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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Effects of Crosswalk location and Pedestrian Volume on Entry Capacity of Roundabouts

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International Journal of Transportation Science and Technology 2013年第1期2卷 31-46页

作者： Carlos Duran Ruey l cheu Walter P Moore 221 N Kansas St#601El PasoTX 79901USA The University of Texas at El Paso 500 W University AveEl PasoTX 79968USA

At roundabout approaches,vehicles must yield to pedestrians who are using *** presence of pedestrians using the crosswalk at a roundabout approach thus decreases the entry capacity of the *** research used a calibrated microscopic traffic simulation model to study the effect of crosswalk location and pedestrian volume on the capacity of a two-lane approach entering a two-lane *** simulation results show that(i)at the same pedestrian volume,the crosswalk located further upstream from the yield line causes a smaller magnitude of reduction in the entry capacity,but there is no significant change in the entry capacity when the crosswalk is beyond three car-length upstream from the yield line;(ii)for the same crosswalk location and conflicting volume,the entry capacity reduces with increasing pedestrian volume,but the marginal reduction diminishes with increasing pedestrian *** regression equations for entry capacity adjustment factor for pedestrians as a function of conflicting volume have been *** adjustment factors are found to be lower than the values provided by the Highway Capacity Manual 2010 which are based on research conducted in Germany.

关键词： upstream capacity approach.

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic lydia Jiménez-Díaz Juan D.navarro-lópez neuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål nicolas GBazan Shuai Tan nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li Department of neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and nutrition Karolinska InstitutetHuddingeSweden neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RnA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RnA-sequencing specialized pro-resolving lipid mediator

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A theoretical investigation of the band alignment of type-I direct band gap dilute nitride phosphide alloy of Gan_xAs_yP_(1-x-y)/GaP quantum wells on GaP substrates

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Chinese Physics B 2014年第7期23卷 640-644页

作者： O l nsal B Gnül M Temiz Department of Engineering Physics University of Gaziantep

The GaP-based dilute nitride direct band gap material Ga（nAsP） is gaining importance due to the monolithic integra- tion of laser diodes on Si microprocessors. The major advantage of this newly proposed laser material system is the small lattice mismatch between GaP and Si. However, the large threshold current density of these promising laser diodes on Si substrates shows that the carrier leakage plays an important role in Ga（nAsP）/GaP QW lasers. Therefore, it is necessary to investigate the band alignment in this laser material system. In this paper, we present a theoretical investigation to optimize the band alignment of type-I direct band gap GanxAsyP1-x-y/GaP QWs on GaP substrates. We examine the effect of nitrogen （n） concentration on the band offset ratios and band offset energies. We also provide a comparison of the band alignment of type-I direct band gap GanxAsyP1-x-y/GaP QWs with that of the GanxAsyP1-x-y/Al2Ga1-2P QWs on GaP substrates. Our theoretical calculations indicate that the incorporations of n into the well and AI into the barrier improve the band alignment compared to that of the GaAsP/GaP QW laser heterostructures.

关键词： quantum well band alignment carrier confinement dilute nitride phosphide alloy

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large-Scale Estimation of Distribution Algorithms with Adaptive Heavy Tailed Random Pro jection Ensembles

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Journal of Computer Science & Technology 2019年第6期34卷 1241-1257页

作者： Momodou l.Sanyang Ata Kabán School of Computer Science University of BirminghamEdgbastonBirmingham B152TTU.K. School of Information Technology and Communication University of The GambiaSerekundaThe Gambia

We present new variants of Estimation of Distribution Algorithms (EDA) for large-scale continuous optimisation that extend and enhance a recently proposed random projection (RP) ensemble based approach. The main novelty here is to depart from the theory of RPs that require (sub-)Gaussian random matrices for norm-preservation, and instead for the purposes of high-dimensional search we propose to employ random matrices with independent and identically distributed entries drawn from a t-distribution. We analytically show that the implicitly resulting high-dimensional covariance of the search distribution is enlarged as a result. Moreover, the extent of this enlargement is controlled by a single parameter, the degree of freedom. For this reason, in the context of optimisation, such heavy tailed random matrices turn out to be preferable over the previously employed (sub-)Gaussians. Based on this observation, we then propose novel covariance adaptation schemes that are able to adapt the degree of freedom parameter during the search, and give rise to a flexible approach to balance exploration versus exploitation. We perform a thorough experimental study on high-dimensional benchmark functions, and provide statistical analyses that demonstrate the state-of-the-art performance of our approach when compared with existing alternatives in problems with 1000 search variables.

