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Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population:a new approach

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 1977-1985页

作者： Hai huang Xiao-Yu Wang Hong Wei Min Kang Jie Zou Qian Ling san-hua xu Hui huang xu Chen Yi-Xin Wang Yi Shao Yao Yu Nanchang Aier Eye Hospital Nanchang 330006Jiangxi ProvinceChina Department of Endocrinology and Metabolism the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Center for Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for Metabolic DiseaseNanchang 330006Jiangxi ProvinceChina The First Clinical Medical College Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200433China Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityJiangxi Branch of National Clinical Research Center for Ocular DiseaseNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology and Visual Sciences Maastricht UniversityMaastricht 6200MALimburg ProvinceNetherlands School of Optometry and Vision Sciences Cardiff UniversityCardiff CF244HQUnited Kingdom

AIM:To study retinal microvascular and microstructural alterations in meibomian gland dysfunction(MGD)in severely obese population using optical coherence tomography angiography(OCTA).METHODS:Twelve MGD patients with severely obese population(PAT group;24 eyes)and 12 healthy controls(HC group;24 eyes)were *** images were segmented into five[superior(S),nasal(N),inferior(I),temporal(T),and central foveal(C)]or nine[inner superior(IS),outer superior(OS),inner nasal(IN),outer nasal(ON),inner inferior(II),outer inferior(OI),inner temporal(IT),outer temporal(OT),and C]*** superficial vessel density(SVD),retinal thickness(RT),foveal avascular zone(FAZ)parameters,and retinal volume were ***:Visual acuity was significantly different between two groups(0.8±0.17 in PAT group vs 0.2±0.06 in HC group).SVD was significantly lower in PATs in N,T,OS,IN,OT,and *** area under the receiver operating characteristic curve(AUC)for T was 0.961[95% confidence interval(CI):0.908 to 1.000],for OS was 0.962(95%CI:0.915 to 1.000).RT was significantly lower in PATs in IS,OS,OI,OT,ON,IT,IN,and *** for OT was 0.935(95%CI:0.870 to 0.999),for IS was 0.915(95%CI:0.838 to 0.992).Angiography results showed significantly lower area and perimeter of FAZ,SVD of the inner retina and both retinal volume and the average volume thickness in the PAT ***:Vision may be affected in patients with MGD due to changes in retinal microvessels and *** changes detected by OCTA may be a potential marker for diagnosing MGD in severe obesity.

关键词： superficial vessel density retinal thickness severely obesity meibomian gland dysfunction optical coherence tomography angiography

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Aldehyde oxidase mediated enantioselective metabolic health risk of dinotefuran

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Science China Chemistry 2024年第6期67卷 2079-2091页

作者： Liwei xu Xinxin xu hua Kuang Chuanlai xu Xiaoling Wu State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan UniversityWuxi214122China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxi214122China

Chiral pollutants often pose significant differential environmental health *** this study,the biotransformation of chiral dinotefuran(DIN)and its enantioselective metabolic toxicity mechanisms have been systemically ***,reversedphase chromatography-high resolution mass spectrometry was developed to quantify the content of DIN R/S chiral enantiomer with pg level sensitivity,revealing a lower elimination rate constant(K_(e))of S-DIN(0.730 h^(-1))than R-DIN(0.746 h^(-1)).Secondly,the interaction mechanism between DIN metabolism and important endogenous bioactive molecules,such as aldehyde oxidase(AOX)and neurotransmitters,was *** DIN nitro-group was converted into a guanidine group by the reducing site of nearby flavin adenine dinucleotide(FAD)in AOX with the preferred higher affinity of ***,the endogenous tryptophan(Trp)aldehyde metabolic intermediate,5-hydroxyindoleacetaldehyde(5-HIAL),provides a persistent electron donor for DIN reduction via the oxidation-catalyzed site in AOX,resulting in remarkable up-regulation of monoamine neurotransmitters such as serotonin and ***,the higher level of neurotransmitters further mediated dysregulation of oxylipin homeostasis via the serotonergic pathway,where S-DIN exhibited more pronounced liver lipid damage and environmental health risk with the accumulated lipid biomarkers,oxidized triglyceride(OxTG)and oxidized sphingomyelin(OxSM).This study elucidates the AOX-mediated enantioselectivity metabolic pathway of DIN,providing a new analytical method for chiral pollutants and paves the way for their health risk assessments.

