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Human Visual Acuity in Analysis of Intervention in the Landscape of Coxilha Rica/Brazil

Journal of Geographic Information System 2020年第2期12卷 70-83页

作者： Vivian Da silva Celestino Reginato samuel Abati Department of Civil Engineering Federal University of Santa Catarina (UFSC) Florianopolis Brazil CGT Eletrosul Centrais Elétricas Florianópolis Brazil

The Drovers’ Paths are remnants of important land access roads from Rio Grande do Sul to São Paulo at the time of Colonial Brazil. They were built and used between the 18th and 20th centuries, particularly in the region of Coxilha Rica. The main objective of this research is to develop a method for decision-making applied to the territorial landscape management in the Coxilha Rica. The method consisted of generating criteria to map the visibility spot reached from the main selected points;define the human visual acuity, realize bibliographic research, use cartographic and historical documents, inter-views, as well as field surveys that enabled the identification, characterization and mapping of historical farms and drovers’ paths. After data processing, the information was entered into the cartographic database;the data were cross-checked and analysis was made of the visibility of the surrounding farms and stone-walled corridors. Quality assessments showed that, with the visibility polygons, and through the use of cartographic tools, we could cross-check between different levels of information and analyze landscape intervention alternatives in order to minimize environmental impacts. When applying the method in the Coxilha Rica it was possible mapping the visibility polygon, taking human visual acuity into consideration, based on historical farms and stone-walled corridors;and making spatial analyses to explore alternatives to intervention (installation of power transmission systems) in order to preserve the scenic environment of the region. In the end, the decision was by does not construct the system.

关键词： Territorial Management Drovers’ Path Visibility Study Human Visual Acuity

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The case of the missing appendix:a case report of appendiceal intussusception at the site of colonic mullerianosis

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Gastroenterology Report 2017年第4期5卷 309-312,I0003页

作者： Federico P Quirante Lisandro M Montorfano Federico Serrot Mary E Billington Giovanna Da silva Emanuele Lo Menzo samuel Szomstein Raul J Rosenthal Department of Surgery Cleveland Clinic FloridaWestonFLUSA

Right lower quadrant pain is a symptom with an exceptionally broad differential *** of the appendix is a very uncommon condition with many ***,the pathologic finding of ectopic presence of a mixture of at least two mullerian-derived tissue components is *** report presents the case of a 49-year-old woman who presented twice with acute right lower abdominal *** of appendiceal inversion was made *** examination of the specimen identified extensive endometriosis,endosalpingiosis and endocervicosis of the colon *** intussusception and colonic mullerianosis,present together,are discussed,and recommendations for the diagnosis and treatment of appendiceal intussusception are discussed.

关键词： appendix appendiceal intussusception mullerianosis endocervicosis

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Biomass-glycerol briquettes are not necessarily mechanically stable and energetically effective

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Waste Disposal and Sustainable Energy 2020年第4期2卷 291-303页

作者： Bruno Rafael de Almeida Moreira Ronaldo da silva Viana samuel Dias Moreira Monique dos Santos Lima Anderson Chagas Magalhães Celso Tadao Miasaki JoséClaudio Caraschi Department of Phytosanitary Rural Engineering and SoilsSchool of EngineeringSão Paulo State University(Unesp)Ilha SolteiraSão PauloBrazil Department of Plant Production College of Agricultural and Technological SciencesSão Paulo State University(Unesp)DracenaBrazil São Paulo State University(Unesp) ItapevaSão PauloBrazil

The re-use of glycerol from biodiesel industry as an alternative lubricant for making high-performance briquettes is ***,the technical performance of this agro-industrial residue is not *** study outlines,accordingly,the real risk of introducing glycerol into the co-briquetting of highly caloric by-products of *** production of hybrid briquettes consisted of pressing mixtures of residues of sugarcane and sorghum with the liquid additive at 10,20,and 30 wt.%in bench-scale hydraulic piston presser *** of the blend,briquettes containing the supplement at the highest level as part of their composition ended up being much more hygroscopic(20.10%)and less energetic(3.15 GJ m^(−3)).The explanation for the negative impact of glycerol on the thermomechanical behavior of briquettes would be overconcen-tration of additive capable of effectively defying compacting *** degree of compaction during co-briquetting has likely gone down quickly with a maximizing level of *** long as the additive is not able to lubricate the feedstock suitably,improbability of biomass particles to successfully bond together to form themselves into mechanically stable and energetically effective briquettes is *** lower density(273.80 kg m^(−3))and higher relaxation(22.75%),briquettes with glycerol at 30 wt.%generally were aesthetically ***,these products resisted no longer to handling,transportation,and *** lost their shape easily during emptying and shifting them,thus,releasing larger quanti-ties of biomass to the *** evidence of high-viscosity glycerol capable of limiting safe and effective production of high-performance briquettes for heating and power exists.

