检索结果-南通市图书馆

Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第9期27卷 1103-1110页

作者： Yu ZHOU san-hua FANG Yi-lu YE Li-sheng CHU Wei-ping ZHANG Meng-ling WANG Er-qing WEI~2 Department of Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310031,China Department of Pharmacology School of Medicine Zhejiang University Hangzhou China

Aim:To investigate the effects of caffeic acid on early and delayed injuries afterfocal cerebral ischemia in rats,and the possible relation to ***:Transient focal cerebral ischernia was induced by middlecerebral artery occlusion in Sprague-Dawley *** acid(10 and 50 mg/kg)was ip injected for 5 d after *** brain injuries were observed,and thelevels of cysteinyl leukotrienes and leukotriene B4in the brain tissue ***:Caffeic acid(50 mg/kg)ameliorated neurological dysfunctionand neuron loss,and decreased infarct volume 24 h after ischemia;it attenuatedbrain atrophy,infarct volume,and particularly astrocyte proliferation 14 d *** addition,it reduced the production of leukotrienes(5-lipoxygenasemetabolites)in the ischemic hemispheres 3 h and 7 d after ***:Caffeic acid has protective effect on both early and delayed injuries after focalcerebral ischemia in rats;and this effect may partly relate to 5-lipoxygenaseinhibition.

关键词： caffeic acid focal cerebral ischemia neuron astrocyte 5-lipoxygenase leukotriene

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

溃疡性结肠炎生物制剂的研究现状和热点分析

河南医学研究 2024年第3期33卷 392-400页

作者：杨二强乔高星卢晓静楚尧娟杜书章郑州大学第一附属医院药学部河南郑州450002

目的分析溃疡性结肠炎(UC)生物制剂的研究现状、热点和发展趋势,为我国UC生物制剂的相关研究提供参考。方法检索Web of Science核心合集数据库中发表于2013年1月1日至2022年12月31日关于UC生物制剂研究的相关文献,利用文献计量在线分... 详细信息

目的分析溃疡性结肠炎(UC)生物制剂的研究现状、热点和发展趋势,为我国UC生物制剂的相关研究提供参考。方法检索Web of Science核心合集数据库中发表于2013年1月1日至2022年12月31日关于UC生物制剂研究的相关文献,利用文献计量在线分析平台(https://***/)和CiteSpace软件统计分析相关研究的发文量、国家/地区、机构、作者、期刊等文献关键特征。结果共纳入文献3 928篇,年发文量整体呈逐年增加的趋势;开展该领域研究的国家/地区有109个,美国占领先优势(1 209篇,占总发文量的31.03%),且与其他国家合作密切;参与该领域研究的机构共456个,加州大学圣地亚哥分校的发文量(121篇)和中心度(0.09)均排名首位;发文量最大的作者是法国洛林大学的Peyrin-Biroulet L(101篇),共被引频次排名首位的作者是加州大学圣地亚哥分校的sandborn W J(1 055次);共计1 012个期刊发表了相关文献,发文量和共被引频次最高的期刊均为Inflammatory Bowel Diseases(267篇,1 376次);共被引频次最高的文献是Ungaro等在2017年发表的综述“Ulcerative colitis”,共被引文献中心度排名首位的是sandborn等在2017年发表的“Tofacitinib as induction and maintenance therapy for ulcerative colitis”;该领域的研究热点主要集中在生物制剂有效性、治疗药物监测、特殊群体用药、药物经济学评价等方面。结论我国UC生物制剂的研究与国外相比还存在一定差距,应加强国际合作交流,及时跟进该领域的研究热点和未来发展趋势。

关键词：溃疡性结肠炎生物制剂研究热点可视化分析

Identification of the hydrogen utilization pathway for the electrocatalytic hydrogenation of phenol