关键词： neonicotinoid dinotefuran enantiomer aldehyde oxidase metabolomics health risk

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A gold-based multiplex immunochromatographic sensor for detecting paclitaxel

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Nano Research 2024年第7期17卷 6420-6429页

作者： Xiaoqian Jiang Aihua Qu Xinxin xu hua Kuang Liqiang Liu Chuanlai xu State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China

Paclitaxel(PTX),methotrexate(MTX),and 5-fluorouracil(5-FU)are commonly-used small molecule anti-tumor drugs for breast ***,drug resistance occurs with long-term treatment or excessive use,and the high concentrations of PTX,MTX,and 5-FU in patients may lead to side effects with dose-limiting toxicities,such as myelosuppression,hepatotoxicity,and peripheral ***,concentration monitoring of PTX,MTX,and 5-FU in clinical treatment is very *** prepared highly sensitive and specific monoclonal antibodies using several haptens,and established a multiple paper-based sensor utilizing optical signals of gold nanoparticles,which simultaneously detected PTX,MTX,and 5-FU in human plasma or urine with 10 min.A portable scanner for quantitative detection in plasma and urine samples was used,and the calculated limit of detection(cLOD)values were 0.002 and 0.142μg/mL for PTX,0.187 and 0.976 ng/mL for MTX,and 0.057 and 0.128μg/mL for 5-FU,*** the recovery test,the recovery rates and the coefficient of variation were 85.84%–108.81%and 1.23%–8.80%,respectively,indicating the reliability and accuracy of the multiple gold immunochromatographic strip(GIS).In addition,for the determination of collected clinical plasma samples,the correlation between the test data of the multiple GIS and liquid chromatography–tandem mass spectrometry(LC–MS/MS)was ***,the developed multiple GIS could be applied to the rapid detection of PTX,MTX,and 5-FU in different clinical samples.

关键词： paclitaxel methotrexate 5-fluorouracil immunochromatographic assay plasma urine

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Evaluation of suitability,adaptability,and reserve potential of construction land on the Qinghai-Tibet Plateau

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Journal of Geographical Sciences 2024年第1期34卷 41-61页

作者： YANG hua xu Yong ZHOU Kan WANG Lijia xu Lin Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Construction land is the leading carrier of human activities such as production and *** the construction land suitability(CLS)on the Qinghai-Tibet Plateau(QTP)holds significant implications for harmonizing the relationship between ecological protection and human activity and promoting population and industry layout ***,no relevant studies provide a complete CLS assessment of the *** this study,we developed a model-based CLS evaluation framework coupling of pattern and process to calculate the global CLS on the QTP based on a previously developed CLS evaluation ***,using the land-use data of 1990,2000,2010,and 2020,we examined the adaptability of existing construction land(ECL)to the CLS assessment result through the adaptability index and vertical gradient index and further analyzed the limitations of maladaptive construction ***,we calculated the potential area of reserve suitable construction *** article includes four conclusions:(1)The highly suitable,suitable,moderately suitable,marginally suitable,and unsuitable CLS classes cover areas of 0.33×10^(4)km^(2),10.42×10^(4)km^(2),18.06×10^(4)km^(2),24.12×10^(4)km^(2),and 205.29×10^(4)km^(2),*** approximately 11%of the study area on the QTP is suitable for large-scale permanent construction land,and approximately 79.50%of the area is unsuitable under current economic and technological conditions.(2)The ECL adaptability index is 85.16%,85.93%,85.18%,and 78.01%during 1990–2020,respectively,with an average adaptability index exceeding 80%on the *** ECL distribution generally conforms to construction land suitable space characteristics but with a significant spatial difference.(3)From 1990 to 2020,the maladaptive ECL was dominated by rural settlement land,transport land,and special land,with a rapidly increasing proportion of urban and other construction *** maladaptive ECL is constrained by both elevation and slope in the southern Qinghai Pla

关键词： land resource construction land suitability existing construction land adaptability human activity Qinghai-Tibet Plateau

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Enhancing source domain availability through data and feature transfer learning for building power load forecasting

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Building Simulation 2024年第4期17卷 625-638页

作者： Fanyue Qian Yingjun Ruan Huiming Lu hua Meng Tingting xu College of Mechanical and Energy Engineering Tongji UniversityShanghai200092China United Automotive Electronic Systems Co. LtdShanghai201206China

