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World Journal of Nephrology 2024年第1期13卷 9-13页

作者： Benjamin Peticca Tomas M Prudencio samuel g robinson Sunil S Karhadkar Department of Surgery Lewis Katz School of Medicine at Temple University HospitalPhiladelphiaPA 19140United States

Non-descriptive and convenient labels are uninformative and unfairly project blame onto *** language clinicians use in the Electronic Medical Record,research,and clinical settings shapes biases and subsequent behaviors of all providers involved in the enterprise of *** such as noncompliant and nonadherent serve as a reason for waitlist inactivation and limit access to life-saving *** labels fail to capture all the circum-stances surrounding a patient’s inability to follow their care regimen,trivialize social determinants of health variables,and bring unsubstantiated subjectivity into decisions regarding organ ***,insufficient Medicare coverage has forced patients to ration or stop taking medication,leading to allograft failure and their subsequent diagnosis of *** argue that perpetuating non-descriptive language adds little substantive information,in-creases subjectivity to the organ allocation process,and plays a major role in reduced access to *** patients with existing barriers to care,such as racial/ethnic minorities,these effects may be even more *** committees must ensure thorough documentation to correctly encapsulate the entirety of a patient’s position and give voice to an already vulnerable population.

关键词： End-stage renal disease Compliance Labeling Social determinants

Cancer screening and management in the transgender population:Review of literature and special considerations for gender affirmation surgery

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World Journal of Clinical Oncology 2023年第7期14卷 265-284页

作者： Juliet C Panichella Sthefano Araya Siddhartha Nannapaneni samuel g robinson Susan You Sarah M gubara Maria T gebreyesus Theresa Webster Sameer A Patel Alireza Hamidian Jahromi Lewis Katz School of Medicine Temple UniversityPhiladelphiaPA 19140United States Division of Plastic and Reconstructive Surgery Fox Chase Cancer CenterPhiladelphiaPA 19111United States Department of Plastic Surgery Temple UniversityPhiladelphiaPA 18045United States Division of Plastic and Reconstructive Surgery Temple University HospitalsPhiladelphiaPA 19140United States

BACKgROUND Literature focused on cancer screening and management is lacking in the transgender *** To action to increase contributions to the scientific literature that drives the creation of cancer screening and management protocols for transgender and gender nonconforming(TgNC)*** We performed a systematic search of PubMed on January 5th,2022,with the following terms:“TgNC”,OR“transgender”,OR“gender non-conforming”,OR“gender nonbinary”AND“cancer screening”,AND“breast cancer”,AND“cervical cancer”,AND“uterine cancer”,AND“ovarian cancer”,AND“prostate cancer”,AND“testicular cancer”,AND“surveillance”,AND“follow-up”,AND“management”.70 unique publications were *** findings are discussed under“Screening”and“Management”*** Screening:Current cancer screening recommendations default to cis-gender ***,long-term genderaffirming hormone therapy and loss to follow-up from the gender-specific specialties contribute to a higher risk for cancer development and possible delayed *** only known screening guidelines made specifically for this population are from the American College of Radiology for breast ***:Prior to undergoing gender Affirmation Surgery(gAS),discussion should address cancer screening and management in the organs remaining in *** treatment in this population requires consideration for chemotherapy,radiation,surgery and/or *** of hormone therapy is decided on a case-by-case *** use of prophylactic vs aesthetic techniques in surgery is still *** When assessing transgender individuals for gAS,a discussion on the future oncologic risk of the sex-specific organs remaining in situ is *** management in this population requires a multidisciplinary approach while the care should be highly individualized with considerations to social,medical,surgical and gender affirming surgery related *** considerations have to

关键词： gender affirmation surgery gender affirming surgery Screening Management Transgender gender diverse

Comprehensive Characterization of Natural Cissus quadrangularis Stem Fiber Composites as an Alternate for Conventional FRP Composites

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Journal of Bionic Engineering 2018年第5期15卷 914-923页

作者： Suyambulingam Indran robinson Dhas Edwin Raj Brainerd samuel Sundar Daniel Joseph Selvi Binoj Department of Mechanical Engineering Rohini College of Engineering and Technology Anjugramam - 629401 Tamil Nadu India Department of Mechanical Engineering St. Xavier's Catholic College of Engineering Nagercoil - 629003 Tamil Nadu India Department of Metallurgical and Materials Engineering Indian Institute of Technology Roorkee - 247667 Uttarakhand India Department of Mechanical Engineering Sree Vidyanikethan Engineering College (Autonomous) Tirupati - 517102 Andhra Pradesh India

Health and sustainability are the major concerns that drive researchers to find novel materials to replace artificial hazardous materials. In this investigation, the mechanical properties of Cissus quadrangularis Stem Fiber （CQSF） reinforced with unsaturated polyester composite were optimized by varying the fiber length and content. To substantiate the findings, chemical property, thermal property, microstructure, and water absorption property were analyzed. Progressive enhancement of mechanical properties was observed with increasing the fiber content and fiber length up to 30 wt.% and 40 ram. However, beyond that limit, there was a decline in the strength due to improper bonding of fiber with matrix. Optimal values of mechanical property for CQSF composite were obtained at 30 wt.% fiber content and 40 mm fiber length, which are comparable with that of common artificial fiber-reinforced polymer composites.

