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MiR-21-5p-expressing bone marrow mesenchymal stem cells alleviate myocardial ischemia/reperfusion injury by regulating the circRNA_0031672/miR-21-5p/programmed cell death protein 4 pathway

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Journal of Geriatric Cardiology 2021年第12期18卷 1029-1043页

作者： Jing ZHANG Chang-Jun LUO Xiao-Qi XIONG Jun LI san-hua tang Lin SUN Qiang SU Department of Cardiovascular Medicine Liuzhou Municipal Liutie Central HospitalLiuzhouChina Department of Clinical Laboratory Liuzhou Municipal Liutie Central HospitalLiuzhouChina Department of Cardiology Affiliated Hospital of Guilin Medical UniversityGuangxiChina

BACKGROUND For patients with coronary heart disease,reperfusion treatment strategies are often complicated by ischemia/reperfusion(I/R)injury(IRI),leading to serious organ damage and *** miR-21/programmed cell death protein 4(PDCD4)pathway is involved in the IRI of cardiomyocytes;however,the aberrant miR-21 expression remains ***,this study aimed to explore whether circRNA_0031672 downregulates miR-21-5p expression during I/R and to dete-rmine whether miR-21-5p-expressing bone marrow mesenchymal stem cells(BMSCs)reduce myocardial *** CircRNA_0031672,miR-21-5p,and PDCD4 expressions were evaluated in the I/R rat model and hypoxia/re-oxy-genation(H/R)-treated H9C2 *** interactions were subsequently investigated using luciferase reporter and RNA pull-down ***-like 3,a methyltransferase catalyzing N6-methyladenosine(m6A),was overexpressed in H9C2 cells to determine whether m6A modification influences miR-21-5p targeting *** stably expressing miR-21 were co-cultured with H9C2 cells to investigate the protective effect of BMSCs on H9C2 cells upon H/*** I/R downregulated miR-21-5p expression and upregulated circRNA_0031672 and PDCD4 ***_0031672 knockdown increased miR-21-5p expression,but repressed PDCD4 expression,indicating that circRNA_0031672 com-petitively bound to miR-21-5p and prevented it from targeting PDCD4 *** m6A modification regulated PDCD4 expres-sion,but had no effect on miR-21-5p targeting *** circRNA_0031672/miR-21-5p/PDCD4 axis regulated myocardial cells viability and apoptosis after H/R treatment;co-culture with miR-21-5p-expressing BMSCs restored miR-21-5p abundance in H9C2 cells and further reduced H9C2 cells apoptosis induced by H/*** We identified a novel circRNA_0031672/miR-21-5p/PDCD4 signaling pathway that mediates the apoptosis of cardiomyocytes and successfully alleviates IRI in myocardial cells by co-culture with miR-21-5p-expres

关键词： protective expressing injury

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Nuclear charge radius predictions by kernel ridge regression with odd-even effects

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Nuclear Science and Techniques 2024年第2期35卷 94-102页

作者： Lu tang Zhen-hua Zhang Mathematics and Physics Department North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071000China

The extended kernel ridge regression(EKRR)method with odd-even effects was adopted to improve the description of the nuclear charge radius using five commonly used nuclear *** are:(i)the isospin-dependent A^(1∕3) formula,(ii)relativistic continuum Hartree-Bogoliubov(RCHB)theory,(iii)Hartree-Fock-Bogoliubov(HFB)model HFB25,(iv)the Weizsacker-Skyrme(WS)model WS*,and(v)HFB25**** the last two models,the charge radii were calculated using a five-parameter formula with the nuclear shell corrections and deformations obtained from the WS and HFB25 models,*** each model,the resultant root-mean-square deviation for the 1014 nuclei with proton number Z≥8 can be significantly reduced to 0.009-0.013 fm after considering the modification with the EKRR *** best among them was the RCHB model,with a root-mean-square deviation of 0.0092 *** extrapolation abilities of the KRR and EKRR methods for the neutron-rich region were examined,and it was found that after considering the odd-even effects,the extrapolation power was improved compared with that of the original KRR *** strong odd-even staggering of nuclear charge radii of Ca and Cu isotopes and the abrupt kinks across the neutron N=126 and 82 shell closures were also calculated and could be reproduced quite well by calculations using the EKRR method.