During the initial phases of operation following the construction or renovation of existing buildings,the availability of historical power usage data is limited,which leads to lower accuracy in load forecasting and hinders normal ***,by transferring load data from similar buildings,it is possible to enhance forecasting ***,indiscriminately expanding all source domain data to the target domain is highly likely to result in negative transfer *** study explores the feasibility of utilizing similar buildings(source domains)in transfer learning by implementing and comparing two distinct forms of multi-source transfer ***,this study focuses on the Higashita area in Kitakyushu City,Japan,as the research *** buildings that exhibit the highest similarity to the target buildings within this area were selected for ***,the two-stage TrAdaBoost.R^(2) algorithm is used for multi-source transfer learning,and its transfer effect is ***,the application effects of instance-based(IBMTL)and feature-based(FBMTL)multi-source transfer learning are compared,which explained the effect of the source domain data on the forecasting accuracy in different transfer *** results show that combining the two-stage TrAdaBoost.R^(2) algorithm with multi-source data can reduce the CV-RMSE by 7.23%compared to a single-source domain,and the accuracy improvement is *** the same time,multi-source transfer learning,which is based on instance,can better supplement the integrity of the target domain data and has a higher forecasting ***,IBMTL tends to retain effective data associations and FBMTL shows higher forecasting *** findings of this study,which include the verification of real-life algorithm application and source domain availability,can serve as a theoretical reference for implementing transfer learning in load forecasting.

关键词： building power load multi-source transfer learning two-stage TrAdaBoost.R2 source domain availability

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Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring

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World Journal of Diabetes 2024年第3期15卷 378-391页

作者： Yan Yi Tao Wang Wei xu san-Hong Zhang Department of Ultrasonography The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Clinical Molecular Immunology Center Yangtze UniversityJingzhou 434023Hubei ProvinceChina Department of Pediatric Xiantao First People’s HospitalXiantao 433000Hubei ProvinceChina

Gestational diabetes mellitus(GDM)is a pregnancy-related complication characterized by abnormal glucose metabolism in pregnant women and has an important impact on fetal *** a bridge between the mother and the fetus,the placenta has nutrient transport functions,endocrine functions,etc.,and can regulate placental nutrient transport and fetal growth and development according to maternal metabolic *** by means of placental transmission can changes in maternal hyperglycemia affect the *** are many reports on the placental pathophysiological changes associated with GDM,the impacts of GDM on the growth and development of offspring,and the prevalence of GDM in offspring after *** epigenetic changes in GDM are involved in the programming of fetal development and are involved in the pathogenesis of later chronic *** paper summarizes the effects of changes in placental nutrient transport function and hormone secretion levels due to maternal hyperglycemia and hyperinsulinemia on the development of offspring as well as the participation of changes in placental epigenetic modifications due to maternal hyperglycemia in intrauterine fetal programming to promote a comprehensive understanding of the impacts of placental epigenetic modifications on the development of offspring from patients with GDM.

关键词： Gestational diabetes mellitus Placental functions Epigenetics Offspring development

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Quantitative assessment of the breast cancer marker HER2 using a gold nanoparticle-based lateral flow immunoassay

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Nano Research 2024年第6期17卷 5452-5460页

作者： Liya Ye Xinxin xu Aihua Qu Liqiang Liu Chuanlai xu hua Kuang International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China

Human epidermal growth factor receptor 2(HER2)is an important biomarker for detection and treatment of breast *** this study,we developed monoclonal antibodies against the extracellular domain(ECD)of HER2 and established a rapid and accurate lateral flow immunoassay(LFIA)for use in community medical *** gene sequence of human HER2-ECD was obtained from the National Center for Biotechnology Information(NCBI)to construct the expression ***2-ECD protein expressed in HEK293F cells was used to immunize BALB/c *** monoclonal antibodies were produced in mouse ascites and isolated by hybridoma cell *** were analyzed for purity by SDS-PAGE(sodium dodecyl sulphate-polyacrylamide gel-electrophoresis)and affinity was assessed by enzyme-linked immunosorbent assay(ELISA)while subtypes were detected using the commercial *** HER2-ECD test strip was prepared based on the sandwich method and evaluated using a portable detection *** affinity of the paired antibodies,4D8 and 8D9,both reached 1×108 L/*** antibodies specifically recognized the HER2-ECD protein in *** limit of detection(LOD)of the gold nanoparticle(AuNP)-based LFIA was 1.7 ng/mL with a detection range of 1.7-400 ng/mL,and the performance of the HER2-ECD strip correlated well with that of a Siemens chemiluminescent immunoassay(CLIA)*** conclusion,the paired antibodies were successfully prepared with high affinity and *** AuNP-based LFIA of HER2-ECD provides a fast and accurate method to detect the concentration of HER2-ECD in serum samples for clinical use in community medical institutions,and could contribute to determining the progress of the disease or the effectiveness of treatment.

