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World Journal of Virology 2023年第3期12卷 193-203页

作者： Marcel silva Luz Fabian Fellipe Bueno Lemos samuel Luca Rocha Pinheiro Hanna Santos Marques Luís Guilherme de Oliveira silva Mariana Santos Calmon Karolaine da Costa Evangelista Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been a major challenge to be faced in recent *** adults suffered the highest morbidity and mortality rates of coronavirus disease 2019,children were thought to be exclusively asymptomatic or to present with mild ***,around April 2020,there was an outbreak of a new clinical syndrome related to SARS-CoV-2 in children-multisystemic inflam-matory syndrome in children(MIS-C)-which comprises a severe and uncon-trolled hyperinflammatory response with multiorgan *** Centers for Disease Control and Prevention considers a suspected case of MIS-C an individual aged2)organ involvement,no alternative plausible diagnoses,and positive for recent SARS-CoV-2 *** its severity,there are no definitive disease management guidelines for this ***,the complex pathogenesis of MIS-C is still not completely understood,although it seems to rely upon immune ***,in this study,we aim to bring together current evidence regarding the pathogenic mechanisms of MIS-C,clinical picture and management,in order to provide insights for clinical practice and implications for future research directions.

关键词： Pediatric multisystem inflammatory disease COVID-19 related Multisystem inflammatory syndrome in children COVID-19 SARS-CoV-2 Etiology Disease management

The Quality of Life for People with Parkinson’s Disease in Relation to Their Oral Health

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Open Journal of Stomatology 2018年第11期8卷 312-318页

作者： Phablo Glewber Torres Bezerra samuel Rodrigo de Andrade Veras Camila Caroline da silva Renato Mariano da silva Deivison Edson Pereira da silva Eduardo Borges da Costa Leite Maria das Gracas Wanderley de Sales Coriolano Carla Cabral dos Santos Accioly Lins Federal University of Pernambuco RecifeBrazil Department of Prosthodontics and Oral and Maxillofacial Surgery Federal University of PernambucoRecifeBrazil Department of Anatomy Federal University of PernambucoRecifeBrazil

The present study aimed to evaluate the correlation between the oral health status and the quality of life for people with Parkinson’s disease. The Decayed, Missing, Filled (DMFT) index and the quality of life questionnaire for people with Parkinson’s disease (Parkinson’s Disease Questionnaire-39) were used as evaluation instruments. Sixty-two people with a clinical diagnosis of Parkinson’s disease between stages 1 and 3, age between 46 and 86 years, of both sexes, with an average time of disease evolution of 7 years, participated in the study. Data were evaluated using the Pearson’s correlation test, and one-way ANOVA (p < 0.05). The mean DMFT obtained was 23;there was no correlation between the DMFT values and the total score of the Parkinson’s Disease Questionnaire-39 neither in its domains, nor between the DMFT and the stages of Parkinson’s disease (p = 0.61). We found that the oral health of parkinsonians is deficient due to the high number of missing teeth, but their perception of quality of life is favorable despite their motor limitations related to mobility, and activities of daily living.

关键词： Parkinson’s Disease Quality of Life DMFT Index

Viscum Album Modulates Apoptotic Related Genes in Melanoma Tumor of Mice

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American Journal of Molecular Biology 2014年第2期4卷 49-58页

作者： Anamaria da silva Facina Gil Facina Ismael Dale Cotrim Guerreiro da silva Giovana Aparecida Goncalves Fernando Augusto de Almeida silvana Aparecida Alves Correa de Noronha samuel Marcos Ribeiro de Noronha Mary Uchiyama Nakamura Departament of Dermatology Federal University of Sao PauloSao PauloBrazil Department of Gynecology Federal University of Sao PauloSao PauloBrazil Department of Surgery Federal University of Sao PauloSao PauloBrazil Departament of Obstetrics Federal University of Sao PauloSao PauloBrazil

