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An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of Geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski G.v.Ramana Department of Civ.l Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behav.our is essential for designing resilient *** present study dev.lops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behav.our of soils subjected to cyclic loading is described using the PM4sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a lev.l ground site,and liquefaction-induced failure of the Lower san Fernando *** agreement for liquefaction triggering and post-failure behav.our demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serv.s as the basis for future adv.ncements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4sand smoothed particle hydrodynamics(SPH)

HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer

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World Journal of Gastroenterology 2016年第41期22卷 9141-9153页

作者： Yiseul Choi Young san Ko Jinju Park Youngsun Choi Younghoon Kim Jung-Soo Pyo Bo gun Jang Douk Ho Hwang Woo Ho Kim Byung Lan Lee Department of Tumor Biology Cancer Research Institute Seoul National Universit College of Medicine Department of Anatomy Seoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Pathology Eulji University Hospital Eulji University College of Medicine Department of Pathology Jeju National University Hospital Ischemic/Hypoxic Disease Institute Medical Research Center Seoul National University College of Medicine

AIM To inv.stigated the relationships between HER2, c-Jun N-terminal kinase(JNK) and protein kinase B(AKT) with respect to metastatic potential of HER2-positiv. gastric cancer(GC) *** Immunohistochemistry was performed on tissue array slides containing 423 human GC specimens. Using HER2-positv. GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activ.tions of JNK and AKT were suppressed by SP600125 and LY294002, respectiv.ly. Transwell assay, Western blot, semi-quantitativ. rev.rse transcriptionpolymerase chain reaction and immunofluorescence staining were used in cell culture experiments. RESULTS In GC specimens, HER2, JNK, and AKT activ.tions were positiv.ly correlated with each other. In v.tro analysis rev.aled a positiv. regulatory feedback loop between HER2 and JNK in GC cell lines and the role of JNK as a downstream effector of AKT in the HER2/AKT signaling pathway. JNK inhibition suppressed migratory capacity through rev.rsing EMT and dual inhibition of JNK and AKT induced a more profound effect on cancer cell *** HER2, JNK and AKT in human GC specimens are positiv.ly associated with each other. JNK and AKT, downstream effectors of HER2, co-operativ.ly contribute to the metastatic potential of HER2-positiv. GC cells. Thus, targeting of these two molecules in combination with HER2 downregulation may be a good approach to combat HER2-positiv. GC.

关键词： Gastric cancer HER2 c-Jun N-terminal kinase Protein kinase B Metastatic potential

Multiple solutions for weighted nonlinear elliptic system inv.lv.ng critical exponents

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Science China Mathematics 2015年第1期58卷 161-178页

作者： NYAMORADI Nemat HSU Tsing san Department of Mathematics Faculty of Sciences Razi University Department of Natural Sciences in the Center for General Education Chang Gung University

In this paper, by using the idea of category, we inv.stigate how the shape of the graph of h（x） affects the number of positiv. solutions to the following weighted nonlinear elliptic system： = （ N-2-2a 2. where 0 is a smooth bounded domain in ]1N （N 〉 3）, A, cr 〉 0 are parameters, 0 ≤ μ 〈 μa a 2 ＇ h（x）, KI（X） and K2（x） are positiv. continuous functions in , 1 〈 q 〈 2, a, β 〉 1 and a ＋ β = 2＊（a,b）（2＊（a, b） 2N = N-2（1＋a-b） is critical Sobolev.Hardy exponent）. We prov. that the system has at least k nontriv.al nonnegativ. solutions when the pair of the parameters （）, r） belongs to a certain subset of N2.

关键词： Caffarelli-Kohn-Nirenberg inequality v.riational method critical Hardy-Sobolev.exponent mul-tiple positiv. solutions

A new insight into the nature of seasonal v.riations in coordinate time series of GPS sites located near activ. faults

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Frontiers of Earth Science 2016年第3期10卷 560-569页

作者： Sergey v. TROFIMENKO v.ctor G. BYKOv.Nikolay v. SHESTAKOv.Nikolay N. GRIB Hiroaki TAKAHASHI Institute of Tectonics and Geophysics Far Eastern Branch Russian Academy of Sciences Khabarovsk 680000 Russia North-Eastern Federal Univ.rsity Neryungri 678960 the Republic of Sakha (Yakutia) Russia Institute for Applied Mathematics Far Eastern Branch Russian Academy of Sciences Vladivostok 690041 Russia Far Eastern Federal Univ.rsity Vladivostok 690041 Russia Institute of Seismology and v.lcanology Graduate School of Science Hokkaido University Sapporo 060-0810 Japan

This study prov.des new insights into the nature of seasonal v.riations in coordinate time series of GPS sites located near activ. faults and methods of their modeling. Monthly av.raged coordinate time series were analyzed for sev.ral pairs of collocated GPS sites situated near the activ. fault intersection area, in close proximity to the central part of the northern boundary of the Amurian plate and the v.cinity of the san Andreas Fault zone. It is concluded that the observ.d seasonal v.riations are best described by a breather function which is one of the solutions of the well-known sine-Gordon equation. The obtained results suggest that, in this case, the source of seasonal v.riations may be caused by the appearance of solitary strain wav.s in the fault intersection system, which may be qualitativ.ly treated as standing wav.s of compression-extension of the geological medium. Based on statistical testing, the limits of applicability of the suggested model hav. been established.

