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Pretreatment inflammatory indices predict Bevacizumab response in recurrent Glioma

Cancer Drug Resistance 2020年第3期3卷 623-635页

作者： Alicia martínez-González Raquel Cabrera marta Lloret Pedro C.Lara Department de Matemáticas Universidad de Castilla-La ManchaETSI IndustrialesAvdaCiudad Real 13071Spain. Oncología Radioterápica Hospital Universitario de Gran Canaria Dr negrin Barranco de la Ballena s/nLas Palmas de Gran CanariaLas Palmas 35010Spain. Facultad de Ciencias de la Salud Universidad de Las Palmas de Gran CanariaPaseo de Blas Cabrera Felipes/nLas Palmas de Gran CanariaLas Palmas 35016Spain. Fundación Canaria del Instituto Canario de Investigación del Cáncer Avda de la Trinidad 61 Torre Agustín Arevalo 7 planta La LagunaSanta Cruz de Tenerife 38204Spain. san Roque University Hospitals Dolores de la Rocha5Las Palmas de Gran CanariaLas Palmas 35001Spain. Fernando Pessoa Canarias University Dolores dela Rocha 14Las Palmas de Gran CanariaLas Palmas 35016Spain.

Aim:It remains unclear what the best therapeutic option for recurrent glioma patients after Stupp treatment ***(BVZ)is commonly administered in progression,but it appears that only some patients *** would be useful to find biomarkers that determine beforehand who these patients ***:The protocol included 31 high-risk progressing glioma patients after Stupp treatment who received BVZ 5-10 mg/kg every 14 days and temozolomide(3-19 cycles,150-200 mg five days each 28-day cycle)during a mean of eight cycles of BVZ or until tumor progression or unacceptable *** analyzed the clinical outcome values of inflammatory indices measured before BVZ ***:Lymphocyte level before BVZ administration was the best independent predictor of overall survival(HR=0.34;95%CI:0.145-0.81;P=0.015).The area under the receiver operating characteristic(ROC)curve was 0.823,with 1.645 being the optimal cut-off value,and 0.80 and 0.85 the sensitivity and specificity values,*** and non-responder survival curves were also significantly different,considering the first and second tertiles as cut-off *** number of BVZ cycles was not related to *** neutrophil platelet levels,platelet-to-lymphocyte ratio(PLR),and neutrophil-to-lymphocyte ratio(nLR)did not have independent predictive *** variables were not correlated with each ***,patients with high nLR and PLR simultaneously(double positive PLR-nLR)showed a worse clinical outcome than the rest(P=0.043).Conclusion:Pretreatment lymphocyte levels and double positive PLR-nLR could be used as non-invasive hematological prognostic markers for recurrent gliomas treated with bevacizumab.A close relationship emerged between inflammation and angiogenesis.

关键词： Recurrent glioma bevacizumab predictive biomarker inflammatory indices lymphocytes

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Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine n-methyltransferase gene

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World Journal of Gastroenterology 2006年第4期12卷 615-620页

作者： ElenaGarcía-martín JuanLMendoza CarlosTaxonera JoséMLadero ManuelDíaz-Rubio Carmenmartínez JoséAGAgúndez ElenaUrcelay EmilioGdelaConcha Department of Biochemistry & Molecular Biology & Genetics University of ExtremaduraBadajozSpain Service of Gastroenterology Hospital Clinico San CarlosComplutense UniversityMadridSpain Department of Pharmacology University of ExtremaduraBadajozSpain Service of Immunology Hospital Clinico San CarlosComplutense UniversityMadridSpain

瞄准：为了在作为它为组织安 metabolising 酶编码的基因分析二普通多型性的角色，联系到风险开发 ulcerative (UC ) 和这些病人的临床的功课。方法：有从一个单个中心和 261 个健康志愿者招募的 UC 的 229 个无关的病人的一个队在组织... 详细信息