Cancer is a major public health problem throughout the world. It is estimated that one third of the American population will develop the disease at some time during their lifetimes. Among these, melanoma will account for 7% of the cases. In Brazil, in 2012, it is estimated that over six thousand new melanoma cases occurred. During recent years, the incidence of melanoma has increased, mainly due to a more constant exposure of the skin to sunlight. In this work, our aim is to assess the expression of apoptotis-related genes melanoma tumors in mice treated with Viscum album (VA). This will allow us to better understand the molecular mechanisms underlying tumor cell death activation caused by this compound. Our results clearly demonstrate upregulation of pro apoptotic genes (Trp53bp2, Nol3, Fadd, Tnfsf10, Traf1, Traf2, Cflar, Card10, Nod1, Casp 2, Casp7, Xiap, Dad1, and Dffb). Further bioinformatics-based tool analysis allowed us to assess which specific cell death-related intracellular pathways were activated by VA treatment. Two major effects of VA in melanoma cells could be observed: generation of an immunomudulatory Th-1 like action, recruiting several interleukines, and cell death activation through Caspase7, associated uspstream with Card10 and downstream with CAD. In summary, VA modulates apoptosis related genes in cancer melanoma cells. Although a deeper study should be conducted, VA seems to interfere with important signaling pathways within melanoma cells that control the cellular mechanisms of apoptosis activation. Therapeutic approaches using VA as an antineoplastic and adjuvant medication compounding should be considered.

关键词： Viscum Album Melanoma Apoptosis Pathways PCR Array Immunohistochemistry

Thermomechanical Behavior and Corrosion Resistance of a 316 L Austenitic Stainless Steel

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Materials Sciences and Applications 2020年第4期11卷 217-233页

作者： Rafael P. Ferreira Carmem C. F. Nascimento Gedeon S. Reis Eden S. silva samuel F. Rodrigues Graduate Program in Materials Engineering Federal Institute of Education Science and Technology of Maranhao (IFMA) Sao Luis Brazil

Hot-formed components are constantly exposed to hostile environments with corrosive substances. Microstructural changes caused by thermomechanical processing can be predicted to increase the corrosion resistance of austenitic stainless steels. The objective of this study is to understand the relationship between the dynamic softening mechanisms and corrosion resistance, thus optimizing the hot-forming process. In the current work, the dynamic recrystallization (DRX) behavior of AISI 316 L austenitic stainless steel was studied in the temperature range of 1273 - 1423 K and strain-rate range of 0.1 - 5.0 s-1 using physical simulation. Subsequently, potentiodynamic polarization tests and scanning electron microscopy were performed on the hot-deformed samples to investigate the influence of temperature and strain-rate on the corrosion resistance and mechanical properties. The results indicated that the DRX fractions increased under low-temperature and high strain-rate conditions, resulting in grain refinement. The potentiodynamic polarization tests indicated that the dynamically recovered samples demonstrated high resistance to corrosion compared with the DRX samples. The best route found for the investigated alloy was for the strain to be applied at a temperature of 1423 K and a strain rate of 0.1 s-1.

关键词： 316 L Austenitic Stainless Steel Softening Phenomena Corrosion

Enhancing Smart Grid with Session-Oriented Communication System to Truly Support Reliability and Robustness

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Smart Grid and Renewable Energy 2012年第4期3卷 260-265页

作者： Augusto V. Neto Helber W. da silva Eduardo C. Cerqueira Jose Neuman de Souza Luci Pirmez Danielo G. Gomes Flavia C. Delicato Rui L. aguiar Computer Engineering (ENGCOMP) Federal University of Pará (UFPA) Belém Brazil Department of Informatics Engineering (DETI) Federal University of Ceará Fortaleza Brazil Federal Institute of Rio Grande do Norte (IFRN) Natal Brazil Federal University of Rio de Janeiro (UFRJ) Rio de Janeiro Brazil. Group of Computer Communications Software Engineering and Systems (GREat) Fortaleza Brazil Telecommunication’s Institute (IT) Aveiro Portugal