关键词： human epidermal growth factor receptor 2 breast cancer monoclonal antibody quantitative lateral flow immunoassay

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Neutron irradiation influence on high-power thyristor device under fusion environment

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Nuclear Science and Techniques 2024年第4期35卷 65-81页

作者： Wei Tong hua Li Meng xu Zhi-Quan Song Bo Chen School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

Because of their economy and applicability,high-power thyristor devices are widely used in the power supply systems for large fusion *** high-dose neutrons produced by deuterium–tritium(D–T)fusion reactions are irradiated on a thyristor device for a long time,the electrical characteristics of the device change,which may eventually cause irreversible *** this study,with the thyristor switch of the commutation circuit in the quench protection system(QPS)of a fusion device as the study object,the relationship between the internal physical structure and external electrical parameters of the irradiated thyristor is ***,a series of targeted thyristor physical simulations and neutron irradiation experiments are conducted to verify the accuracy of the theoretical *** addition,the effect of irradiated thyristor electrical characteristic changes on the entire QPS is studied by accurate simulation,providing valuable guidelines for the maintenance and renovation of the QPS.

关键词： Fusion device Neutron irradiation effects Thyristor Quench protection

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Microstructure and property of laser additive manufactured alloy Ti-6Al-2V-1.5Mo-0.5Zr-0.3Si after aged at different temperatures

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Rare Metals 2024年第5期43卷 2275-2281页

作者： Guo-Chao Li xu Cheng hua-Ming Wang National Engineering Laboratory of Additive Manufacturing for Large Metallic Components and Engineering Research Center of Ministry of Education on Laser Direct Manufacturing for Large Metallic Components School of Materials Science and EngineeringBeihang UniversityBeijing 100191China

The solid solution and aging treatment for conventional manufacturing processes might not be suitable for laser additive manufactured titanium alloys due to the different lamellar *** this study,the influence of aging temperatures(600,700 and 800°C)on microstructure and mechanical properties of titanium alloy Ti-6Al-2V-1.5Mo-0.5Zr-0.3Si was *** results indicate that after solid solution treatment at 970°C followed by water quenching,the alloy mainly consists of coarsening lamellar a phase in martensite α' *** at 600°C will not change the size of primary lamellar α phase but lead to huge amount of secondary a phases(α_(s))generating with very fine *** increasing the aging temperature,the number of α_(s) decreases but with coarsened *** aged at 800°C,the width of the asphase reaches 350 nm,almost 7 times wider than that aged at 600°*** changing size of α_(s) obviously influences the property of the *** fine α_(s) leads to high strength and microhardness but low plasticity,and specimen aged at 700°C with suitable assize has the best comprehensive properties.

关键词： α+βtitanium alloy Laser additive manufacturing Solid solution and aging treatment Microstructure Room temperature tensile property

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A multi-colloidal gold immunochromatography assay for rapid and simultaneous detection of 13 herbicides

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Nano Research 2024年第9期17卷 8368-8376页

作者： Qianqian Lu Xinxin xu Aihua Qu Liqiang Liu Yuzhe Li Maozhong Sun Chuanlai xu hua Kuang International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China China National Center for Food Safety Risk Assessment Beijing 100021China

Herbicide residues in agricultural products can have adverse effects on the environment and human health,therefore,there is an urgent need to establish a sensitive,rapid,and wide-ranging detection *** this study,haptens of phenylurea herbicides(PUs)and sulfonylurea herbicides(SUs)were analyzed and designed based on computational simulation techniques,and two high-performance broad-spectrum monoclonal antibodies against PUs and SUs were *** this basis,a multi-colloidal gold immunochromatography assay(multi-CGIA)was developed to simultaneously detect 13 herbicides in *** visual limit of detection(vLOD)for PUs including diuron,chlortoluron,neburon,chlorbromuron,and linuron was 1-2μg/*** vLOD for SUs including metsulfuron methyl,ethametsulfuron-methyl,sulfometuron-methyl,tribenuron methyl,cinosulfuron,triasulfuron,chlorimuron-ethyl,and chlorsulfuron was 2-10μg/*** results of real sample determination indicated that the multi-CGIA is accurate,stable,and reliable,and adaptable to on-site preliminary screening of actual samples.

关键词： phenylurea herbicides sulfonylurea herbicides monoclonal antibody immunochromatographic assay wheat

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