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Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers

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World Journal of Gastroenterology 2012年第33期18卷 4597-4603页

作者： Doron boltin Marisa Halpern Zohar Levi Alex Vilkin Sara Morgenstern samuel b ho Yaron Niv Department of Gastroenterology Rabin Medical Center Tel Aviv University Petah Tikva 49100 Israel Department of Pathology Rabin Medical Center Hasharon Hospital Petah Tikva 49100 Israel Department of Pathology Rabin Medical Center Beilinson Hospital Petah Tikva 49100 Israel Department of Medicine University of California and VA San Diego Healthcare System San Diego CA 92161 United States

AIM: To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers. METhoDS: We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION: Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers.

关键词： Idiopathic ulcer Mucin Mucin 5AC Mucin 6 Helicobacter pylori

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Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers

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World Journal of Gastroenterology 2014年第40期20卷 14913-14920页

作者： Yaron Niv Doron boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K batra samuel b ho Department of Gastroenterology Rabin Medical Center Tel Aviv University Beilinson Hospital Tel Aviv 49100 Israel Department of Pathology Rabin Medical Center Hasharon Hospital Tel Aviv 49100 Israel Department of Cellular andMolecular Medicine Glycobiology Research and Training Center University of California San Diego San Diego CA 92161 United States Department of Pathology Rabin Medical Center Beilinson Hospital Tel Aviv 49100 Israel Department of Medicine VA San Diego Healthcare System and University of California San Diego San Diego CA 92161 United States Department of biochemistry and Molecular biology University of Nebraska MedicaCenter Omaha NE 68198 United States Department of Pathology Creighton University Medical Center Omaha NE 68114 United States

AIM: To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori (H. pylori)-associated, non-steroidal inflammatory drug (NSAID)-associated and idiopathic-gastric ulc... 详细信息

关键词： Mucin Idiopathic ulcer Helicobacter pylori Glycosylation Peptic ulcer disease Mucosal cytoprotection

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Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： samuel K.H.Sy ho Ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced biomedical Instrumentation Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret K.L.Cheung Research Center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen Research Center of brain Degenerative Diseases in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in ***,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

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Corrosion rate determination of rare-earth Mg alloys in a Na_(2)SO_(4)solution by electrochemical measurements and inductive coupled plasma-optical emission spectroscopy

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Journal of Magnesium and Alloys 2019年第1期7卷 47-57页

作者： samuel Leleu bertrand Rives Nicolas Causse Nadine Pébère CIRIMAT Universitéde ToulouseCNRSINPTUPSENSIACET4 allée Emile Monso BP4436231030 Toulouse cedex 4 France IRT Saint Exupéry 118 route de Narbonne-CS 4424831432 ToulouseFrance

The corrosion resistance of three Mg alloys containing rare-earth elements(WE43,EV31 and ZE41)was studied and compared to that of two Mg-Al alloys(AZ31 and AZ91)and of pure Mg(99.95 wt.%).Current-voltage curves and electrochemical impedance measurements were performed with rotating disk electrodes in an aerated 0.1 M Na_(2)SO_(4)*** all the alloys,it was confirmed that the intermetallic particles acted as local cathodes and that more protective films were formed on the alloys surface by comparison with the pure *** rates were determined from inductive coupled plasma-optical emission spectroscopy measurements and from the electrochemical *** corrosion rates were observed for the rare-earth Mg alloys compared to the AZ series *** data allowed the corrosion mechanisms to be discussed.

关键词： Magnesium alloys Rare-earth elements EIS ICP-OES Interface

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Analytical modeling and simulation of germanium single gate silicon on insulator TFET

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Journal of Semiconductors 2014年第3期35卷 25-28页

作者： T.S.Arun samuel N.b.balamurugan Department of Electronics and Communication Engineering Thiagarajar College of Engineering

This paper proposes a new two dimensional（2D） analytical model for a germanium（Ge） single gate silicon-on-insulator tunnel field effect transistor（SG SOI TFET）. The parabolic approximation technique is used to solve the 2D Poisson equation with suitable boundary conditions and analytical expressions are derived for the surfacepotential,*** is derived further by using the electric fields. The results show that Ge based TFETs have significant improvements ***heanalytical model results with the technology computer aided design（TCAD） simulation results and also comparing them with results from a silicon based TFET.

