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粤港澳大湾区市场一体化发展机制与空间溢出效应——基于中介效应和门槛效应双检验

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经济问题探索 2024年第4期 170-190页

作者：罗琼钟坚深圳大学经济学院广东深圳518060

建设全国统一大市场要求优先开展区域市场一体化工作,而粤港澳大湾区市场一体化建设对推进区域经济协调发展,示范引领全国统一大市场建设有着重要作用。本文基于2011—2021年粤港澳大湾区城市群面板数据,实证分析粤港澳大湾区市场一体... 详细信息

建设全国统一大市场要求优先开展区域市场一体化工作,而粤港澳大湾区市场一体化建设对推进区域经济协调发展,示范引领全国统一大市场建设有着重要作用。本文基于2011—2021年粤港澳大湾区城市群面板数据,实证分析粤港澳大湾区市场一体化对经济增长的空间溢出效应。结果表明:三种空间权重下的市场一体化直接效应均存在显著空间扩散效应,而间接效应呈现空间回波效应,市场一体化本地效应大于邻地效应;港深莞惠都市圈和广佛肇都市圈市场一体化存在显著空间扩散效应,而澳珠中江都市圈市场一体化的空间效应尚未呈现;中介机制效应检验发现,市场一体化通过作用交通基础设施进而促进经济增长;门槛效应检验发现,技术创新和产业结构高级化均存在单一门槛效应,当两者分别高于门槛值4.0089、13.9254时,粤港澳大湾区市场一体化对经济增长的正向促进作用将显著提升。主要结论均通过稳健性检验。

关键词：粤港澳大湾区都市圈市场一体化交通基础设施空间溢出效应

Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury

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World Journal of Gastroenterology 2024年第9期30卷 1189-1212页

作者： Jin-Lian Jiang Yi-Yang Zhou Wei-Wei zhong Lin-Yan luo Si-Ying Liu Xiao-Yu Xie Mao-Yuan Mu Zhi-Gang Jiang Yuan Xue Jian Zhang Yi-Huai He Department of Infectious Diseases Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Infectious Diseases Jingmen Central HospitalJingmen 448000Hubei ProvinceChina Department of Respiratory Medicine Anshun People’s HospitalAnshun 561099Guizhou ProvinceChina Department of General Practice Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Intervention Radiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina School of Public Health Zunyi Medical UniversityZunyi 563099Guizhou ProvinceChina Department of Liver Diseases Third People’s Hospital of ChangzhouChangzhou 213000Jiangsu ProvinceChina Department of Digestion Dafang County People’s HospitalBijie 551600Guizhou ProvinceChina

BACKGROUND Uridine diphosphate glucuronosyltransferase 1A1(UGT1A1)plays a crucial role in metabolizing and detoxifying endogenous and exogenous ***,its contribution to the progression of liver damage remains *** To determine the role and mechanism of UGT1A1 in liver damage *** We investigated the relationship between UGT1A1 expression and liver injury through clinical ***,the impact and mechanism of UGT1A1 on the progression of liver injury was analyzed through a mouse model *** Patients with UGT1A1 gene mutations showed varying degrees of liver damage,while patients with acute-onchronic liver failure(ACLF)exhibited relatively reduced levels of UGT1A1 protein in the liver as compared to patients with chronic *** suggests that low UGT1A1 levels may be associated with the progression of liver *** mouse models of liver injury induced by carbon tetrachloride(CCl_(4))and concanavalin A(ConA),the hepatic levels of UGT1A1 protein were found to be *** mice with lipopolysaccharide or liver steatosis-mediated liver-injury progression,the hepatic protein levels of UGT1A1 were decreased,which is consistent with the observations in patients with ***1A1 knockout exacerbated CCl_(4)-and ConA-induced liver injury,hepatocyte apoptosis and necroptosis in mice,intensified hepatocyte endoplasmic reticulum(ER)stress and oxidative stress,and disrupted lipid *** UGT1A1 is upregulated as a compensatory response during liver injury,and interference with this upregulation process may worsen liver ***1A1 reduces ER stress,oxidative stress,and lipid metabolism disorder,thereby mitigating hepatocyte apoptosis and necroptosis.

