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Frequency and Antimicrobials Susceptibility Pattern of <i>Staphylococcus aureus</i>Associated with Wound Infections in Surgery Department, Wad madani Teaching Hospital, Sudan

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Pharmacology & Pharmacy 2021年第12期12卷 334-343页

作者： sanaa m. Yousif Adam D. Abakar Bakri Y. m. Nour Salma O. Ibrahim Omer m. Abu Elhasan mirgani A. Yousif Sitelbanat Yassin Hajer m. Hussien mohamed Taj-Eldin Elhadi A. Ahmed National Blood Bank Ministry of Health Khartoum Sudan Department of medical Parasitology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of medical microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Wad-madani College of medical Sciences and Technology Wad Medani Sudan Faculty of Pharmacy University of Gezira Wad Medani Sudan

Background: most community and hospital acquired infections are due to Staphylococcus aureus, these infections involve both local suppurative and systemic conditions. There is an increase in the incidence rates of acq... 详细信息

Background: Most community and hospital acquired infections are due to Staphylococcus aureus, these infections involve both local suppurative and systemic conditions. There is an increase in the incidence rates of acquiring resistant strains of Staphylococcus aureus in hospitals and community in Sudan. This study aims to detect frequency of Staphylococcus aureus isolated from surgical-sites infections (SSIs) and traumatic wounds, and to determine susceptibility to commonly used drugs. Methods: Prospective cross-sectional laboratory based study was followed, 250 patients admitted to Surgery Departments at Wad Madani Teaching Hospitals during 2019 and 2020 were recruited;with clinical manifestation of SSIs and or/traumatic wounds. Swab sample was taken from each participant and incubated aerobically on mannitol salt agar. Biochemical tests and 16rRNA gene used for Staphylococcus aureus identification. Antimicrobial susceptibility was accomplished using Kirby Bauer disc diffusion technique. Results:mily:Verdana;"> Infection rate of wounds in males and females equal 71% (17/250) and 29% (73/250), while infection rate in the age group of 41 to 60 y

关键词： Staphylococcus aureus Surgical-Sites Wounds meropeneme Sudan

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Psychotraumatic Interventions and Post-Traumatic Stress Disorder among the lomé Firefighters

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Open Journal of Psychiatry 2023年第S2期13卷 492-502页

作者： Kokou messanh Agbémélé Soedje Adjaré-kamé Fidèle Ahara Guy Gérard Aza-Gnandji Aboudourazak Amadou Tchédié Etdéchié Elvyre Klikpo Hassimou Bramah Doles Hamza Sama mensah Koffi mawussé Josiane Ezin-Houngbe Faculté des Sciences de la Santé Université de Lomé Lomé Togo Faculté des Sciences de la Santé Université d’Abomey-Calavi Abomey-Calavi Benin Equimed Group Sarl Lomé Togo

Aim: This study aimed to assess the quality of the psychological experience of mobile emergency teams, in particular firefighters (FF) in Togo and to identify the psychotraumatic interventions (PI) they face. method: This was a cross-sectional, descriptive, statistical analysis and discourse content analysis study on the PIs of the lomé FFs. Results: PIs were found to be: road accidents;defenestrations;self-immolation murders;bloody and non-bloody suicides;well interventions with or without drowning;extensive burns;and paediatric procedures. Adults aged 25 to 45 were at a percentage of 69.1% and with a sex ratio of 7.1. more than half of the respondents (53%) had PTSD. Conclusion: more than half of the respondents had PTSD, however, coping strategies were not explored, suggesting the need for further research.

关键词： Firefighters Psychotraumatic Interventions (PI) Togo

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Garcinol suppresses the growth of human hepatocellular carcinoma by inducing abrogation of STAT3 phosphorylation,acetylation and dimerization

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中国药理学与毒理学杂志 2015年第S1期29卷 82-83页

作者： muthu K SHANmUGAm Snehajyoti CHATTERJEE Peramaiyan RAJENDRAN Feng lI Parijat SENAPATI Kwong Fai WONG Alan Prem KUmAR John mlUK kam man HUI Gautam SETHI Tapas K KUNDU Department of Pharmacology Yong loo lin School of medicine National University of Singapore Singapore 117957 Jawaharlal Nehru Centre for Advanced Scientific Research molecular Biology and Genetics Unit Transcription and Disease laboratory Jakkur P.O. Bangalore 560064 India Cancer Science Institute of Singapore National University of Singapore Singapore 117456 School of Biomedical Sciences Faculty of Health Sciences Curtin University Western Australia Division of Cellular and molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Institute of molecular and Cell Biology Singapore 138673