关键词： Nuclear charge radius Machine learning Kernel ridge regression method

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Identifying the best common factor model via exploratory eactor analysis

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 24-33页

作者： HE Bao-hua tang Rui TAGN Qi-yi School of Big Data Fuzhou University of International Studies and TradeFuzhou 350202China School of Mathematics Sun Yat-Sen UniversityGuangzhou 510275China Department of Computer Science University of BathUK Institute of Insect Science Zhejiang UniversityHangzhou 310058China.

Currently,there is no solid criterion for judging the quality of the estimators in factor *** paper presents a new evaluation method for exploratory factor analysis that pinpoints an appropriate number of factors along with the best method for factor *** proposed technique consists of two steps:testing the normality of the residuals from the fitted model via the Shapiro-Wilk test and using an empirical quantified index to judge the quality of the factor *** are presented to demonstrate how the method is implemented and to verify its effectiveness.

关键词： factor analysis Shapiro-Wilk normality residuals

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(Parallel) kinetic resolution of 3,3-disubstituted indolines via organocatalyzed reactions with azodicarboxylates

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Science China Chemistry 2024年第3期67卷 973-980页

作者： Qianwen Jiang Dekun Zhang Mengyao tang hua Liu Xiaoyu Yang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

A novel kinetic resolution(KR) method has been developed for 3,3-disubstituted indolines, whose catalytic asymmetric synthesis remains a significant challenge in organic synthesis. The key to the success of this KR protocol lies in the utilization of chiral phosphoric acid-catalyzed triazane formation reaction with azodicarboxylates, which enables the enantioselective synthesis of various substituted indolines bearing C3-quaternary stereocenters with good to high enantioselectivities(with sfactors up to 70). Moreover, an intriguing parallel kinetic resolution(PKR) has been developed by combining triazane formation and dehydrogenation reactions using different azodicarboxylates. Experimental studies have provided insight into the mechanism of this PKR reaction, demonstrating stereoselectivity in both triazane formation and dehydrogenation steps, favoring the opposite enantiomers. The large-scale synthesis and diverse derivatizations of the products, particularly the imine groupcontaining 3H-indoles, demonstrate the value of these(P)KR methods.

关键词： asymmetric organocatalysis kinetic resolution 3 3-disubstituted indolines azodicarboxylate triazanes

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Advancements in S-scheme heterojunction materials for photocatalytic environmental remediation

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Journal of Materials Science & Technology 2024年第2期169卷 182-198页

作者： Changliang Nie Xiaohan Wang Ping Lu Yukun Zhu Xin Li hua tang School of Environmental Science and Engineering State Key Laboratory of Bio-fibers and Eco-textilesQingdao UniversityQingdao266071China Institute of Biomass Engineering Key Laboratory of Energy Plants Resource and UtilizationMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou510642China School of Environmental Science and Engineering Shandong UniversityQingdao266237China

Recently,S-scheme heterojunctions have gained considerable attention in the field of photocatalytic environmental remediation as their potential to achieve efficient spatial charge separation coupled with strong redox ***,this review provides an overview of the current state-of-the-art in the development of S-scheme-based photocatalysts for the purification of environmental *** review first covers the fundamentals of heterogeneous photocatalysis for environmental ***,an introduction to the background,mechanism,design principles,and characterization techniques of S-scheme heterojunctions is ***,the review presents a comparison and summary of using various S-scheme photocatalysts for the removal of several target pollutants,such as bacteria,heavy metals,nitrogen oxides,antibiotics,and ***,the modification strategies of S-scheme heterojunction photocatalysts are also ***,a brief discussion of the challenges and prospects associated with S-scheme photocatalytic systems is demonstrated.