瞄准：为了在作为它为组织安 metabolising 酶编码的基因分析二普通多型性的角色，联系到风险开发 ulcerative (UC ) 和这些病人的临床的功课。方法：有从一个单个中心和 261 个健康志愿者招募的 UC 的 229 个无关的病人的一个队在组织安 n-methyltransferase (HnMT ) 和二胺氧化酶(ABP1 ) 为 Thr105Ile 和 His645Asp 氨基酸替换的存在被分析酶，分别地由扩大限制过程。所有病人是 phenotyped 并且列在后面在上面为至少 2 年(吝啬的时间 11 年) 。结果：在在 ulcerative 病人和健康个人之间的 ABP1 等位基因的分发没有有效差量[或(95% CI ) 为变体 alleles=1.22 (0.91-1.61 )] 。然而，变异 ABP1 等位基因与在要求了抑制免疫力的药的 58 个病人之中的高频率是在场的[或(95 % CI ) 为变异的等位基因的搬运人 2.41 (1.21-4.83；P=0.006 )] ，与重要基因剂量效果(P=0.0038 ) 。与在人的肠的本地组织安新陈代谢上的 ABP1 对 HnMT 的占优势的角色一致，为 HnMT 遗传型或变异的等位基因的搬运人的频率在病人，不管怎样临床的进化，和控制个人之中是类似的。结论：组织安 metabolising 酶 ABP1 的 His645Asp 多型性与 ulcerative 的严厉有关。

关键词：肠溃疡基因多态性氧化酶组胺 n-转甲基酶

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Cardiovascular prevention in elderly patients

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Journal of Geriatric Cardiology 2022年第5期19卷 377-392页

作者： Clara Bonanad Rosa Fernández-Olmo Sergio García-Blas Jose Antonio Alarcon Pablo Díez-Villanueva Carmen Rus Mansilla Héctor García-Pardo Pablo Toledo Ana Ayesta Eva Pereira Antoni Carol Almudena Castro-Conde Carmen de Pablo-Zarzoso Manuel martínez-Sellés Vicente Arrarte Raquel Campuzano Albert Ariza-Solé Servicio de Cardiología Hospital Clínico Universitario de ValenciaValenciaSpain Instituto de Investigación sanitaria InCLIVA ValenciaSpain Servicio Cardiología Hospital Universitario de Jaén Spain Servicio Cardiología Hospital de Donosti Spain Servicio de Cardiología Hospital Universitario La Princesa de MadridSpain Servicio de Cardiología Hospital Alto Gudalquivir de AndújarJaénSpain Servicio de Cardiología Hospital Rio Hortega de ValladolidSpain Servicio Cardiología Hospital Clínico san Cecilio de Granada Spain Servicio de Cardiología Hospital Universitario Central de AsturiasSpain Servicio de Cardiologia Hospital de LugoSpain Servicio de Cardiología Hospital Moisés Broggi de BarcelonaSpain Servicio de Cardiología Hospital Universitario de la Paz de Madrid Spain Servicio de Cardiología Hospital Ramón y Cajal de MadridSpain Department of Cardiology.Hospital Universitario Gregorio Marañón CIBERCV.Universidad EuropeaUniversidad Compluten Servicio de Cardiología del Hospital General de Alicante Spain Servicio de Cardiología Hospital Universitario Fundación de Alcorcón de MadridSpain Servicio de Cardiología Hospital Bellvitge de BarcelonaBioheartGrup de Malalties CardiovascularsInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatBarcelonaSpain

In recent decades,life expectancy has been increasing *** this scenario,health interventions are ne-cessary to improve prognosis and quality of life of elderly with cardiovascular risk factors and cardiovascular ***,the number of elderly patients included in clinical trials is low,thus current clinical practice guidelines do not include specific *** document aims to review prevention recommendations focused in patients≥75 years with high or very high cardiovascular risk,regarding objectives,medical treatment options and also including physical exercise and their inclusion in cardiac rehabilitation ***,we will show why geriatric syndromes such as frailty,dependence,cognitive impair-ment,and nutritional status,as well as comorbidities,ought to be considered in this population regarding their important pro-gnostic impact.

