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Hepatic involvement in children with acute bronchiolitis

World Journal of Hepatology 2022年第10期14卷 1907-1919页

作者： Hasan M Isa Asma Z Hasan sara I Khalifa sana s alhewaizem Abdulrahman D Mahroofi Fatema N Alkhan Mohammed Al-Beltagi Department of Pediatrics Salmaniya Medical ComplexManama 12Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Pediatrics Sulwan Psychiatric HospitalManama 973Bu QuwahBahrain Department of Pediatrics Dream Reem Medical CenterMuharraq 50573Bahrain Department of Pediatrics King Hamad University HospitalMuharraq 24343Bahrain Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31527AlgharbiaEgypt Department of Pediatrics University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain Department of Pediatrics University Medical CenterDr.Sulaiman Al-Habib Medical GroupBahrainManama 26671Bahrain

BACKGROUND Respiratory syncytial virus(RsV)is a prevalent cause of lower respiratory tract *** may be associated with hepatocellular involvement,as indicated by increased liver enzymes aspartate aminotransferase and alanine transaminase(ALT).AIM To evaluate the rate of increased liver enzyme levels in children with acute bronchiolitis and correlate them with clinical,laboratory,and radiological *** The study was a retrospective review of the medical records of children who presented with acute bronchiolitis when admitted to the Pediatric Department,salmaniya Medical Complex,the Kingdom of Bahrain,between 2019 and *** collected the demographic data,the clinical presentation,the laboratory and radiological findings,and the clinical *** compared the patients with elevated liver enzymes to those with normal levels at the time of presentation and at *** We included 166(57.8%)of 287 patients with acute bronchiolitis who fulfilled the inclusion ***-three(56%)patients were *** median age at presentation was 3.4(interquartile range 1.1 to 12.4)***-four(28%)patients tested positive for RsV,which was confirmed in 15 of them(28%)by *** findings of 161 patients tested at presentation showed high ALT levels in 14(8.7%)patients and normal ALT in 147(91.3%).Coagulation profiles were measured in 46(27.7%)of 166 *** prothrombin time was present in 15(32.6%),a high international normalized ratio was present in 13(28.3%),and high activated partial thromboplastin time was present in three(6.5%).Thrombin time was elevated in nine(27.3%)of 33 ***(21.7%)of 23 patients with available radiological data had hepatomegaly;one of them had findings suggestive of fatty *** ALT had a significant association with lengthy hospital stays(Psitive urine culture(Pseventy(42.2%)patients had documented follow-up with liver function tests over a median follow-up period of

关键词： involvement elevated bronchiolitis

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