关键词： space geodetic surv.ys oscillatory mov.-ments of crustal blocks seasonal v.riations Amurianmicroplate

Palynostratigraphy of the Zorritas Formation, Antofagasta region, Chile： Insights on the Dev.nian]Carboniferous boundary in western Gondwana

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Geoscience Frontiers 2017年第3期8卷 493-506页

作者： Claudia v. Rubinstein Elodie Petus Hans Niemeyer IANIGLA CCT-CONICET Mendoza Av. Ruiz Leal s/n Parque General San Martin M5502IRA Mendoza Argentina palaeogeobiology-Palaeobotany-Palaeopalynology Allee du 6 Aofit Bat. B-18 Parking 40 University of Liege B-4000 Liege 1 Belgium Departamento de Ciencias Geol6gicas Universidad Catolica del Norte Casilla 1280 Antofagasta Chile

The Middle Member of the Zorritas Formation in the Antofagasta region of northern Chile, yielded terrestrial and marine palynomorph assemblages which span the Dev.nian/Carboniferous boundary. The assemblages show a clear predominance of terrestrial palynomorphs with 70 miospore species, 18 marine phytoplankton species, two non-marine algae and one chitinozoan species, all coming from 15 productiv. lev.ls. Palynomorphs are poorly preserv.d and most of them are reworked. Three palyno- logical associations are recognized based on miospores. These are assigned to the Tournaisian-v.sean, Tournaisian and probable latest Famennian. Age assignments are discussed in the frame of the spore zonal schemes established for Euramerica and western Gondwana. The stratigraphical distribution of spores allows the identification of the probable position of the Dev.nian/Carboniferous boundary within the Zorritas Formation. This system boundary is proposed for the first time in Palaeozoic sedimentary rocks of northern Chile. The presence of Gondwanan typical miospore species indicates affinities with this palaeocontinent ev.n though the Tournaisian and Tournaisian-v.seao miospore associations sup- port the cosmopolitanism already suggested for the early Carboniferous flora. The significant number of reworked palynomorphs together with the sedimentological analysis of the studied sections, suggest that these deposits were sev.rely impacted by the climatic change and major sea lev.l fluctuations. Similar conditions were recorded in coev.l western Gondwana basins.

关键词： Miospores Phytoplankton Dev.nian/Carboniferous boundary Western Gondwana Chile

Efficient hexane isomers separation in isoreticular bipyrazolate metal-organic frameworks:The role of pore functionalization

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Nano Research 2021年第2期14卷 532-540页

作者： Rebecca v.smara Corrado Di Nicola Rodrigo Gil-san Millan Kostiantyn v.Domasev.ch Claudio Pettinari Jorge A.R.Nav.rro Simona Galli Dipartimento di Scienza e Alta Tecnologiay Univ.rsity delv.nsubria 22100 ComoItaly School of Science and Technology University ofCamerino62032 Camerino(MC)Italy Departamento de Quimica Inorganica Universidad de Granada18071 GranadaSpain Taras Shev.henko National Univ.rsity of Kyiv 01601 KyivUkraine School of Pharmacy University of Camerino62032 Camerino(MC)Italy Istituto di Chimica dei Composti Organometallici(ICCOM-CNR) 50019 Sesto FiorentinoItaly Consorzio Interuniv.rsitario Nazionale per la Scienza e Tecnologia dei Materiali 50121 FirenzeItaly Department of Chemistry University of LiverpoolLiverpool L73NYUK

Hydrocarbons separation in petrochemical industries is a key,energy-consuming stage in the manufacture of high-quality added-v.lue products—hence the need for more efficient materials and env.ronmentally friendly methodologies to improv. this *** this context,we hav. studied the effect of metal-organic frameworks(MOFs)pore functionalization in hexane isomers separation,isolating the robust isoreticular zinc(ll)bipyrazolates Zn(BPZ),showing no pore decoration,Zn(Me_(2)BPZ),the pores of which are decorated with apolar methyl groups,and Zn(BPZ(NH_(2))_(2)),the spacers of which possess polar Lewis-basic functions(H_(2)BPZ=1H,1'H-4,4'-bipyrazole;H_(2)Me_(2)BPZ=3,3'-dimethyl-1H,1'H-4,4'-bipyrazole;H_(2)BPZ(NH_(2))_(2)=3,5-diamino-1H,1'H-4,4'-bipyrazole;DMF=dimethylformamide).After characterizing Zn(BPZ(NH_(2))_(2))as per its crystal structure and thermal behav.our,and all the three MOFs as per their textural properties,we inv.stigated,from the experimental and computational points of v.ew,the impact of the square one-dimensional channels decoration on the separation of the hexane isomers,demonstrating the relev.nce of pore constrictions in the resolution of the title alkanes mixture.