关键词： prevention patients cardiovascular

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Raman spectroscopy for detection of imatinib in plasma: A proof of concept

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Journal of Innovative Optical Health Sciences 2015年第5期8卷 56-66页

作者： sanhita Rath Aditi Sahu Vikram Gota P.G.martínez-Torres J.L.Pichardo-Molina C.Murali Krishna Department of Clinical Pharmacology ACTREC Tata Memorial CenterKharghar Navi Mumbai 410210 India Chilakapati Lab ACTRECTata Memorial Center KhargharNavi Mumbai 410210 India Instituto de Fisica y Matematicas Universidad Michoacana de san nicolas de Hidalgo Edificio C-3 Ciudad Universitaria CP.58040 MoreliaMichoacanMexico Centro de Investigaciones enOptica AC C.P.37#150 Leon Gto.Mexico

Imatinib is the standard first line treatment for chronic myeloid leukemia(CML).Owing to doserelated toxicities of Imatinib such as neutropenia,there is scope for treatment optimization through therapeutic drug monitoring(TDM).Trough concentration of 1g/mL is considered the therapeutic *** methods for the detection of Imatinib in plasma are limited by long read out time and expensive ***,Raman spectroscopy was explored as a rapid and objective tool for monitoring Imatinib *** approaches:conventional Raman spectroscopy(CRS),Drop coating deposition Raman(DCDR)spectroscopy and surface-enhanced Raman spectroscopy(SERS)were employed to detect the required trough concentration of 1g/mL and *** of therapeutically relevant concentrations(1g/mL)using SERS and suitable nanoparticle substrates has been ***,rigorous validation using clinical samples is necessary to confirm the utility of this approach in routine clinical usage.

关键词： Therapeutic drug monitoring Raman spectroscopy Imatinib SERS DCDR chronic myeloid leukemia

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Thermal analysis of olive tree pruning and the by-products obtained by its gasification and pyrolysis: The effect of some heavy metals on their devolatilization behavior

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Journal of Energy Chemistry 2019年第5期28卷 105-117页

作者： Irene lanez-Rodriguez Maria Angeles martin-Lara Gabriel Blazquez Oscar Osegueda Monica Calero Department of Chemical Engineering Faculty of SciencesUniversity of GranadaAvda.Fuentenuevas/n 18071 GranadaSpain Department of Process Engineering and Environmental Sciences Jose Simeon Canas Central American UniversityBulevar Los ProceresSan SalvadorEl Salvador

In this work, the effect of the presence of nickel and lead in thermal decomposition of olive tree pruning (OTP), OTP-char and OTP-ashes was studied by thermogravimetry. Experiments were conducted in two kinds of atmosphere (nitrogen atmosphere and oxidizing atmosphere with 20% of O2) at a heating rate of 10 ℃/min. This investigation describes the chemical, physical and fuel properties of the OTP, which shows a similar composition to other lignocellulosic materials such as hazelnut husk and wood sawdust. In addition, SEM analysis indicated that OTP-char surface is higher than OTP surface with plenty of holes and channels. It makes the char an ideal support for metal retention specially for Pb metal (OTP retained 8.55 mg/g whereas OTP char retained 11.57 mg/g). On the other hand, metal retention occurred by adsorption or ion exchange, according to the IR spectrum of the samples. The results of thermogravimetric tests proved that the presence of lead did not have a strong effect on the decomposition of the samples, since TG and DTG curves were very similar. However, nickel increased the mass loss rate, accelerating the decomposition process, showing higher peaks in DTG curves. Additionally, for temperatures higher than 360 ℃, the volatilization of the samples was improved in the nickel-polluted sample, achieving a higher mass loss, getting more energy from the biomass and reducing the quantity of residues left after the process.

关键词： Biosorption Lead Metal-polluted biomass nickel Thermal decomposition Thermogravimetric analysis

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Luminescent Properties of the Mn<sup>2+</sup>Ion in Zinc Phosphate Glass

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Open Journal of Applied Sciences 2021年第11期11卷 1212-1217页

作者： Frida Lissete Flores Rivera Dulce Yolotzin Medina Velazquez Gabriela Verenice Arredondo martínez Jorge roberto Oliva Uc Carlos Eduardo Rodriguez Garcia Miguel Angel Barron-Meza Joan Reyes Miranda Autonomus Metropolitan University Material Area Mexico City Mexico Potosino Institute for Scientific and Technological Research Advanced Materials Division San Luis Mexico Faculty of Physics-Mathematics Autonomous University of Coahuila Saltillo Mexico