OBJECTIVE Hepatocellular carcinoma(HCC)is the fifth most common malignancy worldwide and the third cause of global cancer *** of signal transducer and activator of transcription 3(STAT3)is commonly observed in tumor cells and is a critical mediator of on cogenic signaling in HCC and controls the expression of several genes involved in proliferation,survival,metastasis and *** drug-targeted therapies,besides being expensive,are associated with serious side effects and ***,novel agents that can suppress STAT3 activation have potential for both prevention and treatment of *** the present report,we investigated whether the potent HAT/KAT inhibitor,garcinol,(apolyisoprenylatedbenzophenone),could suppress STAT3 activation in HCC cells and in nude mice *** The effect of garcinol on HCC cell lines wasdetermined by mTT assay,immunoblotting,DNA binding assays,immuno-fluorescenceand immune-histochemical *** effect of garcinolon the inhibition of tumor growth in vivo was also investigated using HCCxenograft tumor modelin athymic nu/nu *** We found that garcinol could inhibit constitutive STAT3 activation in a dose-and time-dependent manner both by inhibiting STAT3 phosphorylation and acetylation in HCC *** investigated for molecular mechanism(s),we found that garcinol interferes with the dimer formation of STAT3 thereby inhibits its nuclear *** modeling showed that garcinol could bind to the SH2 domain of STAT3 and suppresses its dimerization in *** understand the cellular mechanism(s)of inhibition of STAT3 function by garcinol,we observed that upon inhibition of STAT3 dimerization bygarcinol,STAT3 DNA binding ability gets *** inhibition of STAT3 activation by garcinol led to the suppression of various gene products involved in proliferation,survival,and ***,when administered i.p.,garcinol inhibited the growth of human HCC xenograft tumors in

关键词： STAT3 HCC garcinol acetylation dimerization nude m

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香港实施DOT后(1986-1999)结核分支杆菌的耐药性监测

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国际结核病与肺部疾病杂志 2002年第3期 92-99页

作者： K.m.kam C.W.Yip 贺晓新 Tuberculosis Reference laboratory Yung Fung Shee Memorial Center Department of Health Hong Kong

目的:了解香港1986-1999年间不同年龄组结核病流行病学,尤其是耐药率的变化趋势。设计:在香港某结核病中心实验室连续收集了临床结核分支杆菌对链霉素(Sm)、异烟肼(INH)、利福平(RmP),以及对乙胺丁醇(EmB)的药物敏感性检测数据。测量... 详细信息

目的:了解香港1986-1999年间不同年龄组结核病流行病学,尤其是耐药率的变化趋势。设计:在香港某结核病中心实验室连续收集了临床结核分支杆菌对链霉素(Sm)、异烟肼(INH)、利福平(RmP),以及对乙胺丁醇(EmB)的药物敏感性检测数据。测量并分析了新发病例和复治病例中诸如年龄性别以及耐药率等流行病学参数的时间变化趋势。结果:在分离于新发病例的48924株非复制分支杆菌中,7045株(14.4％)对一种或一种以上药物耐受,5773株(11.8％)对Sm和/或INH耐药,881株(1.8％)为耐多药株(mDR-TB)。在分离于复治病例的3857株分支杆菌中,1176株(30.5％)对一种或一种以上的药物耐受,616株(16.0％)对Sm和/或INH耐药,467株(12.1％)为耐多药株(mDR-TB)。在新发病例的分支杆菌中,总和耐药率、Sm单耐药率、INH单耐药率、Sm+INH耐药率以及INH+RmP耐药率均表现出明显下降趋势。对于复治病例的分支杆菌中,也观察到了总和耐药率和INH+RmP耐药率的明显下降趋势。无论是在新发病例还是在复治病例,与其他年龄组相比(16-34岁和35-65岁),65岁以上病人分支杆菌的耐药率(总和耐药率和INH+RmP耐药率)明显低于其他年龄组(16-34和35-65岁组)。结论:经过14年成功实施DOTS策略,以实验室检测数据为基础的监测结果显示分支杆菌的耐药率包括mDR率?