关键词： Uridine diphosphate glucuronosyltransferase 1A1 Liver injury progression Endoplasmic reticulum stress Oxidative stress Lipid metabolism disorders

Temperature-Based Fan Speed Optimization Strategy

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Journal of Electronic Research and Application 2024年第3期8卷 135-141页

作者： Chucheng Wang Chongyi luo Junnian Wei Haiyang Peng Xiaorong zhong Cai Ye Guangxi Power Grid Co. Ltd.Beihai Power Supply BureauBeihai 536006Guangxi Zhuang Autonomous RegionChina

As energy efficiency and indoor comfort increasingly become key standards in modern residential and office environments,research on intelligent fan speed control systems has become particularly *** study aims to develop a temperature-feedback-based fan speed optimization strategy to achieve higher energy efficiency and user ***,by analyzing existing fan speed control technologies,their main limitations are identified,such as the inability to achieve smooth speed *** address this issue,a BP-PID speed control algorithm is designed,which dynamically adjusts fan speed based on indoor temperature *** validation demonstrates that the designed system can achieve smooth speed transitions compared to traditional fan systems while maintaining stable indoor ***,the real-time responsiveness of the system is crucial for enhancing user *** research not only demonstrates the feasibility of temperature-based fan speed optimization strategies in both theory and practice but also provides valuable insights for energy management in future smart home ***,this research outcome will facilitate the development of smart home systems and have a positive impact on environmental sustainability.

关键词： Smart temperature control Fan speed optimization Temperature feedback control Dynamic speed adjustment Smart home systems Energy-saving technology

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基于事件逻辑的PUFs认证协议形式化分析

华中科技大学学报（自然科学版） 2024年第2期52卷 69-76页

作者：钟小妹肖美华杨科罗运先华东交通大学软件学院江西南昌330013

提出两个事件时序概念与相关规则,用于分析事件关联消息类型为挑战数的时态性质,形式化抽象物理不可克隆函数(PUFs)随机会话秘钥生成功能,扩展事件逻辑(LoET)用于形式化分析PUFs安全协议的理论.以一个基于SRAM PUFs(基于静态随机存取存... 详细信息

提出两个事件时序概念与相关规则,用于分析事件关联消息类型为挑战数的时态性质,形式化抽象物理不可克隆函数(PUFs)随机会话秘钥生成功能,扩展事件逻辑(LoET)用于形式化分析PUFs安全协议的理论.以一个基于SRAM PUFs(基于静态随机存取存储器的PUF类型)的安全双向认证协议分析为例,形式化规约了协议基于PUFs随机秘钥生成和双向认证过程,基于扩展的事件逻辑,采用定理证明方法推理证明了该协议在合理假设下满足双向强认证性质.研究表明扩展的事件逻辑理论可用于设计和分析基于PUFs安全协议.

关键词：形式化方法事件逻辑(LoET) 物理不可克隆函数(PUFs) 双向认证协议定理证明

MOOCDR-VSI:一种融合视频字幕信息的MOOC资源动态推荐模型

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计算机研究与发展 2024年第2期61卷 470-480页

作者：吴水秀罗贤增钟茂生吴如萍罗玮江西师范大学计算机信息工程学院南昌330022 江西师范大学江西教育数字化转型研究中心南昌330022

学习者在面对浩如烟海的在线学习课程资源时往往存在“信息过载”和“信息迷航”等问题,基于学习者的学习记录,向学习者推荐与其知识偏好和学习需求相符的MOOC资源变得愈加重要.针对现有MOOC推荐方法没有充分利用MOOC视频中所蕴含的隐... 详细信息

学习者在面对浩如烟海的在线学习课程资源时往往存在“信息过载”和“信息迷航”等问题,基于学习者的学习记录,向学习者推荐与其知识偏好和学习需求相符的MOOC资源变得愈加重要.针对现有MOOC推荐方法没有充分利用MOOC视频中所蕴含的隐式信息,容易形成“蚕茧效应”以及难以捕获学习者动态变化的学习需求和兴趣等问题,提出了一种融合视频字幕信息的动态MOOC推荐模型MOOCDR-VSI,模型以BERT为编码器,通过融入多头注意力机制深度挖掘MOOC视频字幕文本的语义信息,采用基于LSTM架构的网络动态捕捉学习者随着学习不断变化的知识偏好状态,引入注意力机制挖掘MOOC视频之间的个性信息和共性信息,最后结合学习者的知识偏好状态推荐出召回概率Top N的MOOC视频.实验在真实学习场景下收集的数据集MOOCCube分析了MOOCDR-VSI的性能,结果表明,提出的模型在HR@5,HR@10,NDCG@5,NDCG@10,NDCG@20评价指标上比目前最优方法分别提高了2.35%,2.79%,0.69%,2.2%,3.32%.

