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Current Medical Science 2019年第5期39卷 766-777页

作者： Xiao-qun HAN san-qing XU Jian-guo lin Department of Microbiology and Immunology Medical College of Yichun UniversityYichun 336000China Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China P3 Biosafety Laboratory Guangdong Second Provincial General HospitalGuangzhou 510317China Affiliated Nanyue Hospital Southern Medical UniversityGuangzhou 510317China

The activation of hepatic stellate cells(HSCs)is a major event during hepatic *** of intracellular lipid droplet(LD)formation turns the activated HSC back to a quiescent *** previous studies have shown that curcumin suppresses HSC activation through increasing peroxisome proliferator-activated receptor,gamma(PPARγ)and 5′adenosine monophosphate-activated protein kinase(AMPK)*** study aims at evaluating the effect of curcumin on lipid accumulation in HSCs and hepatocytes,and further elucidating the underlying *** we showed that curcumin increased LD formation in activated HSCs and stimulated the expression of sterol regulatory element-binding protein and fatty acid synthase,and reduced the expression of adipose triglyceride *** perilin5 expression in primary HSCs promoted LD *** 5 siRNA eliminated curcumin-induced LD formation in *** results suggest that curcumin recovers LD formation and lipid accumulation in activated HSCs by increasing perilipin 5 gene ***,inhibition of AMPK or PPARy activity blocked curcumin's effect on Plin5 gene expression and LD *** results provide a novel evidence in vitro for curcumin as a safe,effective candidate to treat liver fibrosis.

关键词： hepatic stellate cells lipid droplets perilipins curcumin liver fibrosis

Distribution and features of landslides in the Tianshui Basin, Northwest China

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Journal of Mountain Science 2020年第3期17卷 686-708页

作者： ZHANG Ze-lin WANG Tao WU Shu-ren China Agricultural University Beijing 100083China Chinese Academy of Geological Sciences Institute of Geomechanics Beijing 100081China

Landslides in Tianshui Basin, Gansu Province, Northwest China, severely affect the local population and the economy;therefore,understanding their evolution and kinematics is of great interest for landslide risk assessment and prevention. However, there is no unified classification standard for the types of loess landslides in *** this study, we explored the landslide distribution and failure characteristics by means of field investigation,remotesensinginterpretation,geological mapping, drilling exploration and shearwave velocity tests, and established a database of Tianshui landslides. Our analysis shows that shear zones in mudstone usually develop in weak intercalated layers. Landslides occur mainly along the West Qinling faults on slopes with gradients of 10° to 25° and on southeast-and southwest-facing *** landslides were classified into five types: loess landslides, loess–mudstone interface landslides, loess flow-slides, loess–mudstone plane landslides and loess–mudstone cutting landslides. We discussed the evolution and failure process of each landslide type and analyzed the formation mechanism and motion characteristics of large-scale landslides. The analysis results show that the landslides in the study area are characterized by a gentle slope, long runout and high risk. The relationship between the runout L and the vertical drop H of the large-scale landslides in the study area is L > 4 H. There are good correlations between the equivalent friction coefficient of largescale landslides and their maximum height, runout,area and volume. The sliding zone of large-scale landslides often develops in the bedrock contact zone or in a weak interlayer within mudstone. From microstructure analysis, undisturbed mudstone consists mainly of small aggregates with dispersed inter-aggregate pores, whereas sheared clay has a more homogeneous structure. linear striations are well developed on shear surfaces, and the clay pores in those surfaces have a more uni

关键词： Loess Plateau Landslide distribution large-scale landslide landslide types slide distance Qinling fault

Bootstrap inference of the skew-normal two-way classification random effects model with interaction

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Applied Mathematics(A Journal of Chinese Universities) 2022年第3期37卷 435-452页

作者： YE ren-dao AN Na LUO Kun lin Ya School of Economics Hangzhou Dianzi UniversityHangzhou 310018China Alibaba Business College Hangzhou Normal UniversityHangzhou 310016China

In this paper,we consider the statistical inference problems for the fixed effect and variance component functions in the two-way classification random effects model with skewnormal ***,the exact test statistic for the fixed effect is ***,using the Bootstrap approach and generalized approach,the one-sided hypothesis testing and interval estimation problems for the single variance component,the sum and ratio of variance components are discussed ***,the Monte Carlo simulation results indicate that the exact test statistic performs well in the one-sided hypothesis testing problem for the fixed *** the Bootstrap approach is better than the generalized approach in the one-sided hypothesis testing problems for variance component functions in most ***,the above approaches are applied to the real data examples of the consumer price index and value-added index of three industries to verify their rationality and effectiveness.