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2021年第9期64卷 1586-1595页

作者： Ling Zhou Xiaorong Zhu Hui Su Hongzhen Lin Yanhong Lyu Xu Zhao Chen Chen Nana Zhang Chao Xie Yingying Li Yuxuan lu Jianyun Zheng Benrt Johannessen san Ping Jiang Qinghua Liu Yafei Li Yuqin Zou Shuangyin Wang State Key Laboratory of Chem/Bio-Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and DevicesCollege of Chemistry and Chemical Engineeringthe National Supercomputer Centers in ChangshaHunan UniversityChangsha410082China College of Chemistry and Materials Science Nanjing Normal UniversityNanjing210023China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230026China i-LAB Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou215123China Department of Educational Science Hunan First Normal UniversityChangsha410205China Australian Synchrotron ClaytonVictoria3168Australia Western Australian School of Mines:Minerals Energy and Chemical Engineering and Fuels and Energy Technology InstituteCurtin UniversityPerthWA6102Australia

Electrochemical hydrogenation(ECH)of biomass-derived platform molecules is a burgeoning route for the sustainable utilization of ***,the noble-metal-catalyzed ECH of phenolic compounds suffers from intense competition with hydrogen evolution *** prepared Pt Rh bimetallic nanoparticles dispersed on highly ordered mesoporous carbon nanospheres,which improves the utilization efficiency of adsorbed hydrogen(H_(ad))to ECH in H-UPD region(>0 V ***).Further analysis reveals(i)the strong overlapping between the d-orbitals of Pt and Rh enhances specific adsorption of phenol;(ii)incorporation of Rh devotes an electronic effect on weakening the alloy-H_(ad)interaction to increase the FE of *** calculations confirm the selectivity difference and the ECH parallel pathways:cyclohexanol and cyclohexanone are formed via hydrogenation/dehydrogenation of the intermediate ^(*)C_(6)H_(10) *** findings deepen our fundamental understanding of the ECH process,and cast new light on exploration of highly efficient electrocatalysts for biomass upgrading.

关键词： electrohydrogenation aromatic hydrogenation biomass conversion Pt Rh alloy

虎七散含药血清对食管癌细胞Ec9706糖酵解的影响及AMPK/FOXO3a通路的调节作用研究

在线全文

学校读者我要写书评

暂无评论

世界科学技术-中医药现代化 2024年第2期26卷 328-335页

作者：李洪霖高付彦李娜娜张颖卢娟娟马祯慧马纯政河南省中医院河南中医药大学第二附属医院郑州450053 河南中医药大学郑州450099 河南中医药大学第一附属医院郑州450046

目的研究虎七散含药血清对食管癌细胞Ec9706糖酵解的影响及对磷酸腺苷激活的蛋白激酶(AMPK)/叉头框蛋白O3a(FOXO3a)通路的调节作用。方法收集Ec9706细胞,接种于细胞培养皿中,分别设置空白对照组、虎七散低、中、高剂量组及顺铂组,虎七... 详细信息