关键词：结核病耐药流行病学香港

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DOTS-Plus实施后1995-2000年香港地区结核分枝杆菌的二线药物敏感性监测

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结核与肺部疾病杂志 2005年第1期8卷 22-27页

作者： K.m.kam C.W.Yip 张宗德 Public Health laboratory Centre Tuberculosis Reference Laboratory Kowloon Hong Kong SAR China

目的:确定有抗结核治疗史病人在实施“DOTS-Plus”项目后结核分枝杆菌对二线抗结核药物敏感性的变化趋势。方法:对结核分枝杆菌中心实验室过去8年间的全部培养阳性病例的记录进行回顾性调查。药敏试验使用绝对浓度法。对于有抗结核治疗... 详细信息

目的:确定有抗结核治疗史病人在实施“DOTS-Plus”项目后结核分枝杆菌对二线抗结核药物敏感性的变化趋势。方法:对结核分枝杆菌中心实验室过去8年间的全部培养阳性病例的记录进行回顾性调查。药敏试验使用绝对浓度法。对于有抗结核治疗史病人的分离株进一步分析其对一线和二线抗结核药物敏感性变化趋势。结果:在1921例有抗结核治疗史的培阳病人中,1425例(74.2%)对所有4种一线药物均敏感,而176例(9.2%)为耐多药(mDR-TB)。mDR-TB组中,101例(57.4%)对所有二线药物均敏感,而30例(17.0%)对3种及3种以上二线药物耐药。结论:在实施DOTS-Plus项目的情况下,由于严格控制二线抗结核药物的使用,因此复治病例中的mDR-TB比例比较低,在DOTS-Plus执行较好的人群中未见超强耐药株产生。鉴于大多数复治病例仍敏感并且存在较好的mDR实验室检测支持情况下,一线抗结核药用于复治是可行的。

关键词：结核分枝杆菌 1995-2000年二线药物敏感性监测香港地区抗结核药物 mDR-TB 药物敏感性回顾性调查中心实验室绝对浓度法敏感性变化实验室检测治疗史阳性病例药敏试验一线药物分离株耐多药复治耐药株项目

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长江水下三角洲沉积物磁性特征空间差异及其冲淤指示意义

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沉积学报 2020年第6期38卷 1215-1225页

作者：成沁梓王峰陈锦葛灿赵旋琪陈莹璐年小美张卫国陈中原 lIU kam-biu 华东师范大学河口海岸学国家重点实验室上海200241 浙江省水利河口研究院杭州310020 Department of Oceanography and Coastal Sciences Louisiana State UniversityBaton RougeLA 70803U.S.A.

三角洲冲淤具有空间异质性,而沉积物的磁性特征可灵敏地反映物源、沉积动力特征以及早期成岩作用影响,是揭示空间异质性的有效方法。选取长江水下三角洲20~35 m水深的四个约2 m长的柱样进行磁学和碳、硫地球化学分析,结合粒度及年代资料... 详细信息

三角洲冲淤具有空间异质性,而沉积物的磁性特征可灵敏地反映物源、沉积动力特征以及早期成岩作用影响,是揭示空间异质性的有效方法。选取长江水下三角洲20~35 m水深的四个约2 m长的柱样进行磁学和碳、硫地球化学分析,结合粒度及年代资料,探讨了长江水下三角洲沉积物柱样磁性特征空间差异及其冲淤指示意义。研究结果显示,粒度表征的动力分选影响沉积物的磁性特征,这在年代较新(<350 a)的柱样中表现尤为明显,即细颗粒沉积物中富集亚铁磁性矿物,从而具有较高的磁化率。铁、碳、硫及硫同位素特征揭示了长江水下三角洲沉积物较弱的硫酸盐还原特征。沉积物年龄及沉积速率影响沉积物成岩改造强度,进而导致了磁性特征垂向变化的空间差异,整体上看,远离现代沉积中心的柱样,成岩改造特征更为明显。磁化率值的大小、成岩分带的完整性及其反映的铁还原带和硫酸盐还原带转换深度,一定程度上可以揭示三角洲的淤积和侵蚀特征。

关键词：磁性特征粒度成岩作用碳硫侵蚀长江水下三角洲

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Thoracic Aortic Aneurysm Revealed by Haemoptysis on a 10-Year-Old Girl at Paediatrics Department of Yalgado Ouedraogo University Hospital

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Open Journal of Pediatrics 2017年第1期7卷 13-17页