关键词： skew-normal two-way classification random effects model with interaction fixed effect variance component functions Bootstrap generalized approach

PREPARATION AND MAGNETIC PROPERTIES OF POLYMERIC COMPLEXES CONTAINING 1,10-PHENANTHROlinE

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Chinese Journal of Polymer Science 2006年第1期24卷 81-86页

作者： Hua-jiang Jiang Wei-lin Sun ren-hua Zheng Departrnent of Chemistry and Materials Taizhou Colledge Taizhou 317000 China Department of Polyrner Science and Engineering Zhejiang University Hangzhou 310027 China

A series of polymeric complexes were prepared from Fe^2＋, Co^2＋ or Ni^2＋ and poly（Schiff base）（DAPcIPA）, which was obtained by polycondensation of 5,6-diamino-1,10-phenanthroline （DAP） with isophthalaldehyde （IPA）. The structures of the polymer and the polymeric complexes were characterized by IR, 1^H-NMR and elemental analysis. The magnetic behavior of these complexes was measured as a function of magnetic field strength （0-3.98 ~ 106 A/m） at 5 K and as a function of temperature （5-300 K） at a magnetic field strength of 2.39 × 10^6 A/re. Experimental results show that DAPcIPA-Ni^2＋, DAPcIPA-Co^2＋ are soft ferromagnets while DAPcIPA-Fe^2＋ exhibits features of an antiferromagnet.

关键词： Synthesis Polymer containing phenanthroline Polymeric complexes Organic soft ferromagnets.

The SPH approach to the process of container filling based on non-linear constitutive models

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Acta Mechanica Sinica 2012年第2期28卷 407-418页

作者： Tao Jiang Jie Ouyang lin Zhang Jin-Lian ren Department of Applied Mathematics Northwestem Polytechnical University710129 Xi'anChina

In this work, the transient free surface of con- tainer filling with non-linear constitutive equation＇s fluids is numerically investigated by the smoothed particle hydrody- namics （SPH） method. Specifically, the filling process of a square container is considered for non-linear polymer fluids based on the Cross model. The validity of the presented SPH is first verified by solving the Newtonian fluid and Oldroyd- B fluid jet. Various phenomena in the filling process are shown, including the jet buckling, jet thinning, splashing or spluttering, steady filling. Moreover, a new phenomenon of vortex whirling is more evidently observed for the Cross model fluid compared with the Newtonian fluid case.

关键词： Non-linear. SPH Free surface Navier-Sto- kes Filling

Radix Ilicis Pubescentis total flavonoids ameliorates neuronal damage and reduces lesion extent in a mouse model of transient ischemic attack

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Neural Regeneration Research 2016年第3期11卷 441-446页

作者： Ming-san Miao lin Guo Rui-qi Li Xiao-lei Zhang College of Pharmacy Henan University of Traditional Chinese Medicine

Flavonoids are a major component in the traditional Chinese medicine Radix Ilicis *** studies have shown that the administration of Radix Ilicis Pubescentis total flavonoids is protective in cerebral ***,to our knowledge,no studies have examined whether the total flavonoids extracted from Radix Ilicis Pubescentis prevent or ameliorate neuronal damage following transient ischemic ***,Radix Ilicis Pubescentis total flavonoids question and the potential underlying ***,beginning 3 days before the induction of a mouse model of transient ischemic attack using tert-butyl hydroperoxide injections,mice were intragastrically administered 0.3,0.15,or 0.075 g/kg of Radix Ilicis Pubescentis total flavonoids daily for 10 *** results of spectrophotometric analyses demonstrated that Radix Ilicis Pubescentis total flavonoids enhanced oxygen free radical scavenging and reduced pathological alterations in the ***-eosin staining results showed that Radix Ilicis Pubescentis total flavonoids reduced hippocampal neuronal damage and cerebral vascular injury in this mouse model of transient ischemic *** results suggest that the antioxidant effects of Radix Ilicis Pubescentis total flavonoids alleviate the damage to brain tissue caused by transient ischemic attack.