目的研究虎七散含药血清对食管癌细胞Ec9706糖酵解的影响及对磷酸腺苷激活的蛋白激酶(AMPK)/叉头框蛋白O3a(FOXO3a)通路的调节作用。方法收集Ec9706细胞,接种于细胞培养皿中,分别设置空白对照组、虎七散低、中、高剂量组及顺铂组,虎七散各剂量组分别加入虎七散含药血清,顺铂组加入2μg·mL^(-1)的顺铂,空白对照组加入新鲜DMEM培养液,四噻唑蓝(MTT)法测定Ec9706细胞增殖率,酶联免疫吸附法(ELISA)测定Ec9706细胞葡萄糖摄取量、乳酸生成量、己糖激酶(HK)及乳酸脱氢酶(LDH)活性,划痕实验测定Ec9706细胞24h迁移率,Transwell实验测定Ec9706细胞侵袭率,流式细胞术测定Ec9706细胞凋亡率,实时定量聚合酶链式反应(RT-qPCR)测定Ec9706细胞FOXO3a、B细胞淋巴瘤-2相关X蛋白(Bax)、B淋巴细胞瘤2(Bcl-2)及乳酸脱氢酶A(LDHA)mRNA水平,免疫印迹法(Western blot)测定Ec9706细胞p-AMPK、FOXO3a、Bax、Bcl-2及LDHA蛋白水平。结果与空白对照组比较,虎七散各剂量组及顺铂组Ec9706细胞24 h、48 h及72 h增殖率、葡萄糖摄取量、乳酸生成量、HK活性及LDH活性,Ec9706细胞24 h迁移率、侵袭率、Bcl-2及LDHA mRNA及蛋白水平、p-AMPK/AMPK水平显著降低(P<0.05),Ec9706细胞凋亡率、FOXO3a、Bax mRNA及蛋白水平显著升高(P<0.05),且随着虎七散剂量的增加,Ec9706细胞各项指标变化更优。结论虎七散能够显著抑制食管癌Ec9706细胞糖酵解过程,进而抑制Ec9706细胞增殖、迁移及侵袭过程,促进Ec9706细胞凋亡,其机制可能与调节AMPK/FOXO3a通路有关。

关键词：虎七散食管癌 AMPK/FOXO3a通路糖酵解

同方期刊数据库

补饲泰山磐石散加减方对英纯血马驹血常规和血清生化指标的影响

在线全文

学校读者我要写书评

暂无评论

饲料研究 2024年第12期47卷 56-61页

作者：缪荣浩买占海付涵卢冲温丽翠马玉辉况玲郭庆勇新疆农业大学动物医学学院新疆乌鲁木齐830052 昭苏县畜牧兽医站新疆伊犁835600

试验旨在研究中草药泰山磐石散加减方剂(TSPSS)对英纯血马驹血常规和血清生化指标的影响。选用500~580 kg的自繁英纯血母马12匹,随机分为3组,每组4个重复,每个重复1匹马。对照组(NC组)不进行任何补喂,隔月喂药组(GY组)以60 d为一个阶段... 详细信息

试验旨在研究中草药泰山磐石散加减方剂(TSPSS)对英纯血马驹血常规和血清生化指标的影响。选用500~580 kg的自繁英纯血母马12匹,随机分为3组,每组4个重复,每个重复1匹马。对照组(NC组)不进行任何补喂,隔月喂药组(GY组)以60 d为一个阶段进行补喂,每月喂药组(MY组)以30 d为一个阶段进行补喂,妊娠期300 d。采集马驹出生后0、30、60和90 d颈静脉血液,测定血常规、血清生化指标。结果显示,与NC组相比,GY组90 d马驹血液的白细胞数量(WBC)、淋巴细胞数量(LYM)极显著下降(P<0.01);MY组0、90 d马驹血液LYM显著或极显著下降(P<0.05或P<0.01),60 d马驹血液WBC数量显著升高(P<0.05),30 d马驹血液血小板分布宽度(PDW)极显著升高(P<0.01),90 d马驹血液的WBC显著降低(P<0.05)。与MY组相比,GY组0 d马驹血液血小板平均容积(MPV)显著升高(P<0.05),30 d马驹血液PDW显著降低(P<0.05),60 d马驹血液平均红细胞血红蛋白量(MCH)显著升高(P<0.05),PDW显著降低(P<0.05)。与NC组相比,GY组30 d马驹血清谷丙转氨酶(ALT)、碱性磷酸酶(ALP)活性极显著或者显著升高(P<0.01或P<0.05),MY组0 d马驹血清ALT活性显著升高(P<0.05),ALP、总蛋白(TP)含量显著降低(P<0.05),30 d马驹血清ALT、ALP活性极显著升高(P<0.01),60 d血清ALT活性显著升高,ALP、TP、白蛋白(ALB)含量显著降低(P<0.05)。GY组60 d马驹血清Ca2+含量、谷草转氨酶(AST)活性显著高于MY组(P<0.05),ALP、TP、ALB含量极显著高于MY组(P<0.01)。研究表明,妊娠母马补饲泰山磐石散加减方剂不同频次对产马驹免疫和肝脏造成的影响不同,隔月补饲能够提高马驹免疫活性,促进骨骼和肝功能发育,有利于为马驹补充营养,而每月补饲会对马驹肝功能造成一定负面影响。

