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Metastatic clear cell variant of hepatocellular carcinoma with an occult hepatic primary

Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 306-307页

作者： samir shahsamir shah Sudeep Gupta Tanuja Shet Amita Maheshwari Rekha Wuntkal and Kunisshery Mallath Mohandas Mumbai India Department of Medical Oncology Tata Memorial Hospital Mumbai 4110012 India

Metastatic clear cell carcinomas are commonly seen in the kidney and lung. Clear cell variant of hepatocellular carci- noma is an uncommon tumour. Diagnosis is usually made by correlation of histopathology. tumour markers and im- munohistochemistry, especially HepPar 1. In this unusual case of metastatic clear cell carcinoma presenting as Sister Mary Joseph's nodule, no primary evidence was observed radiologically in the liver, but the level of alfa fetoprotein was markedly elevated. Metastatic clear cell carcinoma of the liver with an occult hepatic primary was diagnosed by immunohistochemical profile of the tumour.

关键词： clear cell hepatocellular occult primary

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Bone mineral density and disorders of mineral metabolism in chronic liver disease

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World Journal of Gastroenterology 2009年第28期15卷 3516-3522页

作者： Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia samir shah Padmavathy S Menon Nalini shah Department of Endocrinology Seth G.S. Medical College and KEM Hospital Department of Gastroenterology Seth G.S Medical College and KEM Hospital Department of Gastroenterology Jaslok Hospital

AIM： To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis. METHODS： The study was performed on 72 Indian patients with cirrhosis （63 male, 9 female; aged 〈 50 years）. Etiology of cirrhosis was alcoholism （n = 37）, hepatitis B （n = 25） and hepatitis C （n = 10）. Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C. Secondary causes for metabolic bone disease and osteoporosis were ruled out. Sunlight exposure, physical activity and dietary constituents were calculated. Complete metabolic profiles were derived, and bone mineral density （BMD） was measured using dual energy X ray absorptiometry. Low BMD was defined as a Z score below -2. RESULTS： Low BMD was found in 68% of patients. Lumbar spine was the most frequently and severely affected site. Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass. Calcium intake was adequate, with unfavorable calcium： protein ratio and calcium： phosphorus ratio. Vitamin D deficiency was highly prevalent （92%）. There was a high incidence of hypogonadism （41%）. Serum estradiol level was elevated significantly in patients with normal BMD. Insulin-like growth factor （IGF） 1 and IGF binding protein 3 levels were below the age-related normal range in both groups. IGF-1 was significantly lower in patients with low BMD. Serum osteocalcin level was low （68%） and urinary deoxypyridinoline to creatinine ratio was high （79%）, which demonstrated low bone formation with high resorption. CONCLUSION： Patients with cirrhosis have low BMD. Contributory factors are reduced physical activity, low lean body mass, vitamin D deficiency and hypogonadism and low IGF-1 level.

关键词： Bone mineral density Liver disease Chronic disease Cirrhosis Bone mineral metabolism Hepatic osteodystrophy

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Prime Cordial Labeling of Some Graphs

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Open Journal of Discrete Mathematics 2012年第1期2卷 11-16页

作者： samir K. Vaidya Nirav H. shah 不详

In this paper we prove that the split graphs of K1,n and Bn,n are prime cordial graphs. We also show that the square graph of Bn,n is a prime cordial graph while middle graph of Pn is a prime cordial graph for n≥4 . ... 详细信息

关键词： Prime Cordial Labeling Split Graph Square Graph Middle Graph

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MEDICLOUD:a holistic study on the digital evolution of medical data

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Digital Chinese Medicine 2022年第2期5卷 112-122页

作者： Astha Modi Nandish Bhayani samir Patel Manan shah Department of Information and Communication Technology Pandit Deendayal Energy UniversityGandhinagarGujarat 382007India Department of Information Technology Charotar University of Science and TechnologyChangaGujarat 388421India Department of Computer Science and Engineering Pandit Deendayal Energy UniversityGandhinagarGujarat 382007India Department of Chemical Engineering Pandit Deendayal Energy UniversityGujarat 382007India

The Corona Virus Disease 2019(COVID-19) pandemic has taught us many valuable lessons regarding the importance of our physical and mental health. Even with so many technological advancements, we still lag in developing a system that can fully digitalize the medical data of each individual and make it readily accessible for both the patient and health worker at any point in time. Moreover, there are also no ways for the government to identify the legitimacy of a particular clinic. This study merges modern technology with traditional approaches,thereby highlighting a scenario where artificial intelligence(AI) merges with traditional Chinese medicine(TCM), proposing a way to advance the conventional approaches. The main objective of our research is to provide a one-stop platform for the government, doctors,nurses, and patients to access their data effortlessly. The proposed portal will also check the doctors’ authenticity. Data is one of the most critical assets of an organization, so a breach of data can risk users’ lives. Data security is of primary importance and must be prioritized. The proposed methodology is based on cloud computing technology which assures the security of the data and avoids any kind of breach. The study also accounts for the difficulties encountered in creating such an infrastructure in the cloud and overcomes the hurdles faced during the project, keeping enough room for possible future innovations. To summarize, this study focuses on the digitalization of medical data and suggests some possible ways to achieve it. Moreover, it also focuses on some related aspects like security and potential digitalization difficulties.

关键词： Cloud computing Medical data Digitalization One-stop platform Artifical intelligence(AI) Traditional Chinese medicine(TCM)

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小婴儿腰椎穿刺脑脊液参考值

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中国循证儿科杂志 2019年第4期14卷 317-318页

作者： Joanna Thomson Heidi Sucharew Andrea T. Cruz Lise E. Nigrovic MD, MPH Stephen B. Freedman Aris C. Garro Fran Balamuth Rakesh D. Mistry Joseph L. Arms Paul T. Ishimine Dina M. Kulik Mark I. Neuman samir S. shah 郑继翠(译) 李凯(校) Divisions of Hospital Medicine Cincinnati Children's Hospital Medical CenterCincinnatiOhio Departments of Emergency Medicine and Pediatrics School of MedicineUniversity of CaliforniaSan Diego and Rady Children's Hospital-San DiegoSan DiegoCalifornia University of Toronto TorontoCanada 不详 Biostatistics and Epidemiology and lInfectious DiseasesCincinnati Children's Hospital Medical CenterCincinnatiOhio Sections of Emergency Medicine and Infectious Diseases Baylor College of MedicineHoustonTexas Division of Emergency Medicine Boston Children's HospitalBostonMassachusetts Sections of Pediatric Emergency Medicine and Gastroenterology Department of PediatricsAlberta Children's Hospital Research InstituteAlberta Children's HospitalCumming School of MedicineUniversity of CalgaryCalgaryCanada Warren Alpert Medical School Brown UniversityProvidenceRhode Island Perelman School of Medicine University of PennsylvaniaPhiladelphiaPennsylvania School of Medicine University of ColoradoAuroraColorado Children's Hospitals and Clinics of Minnesota MinneapolisMinnesota

研究背景既往有关脑脊液(CSF)参考值的研究为单中心研究,且样本量较小,因此其应用价值有限。研究新知这项多中心横断面调查研究确定了不同日龄段婴儿的CSF参考值,并且提供了日龄相关CSF百分位参考曲线。

关键词：参考值脑脊液小婴儿腰椎穿刺横断面调查 CSF 样本量多中心

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