关键词： nerve regeneration transient ischemic attack Radix Ilicis Pubescentis total flavonoids tert-butyl hydroperoxide malondialdehyde nitric oxide nitric oxide synthetase superoxide dismutase neural regeneration

Structural Evolution of UHMWPE Fibers during Poststretching with Distinct Initial Structures

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Journal of Wuhan University of Technology(Materials Science) 2023年第2期38卷 280-285页

作者： CAO Tian ren lin MENG lingpu CHEN Xiaowei WANG Ping School of Materials and Chemical Engineering Anhui Jianzhu UniversityHefei230601China National Synchrotron Radiation Lab CAS Key Laboratory of Soft Matter ChemistryUniversity of Science and Technology of ChinaHefei230026China

By adopting a homemade extension apparatus and wide-angle X-ray diffraction(WAXD)technique,the structural evolutions of the extracted ultra-high molecular weight polyethylene(UHMWPE)fibers with different spinning draw ratios were investigated during the poststretching *** chains oriented along the axis quickly at the early stage of drawing,which is quite different from the situation of drawing with *** crystal regions,which have not melted at higher temperature,show stronger rigidity in the absence of *** characteristics show faster response to the external ***,the surface morphologies of fibers after poststretching are characterized by scanning electron microscopy(SEM).The lamellae stack disordered before stretching,but arranged in order along the draw direction when the draw ratios were larger than 1.

关键词： UHMWPE fibre gel-spinning draw ratio WAXD SEM

Isogeometric Least-Squares Collocation Method with Consistency and Convergence Analysis

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Journal of Systems Science & Complexity 2020年第5期33卷 1656-1693页

作者： lin Hongwei XIONG Yunyang WANG Xiao HU Qianqian ren Jingwen School of Mathematical Science State Key Lab.of CAD&CGZhejiang UniversityHangzhou 310027China Department of Mathematics Zhejiang Gongshang UniversityHangzhou 310018China

This paper presents the isogeometric least-squares collocatio method,which determines the numerical solution by making the approximate differential operator fit the real differential operator in a least-squares *** number of collocation points employed in IGA-L can be larger than that of the *** analysis and numerical examples presented in this paper show the superiority of IGA-L over state-of-the-art collocation ***,a small increase in the number of collocation points in IGA-L leads to a large improvement in the accuracy of its numerical ***,IGA-L method is more flexible and more stable,because the number of collocation points in IGA-L is ***,IGA-L is convergent in some cases of singular ***,the consistency and convergence analysis are also developed in this paper.

关键词： Collocation method consistency and convergence least-squares fitting isogeometric analysis NURBS

Smoke suppressant in flame retarded thermoplastic polyurethane composites: Synergistic effect and mechanism study

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Nano Research 2021年第11期14卷 3926-3934页

作者： Hongyuan ren Kelan Qing Ying Chen Yanjun lin Xue Duan State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China

Considerable smoke and toxic volatiles generation has compromised the application of thermoplastic polyurethane (TPU) and caused a great threat to human life. Here, nano-MgFe layered double hydroxide (MgFe-LDH) with uniform particle size was synthesized to reduce smoke density and toxic gases of TPU composites using ammonium polyphosphate (APP) as a flame retardant agent. The results show that the combination of 16 wt.% APP and 4 wt.% MgFe-LDH greatly decreased the smoke density (D20min and Ds, max), smoke production rate (SPR) and heat release rate (HRR) of TPU composites. Furthermore, the MgFe-LDH synergist demonstrated high efficiency in decreasing total volatiled products and toxic volatiles evolved, such as the CO, HCN and isocyanates. The reason was mainly attributed to the chemical reaction between MgFe-LDH and APP, which can promote the compactness of char layers with fine microstructure formed in the decomposition process of MgFe-LDH/APP/TPU composites. The protective char layers could act as barriers between combustion zone and matrix to protect the unburned substrate and promote smoke suppression effect.

关键词： layered double hydroxide thermoplastic polyurethane smoke suppression synergistic effect

Recent advances in acoustofluidic separation technology in biology

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Microsystems & Nanoengineering 2022年第5期8卷 1-16页

作者： Yanping Fan Xuan Wang Jiaqi ren Francis lin Jiandong Wu School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Physics and Astronomy University of ManitobaWinnipegMB R3T 2N2Canada

Acoustofluidic separation of cells and particles is an emerging technology that integrates acoustics and *** the last decade,this technology has attracted significant attention due to its biocompatible,contactless,and labelfree *** has been widely validated in the separation of cells and submicron bioparticles and shows great potential in different biological and biomedical *** review first introduces the theories and mechanisms of acoustofluidic ***,various applications of this technology in the separation of biological particles such as cells,viruses,biomolecules,and exosomes are ***,we discuss the challenges and future prospects of this field.

关键词： fluid separation acoustics