关键词： covariance adaptation estimation of distribution algorithm random projection ensemble t-distribution

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nonlinear-Optical Analogies in nuclear-like Soliton Reactions:Selection Rules,nonlinear Tunneling and Sub-Barrier Fusion–Fission

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Chinese Physics letters 2024年第8期41卷 1-7页

作者： T.l.Belyaeva V.n.Serkin Universidad Autonoma del Estado de Mexico Av.Instituto Literario 100C.P.50000TolucaMexico Benemerita Universidad Autonoma de Puebla Av.4 Sur 104C.P.72001PueblaMexico

The main goal of our study is to reveal unexpected but intriguing analogies arising between optical solitons and nuclear physics,which still remain hidden from *** consider the main cornerstones of the concept of nonlinear optics of nuclear reactions and the well-dressed repulsive-core *** the base of this model,we reveal the most intriguing properties of the nonlinear tunneling of nucleus-like solitons and the soliton selfinduced sub-barrier transparency *** describe novel interesting and stimulating analogies between the interaction of nucleus-like solitons on the repulsive barrier and nuclear sub-barrier *** main finding of this study concerns the conservation of total number of nucleons(or the baryon number)in nuclear-like soliton *** show that inelastic interactions among well-dressed repulsive-core solitons arise only when a“cloud”of“dressing”spectral side-bands appears in the frequency spectra of the *** property of nucleus-like solitons is directly related to the nuclear density distribution described by the dimensionless small shape-squareness *** the Fourier spectra of nucleus-like solitons are similar to the nuclear form *** show that the nuclear-like reactions between well-dressed solitons are realized by“exchange”between“particle-like”side bands in their spectra.

关键词： solitons soliton nonlinear

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On The Role of Preparative Parameters in Growing nanocrystalline PbS Thin Films by liquid Phase Chemical Bath Deposition

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稀有金属材料与工程 2012年第S1期41卷 28-32页

作者： Chattarki A n Deshmukh l P Thin Film&Solar Studies Research laboratory Department of Physics&ElectronicsSolapur UniversitySolapur-413255M.SIndia

A liquid phase chemical bath deposition(lPCBD)method for deposition of PbS thin films is *** growth kinetics and reaction mechanism have been *** the deposition,triethanolamine complex of lead acetate was allowed to react with aqueous thiourea *** micro-slides were used as the *** deposition of PbS films was carried out under different growth parameters such as temperature,time,and reaction *** growth rate,under different conditions,was measured in terms of a terminal layer thickness and the possible reaction kinetics and mechanism is *** optimum values of the parameters to produce good quality films are 60 min,80℃and 10.5±*** EDS analysis showed that the film stoichiometry is dependent on the reaction pH and the films tend to be almost stoichiometric in high alkaline environment(>10.5).The PbS deposits appeared smooth,tightly adherent,uniform and reflecting with blackish-grey *** XRD studies showed crystalline cubic type of structure with preferred orientation along(200)*** calculated d-values,intensities of reflections and lattice parameter have excellent match with that of the JCPD *** crystallite size is found to be few tens of *** surface morphology revealed by SEM showed that the crystallites are randomly oriented and are of different shapes and *** of the crystallites appeared smaller and spherical in shape whereas,growth of some elongated irregular crystallites;bit larger in size and differing in shapes,have also been favoured.

关键词： lPCBD preparative parameters XRD SEM nanocrystals surface morphology

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Multilevel atomic Ramsey interferometry for precise parameter estimations

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Chinese Physics B 2021年第12期30卷 321-328页

作者： X n Feng l F Wei Guangdong Provincial Key laboratory of Quantum Metrology and Sensing&School of Physics and Astronomy Sun Yat-Sen University(Zhuhai Campus)Zhuhai 519082China Information Quantum Technology laboratory School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 610031China

Multi-path(or multi-mode)entanglement has been proved to be a useful resource for sub-shot-noise sensitivity of phase estimation,which has aroused much research interest in quantum metrology *** schemes of multi-path interferometers based on optical systems have been put ***,we study a multi-state interferometer with multilevel atoms by projective ***,we investigate its ultimate sensitivity described by quantum Fisher information theory and find that the Cramer-Rao bound can be *** particular,we investigate a specific scheme to improve the sensitivity of magnetometery with a three-state interferometry delivered by a single nitrogen-vacancy(nV)center of diamond with tailor *** impacts of imperfections of the atomic beam-splitter,described by the three-level quantum Fourier transform,on the sensitivity of phase estimation is also discussed.

关键词： quantum metrology multi-path interferometers quantum measurement

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