关键词： Additive Agro-residues Densification Biosolids Waste-to-energy

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Neoarchean and Rhyacian TTG-Sanukitoid suites in the southern S?o Francisco Paleocontinent,Brazil:Evidence for diachronous change towards modern tectonics

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Geoscience Frontiers 2020年第5期11卷 1763-1787页

作者： Henrique Bruno Vitalino Elizeu Monica Heilbron Claudio de Morisson Valeriano Rob Strachan Mike Fowler samuel Bersan Hugo Moreira Ivo Dussin Luiz Guilherme do Eirado silva Miguel Tupinamba Julio Almeida Carla Neto Craig Storey Universidade Do Estado Do Rio de Janeiro Faculdade de GeologiaTektosGrupo de Pesquisa Em GeotectonicaRua Sao Francisco Xavier 524MaracanaRio de JaneiroBrazil University of Portsmouth School of Earth and Environmental SciencesBurnaby BuildingBurnaby RoadPortsmouthUK Universit€at Salzburg Department of Geography and GeologyKapitelgasse4-65020SalzburgAustria Universidade Federal de Ouro Preto Departamento de GeologiaCampus Morro Do CruzeiroOuro PretoMGBrazil Laboratorio de Geocronologia e Isotopos Radiog^enicos Universidade Do Estado Do Rio de JaneiroRua Sao Francisco Xavier 524MaracanaRio de JaneiroBrazil

The southern portion of the Sao Francisco Palaeocontinent in Brazil is denoted by Archean nuclei and Paleoproterozoic magmatic arcs that were amalgamated during Siderian to Orosirian orogenic processes(ca.2.4-2.1 Ga).New isotopic U-Pb in zircon and Sm-Nd whole rock combined with major and trace element composition analyses constrain the crystallization history of the Neoarchean Piedade block(at ca.2.6 Ga)and the Paleoproterozoic Mantiqueira Complex(ca.2.1-1.9 Ga).These therefore display quite different magmatic histories prior to their amalgamation at ca.2.05 ***-Nd and Rb-Sr isotopes imply a mixed mantle-crustal origin for the samples in both units.A complete Palaeoproterozoic orogenic cycle,from subduction to collision and collapse,is recorded in the Piedade Block and the Mantiqueira *** to Orosirian subduction processes(ca.2.2-2.1 Ga)led to the generation of coeval(ca.2.16 Ga)TTG suites and sanukitoids,followed by late(2.10-2.02 Ga)high-K granitoids that mark the collisional *** collisional accretion of the Mantiqueira Complex against the Piedade Block at 2.08-2.04 Ga is also recorded by granulite facies metamorphism in the latter terrane,along the Ponte Nova suture *** collisional stage was closely followed by the emplacement of within-plate tholeiites at ca.2.04 Ga and by alkaline rocks(syenites and enriched basic rocks)at ca.1.98 Ga,marking the transition to an extensional tectonic *** discovery of two episodes of TTG and sanukitoid magmatism,one during the Neoarchean in the Piedade Complex and another during the Rhyacian in the Mantiqueira Complex,indicates that the onset of subduction-related melting of metasomatized mantle was not restricted to Neoarchean times,as generally believed,but persisted much later into the Paleoproterozoic.