关键词： tunnel field effect transistor(TFET) analytical modelling Poisson equation surface potential electric field

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Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation

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World Journal of Gastroenterology 2010年第19期16卷 2401-2406页

作者： samuel C Lüthold Mascha K Rochat Peter bhler Division of Gastroenterology Departement of Pediatrics Hospital of Fribourg CH-1708 Fribourg Switzerland Asthma and Allergy Research Group University of Munich Lindwurmstrasse 4 D 80337 Munich Germany

AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METhoDS: Twenty three infants with suspected GERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA ***: Evaluating the GER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P b = 0.36, P howed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (Kendall’s tau b = 0.33, P howed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants.

关键词： Gastroesophageal reflux disease Infant Symptom-reflux association analysis Intraluminal impedance monitoring pH

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Optimized Mn and bi co-doping in SnTe based thermoelectric material:A case of band engineering and density of states tuning

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Journal of Materials Science & Technology 2021年第26期85卷 76-86页

作者： samuel Kimani Kihoi Joseph Ngugi Kahiu Hyunji Kim U.Sandhya Shenoy D.Krishna bhat Seonghoon Yi ho Seong Lee School of Materials Science and Engineering Kyungpook National University80 Daehak-roBuk-guDaegu 41566Republic of Korea Department of Hydrogen and Renewable Energy Kyungpook National University80 Daehak-roBuk-guDaegu 41566Republic of Korea Department of Chemistry College of Engineering and TechnologySrinivas UniversityMukka574146 MangaloreKarnatakaIndia Department of Chemistry National Institute of Technology KarnatakaSurathkalSrinivasnagar575025 MangaloreKarnatakaIndia

Tin telluride(SnTe)overwhelmingly continues to be studied owing to its promising thermoelectric properties,tunable electronic structure,and its potential as an alternate to toxic lead telluride(PbTe)based *** this research,we engineer the electronic properties of SnTe by co-doping Mn and bi below their individual solubility *** First principles density functio nal theory studies reveal that both bi and Mn introduce resonance states,thereby increasing the density of states near the Fermi level leading to enhanced Seebeck *** unique combination of using two resonant dopants to introduce flatter bands is effective in achieving higher performance at lower tempe ratures manifesting into a large Seebeck value of~91μV/K at room temperature in the present *** elements optimally co-doped results in a very high power factor value of~24.3μW/cmK^(2) at 773 K when compared to other high performance SnTe based materials.A zT of~0.93 at 773 K is achieved by tuning the proportion of the co-dopants Mn and bi in *** hardness value of pristine SnTe was also seen to increase after *** a result,synergistic optimized doping proves to be a suitable means for obtaining thermoelectric materials of superior characteristics without the need for heavy doping.

关键词： SnTe Thermoelectric Electronic structure engineering Solubility Thermal conductivity

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Flow, thermal criticality and transition of a reactive third-grade fluid in a pipe with Reynolds' model viscosity

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Journal of Hydrodynamics 2016年第1期28卷 84-94页

作者： samuel S.OKOYA Department of Mathematics Obafemi Awolowo University

Neglecting the consumption of the material, a steady incompressible flow of an exothermic reacting third-grade fluid with viscous heating in a circular cylindrical pipe is numerically studied for both cases of constant viscosity and Reynolds＇ viscosity model. The coupled ordinary differential equations governing the flow in cylindrical coordinates, are transformed into dimensionless forms using appropriate transformations, and then solved numerically. Solutions using Maple are presented in tabular form and given in terms of dimensionless central fluid velocity and temperature, skin friction and heat transfer rate for three parametric values in the Reynolds＇ case. The numerical results for the velocity and temperature fields are also presented through graphs. bifurcations are discussed using shooting method. Comparisons are also made between the present results and those of previous work, and thus verify the validity of the provided numerical solutions. Important properties of thermal criticality are provided for variable viscosity parameter and reaction order. Further numerical results are presented in the form of tables and graphs for transition of physical parameters, while varying certain flow and fluid material parameters. Also, the flow behaviour of the reactive fluid of third-grade is compared with those of the Newtonian reactive fluid.