作者： Chantal Zoungrana Ouattara Caroline Yonaba Angèle Kalmogho Flore Ouédraogo Chantal Bouda Ousseini Diallo ludovic kam Departement de Pédiatrie Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina-Faso Departement d’imagerie médicale et Radiodiagnostic Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina-Faso

Thoracic aortic aneurysm is a rather rare disorder in children and difficult to diagnose. It is generally linked to congenital heart defects or connective-tissue diseases. Our case is a 10-year-old girl admitted in the pediatric emergency care unit on January 19th, 2015 for massive haemoptysis and severe anaemia. Examination revealed severe anemia and a silent left lung. The Chest X-Ray revealed an abnormal mass on the upper left side of the mediastinum, and left lower lobe consolidation. The thoracic CT scan highlighted a 64 mm aneurysm of the subisthmic aorta with a thin 5 mm hole. It also showed pseudocoarctation of the aorta. Treatment in intensive care consisted of blood transfusion and iron supplement. She was due to travel abroad for cardio vascular surgery, but died on November 2016. Thoracic Aortic Aneurysm in our setting was discovered incidentally. In spite the fact that it is an extreme surgical emergency, in Burkina Faso, treatment can only be possible abroad upon medical evacuation.

关键词： Aorta Aneurysm Haemoptysis Coarctation Burkina Faso

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Experimental Evaluating of the Physical, mechanical and Durability Properties of Natural, Recycled and Both Combined Aggregates Based Concretes

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materials Sciences and Applications 2023年第3期14卷 117-141页

作者： Etienne malbila Arba A.T. Ouedraogo Nicolas Kagambega Gilbert G. Nana Sié kam David Y. K. Toguyeni Ecole Supérieure d’Ingénierie (ESI) Université de Fada N’Gourma (UFDG) Fada-N’Gourma Burkina Faso laboratoire d’Energies Thermiques Renouvelables (lETRE) Université Joseph KI ZERBO Ouagadougou Burkina Faso laboratoire de Géosciences et Environnement (laGE) Université Joseph KI ZERBO Ouagadougou Burkina Faso laboratoire de Physique et Chimie de l’Environnement (lPCE) Université Joseph KI ZERBO Ouagadougou Burkina Faso Ecole Polytechnique de Ouagadougou (EPO) Ouagadougou Burkina Faso

This experimental study aims at the reuse of recycled aggregates (RA), resulting from the demolition of concrete, cement block and cement mortar, in the manufacture of common construction in Burkina Faso. The RA can readily replace natural aggregates in concrete. Then five formulations of natural and recycled aggregates based concrete for characteristic strength of 25 mpa were prepared in addition to the natural aggregates base concrete named reference concrete (BN): two types of recycled aggregates concrete (BR), three types of recycles and natural combined aggregates base concrete (BC). The properties of natural and recycled aggregates were characterized and the physical, mechanical strength and durability properties were also evaluated for all concrete specimens. All the studied concrete formulation present a density between 2000 kg/m3 ≤ ρ ≥ 2600 kg/m3 and an average slump of 4.9 ± 0.1 cm. The obtained results indicate that the recycled aggregates are suitable for current concrete. Two out of the five combinations studied, such as the natural (BN) and combined aggregate (BC2) based concretes satisfy the mechanical characteristics (Rc28 > 25 mPa) at 28 days of age and an average absorption coefficient of 2.93% and 3.98%. The recycled aggregate based concrete (BR1, BR2) and combined aggregate based concrete (BC1), gave respective average compressive strength of 21.55 mPa, 20.50 mPa and 20.30 mPa, i.e. a difference of 13.80% to 18.80% under the characteristic strength (25 mPa) aimed at 28 days of age. Thus, the recycled aggregates are in conformity with the normative prescriptions and their use for standard concrete gives adequate physical, mechanical and durability properties for the production of the C20/25 concrete series in the common civil engineering applications.