关键词： MOOC推荐 BERT 多头注意力机制字幕信息长短期记忆

Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

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Petroleum Science 2024年第2期21卷 806-822页

作者： Jin-Min Song Xin Jin zhong luo Shu-Gen Liu Shao-Bo Liu Xing-Zhi Ma Zhi-Wu Li Xue-Song Lu Ling-Li Zhao Ke-Ran Li Jia-Xin Ren Li-Zhou Tian Hao-Shuang Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Xihua University Chengdu610039SichuanChina

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain late

关键词： Sichuan Basin The Member Deng-2 Marginal microbial mound-bank complex Depositional model Exploration implications

Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2791-2803页

作者： Gang Yang Jinpeng Cao Jian Qin Xinyue Mei Shidong Deng Yingjiao Xia Jun Zhao Junxiang Wang Tao Luan Daxiang Chen Peiyu Huang Cheng Chen Xi Sun Qi luo Jie Su Yunhui Zhang Nanshan zhong zhongfang Wang The Affiliated Hospital of Kunming University of Science and Technology.Department of Respiratory and Critical Care Medicine The First People’s Hospital of Yunnan provinceKunmingYunnanChina Guangzhou National Laboratory BiolandGuangzhouGuangdongChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina

The immunoprotective components control COVID-19 disease severity,as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity,remain ***,we longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by *** found that early and robust SARS-CoV-2-specific CD4^(+)and CD8^(+)T cell responses ameliorate disease progression and shortened hospital stay,while delayed and attenuated virus-specific CD8^(+)T cell responses are prominent severe COVID-19 *** antiviral antibody generation rather than titer level associates with severe ***,initial COVID-19 severity imprints the long-term maintenance of SARS-CoV-2-specific adaptive immunity,demonstrating that severe convalescents exhibited more sustained virus-specific antibodies and memory T cell responses compared to mild/moderate ***,initial COVID-19 severity inversely correlates with SARS-CoV-2 reinfection ***,our study unravels the complicated interaction between temporal characteristics of virus-specific T cell responses and COVID-19 severity to guide future SARS-CoV-2 wave management.

关键词： severity immunity infection

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大断面回采巷道超前支护技术研究与应用

煤炭工程 2024年第3期56卷 57-65页

作者：钟阳罗伙根国能神东煤炭集团有限责任公司寸草塔二矿内蒙古鄂尔多斯017209

为探究大断面回采巷道超前支护技术,以寸草塔二矿31205工作面主运输巷道为工程背景,采用现场调研、理论力学分析、FLAC3D数值模拟相结合的手段,分析了主动超前支护替换单体液压支柱的可行性,基于主动超前控制机理,提出了在顶板中央进行... 详细信息

为探究大断面回采巷道超前支护技术,以寸草塔二矿31205工作面主运输巷道为工程背景,采用现场调研、理论力学分析、FLAC3D数值模拟相结合的手段,分析了主动超前支护替换单体液压支柱的可行性,基于主动超前控制机理,提出了在顶板中央进行补强支护的超前支护技术方案。通过现场监测表明,主动超前支护下顶底板及两帮最大位移量分别为21 mm和23 mm;根据锚索轴力监测,主动超前支护锚索可以实现及时承载;且窥视结果表明巷道围岩完整性较好,验证了该方案的可行性,可以满足工作面安全高效的生产要求,推动工作面的智能化发展。

关键词：巷道主动超前支护锚索支护数值模拟

超声引导下针状肾镜联合标准通道与多通道经皮肾镜碎石术治疗肾结石的临床效果对比

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泌尿外科杂志(电子版) 2024年第3期16卷 8-11页

作者：罗开顺钟媛昭通市第一人民医院泌尿外科

目的对比经超声引导下针状肾镜联合标准通道与多通道经皮肾镜碎石术(percutaneous nephrolithotomy,PCNL)治疗肾结石的疗效。方法回顾性分析2022年8月至2023年9月昭通市第一人民医院收治的94例肾结石患者的临床资料,根据术中采用不同... 详细信息

目的对比经超声引导下针状肾镜联合标准通道与多通道经皮肾镜碎石术(percutaneous nephrolithotomy,PCNL)治疗肾结石的疗效。方法回顾性分析2022年8月至2023年9月昭通市第一人民医院收治的94例肾结石患者的临床资料,根据术中采用不同的通道分为对照组(n=44)和观察组(n=50),分别采取超声引导下多通道PCNL和超声引导下针状肾镜联合标准通道PCNL。对比两组手术相关指标、术前及术后24 h炎症指标、氧化应激指标、结石清除率、术后并发症发生率。结果观察组术中出血量少于对照组,手术时间和住院时间均短于对照组,差异有统计学意义(P0.05);观察组(10.00%)并发症发生率低于对照组(27.27%),差异有统计学意义(P<0.05)。结论超声引导下多通道PCNL和超声引导下针状肾镜联合标准通道PCNL治疗肾结石的临床疗效相当,但后者在降低患者术后炎症应激反应和并发症发生率方面效果更为理想。

关键词：肾结石经皮肾镜碎石术超声