关键词： non-Newtonian fluids third-grade fluid thermal transition heat generation temperature dependent viscosity numerical solutions

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Wildfire and floral herbivory alter reproduction and pollinator mutualisms of Yuccas and Yucca moths

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Journal of Plant Ecology 2017年第5期10卷 851-858页

作者： Andrew H.Lybbert samuel b.St.Clair Department of Evolution Ecology and Organismal BiologyThe Ohio State UniversityColumbusOH 43210USA Department of Plant and Wildlife Sciences Brigham Young UniversityProvoUT 84602USA

Aims Wildfire and ungulate herbivore pressure are increasing globally due to human activities,including arid ecosystems that are sensitive to disturbance,and are highly dependent on pollinator *** evaluated how wildfire and ungulate herbivore pressure influ-ence plant reproductive success and pollinator *** We evaluated flower production,floral herbivory,pollinator visita-tion and fruit set of two Yucca species with highly specialized polli-nator mutualisms(Yucca baccata and Yucca brevifolia)in unburned and burned landscapes created by fires that occurred in the Mojave Desert in *** Findings Yucca baccata plants in burned landscapes had a greater propor-tion of flowering individuals than plants in unburned areas(23 versus 12%).All *** individuals in burned and unburned landscapes produced ***-four percent of *** inflorescences were removed due to herbivory by cattle in burned areas,compared to 51%in unburned ***-two percent of *** inflorescences on branches≤2 m in height were removed in burned areas due to cattle herbivory compared to 39%in unburned ***,we did not observe any inflores-cence removal on *** branches>2 m where the major-ity of *** inflorescences are *** moths,the only known pollinators of these two species,visited *** uniformly in burned and unburned areas but failed to visit ***-cata *** brevifolia had strong fruit production,but not a single fruit was produced among the thousands of flowering *** plants *** herbivory and the loss of obligate pollinator mutualisms appear to be critical threats to the long-term viability of *** populations in this *** reproduc-tive resilience of *** and the maintenance of its pollinator populations appear to be due to its taller stature,which allows verti-cal escape of flowers from ungulate *** of live-stock during

关键词： cattle disturbance Mojave Desert pollination Yucca brevifolia Yucca baccata

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Single-model uncertainty quantification in neural network potentials does not consistently outperform model ensembles

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npj Computational Materials 2023年第1期9卷 49-59页

作者： Aik Rui Tan Shingo Urata samuel Goldman Johannes C.b.Dietschreit Rafael Gómez-bombarelli Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMAUSA Innovative Technology Laboratories AGC IncTokyoJapan Computational and Systems biology Massachusetts Institute of TechnologyCambridgeMAUSA

Neural networks(NNs)often assign high confidence to their predictions,even for points far out of distribution,making uncertainty quantification(UQ)a *** they are employed to model interatomic potentials in materials systems,this problem leads to unphysical structures that disrupt simulations,or to biased statistics and dynamics that do not reflect the true *** UQ techniques can find new informative data and drive active learning loops for robust ***,a variety of UQ techniques,including newly developed ones,exist for atomistic simulations and there are no clear guidelines for which are most effective or suitable for a given *** this work,we examine multiple UQ schemes for improving the robustness of NN interatomic potentials(NNIPs)through active *** particular,we compare incumbent ensemble-based methods against strategies that use single,deterministic NNs:mean-variance estimation(MVE),deep evidential regression,and Gaussian mixture models(GMM).We explore three datasets ranging from in-domain interpolative learning to more extrapolative out-of-domain generalization challenges:rMD17,ammonia inversion,and bulk silica *** is measured across multiple metrics relating model error to *** experiments show that none of the methods consistently outperformed each other across the various *** remained better at generalization and for NNIP robustness;MVE only proved effective for in-domain interpolation,while GMM was better out-of-domain;and evidential regression,despite its promise,was not the preferable alternative in any of the *** broadly,cost-effective,single deterministic models cannot yet consistently match or outperform ensembling for uncertainty quantification in NNIPs.

关键词： ensemble evident neural

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