关键词：泰山磐石散马驹血常规血清生化指标

同方期刊数据库博看期刊

外翻肠囊法研究五味清浊散的肠吸收成分及其吸收特征

在线全文

学校读者我要写书评

暂无评论

中国中药杂志 2024年第2期49卷 509-517页

作者：廖翠平董世奇刘云璐额尼日勒高雅樊慧蓉蔡秋杰代金刚图雅中国中医科学院医学实验中心北京100700 中国医学科学院放射医学研究所天津300192 内蒙古民族大学蒙医药学院内蒙古通辽028000 中国中医科学院临床基础研究所北京100700 中国中医科学院中医药研究发展中心北京100700

研究五味清浊散在不同肠段的吸收情况,以及其生物碱类成分胡椒碱、胡椒新碱、荜茇宁和二氢荜茇宁的吸收特征。通过构建大鼠肠外翻模型,应用UPLC-Q-TOF-MS技术测定五味清浊散在不同肠段透过的化学成分,以及采用UPLC-Q-TRAP-MS技术测定肠... 详细信息

研究五味清浊散在不同肠段的吸收情况,以及其生物碱类成分胡椒碱、胡椒新碱、荜茇宁和二氢荜茇宁的吸收特征。通过构建大鼠肠外翻模型,应用UPLC-Q-TOF-MS技术测定五味清浊散在不同肠段透过的化学成分,以及采用UPLC-Q-TRAP-MS技术测定肠吸收液中胡椒碱、胡椒新碱、荜茇宁和二氢荜茇宁的含量,计算其吸收参数,并分析其在大鼠不同肠段、不同时间的吸收特征。实验结果显示,在建立的UPLC-Q-TOF-MS条件下,在空肠、回肠、十二指肠和结肠段的肠囊液中分别检测到27、27、8、6个吸收成分;且发现五味清浊散中胡椒碱、胡椒新碱、荜茇宁和二氢荜茇宁在各肠段均为线性吸收,r均达到0.9以上,各肠段的吸收量胡椒碱>胡椒新碱>二氢荜茇宁>荜茇宁,但各成分在各个肠段的吸收速率及其机制不尽相同,提示在不同肠段五味清浊散提取液各成分的吸收具有选择性,并不是简单的半透膜渗透过程。

关键词：五味清浊散胡椒碱胡椒新碱荜茇宁二氢荜茇宁肠外翻模型

Effects of Incretin-based Therapies on Weight-related Indicators among Patients with Type 2 Diabetes: A Network Meta-analysis

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2020年第1期33卷 37-47页

作者： XU lu YU Shu Qing GAO Le HUANG Yi WU Shan Shan YANG Jun SUN Yi Xin YANG Zhi Rong CHAI san Bao ZHANG Yuan JI Li Nong SUN Feng ZHAN Si Yan Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Mathematics and Statistics University of Maryland Baltimore CountyBaltimore MD 21250MarylandUSA National Clinical Research Center of Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China The Primary Care Unit School of Clinical MedicineUniversity of CambridgeCambridge CB21TNUK Department of Endocrinology and Metabolism Peking University International HospitalBeijing 102206China Department of Clinical Epidemiology and Biostatistics McMaster UniversityHamilton L8S 4L8OntarioCanada Department of Endocrinology and Metabolism Peking University People’s HospitalBeijing 100044China

