15卷 180-186页

作者： Carlos Lazaro Carlos sanchez-García Fabian Casas E.Jorge Tizado Department of Research Fundacion Artemisan13001 Ciudad RealSpain Department of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain Department of Biodiversity and Environmental Management Universidad de Leon24401 PonferradaSpain

Cold spells and severe weather may have detrimental effects in wild birds,but owing to the stochastic nature of these events,it is not always possible to measure their *** January 2021,a strong snowstorm known as‘Filomena’affected Spain,mainly the region of Madrid(Central Spain),which was fully covered with snow and suffered freezing temperatures for a *** bird surveys conducted in the winter-spring of 2020 and 2021(before and after Filomena)at same locations,we addressed the possible impact of the cold spell in three widespread gamebirds:Wood Pigeon(Columba palumbus),Eurasian Magpie(Pica pica)and Red-legged Partridge(Alectoris rufa).no significant abundance differences were found between years for none of the species and hunting pressure was only significantly reduced for Partridges,hence this species may have been negatively affected by *** suggest that in response to Filomena,Pigeons conducted partial migration in search of better conditions,while Magpies aggregated in certain areas of Madrid and Partridges endured the harsh conditions within their home *** results highlight the importance to alleviate negative impacts of extreme weather events in wild birds through management actions,especially for sedentary species.

关键词： Alectoris rufa Climate change Cold spell Columba palumbus Migration Pica pica Winter

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Dose-response associations,physical activity intensity and mortality risk:A narrative review

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Journal of Sport and Health Science 2024年第1期13卷 24-29页

作者： Ulf Ekelund Miguel Adriano sanchez-Lastra Knut Eirik Dalene Jakob Tarp Department of Sport Medicine Norwegian School of Sport SciencesOslo 0806Norway Department of Chronic Diseases Norwegian Institute of Public HealthOslo 0213Norway Department of Special Didactics Faculty of Education and Sports SciencesUniversity of VigoPontevedra 36005Spain Well-Move Research Group Galicia-Sur Health Research Institute(SERGAS-UVIGO)Vigo 36213Spain

Physical activity is consistently associated with reduced mortality,decreased risk for non-communicable diseases,and improved mental health in observational *** controlled trials and observational Mendelian randomization studies support causal links between physical activity and health ***,the scarcity of evidence from randomized controlled trials,along with their inherent challenges like exposure contrasts,healthy volunteer biases,loss to follow-up,and limited real-world dose-response data,warrants a comprehensive *** review advocates synthesizing insights from diverse study designs to better understand the causal relationship between physical activity,mortality risk,and other health ***,it summarizes recent research since the publication of current physical activity *** observational studies utilizing device-measured physical activity underscore the importance of every minute of activity and suggest that all intensity levels confer health benefits,with vigorous-intensity potentially requiring lower volumes for substantial *** guidelines,informed by device-measured physical activity studies,may offer refined age-specific recommendations,emphasize vigorous-intensity physical activity,and include daily step counts as a simple,easily assessable metric using commercial wearables.

关键词： Accelerometers non-communicable diseases Public health Sedentary behavior

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Breaking paradigms: Long non-coding RnAs forming gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： David sanchez-Marin Macrina Beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman Alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RnAs(lncRnAs)are non-coding RnAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DnA,RnA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRnAs are susceptible to form gene fusions with mRnAs or other IncRnAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRnA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRnAs ncRnAs Therapy

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How to fill the biodiversity data gap:Is it better to invest in fieldwork or curation?

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Plant Diversity 2024年第1期46卷 39-48页

作者： Carlos A.Vargas Marius Bottin Tiina Sarkinen James E.Richardson Marcela Celis Boris Villanueva Adriana sanchez Programa de Biología Facultad de Ciencias NaturalesUniversidad del RosarioBogotaD.C.Colombia Subdireccion Científica Jardín Botanico de Bogota“Jose Celestino Mutis”BogotaD.C.Colombia Independent Researcher BogotaD.C.Colombia Tropical Diversity Section Royal Botanic Garden EdinburghUK School of Biological Earth and Environmental SciencesUniversity College CorkCorkIreland Departamento de Química y Biología Universidad del NorteKm.5 Vía Puerto ColombiaArea Metropolitana de Barranquilla 081007Colombia

Data gaps and biases are two important issues that affect the quality of biodiversity information and downstream *** how best to fill existing gaps and account for biases is necessary to improve our current information most *** current main approaches for obtaining and improving data include(1)curation of biological collections,and(2)***,the comparative effectiveness of these approaches in improving biodiversity data remains little *** used the Flora de Bogota project to study the magnitude of change in species richness,spatial coverage,and sample coverage of plant records based on curation versus *** process of curation resulted in a decrease in species richness(synonym and error removal),but it significantly increased the number of records per *** contributed to a slight increase in species richness,via accumulation of new ***,curation led to increases in spatial coverage,species observed by locality,the number of plant records by species,and localities by species compared to ***,curationwas more efficient in producing new information compared to fieldwork,mainly because of the large number of records available in *** recommend intensive curatorial work as the first step in increasing biodiversity data quality and quantity,to identify bias and gaps at the regional scale that can then be targeted with *** stepwise strategy would enable fieldwork to be planned more costeffectively given the limited resources for biodiversity exploration and characterization.