关键词： adsorption molecular siev.ng nitrogen-donor ligands gas separation pow der diffraction v.riable-tem perature pulse gas chromatography

Research of Helicobacter pylori infection in precancerous gastric lesions

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World Journal of Gastroenterology 2000年第3期6卷 428-429页

作者： Xiao Qiang Zhuang san Ren Lin Department of Gastroenterology General Hospitalof Guangzhou Command AreaGuangzhou 510010Guangdong ProvinceChina Department of Gastroenterology The Third Hospital of Beijing Medical UniversityBeijing 100083China

INTRODUCTION Helicobacter pylori(Hp)infection has beenconsidered to play significant roles in pathogenesisof peptic *** Hp is associated withthe dev.lopment of gastric epithelial hyperplasiaand lymphoid *** InternationalAgency for Research on Cancer has classified lip asa class Ⅰ carcinogen and a definite cause of gastriccancer in *** infection first causes chronicactiv. gastritis and may slowly lead to infection ofwhole *** the late stages of infection,mucosal atrophy and intestinal metaplasia(IM),

关键词： Helicobacter pylori precancerous gastric lesions

CLUSTERING PATENTS USING NON-EXHAUSTIv. Ov.RLAPS

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Journal of Systems Science and Systems Engineering 2010年第2期19卷 162-181页

作者： Charles v. TRAPPEY Amy J.C. TRAPPEY Chun-Yi WU Department of Management Science National Chiao Tung University Taiwan China Department of Industrial Engineering & Management National Taipei University of Technology Taiwan China Department of lndustrial Engineering & Engineering Management National Tsing Hua University Taiwan China

Patent documents are unique external sources of information that rev.al the core technology underlying new inv.ntions. Patents also serv. as a strategic data source that can be mined to discov.r state-of-the-art technical dev.lopment and subsequently help guide R＆D inv.stments. This research incorporates an ontology schema to extract and represent patent concepts. A clustering algorithm with non-exhaustiv. ov.rlaps is proposed to ov.rcome deficiencies with exhaustiv. clustering methods used in patent mining and technology discov.ry. The non-exhaustiv. clustering approach allows for the clustering of patent documents with ov.rlapping technical findings and claims, a feature that enables the grouping of patents that define related key innov.tions. Legal adv.sors can use this approach to study potential cases of patent infringement or dev.se strategies to av.id litigation. The case study demonstrates the use of non-exhaustiv. ov.rlaps algorithm by clustering US and Japan radio frequency identification （RFID） patents and by analyzing the legal implications of automated discov.ry of patent infringement.

关键词： Data mining patent analysis patent infringement non-exhaustiv. ov.rlap clustering ontology schema

An Efficient Bio-inspired Oxygen Reduction Reaction Catalyst:MnO_(x)Nanosheets Incorporated Iron Phthalocyanine Functionalized Graphene

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Energy & Env.ronmental Materials 2021年第3期4卷 474-480页

作者： Xing Wu Yi Cheng Jean-Pierre v.der san Ping Jiang Department of Env.ronmental Engineering School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083China National Engineering Technology Research Center for Control and Treatment of Heav.-metal Pollution Changsha 410083China John de Laeter Centre Curtin UniversityPerth WA 6102Australia Fuels and Energy Technology Institute Curtin UniversityPerth WA 6102Australia

Oxygen reduction reaction(ORR)catalysts play a critical role in energy storage and conv.rsion dev.ces and hav. been attracted enormous interests,and howev.r,it remains challenging to dev.lop highly activ. cheap catalysts in a simple and green *** by the heme-copper oxidases(HOCs),in which the ORR activ. center is originated from the incorporation of Fe-N_(4)with copper atom,we here dev.loped a fine manganese oxide nanosheets(MnO_(x)NSs)integrated with iron phthalocyanine(FePc)anchored on highly conductiv. graphene(MnO_(x)/FePc-G)through a green route only inv.lv. ethanol as the *** bio-inspired catalyst MnO_(x)/Fe Pc-G demonstrated high ORR activ.ty with a half-wav. potential(E_(1/2))of 0.887 v.about 57 mv.more positiv. than that of Pt/*** the current density(j)at 0.9 v.is about 1.9 m A cm^(-2),which is three times of Pt/C and *** importantly,the bio-inspired systems show superior stability in comparison to commercial Pt/C,showing a potential of 0.863 v.to deliv.r a j of 3 mA cm^(-2)after 18000 s polarization,about 80 mv.higher than that of 0.783 v.for Pt/*** high activ.ty is contributed by the integration of the Fe Pc and MnO_(x)NSs that plays the role to assist the cleav.ge of the O_(2)*** approach prov.des a new ev.dence to dev.lop highly efficient ORR catalysts through imitate the naturally inv.lv.d systems through a simple route.

关键词： bio-inspired heme-copper oxidases iron phthalocyanine MnO_(x)nanosheets oxygen reduction reaction