Objective To evaluate the effects of incretin-based therapies on body weight as the primary outcome,as well as on body mass index(BMI)and waist circumference(WC)as secondary *** Databases including Medline,Embase,the Cochrane Library,and ***(***)were searched for randomized controlled trials(RCTs).Standard pairwise meta-analysis and network meta-analysis(NMA)were both carried *** risk of bias(ROB)tool recommended by the Cochrane handbook was used to assess the quality of *** analysis,sensitivity analysis,meta-regression,and quality evaluation based on the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)were also *** A total of 292 trials were included in this *** with placebo,dipeptidyl-peptidase IV inhibitors(DPP-4 Is)increased weight slightly by 0.31 kg[95%confidence interval(CI):0.05,0.58]and had negligible effects on BMI and *** with placebo,glucagon-like peptide-1 receptor agonists(GLP-1 RAs)lowered weight,BMI,and WC by-1.34 kg(95%CI:-1.60,-1.09),-1.10 kg/m2(95%CI:-1.42,-0.78),and-1.28 cm(95%CI:-1.69,-0.86),*** GLP-1 RAs were more effective than DPP-4 Is in lowering the three ***,the effects of GLP-1 RAs on weight,BMI,and WC were favorable.

关键词： Body mass index Body weight Diabetes mellitus Dipeptidyl-peptidase IV inhibitors Glucagon-like peptide-1 receptor agonists Network meta-analysis Waist circumference

Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2013年第11期26卷 930-933页

作者： YAO san Qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang lu Yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun Department of Occupational and Environmental Health School of Public Health Hebei Union University Division of Pneumoconiosis School of Public Health China Medical University Department of Pneumoconiosis Beidaihe Sanitarium for China Coal Miners Department of Community Medicine Tangshan Workers’ Hospital

The role of Fas/Fas ligand （FasL） in mediating alveolar macrophage （AM）-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied. It showed that the serum levels of IL-1β, TNF-a, IL-8, MIP-la, MCP-1, and TGF-β1 were higher in silicosis patients than in controls, and increased with the progression of silicosis except TGF-β1 and IL-8. TGF-β1, IL-8, MCP-1,

关键词： FasL AM

Calcium hydride reduced high-quality Nd-Fe-B powder from Nd-Fe-B sintered magnet sludge

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2022年第12期40卷 1905-1912,I0004页

作者： Haibo Xu Qingmei lu Liying Cong Haowen Tian Weiqiang Liu Youhao Liu Yunqiao Wang Jingwu chen Xiaofei Yi Ming Yue Key Lab of Advanced Functional Materials Ministry of EducationFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China State Key Laboratory of Rare Earth Permanent Magnetic Materials Hefei 231500China Earth–Panda Advanced Magnetic Materials Co. Ltd.Hefei 231500China Beijing Zhong Ke san Huan Research Beijing 102200China

The structural and magnetic properties were studied for recycling Nd-Fe-B powders from Nd-Fe-B sintered magnets sludge via reduction diffusion(RD)with calcium hydride(CaH_(2))*** comparison,traditional reducing agent calcium granules were applied to prepare recycled Nd-Fe-B *** particle size and better size distribution as well as lower impurity content are achieved by using CaH_(2)instead of *** detail,the average particle size of the recycled Nd-Fe-B powder is reduced from 4.66 to 3.43μm,and the bimodal distribution ***,the residual calcium content and oxygen content are reduced to about 0.080 wt%and 0.32 wt%.As a consequence,the roomtemperature magnetization of the CaH_(2)-recycled Nd-Fe-B powder is increased to 146.30 emu/g,6.8%and 33%,respectively,higher than that of Ca-reduced powder and the initial *** analysis indicates that CaH_(2)is able to reduce the sludge at lower tempe rature to fabricate well-dispersed,unifo rm recycled powder with high magnetization arising from a combination factors of its low melting point,low thermodynamic behavior,and the release of hydrogen during the reaction.

关键词： Recycled Nd-Fe-B powders Magnetic properties Microstructure Reducing agent Reduction diffusion Rare earths