In the development of new optoelectronic devices, mainly those related to solid state technology (SSL), the generation of luminescent materials with high intensity in visible region and low cost is of vital importance. For this reason, this work presents the luminescent properties of zinc phosphate glasses doped with the manganese ion 2+. The manganese ion offers a series of advantages with respect to rare earths, such as a more accessible cost and an intense emission in the red color that make it a great candidate for the generation of new optoelectronic devices. The methodology for the synthesis is presented in this work, as well as its luminescent properties, for concentrations of 2%, 10%, 13% and 15% atomic.n>

关键词： Luminescence Manganese Advanced Glasses

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Inhibitory Effect of n,n-Dimethylhexadecylamine on the Growth of White-Rot Fungus Trametes versicolor(L.)in Wood

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Phyton-International Journal of Experimental Botany 2021年第1期90卷 193-206页

作者： Wilber Montejo-Mayo Eduardo Días-Rivera Mauro martínez-Pacheco Abril Munro-Rojas Enrique Ambriz-Parra Crisanto Velázquez-Becerra Universidad Michoacana de san nicolás de Hidalgo Facultad de Ingeniería en Tecnología de la MaderaCiudad UniversitariaMorelia58030México Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoCiudad UniversitariaMorelia58030México

Wood is an organic material that is a source of carbon of organisms called Wood-decay fungi,and to preserve the wood,various toxic compounds to man and the environment have been *** analyze the effect of n,nDimethylhexadecylamine(DMHDA)on wood attacked by the rotting fungus Trametes versicolor *** used an in vitro system to expose the fungus *** to different concentrations of the DMHDA(50,150 and 450µM).We quantified the diameter of mycelial growth and laccase activity,also,under these experimental conditions we studied morphological details of the organisms using different scanning equipment including scanning electron *** growth of *** exposed to DMHDA for 60 days,showed a concentration-dependent dose behavior,also,the electron microscopy analysis revealed that the morphology and mycelial density was affected by the DMHDA,showing a formation of atypical morphological and thickener ***,the pieces of wood treated with DMHDA and exposed to the fungus had a lower mass loss,after a period of 60 days of exposure,the values obtained were 0.7,1.0 and 0.5 g of mass lost for the control,LoC and LoDMHDA treatments ***-rot fungi have represented economic losses worldwide,the strategies used have been supported by toxic compounds for the *** DMHDA both in the Petri dish system and as a wood preservative was shown to significantly inhibit the growth of ***.

关键词： Wood-decay fungi n,n-dimethylhexadecylamine wood preservative

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Inhibition of Acinetobacter baumannii Biofilm Formation by Methanolic Extract of nothoscordum bivalve

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Advances in Microbiology 2018年第5期8卷 422-438页

作者： Hernández-Marín David Alejandro Munoz-Ortega martín Humberto Guevara-Lara Fidel Gúzman-Lucio Marco Antonio Sánchez-García Eduardo Laboratorio de Química Analítica Facultad de Ciencias BiológicasUniversidad Autónoma de Nuevo LeónSan Nicolás de los GarzaNuevo LeónMéxico Laboratorio de Patología Molecular Experimental Departamento de QuímicaCentro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientesMéxico Laboratorio de Biotecnología y Funcionalidad de Alimentos Departamento de QuímicaCentro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientesMéxico Departamento de Botánica Facultad de Ciencias BiológicasUniversidad Autónoma de Nuevo LeónMonterreyNuevo LeónMéxico

Acinetobacter baumannii is one of the most prevalent pathogens in nosocomial infections and has been cause of concern in recent years because, it has presented multiresistance to antibiotics and besides can form biofilms on biotic and abiotic surfaces like tissues and medical devices. Therefore, the search for new alternatives of natural origin to inhibit biofilm formation is being conducted. In the present investigation, sub-lethal concentrations (5.61 mg/mL, 3.74 mg/mL and 1.87 mg/mL) of methanolic extract of nothoscordum bivalve were evaluated, showing biofilm formation inhibition up to 40.8%, in one nosocomial isolated of A. baumannii by the microtiter biofilm formation assay using crystal violet. On the other hand, the concentrations of 5.61 mg/mL and 3.74 mg/mL, caused an overexpression (up to 15.4 times) in the genes involved in the formation of biofilm (abaI, bap and csuE);due to this, the interaction of the extract with the bacteria was analyzed by scanning electron microscopy (SEM) and cellular damage was observed in the structure and stability of biofilm.