关键词： S-scheme heterojunctions Photocatalyst Pollutant Environmental remediation

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Quantification of perfluorinated compounds in atmospheric particulate shows potential connection with environmental event

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Journal of Environmental Sciences 2024年第2期136卷 237-247页

作者： hua tang Ying Wang Shengling Si Hongli Li David Da Yong Chen National Institute of Metrology 18 BeisanhuandongluChaoyang DistrictBeijing 100029China School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China Si Chuan Zhong Ce Biao Wu Technology Co.Ltd. Sichuan 610052China Department of Chemistry University of British ColumbiaVancouver V6T 1Z1BCCanada

A method of quantification of perfluorinated compounds(PFCs)from atmospheric particulate matter(APM)is described.A single step pretreatment method,selective pressurized liquid extraction(SPLE),was developed to reduce the high matrix background and avoid contamination from commonly used multiple sample pretreatment *** effective sorbent was selected to purify the PFCs during SPLE,followed by liquid chromatography-tandem mass spectrometry(LC–MS/MS),for quantification of *** affecting the SPLE efficiency,including temperature,static extraction time,and number of extraction cycles used,were *** optimum conditions were found to be 120℃,10 min,and 3 cycles,***-MS/MS method was developed to obtain the optimal sensitivity specific to *** method detection limits(MDLs)were 0.006 to 0.48 ng/g for the PFCs studied and the linear response range was from 0.1 to 100 ng/*** ensure accurate values were obtained,each step of the experiment was evaluated and controlled to prevent *** optimized method was tested by performing spiking experiments in natural particulate matter matrices and good rates of recovery and reproducibility were obtained for all target ***,the method was successfully used to measure 16 PFCs in the APM samples collected in Beijing over five years from 2015 to *** is observed that some PFCs follow the trend of total PFC changes,and can be attributed to the environment influencing events and policy enforcement,while others don't seem to change as much with time of the year or from year to year.

关键词： Selective pressurized liquid extraction Liquid chromatography-mass spectrometry Perfluorinated compounds Atmospheric particulate matter Pollution control

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Recent advances in g-C_(3)N_(4)-based direct Z-scheme photocatalysts for environmental and energy applications

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Chinese Journal of Structural Chemistry 2024年第2期43卷 66-84页

作者： Xiaoming Fu Haibo huang Guogang tang Jingmin Zhang Junyue Sheng hua tang School of Intelligent Engineering and Technology Jiangsu Vocational College of Finance&EconomicsHuai'anJiangsu223003PR China School of Modem Equipment Manufacturing Changzhou Institute of Light Industry Technology ChangzhouJiangsu213164PR China School of Environmental Science and Engineering Qingdao UniversityQingdao266071PR China School of Materials Science and Engineering Hainan UniversityHaikou570228PR China

In the midst of the rapid advancement of photocatalysis,direct Z-scheme heterojunction photocatalysts have emerged as a powerful solution to address environmental challenges and the looming energy *** precise engineering of direct Z-scheme heterojunction photocatalysts proves highly beneficial in optimizing their elec-tronic structure,ultimately enhancing their photocatalytic ***,graphitic carbon nitride(g-C_(3)N_(4))has recently gained recognition as a leading candidate for the creation of direct Z-scheme heterojunctions,owing to its favorable attributes such as a moderate band-gap(2.7 eV),high reduction potential and abundant active *** this review,we offer a concise overview of the fundamental principles and recent advancements in g-C_(3)N_(4)-based direct Z-scheme photocatalytic ***,we delve into the various practical applica-tions of g-C_(3)N_(4)-based direct Z-scheme photocatalysts,specifically in the realms of energy conversion and envi-ronmental *** applications include the removal of contaminant pollutants through photocatalytic degradation,water splitting(comprising H_(2)-generation,O_(2)-evolution,and overall water splitting),and CO_(2)***,we present comprehensive characterization methods and strategies aimed at further enhancing the photocatalytic activity of g-C_(3)N_(4)-based direct Z-scheme photocatalytic *** conclude,this review offers summarizing insights and a brief discussion on future challenges and prospects pertaining to g-C_(3)N_(4)-based direct Z-scheme *** believe that this review will inspire continued exploration and foster a deeper understanding of the groundbreaking possibilities within photocatalytic *** also provides valuable guidance for the design and construction of innovative direct Z-scheme photocatalysts.