Environmental sustainability issues and the costs of new power generation and transmission have increased the interest in evolving current power grid to new technologies. The Smart Grid is a promising technology, since it allows a distributed computing approach with potentials for self-diagnosing/-healing, reliable multi-user communication and fast hard real-time control. However, the missing standardization associated with heterogeneity of legacy systems and wide-area service demands, makes very challenging to adopt Smart Grid in a cost-effective way. By considering this, we propose the Session-Oriented Communication System (SOCSys) to overcome the above issues by enhancing Smart Grid with truly reliable and robust capabilities over heterogeneous environments. SOCSys achieves this goal by orchestrating session-control with innovative network-centric facilities operating over a wireless mesh Information Network compliant with IEEE 802.11e/s standard. The simulation results show that SOCSys improved network performance in terms of bandwidth utilization and minimization of delay, while consuming low network resources. Graphical analyses showed that SOCSys supported multimedia sessions with excellent quality, where it outperforms the experiments with regular settings.

关键词： Smart Grid Session Control Quality of Service IP Multicast Wireless Mesh Networks

Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

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World Journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel silva Luz samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GML following bacterial *** We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September *** and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in ***-positive *** risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GML patients,in whom *** was successfully eradicated,were incl

关键词： Lymphoma B-cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy

Musculoskeletal Tuberculosis in Dermatomyositis: Association or Coincidence?

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Open Journal of Rheumatology and Autoimmune Diseases 2014年第1期4卷 58-61页

作者： Andressa silva Abreu Geórgea Hermogenes Fernandes Eduardo Ferreira Borba Lissiane Karine Noronha Guedes Jéssica Fernandes Ramos samuel Katsuyuki Shinjo Division of Rheumatology and Infectious Disease Department Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil.

Dermatomyositis is a rare idiopathic inflammatory myopathy characterized by proximal muscle weakness associated with typical skin abnormalities and compatible electromyographic finds. Tuberculosis could determine several clinical manifestations but the classic one is the lung presentation. Among the extra pulmonary manifestations of tuberculosis, the musculoskeletal form is rare and it is usually a direct extension of the bone involvement nearby. In the present study, the authors described two dermatomyositis patients and musculoskeletal tuberculosis. In both cases, there was presence of bilateral tenosynovitis, which is considered atypical for further infectious.

关键词： Dermatomyositis Tenosynovitis Tuberculosis

Bibliographical Review on Rehabilitation of Executive Functions in Patients With Developmental Coordination Disorder(DCD)

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Psychology Research 2024年第2期14卷 45-56页

作者： Keiko da Costa Oikawa Fabrício Bruno Cardoso Filipe M.Bonone samuel Pereira de Souza Vitor da silva Loureiro Alfred Sholl-Franco Faculdade Censupeg JoinvilleBrazil Faculdade Censupeg JoinvilleBrazil Universidade Federal do Rio de JaneiroRio de JaneiroBrazil

The present study aims to establish a literature review on intervention programs for executive functions(EFs)through the use of fundamental motor skills,from a neuropsychopedagogical perspective in subjects with Developmental Coordination Disorder(DCD).An exploratory study was carried out through an integrative literature *** research was carried out in the Scientific databases Electronic Library Online(SciELO),Latin American and Caribbean Literature in Health Sciences(LILACS),Virtual Health Library-Psychology Brazil(BVSPSI),Electronic Journals of Psychology(PePSIC),in the periodicals available in the Brazilian Digital Library of Theses and Dissertations(BDTD)and on the website of the Coordination for the Improvement of Higher Education Personnel(CAPES).The covering publications took place from 2018 to 2023,14 articles were selected for *** literature review made it possible to create strategies for stimulating EF and Visuomotor Functions so that educators and other professionals can better deal with students with *** was perceived the need to carry out and develop more empirical research regarding the intervention of EFs and Visuomotor Functions by educators and professionals,with a greater sampling amplitude,to increase the number of studies that enable interventions both in children and in teenagers with DCD.