关键词： Geodynamics High Ba–Sr granitoids Diachronous TTG-Sanukitoid transition Paleoproterozoic Mantiqueira complex

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Transmission of severe acute respiratory syndrome coronavirus 2 via fecal-oral:Current knowledge

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World Journal of Clinical Cases 2021年第28期9卷 8280-8294页

作者： Filipe Antônio França da silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Hanna Santos Marques Ronaldo Teixeira da silva Júnior Lorena Sousa de Carvalho samuel de Sousa Cruz Gabriel Reis Rocha Gabriel Lima Correa Santos Kathlen Coutinho de Souza Rebeca Gabrielle Almeida Maciel Daiana silva Lopes Natália Oliveira e silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Ciências Naturais Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Bioquímica e Biofísica Universidade Federal da BahiaSalvador 40.110-100BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 93 million cases and 2 million deaths in the ***-CoV-2 respiratory tract infection and its main clinical manifestations such as cough and shortness of breath are well known to the scientific ***,a growing number of studies have reported SARS-CoV-2-related gastrointestinal involvement based on clinical manifestations,such as diarrhea,nausea,vomiting,and abdominal pain as well as on the pathophysiological mechanisms associated with coronavirus disease ***,current evidence suggests SARS-CoV-2 transmission via the fecal-oral route and aerosol ***,studies have shown a high risk of contamination through hospital surfaces and personal ***,viable SARS-CoV-2 specimens can be obtained from aerosols,which raises the possibility of transmission through aerosolized viral particles from ***,the infection by SARS-CoV-2 via fecal-oral route or aerosolized particles should *** addition,a possible viral spread to sources of drinking water,sewage,and rivers as well as the possible risk of viral transmission in shared toilets become a major public health concern,especially in the least developed *** authors have emphasized the presence of viral RNA and even viable SARS-CoV-2 in human feces,studies on the possible fecal-oral coronavirus disease 2019 transmission become essential to understand better the dynamics of its transmission and,then,to reinforce preventive measures against this infection,leading to a more satisfactory control of the incidence of the infection.

关键词： COVID-19 SARS-CoV-2,Transmission Via fecal-oral

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Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors

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World Journal of Clinical Cases 2022年第31期10卷 11283-11291页

作者： Fabrício Freire de Melo Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel silva Luz samuel Luca Rocha Pinheiro Lorena Sousa de Carvalho Cláudio Lima Souza Márcio Vasconcelos Oliveira Institution Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

Helicobacter pylori(***)is a Gram-negative bacterium that infects about half of the world's *** infection prevails by several mechanisms of adaptation of the bacteria and by its virulence factors including the cytotoxin associated antigen A(CagA).CagA is an oncoprotein that is the protagonist of gastric carcinogenesis associated with prolonged *** *** this sense,small regulatory RNAs(sRNAs)are important macromolecules capable of inhibiting and activating gene *** function allows sRNAs to act in adjusting to unstable environmental conditions and in responding to cellular stresses in bacterial *** discoveries have shown that nickelregulated small RNA(NikS)is a post-transcriptional regulator of virulence properties of ***,including the oncoprotein ***,high concentrations of nickel cause the reduction of NikS expression and consequently this increases the levels of *** addition,NikS expression appears to be lower in clinical isolates from patients with gastric cancer when compared to patients *** that in mind,this minireview approaches,in an accessible way,the most important and current aspects about the role of NikS in the control of virulence factors of *** and the potential clinical repercussions of this modulation.

关键词： Helicobacter pylori Small regulatory RNAs Nickel-regulated small RNA Virulence factors Cytotoxin associated antigen A Gastric cancer

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Previous Pulmonary Fibrosis in Dermatomyositis/Polymyositis: A Predictive Factor for Pulmonary and Extra-Pulmonary Tuberculosis

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Open Journal of Rheumatology and Autoimmune Diseases 2018年第4期8卷 99-110页

作者： Taysa Cristiane Moreira da silva Adriana Coracini Tonacio de Proenca samuel Katsuyuki Shinjo Division of Rheumatology Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Infectious and Parasitic Diseases Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil

Objective: With scant studies in the literature, little is known about the risk factors for tuberculosis in patients with dermatomyositis/polymyositis. Therefore, the aim of the present study was to analyze the predictive factors for tuberculosis development in dermatomyositis/polymyositis. Methods: This single-center, retrospective, cohort study initially included 290 patients with dermatomyositis/polymyositis, from 2002 to 2016. Tuberculosis (pulmonary and/or extra-pulmonary) was confirmed after dermatomyositis/polymyositis diagnosis in 12 patients (4.1%) (Tuberculosis+ group). For the control group (Tuberculosis−), 24 patients without tuberculosis were arbitrarily selected in the same period and matched for age, ethnicity, gender, age at disease diagnosis, disease duration and type (dermatomyositis or polymyositis). Results: Tuberculosis occurred for a median of 16 months after dermatomyositis/polymyositis diagnosis. Clinical, laboratory and treatment features were similar in Tuberculosis+ and Tuberculosis−groups (P > 0.05). However, previous pulmonary fibrosis in dermatomyositis/polymyositis was more prevalent in the Tuberculosis+ group (41.7 vs. 8.3%;P = 0.029). Moreover, on a multivariate logistic regression model, pulmonary fibrosis was significantly associated with Tuberculosis (Odds ratio: 9.59, 95% confidence interval: 1.17 - 78.82). Tuberculosis affected 3 dermatomyositis cases for every 1 polymyositis case, with predominantly pulmonary followed by extra-pulmonary involvement (pleura, cutaneous, muscular, joint, soft tissue and hematologic). Two or more sites were affected in 41.7% of cases. Conclusions: Previous pulmonary fibrosis in dermatomyositis/polymyositis was a predictive factor associated with tuberculosis development. Further studies are needed to confirm these results.

关键词： Dermatomyositis Infectious Myositis Polymyositis Tuberculosis

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Characterization of the Sexual Self- and Cross-Compatibility in Genotypes of Cacao

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American Journal of Plant Sciences 2018年第9期9卷 1794-1806页

作者： samuel Martins de Jesus Branco Daniela Viana da silva Uilson Vanderlei Lopes Ronan Xavier Corrêa Universidade Estadual de Santa Cruz Ilhéus Brazil Centro de Pesquisas do Cacau (CEPEC/CEPLAC) Ilheus Brazil

Cacao is a tree crop of high economic importance and the subject of several studies aiming the genetic improvement of the species with the incorporation of characteristics that are agronomically important to create superior genotypes. In this context, this study aimed to characterize 22 genotypes of cacao for sexual compatibility, which is a trait that is strongly associated with yield. Additionally, we identify genotypes incompatible with clone TSH-1188 through controlled intercrosses, due to the great importance of this clone in cocoa breeding. Fifteen genotypes were characterized as self-incompatible and other seven as self-compatible, considering the retention index (20%) of self-pollinated flowers. Nine genotypes were characterized for the first time: CCN-16, COCA-3310, COCA-3370/5, EB-1017, IMC-119, IMC-97, LCTEEN-37A, NA-45, and UF-612. Cacao genotypes showed flower retention index ranging from 0.0% to 55.1% after 15 days of self-pollinations. The number of retained flowers varied after self-pollination of cacao genotypes at 1, 5 and 15 days after pollination. CCN-51, Catongo, CCN-10 and P-4B, were the genotypes with minor losses of flowers after 15 days of pollination, while IMC-119 and TSH-516 had 100% of loss of flowers between 1 and 5 days after pollination. Moreover, the flower retention index 15 days after cross-pollination with TSH-1188 ranged from 0.0% to 87.5% among the tested genotypes. The results of cross-pollinations identified two genotypes that are incompatibles, EB-1017 and IMC-119. This result is important for future allelic studies of incompatibility in cacao, because it might indicate that these genotypes share the same self-incompatibility allele(s). We conclude, therefore, that this study enable the characterization of this working collection of cocoa germplasm for sexual compatibility and this information is important for subsequent crosses between cacao genotypes.