关键词： Carbon nitride Photocatalyst Z-scheme systems Environmental remediation Energy conversion

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A coordinated operation method of wind-PV-hydrogenstorage multi-agent energy system

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Global Energy Interconnection 2024年第4期7卷 446-461页

作者： Tengfei Ma Wei Pei Yanhong Yang Hao Xiao Chenghong tang Weiqi hua Institute of Electrical Engineering of Chinese Academy of Sciences Beijing 100190P.R.China State Grid Electric Power Research Institute Nanjing 211103P.R.China Department of Electronic Electrical and Systems EngineeringUniversity of BirminghamBirmingham B152TTUK

Wind-photovoltaic(PV)-hydrogen-storage multi-agent energy systems are expected to play an important role in promoting renewable power utilization and *** this study,a coordinated operation method was proposed for a wind-PVhydrogen-storage multi-agent energy ***,a coordinated operation model was formulated for each agent considering peer-to-peer power ***,a coordinated operation interactive framework for a multi-agent energy system was proposed based on the theory of the alternating direction method of ***,a distributed interactive algorithm was proposed to protect the privacy of each agent and solve coordinated operation ***,the effectiveness of the proposed coordinated operation method was tested on multi-agent energy systems with different structures,and the operational revenues of the wind power,PV,hydrogen,and energy storage agents of the proposed coordinated operation model were improved by approximately 59.19%,233.28%,16.75%,and 145.56%,respectively,compared with the independent operation model.

关键词： Wind-PV-hydrogen-storage Multi-agent energy system Renewable power to hydrogen Coordinated operation Peer-to-peer power trading

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First identification of a novel Aichivirus D in goats with diarrhea

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Journal of Integrative Agriculture 2024年第4期23卷 1442-1446页

作者： Chen Yang Keha-mo Abi hua Yue Falong Yang Cheng tang College of Animal&Veterinary Sciences Southwest Minzu UniversityChengdu 610041China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Chengdu 610041China

Kobuvirus comprises 6 officially recognized species,namely Aichivirus A-F,and can be further divided into 20 genotypes through VP1 gene phylogenetic analysis(https://***/report/chapter/picornaviridae/picornaviridae/kobuvirus).Aichivirus A in human,Aichivirus B in bovine,Aichivirus C in porcine and caprine,Aichivirus D in yak have been proved to be associated with diarrhea(Chen Y S et al.2013;Yang et al.2015;Zhu et al.2016;Zhai et al.2017;Wang et al.2020;Abi et al.2022;Yan et al.2023).

关键词： corn diarrhea official

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FPGA-based plasma sterilization device for wound-edge recognition

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Nanotechnology and Precision Engineering 2024年第3期7卷 56-70页

作者： Huijuan Lu Xiaorong tang Minglei Li Xueping Jiang Wenxiang Xiao hua Li School of Life and Environmental Sciences Guilin University of Electronic TechnologyGuilin 541004People’s Republic of China Guilin URIT MEDICAL Electronic Sales Co. Ltd.Guilin 541004People’s Republic of China

There is a currently a lack of large-area plasma sterilization devices that can intelligently identify the shape of a wound for automatic *** this reason,in this work,a plasma sterilization device with wound-edge recognition was developed using aﬁeld-programmable gate array(FPGA)and a high-performance image-processing platform to realize intelligent and precise sterilization of *** was used to design the mechanical structure of the device,and it was manufactured using 3D *** device used an improvement of the traditional Sobel detection algorithm,which extends the detection of edges in only the x and y directions to eight directions(0○,45○,90○,135○,180○,225○,270○,and 315○),completing the wound-edge detection by adaptive *** device can be controlled according to different shapes of sterilization area to adjust the positioning of a single plasma-jet tube in the horizontal plane for two-dimensional move-ment;the distance between the plasma-jet tube and the surface of the object to be sterilized can be also adjusted in the vertical *** this way,motors are used to move the plasma jet and achieve automatic,efﬁcient,and accurate plasma *** was found that a good sterilization effect could be achieved at both the culture-medium level and the biological-tissue *** ideal sterilization parameters at the culture-medium level were a speed of 2 mm/s and aﬂow rate of 0.6 slm,while at the biological-tissue level,these values were 1 mm/s and 0.6 slm,respectively.

关键词： FPGA Wound-edge recognition Improvement of the Sobel algorithm Plasma Automatic and precise sterilization

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