关键词： CQSF mechanical properties thermogravimetric anlaysis microstructure water absorption

Mochi: Composing Data Services for High-Performance Computing Environments

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Journal of Computer Science & Technology 2020年第1期35卷 121-144页

作者： Robert BRoss george Amvrosiadis Philip Carns Charles DCranor Matthieu Dorier Kevin Harms greg ganger garth gibson samuel Kgutierrez Robert Latham Bob Robey Dana robinson Bradley Settlemyer galen Shipman Shane Snyder Jerome Soumagne Qing Zheng Argonne National Laboratory LemontIL 60439U.S.A Parallel Data Laboratory Carnegie Mellon UniversityPittsburghPA 15213U.S.A Vector Institute for Artificial Intelligence TorontoOntarioCanada Los Alamos National Laboratory Los Alamos NMU.S.A The HDF group Champaign ILU.S.A

Technology enhancements and the growing breadth of application workflows running on high-performance computing(HPC)platforms drive the development of new data services that provide high performance on these new platforms,provide capable and productive interfaces and abstractions for a variety of applications,and are readily adapted when new technologies are *** Mochi framework enables composition of specialized distributed data services from a collection of connectable modules and *** than forcing all applications to use a one-size-fits-all data staging and I/O software configuration,Mochi allows each application to use a data service specialized to its needs and access *** paper introduces the Mochi framework and *** Mochi core components and microservices are *** of the application of the Mochi methodology to the development of four specialized services are ***,a performance evaluation of a Mochi core component,a Mochi microservice,and a composed service providing an object model is *** paper concludes by positioning Mochi relative to related work in the HPC space and indicating directions for future work.

关键词： storage and I/O data-intensive computing distributed services high-performance computing

Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

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Journal of Molecular Cell Biology 2021年第4期13卷 282-294页

作者： Maarten C.Hardenberg Tessa Sinnige Sam Casford samuel T.Dada Chetan Poudel Elizabeth A.robinson Monika Fuxreiter Clemens F.Kaminksi gabriele S.Kaminski Schierle Ellen A.A.Nollen Christopher M.Dobson Michele Vendruscolo Centre for Misfolding Diseases Department of ChemistryUniversity of CambridgeCambridge CB21EWUK Department of Chemical Engineering and Biotechnology University of CambridgeCambridge CB3 OASUK MTA-DE Laboratory of Protein Dynamics Department of Biochemistry and Molecular BiologyUniversity of DebrecenHungary European Research Institute for the Biology of Aging University Medical Center GroningenUniversity of GroningenGroningen 9713 AVThe Netherlands Present address Bijvoet Centre for Biomolecular Research Department of ChemistryUtrecht UniversityUtrecht 3584 CHThe Netherlands

Misfoldedα-synudein is a major component of Lewy bodies,which are a hallmark of Parkinson's disease(PD).A large body of evidence shows thatα-synuclein can aggregate into amyloid fibrils,but the relationship between a-synuclein self-assembly and Lewy body formation remains ***,we show,both in vitro and in a Caenorhabditis elegans model of PD,thatα-synuclein undergoes liquid-liquid phase separation by forming a liquid droplet state,which converts into an amyloid-rich hydrogel with Lewy-body-like *** maturation process towards the amyloid state is delayed in the presence of model synaptic vesicles in *** together,these results suggest that the formation of Lewy bodies may be linked to the arrested maturation ofα-synuclein condensates in the presence of lipids and other cellular components.

关键词： α-synuclein,liquid-liquid phase separation,Parkinson's disease

Mechanically induced Ca^(2+) oscillations in osteocytes release extracellular vesicles and enhance bone formation

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Bone Research 2018年第1期6卷 72-82页

作者： Andrea E.Morrell genevieve N.Brown samuel T.robinson Rachel L.Sattler Andrew D.Baik gehua Zhen Xu Cao Lynda F.Bonewald Weiyang Jin Lance C.Kam X.Edward guo Bone Bioengineering Laboratory Department of Biomedical Engineering Columbia University Center for Musculoskeletal Research Department of Orthopaedic Surgery Johns Hopkins University Indiana Center for Musculoskeletal Health Indiana University School of Medicine Microscale Biocomplexity Laboratory Department of Biomedical Engineering Columbia University