关键词： Concrete Demolition Waste Aggregate Recycled Aggregate Strength Water Absorption

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Incidence of Oxa23 and Oxa51 Genes Associated with Bacterial Isolated from Patients with Urosepsis: Single Centre Prespective

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American Journal of molecular Biology 2022年第3期12卷 85-96页

作者： Salma Omer Ibrahim Elimam m. A. mohammed Sami mahjoub Taha sanaa mohammed Yousif Hajir Omer Omer Omer mirghani Seif-Elnasr Seitelbanat Yassin Yousif Abdelhameed mohammed Omer Abu Elhasan mohamed Taj-Eldin Adam Dawoud Abakar Elhadi Abdalla Ahmed Salaheldein G. Elzaki Department of medical microbiology Faculty of Medical Lab Sciences University of Gezira Wad Medani Sudan Department of Urology Faculty of Medicine University of Gezira Wad Medani Sudan National Blood Bank Ministry of Health Khartoum Sudan University Hospital Galway Galway Ireland Department of Urology Gezira Hospital for Renal Disease and Surgery Wad Medani Sudan Department of Pharmaceutics Faculty of Pharmacy University of Gezira Wad Medani Sudan Department of Clinical Chemistry National Cancer Institute University of Gezira Wad Medani Sudan Department of medical microbiology Wad Medani College for Medical Science and Technology Wad Medani Sudan Department of medical Parasitology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Epidemiology Tropical Medicine Research Institute Khartoum Sudan

Background: Urosepsis is one of the most common infections that require empirical broad spectrum antibiotics immediately after diagnosis. This has led to development of bacterial resistance by acquiring the capability to destroy the β-lactam ring. methodology: This is a cross-sectional hospital-based study. The study was conducted from 2019 to 2020 at Gezira Hospital for Renal diseases and surgery (GHRDS). A hundred patients were diagnosed clinically with urosepsis and the isolated organisms were Escherichia coli, Staphylococcus aureus, Proteus mirabilis, Klebsiella pneumonia and Pseudomonas aeruginosa. The susceptibility test was conducted by Kirby Bauer disc diffusion technique according to clinical laboratory standard institute (ClSI) guidelines. Seventy eight samples of bacterial genomic DNA were confirmed by 16srRNA and multiplex PCR, were performed for genotypic blaOXA-51 and blaOXA-23 gene characterization of isolated bacteria. Then gel electrophoresis was used to identify the presence or absence of (blaOXA-51 and blaOXA-23) genes. Results: 88.5% (69/78) in 16srRNA detected. Using multiplex PCR, the frequencies of blaOXA-51 and blaOXA-23 genes were 13% and 10.1%, respectively. The percentages of isolates which yielded both blaOXA-51 and blaOXA-23 among P. aeruginosa was 25% (1/4), among K. pneumonia was 17% (1/6), and among E. coli was 8% (3/37). Only blaOXA-51 was detected in P. mirabilis 10% (1/10) and only blaOXA-23 was detected in S. aureus 5% (1/18). Conclusion: In this study, the presence of blaOXA-51 and blaOXA-23 genes was increased in the isolated bacteria.

关键词： Urosepsis Carbapenem-Resistant Enterobacteriaceae (CRE) blaOXA-51 and blaOXA-23

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结核病实验室常规工作中收集的碱性复红质量差异

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国际结核病与肺部疾病杂志 2010年第1期5卷 10-13页

作者： C.W.Yip K.m.kam 姜广路刘宇红 Tuberculosis Reference laboratory Centre for Health ProtectionDepartment of Health

背景:从10个不同的常规开展抗酸菌涂片显微镜检查的实验室,收集了正在使用中的碱性复红样本。目的:检查碱性复红染色液组份的差异。方法:首先使用分光光度计在547nm处检测吸光度,以确定碱性复红浓度。再用高效液相色谱分离和定量4种复... 详细信息

背景:从10个不同的常规开展抗酸菌涂片显微镜检查的实验室,收集了正在使用中的碱性复红样本。目的:检查碱性复红染色液组份的差异。方法:首先使用分光光度计在547nm处检测吸光度,以确定碱性复红浓度。再用高效液相色谱分离和定量4种复红的同系物:副品红碱(pararosaniline)、蔷薇苯胺(rosaniline)、品红Ⅱ(magentaⅡ)和新品红(new fuchsin),然后通过质谱(mass spectrometry)鉴定。结果:吸光度方法测量显示10个样本中有3个(30%)碱性复红含量不足(<70%)。发现各样本的组份及其所占比例差异很大。结论:在不同实验室的样本中,蔷薇苯胺+新品红的相对丰度十分稳定。吸光度法和高效液相/质谱对监测碱性复红质量是必要、敏感的方法。

关键词：碱性复红质量 HPlC 分光光度法

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