关键词： Biofilm Sub-Lethal nothoscordum bivalve Acinetobacter baumannii

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Parkin and <i>LRRK2</i>/Dardarin Mutations in Early Onset Parkinson’s Disease in the Basque Country (Spain)

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Journal of Behavioral and Brain Science 2015年第3期5卷 101-108页

作者： J. F. martí Massó J. Ruiz-martínez C. Paisán-Ruiz A. Gorostidi A. Bergareche A. Lopez de Munain A. Alzualde J. Pérez-Tur Servicio neurologia Hospital Donostia San Sebastián Spain Center for Biomedical Research in neurodegenerative Diseases network (CIBERnED) Spain neurosciences Area Biodonostia Institute San Sebastián Spain Department of neuroscience University of Basque Country UPV-EHU San Sebastián Spain Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York USA Molecular Genetics Unit Instituto de Biomedicina de Valencia-CSIC Valencia Spain

We have performed a complete screening of the Parkin gene (PRKn2) and looked for ***2019Ser (G2019S) and ***1441Gly (R1441G) LRRK2/dardarin gene mutations in twenty seven patients with Parkinson’s disease (PD) with an age at onset younger than 50 years (EOPD), living in Gipuzkoa (Basque Country, Spain). Thirteen of them (48%) were PRKn2 mutation carriers. The c.255-256DelA mutation was the most frequent, followed by a deletion involving exons 3 and 4. A deletion involving exons 3 and 12 of the PRKn2 gene and R1441G LRRK2 mutation was found together in one PD patient. Four out of fourteen PRKn2 negative patients carried the p.G2019S mutation. Both PRKn2 mutation carriers and non-carriers presented frequently with family history (10 PRKn2 mutation carriers and 8 PRKn2 non-carriers);in fact, five patients without a known gene mutation had a first degree relative affected, suggesting another monogenic disease. PRKn2 carriers presented with a younger age at onset (36.7 vs. 41.7) and more benign disease progression. Indeed, those PD patients younger than forty who initially presented with unilateral tremor became shortly bilateral. Relatively, symmetric parkinsonism and slow disease progression carried more frequently PRKn2 mutations than patients with unilateral akinetic rigid parkinsonism and age at onset later than 40 years. As expected in a recessive disease, PRKn2 patients present more often with affected siblings and unaffected patients. The G2019S LRRK2 mutation, less prevalent than R1441G in our area, may be also a frequent cause of PD in EOPD (4 patients).

关键词： Parkin Early Onset Parkinsonism Parkinson’s Disease LRRK2 Dardarin

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Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?

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World Journal of Gastroenterology 2010年第25期16卷 3144-3152页

作者： Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio nach-man Horacio Vázquez Sonia niveloni Julio Argonz roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai Small Bowel Section Department of Medicine Gastroenterology Hospital "Dr. C. Bonorino Udaondo" Caseros 2061 Ciudad de Buenos Aires Argentina Pathology Service Hospital de Gastroenter-ología "Dr. C. Bonorino Udaondo" Av. Caseros 2061 Ciudad de Buenos Aires Argentina USnMA HIGA "San Martín" La Plata B1900 Provincia de Buenos Aires Argentina Endoscopy Service Hospital de Gastroenter-ología "Dr. C. Bonorino Udaondo" Av. Caseros 2061 Ciudad de Buenos Aires Argentina Endoscopy Service HIGA "San Martín" La Plata

AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. COnCLUSIOn: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects.

关键词： Celiac disease Serology Gliadin peptide antibodies Tissue transglutaminase Antigliadin antibodies Small bowel biopsy Diagnostic accuracy

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