关键词： Colombia Flora de Bogota Sample coverage Species richness Tropical Andes

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Chebyshev polynomial-based Ritz method for thermal buckling and free vibration behaviors of metal foam beams

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 891-910页

作者： n.D.nGUYEn T.n.nGUYEn Faculty of Civil Engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh City 71309Viet Nam Faculty of Engineering and Technology Kien Giang UniversityChau Thanh 92000Viet Nam

This study presents the Chebyshev polynomials-based Ritz method to examine the thermal buckling and free vibration characteristics of metal foam *** analyses include three models for porosity distribution and two scenarios for thermal *** material properties are assessed under two conditions,i.e.,temperature dependence and temperature *** theoretical framework for the beams is based on the higher-order shear deformation theory,which incorporates shear deformations with higher-order *** governing equations are established from the Lagrange equations,and the beam displacement fields are approximated by the Chebyshev *** simulations are performed to evaluate the effects of thermal load,slenderness,boundary condition(BC),and porosity distribution on the buckling and vibration behaviors of metal foam *** findings highlight the significant influence of temperature-dependent(TD)material properties on metal foam beams'buckling and vibration responses.

关键词： Ritz method Chebyshev function buckling vibration metal foam beam higher-order beam theory(HOBT)

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Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society Consensus Conference: towards better clinical care in transplant hepatology

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Hepatobiliary Surgery and nutrition 2024年第3期13卷 512-515页

作者： Yu Jun Wong noreen Singh norberto sanchez-Fernandez Aldo J.Montano-Loza Division of Gastroenterology and Liver Unit University of Alberta HospitalEdmontonCanada Division of Transplantation Department of SurgeryUniversity of Alberta HospitalEdmontonCanada

Liver transplantation(LT)was first performed over six decades ago and is currently the standard of care for patients with end-stage liver disease and life-threatening *** have been significant advances in the area of LT;however,it remains a highly morbid,restrictive,expensive and resource-intensive intervention(1).Early recovery for LT(***)is a multimodal concept aimed at promoting faster recovery in patients undergoing *** development of a dedicated protocol for early recovery following LT has been challenging due to the complexity of developing a treatment approach,patient comorbidities associated with decompensated cirrhosis,and low case volume.

关键词： Liver transplantation(LT) outcome recovery

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Compression properties of cost-efficient porous expanded clay reinforced AA7075 syntactic foams fabricated by industrial-oriented die casting technology

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China Foundry 2024年第1期21卷 60-70页

作者： İsmail Cem Akgün Çağın Bolat Ali Gökşenli Faculty of Mechanical Engineering Istanbul Technical University34437İstanbulTurkey Faculty of Engineering Samsun University55420SamsunTurkey

In today’s manufacturing industries,hard competition between rival firms makes it compulsory for researchers to design lighter and cheaper machine components due to the megatrends of cost-effectiveness and *** this point,aluminum syntactic foams(ASFs)are new-generation engineering composites and come into the upfront as a *** to their features like low density,sufficient elongation,and perfect energy absorption ability,these advanced foams have been considerably seductive for many industrial sectors *** this study,an industrial-oriented automatic die casting technology was used for the first time to manufacture the combination of AA7075/porous expanded clay(PEC).Micro evaluations(optical and FESEM)reveal that there is a homogenous particle distribution in the foam samples,and inspections are compatible with the other ASF ***,T6 aging heat treatment was operated on one half of the produced foams to explore the probable impact of aging on the compressive *** results show that PEC particles can be an alternative to expensive hollow spheres used in the previous ***,a favorable relationship is ascertained between the aging treatment and mechanical properties such as compression strength and plateau strength.

关键词： die casting porous materials metal matrix sytanctic foams expanded clay compressive deformation

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Exploring research on ecotechnology through artificial intelligence and bibliometric maps

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Environmental Science and Ecotechnology 2024年第5期21卷 405-412页

作者： Ricardo Ruiz-sanchez Ricardo Arencibia-Jorge Julia Tagüena Jose Luis Jimenez-Andrade Humberto Carrillo-Calvet Unidad Profesional Interdisciplinaria de Ingeniería Palenque(UPIIP) Instituto Politecnico NacionalPalenqueChiapasCP 29960Mexico Complexity Sciences Center National Autonomous University of MexicoCircuito Centro Cultural s/nCoyoacan04510Mexico CityMexico Institute of Renewable Energies(IER) National Autonomous University of MexicoPriv.Xochicalco s/nCol.CentroTemixcoMorelosCP 62580Mexico Faculty of Sciences National Autonomous University of MexicoCircuito Centro Cultural s/nCoyoacan04510Mexico CityMexico

Ecotechnology,quintessential for crafting sustainable socio-environmental strategies,remains tantalizingly *** analysis,steered by the nuances of machine learning and augmented by bibliometric insights,delineates the expansive terrain of this domain,elucidates pivotal research themes and conundrums,and discerns the vanguard nations in this ***,we deftly connect our discoveries to the United nations'2030 Sustainable Development Goals,thereby accentuating the profound societal ramifications of ecotechnology.

关键词： Ecotechnologies Bibliometrics Sustainable development goals network analysis SOM neural networks

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