关键词： developmental coordination disorder executive functions school neuropsychology stimulation of executive functions

Impacts of Residual Phosphorus on the Production of Cowpea in the Cerrado Region

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American Journal of Plant Sciences 2018年第4期9卷 645-658页

作者： Jair da Costa Gaspar Marileia Barros Furtado Welder José dos Santos silva Isaías dos Santos Reis Nítalo André Farias Machado Maryzélia Furtado de Farias Jomar Livramento Barros Furtado Hosana aguiar Freitas de Andrade Raquel da silva Sobral Luisa Julieth Parra-Serrano Khalil de Menezes Rodrigues Raissa Rachel Salustriano silva-Matos Center of Agrarian Sciences and Environmental Federal University of Maranhao Chapadinha Brazil Center of Agrarian Sciences Federal University of Piauí Teresina Brazil Faculty of Agrarian and Veterinary Sciences State University Paulista Júlio de Mesquita Filho UNESP Sao Paulo Brazil Exact and Technological Science Center State University of Western Paraná Cascavel Brazil

Phosphate fertilizers when applied to the soil, besides being harvested by the crops, promote a residual effect that can be offered to subsequent crops. The objective of this research was to evaluate the residual effect of phosphate fertilization applied to maize cultivation on the successor crop, cowpea, in the Cerrado region in Maranhao. The research was carried out in the experimental area of Federal University of Maranhao (UFMA), located in the city of Chapadinha, MA (3°44'30"S, 43°21'37''W). The experimental design was in randomized blocks, with six treatments and four replications. The treatments were composed of the following residual P doses: 0, 60, 70, 80, 90, 100 kg·ha-1 of P2O5. The cultivation of cowpea (cultivar BRS guariba) was sown at a spacing of 1.0 × 0.20 m. The cowpea proved to be efficient in the use of residual phosphate fertilization, since it promoted grain yield close to the national average. The cultivation of cowpea in previously cultivated areas is feasible, in order to take advantage of the residual phosphate fertilization in the Cerrado of East of Maranhao. The phosphorus dose applied in the predecessor crop corresponding to 80 kg·ha-1 of P2O5 promoted higher grain yield (393.44 Mg·ha-1) and a greater profit margin (US $326.26). Thus, it is feasible to grow cowpea in previously cultivated areas, in order to take advantage of residual phosphate fertilization.

关键词： Fertilizing Vigna unguiculata L. Walp Phosphate Fertilization Residue

Alkaline phosphatase-positive cells isolated from human hearts have mesenchymal stem cell characteristics

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Stem Cell Discovery 2011年第3期1卷 71-80页

作者： Alessandra Melo de aguiar Crisciele Kuligovski Marise Teresinha Brenner Affonso da Costa Marco Augusto Stimamiglio Carmen Lúcia Kuniyoshi Rebelatto Alexandra Cristina Senegaglia Paulo Roberto Slud Brofman Bruno Dallagiovanna samuel Goldenberg Alejandro Correa 不详

Tissue-specific resident cells have been identified as a promising population of progenitor cells for cell-based therapies. We describe here the isolation from adult human hearts of tissue nonspecific alkaline phosphatase-positive cells (ALPL+ cells) with mesenchymal stem cell (MSC) characteristics. Samples from 24 adult cadaveric donors were obtained from a valve bank. Mean total ischemia time was 21.5 ± 9.1 hours. The success rate for the isolation of human heart-derived cells by the explant culture technique was 70% for the right auricle (14 of 20 trials) and 33% for the right ventricle (7 of 21 trials). The total auricle-derived cell population (TAD) was used for the purification of ALPL+ cells. TAD and ALPL+ cells expressed markers for MSC and pericytes. TAD cells and ALPL+ cells differentiated into adipocytes, osteoblasts and chondroblasts, and ALPL+ cells expressed markers of these three lineages more strongly than TAD cells, as shown by RT-PCR. This population therefore has a greater potential for differentiation into mesechymal lineages than TAD cells. Both cell populations express some markers of cardiac progenitors, such as GATA4, CD117 and VEGF. ALPL+ cells expressed troponin T and ABCG2, which are also markers of the cardiac lineage. Heart samples from tissue banks could be considered as sources of MSC with putative commitment towards cardiac lineages, even after prolonged ischemia times.

关键词： Alkaline Phosphatase Mesenchymal Stem Cell Pericyte Heart Cell Differentiation