The vast osteocytic network is believed to orchestrate bone metabolic activity in response to mechanical stimuli through production of sclerostin, RANKL, and osteoprotegerin(OPg). However, the mechanisms of osteocyte mechanotransduction remain poorly understood. We've previously shown that osteocyte mechanosensitivity is encoded through unique intracellular calcium (Ca^(2+) ) dynamics. Here, by simultaneously monitoring Ca^(2+) and actin dynamics in single cells exposed to fluid shear flow, we detected actin network contractions immediately upon onset of flow-induced Ca^(2+) transients, which were facilitated by smooth muscle myosin and further confirmed in native osteocytes ex vivo. Actomyosin contractions have been linked to the secretion of extracellular vesicles(EVs), and our studies demonstrate that mechanical stimulation upregulates EV production in osteocytes through immunostaining for the secretory vesicle marker Lysosomal-associated membrane protein 1(LAMP1) and quantifying EV release in conditioned medium, both of which are blunted when Ca^(2+) signaling was inhibited by neomycin. Axial tibia compression was used to induce anabolic bone formation responses in mice, revealing upregulated LAMP1 and expected downregulation of sclerostin in vivo. This load-related increase in LAMP1 expression was inhibited in neomycin-injected mice compared to ***-computed tomography revealed significant load-related increases in both trabecular bone volume fraction and cortical thickness after two weeks of loading, which were blunted by neomycin treatment. In summary, we found mechanical stimulation of osteocytes activates Ca^(2+) -dependent contractions and enhances the production and release of EVs containing bone regulatory proteins. Further, blocking Ca^(2+) signaling significantly attenuates adaptation to mechanical loading in vivo, suggesting a critical role for Ca^(2+) -mediated signaling in bone adaptation.

关键词： OPg conditioned medium Ca2+-dependent

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How does Mechanical Loading Make Bone Microstructure: Modeling vs. Remodeling

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医用生物力学 2019年第A1期34卷 11-11页

作者： samuel T.robinson Yizhong Hu X.Edward guo Bone Bioengineering Laboratory Department of Biomedical EngineeringColumbia University

Bone modeling and remodeling are governed by distinct biochemical processes that may hold unique opportunities for optimizing bone mass[1,2].Remodeling refers to the coupled resorption and subsequent formation on the bone surface,while modeling represents uncoupled formation or *** loading is known to improve bone mass,though whether this occurs through modeling or remodeling(or by some combination)is *** in vivo morphometry utilizing high resolution micro-CT and image registration has only recently become feasible and thus holds an untapped and expanding potential for understanding bone metabolism by quantifying and localizing formation/resorption and modeling/remodeling events.16-week-old mice were given 2 baseline weekly micro-CT scans of both tibiae prior to the initiation of daily unilateral loading(contralateral limb for nonloaded control).Weekly scanning and daily loading continued for 5 *** images for each mouse in a global coordinate system revealed the time course of each voxel,and changes in bone mass were quantified as modeling or remodeling starting at the onset of *** cortical bone,after an initial response to loading in both regimes,modeling emerged as the dominant *** effects were largest in areas of mechanical *** example,anabolic modeling on the periosteal surface of the half of the tibia in compression under axial load presented a strong effect of loading,whereas the same measure on the endosteal surface in the area in tension showed no ***,in trabecular bone anabolic modeling was significantly increased with loading on trabecular plates but not rods(plates have been shown to be the major contributor to overall bone strength).The catabolic modeling response on the endosteal surface showed an interesting transition over *** initially led to a significant suppression of catabolic modeling,but over time increased it to levels significantly beyond tha

关键词： Mechanical Loading Make Bone Microstructure Modeling vs Remodeling

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JEALOUS

英语学习 1999年第2期 39-40页

作者： CHRISTINA robinson 宁宁

When I looked across the scarcelylit room,I couldn't believe *** was there.I saw thehatred burning in her continuous *** determined to get rid ofme...*** all started a few weeks after mymother's 74th *** had suddenlyfallen seriously ill,and the doctors didn'tthink she would *** mother's lawyer,samuel Thomas,soon came to see me *** see,our family was what mostwould have considered *** wanted totalk to me about inheriting my mother's

关键词： JEALOUS

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告别“失落的十年”欧元区经济正在回暖

商业周刊（中文版） 2017年第24期 30-31页

作者： Jana Randow samuel Potter Cormac Mullen Blaise robinson 融汐

欧洲到处都是令人沮丧的消息：英国脱欧谈判陷入僵局、加泰罗尼亚与西班牙中央政府的宪法对峙、东欧的反移民敌意。但好消息也有一条：欧洲已不再是世界经济中的“病人”了。经济学家们表示，有19个成员的欧元区已经出现了十年内最强劲... 详细信息

欧洲到处都是令人沮丧的消息：英国脱欧谈判陷入僵局、加泰罗尼亚与西班牙中央政府的宪法对峙、东欧的反移民敌意。但好消息也有一条：欧洲已不再是世界经济中的“病人”了。经济学家们表示，有19个成员的欧元区已经出现了十年内最强劲的经济增长，也没有任何通胀迹象，

关键词：欧元区经济失落告别加泰罗尼亚中央政府世界经济经济学家经济增长

Microwave remediation of oil contaminated soils

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Chinese Journal Of geochemistry 2006年第B8期25卷 113-113页

作者： samuel W. Kingman Colin E. Snape John P. robinson School of Chemical Environmental and Mining Engineering University of Nottingham University Park Nottingham UK

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