关键词： Breeding System Pollination Retention Index Cocoa Germplasm Theobroma cacao

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Leptin Signaling Modulates Expression of Polycomb and Trithorax Complexes in the Brain of Fat Tissue Implanted Polycystic Ovarian Sindrome Mice

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American Journal of Molecular Biology 2014年第4期4卷 177-192页

作者： Eduardo Henrique da silva Freitas samuel Marcos Ribeiro de Noronha Maria Nazareth Gamboa Ritto Carlos Fernandes Baptista Ismael Dale Cotrim Guerreiro da silva silvana Aparecida Alves Correa-Noronha Ivaldo da silva Gynecology Department Federal University of Sao Paulo Paulista School of Medicine (UNIFESP-EPM) Sao Paulo Brazil General Medicine Department Federal University of Rio de Janeiro State (UNIRIO) Rio de Janeiro Brazil Translacional Surgery Division Surgery Department Federal University of Sao Paulo Paulista School of Medicine (UNIFESP-EPM) Sao Paulo Brazil General and Specialized Surgery Department Federal University of Rio de Janeiro State (UNIRIO) Rio de Janeiro Brazil

The Polycystic Ovary Syndrome (PCOS) is the most common androgenic disorder in women during reproductive life. PCOS may also be accompanied by metabolic syndrome and recent studies point to leptin as playing a role in disrupting infertility and in changing the energy balance in obese mice through its action on the hypothalamus. The aim is to assess the expression of the Polycomb & Trithorax Complexes genes in brain of mice transplanted with fat tissue from normal mice, in order to better understand the neuronal mechanisms underlying the reversion of PCOS. Three B6 V-Lepob/J mouse groups: Normal weight, obese and seven-day-treatment obese had their brain RNA extracted and submitted to an 84 Polycomb & Trithorax Complexes genes PCR Array plate and MetacoreTM pathways localization. Genomic profiles obtained were compared to the ones of the normal-weight-mice group. Differentially expressed genes were 13% and 26% respectively to control and treatment. Major changes were in genes: Snai1/31;Smarca1/?17;Dnmt3b/4.7;Ezh1/ 15. Altered genes were associated to canonical pathways and provided 3 networks related to epigenetics. Underlying neuronal changes caused by leptin in obese mice brain, there is an important role being played by the histone code. Here there is evidence that leptin drives the chromatin packing to a more condensed pattern. Upregulation of methyltransferase genes, like Ezh1, favors this thought. In summary the Polycomb & Trithorax complexes might answer for the silencing of some downregulated genes in the obese mice brain when exposed to leptin.

关键词： Polycistic Ovarian Sindrome Obesity Polycomb and Trithorax Complexes Leptin Fat Mouse

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Kaphta:Text mining web tool to extract information on the anticancer activity of polyphenols

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Journal of Polyphenols 2022年第2期4卷 87-100页

作者： Ramon Gustavo Teodoro Marques da silva samuel Lucas Santos Gomes Paulo Muniz deÁvila Gustavo Joséda silva Ana Lucia Fachin Edilson Carlos Caritá Mozart Marins Biotechnology Unit University of Ribeirão PretoAv.Costábile Romano 2201Ribeirão PretoSP 14096-900Brazil Federal Institute of Education Science and Technology of South of Minas Gerais–IFSULDEMINASPouso AlegreMG 37550-000Brazil Medicine School University of Ribeirão PretoRibeirão PretoSP 14096-900Brazil Centro de Ciências Exatas Naturais e TecnológicasUniversidade de Ribeirão PretoRibeirão Preto SP 14096-900Brazil

In this paper,we describe the application of Kaphta architecture,a resource for text mining of the anticancer activity of *** anticancer activity of these compounds against different types of cancer has been widely reported in the literature and they are one of the most promising molecules for the development of anticancer *** architecture,which comprises four sequential and well-defined steps,uses a hybrid approach composed of a dictionary,rules and machine learning to identify abstracts containing sentences with associations between polyphenol,cancer and gene *** application of the architecture on 23826 PubMed abstracts generated a knowledge base of indexed abstracts with 172169 sentences containing,polyphenol-cancer and polyphenol-gene associations.A Web tool was implemented that allowed the user to search for information on 2006 polyphenols,240 cancers and 3121 genes entities,and 11750 polyphenol-cancer and 9160 polyphenol-gene associations indexed in the knowledge base.A ranking algorithm calculates scores for each indexed abstract considering the number and type of sentences with entities and rules recognized.A test with users demonstrated that the visualization resources on the web tool contributes to the understanding of the association between polyphenols,genes and cancers,in comparison with the PubMed *** Kaphta architecture and web tool permits to extract knowledge on the anticancer activity of polyphenols and can thus contribute to the exploration of these molecules in the development of anticancer therapies.

关键词： polyphenols cancer text-mining

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