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Current and novel modalities for management of chronic hepatitis B infection

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World Journal of Hepatology 2023年第5期15卷 585-608页

作者： Iman Ibrahim Salama samia M Sami Somaia I Salama Ghada A Abdel-Latif Fatma A Shaaban Walaa A Fouad Aida M Abdelmohsen Hala M Raslan Department of Community Medicine Research National Research CentreGiza 12411DokkiEgypt Department of Child Health National Research CentreGiza 12411DokkiEgypt Department of Internal Medicine National Research CentreGiza 12411DokkiEgypt

Over 296 million people are estimated to have chronic hepatitis B viral infection(CHB),and it poses unique challenges for *** is the result of hepatitis B virus(HBV)-specific immune tolerance and the presence of covalently closed circular DNA as mini chromosome inside the nucleus and the integrated *** hepatitis B core-related antigen is the best surrogate marker for intrahepatic covalently closed circular *** HBV“cure”is the durable loss of hepatitis B surface antigen(HBsAg),with or without HBsAg seroconversion and undetectable serum HBV DNA after completing a course of *** currently approved therapies are nucleos(t)ide analogues,interferon-alpha,and *** these therapies,functional cure can be achieved in<10%of CHB *** variation to HBV or the host immune system that disrupts the interaction between them can lead to reactivation of *** therapies may allow efficient control of *** include direct acting antivirals and *** of the viral antigen load is a crucial factor for success of immune-based *** therapy may lead to modulation of the host immune *** may enhance/restore innate immunity against HBV(as toll-like-receptors and cytosolic retinoic acid inducible geneⅠagonist).Others may induce adaptive immunity as checkpoint inhibitors,therapeutic HBV vaccines including protein(HBsAg/pre S and hepatitis B core antigen),monoclonal or bispecific antibodies and genetically engineered T cells to generate chimeric antigen receptor-T or T-cell receptor-T cells and HBV-specific T cells to restore T cell function to efficiently clear *** therapy may successfully overcome immune tolerance and lead to HBV control and *** approaches carry the risk of overshooting immune responses causing uncontrolled liver *** safety of any new curative therapies should be measured in relation to the excellent safety of currently appro

关键词： immunity infection overcome

Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection

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World Journal of Hepatology 2022年第6期14卷 1053-1073页

作者： Iman Ibrahim Salama Hala M Raslan Ghada A Abdel-Latif Somaia I Salama samia M Sami Fatma A Shaaban Aida M Abdelmohsen Walaa A Fouad Department of Community Medicine Research National Research CenterGiza 12622DokkiEgypt Department of Internal Medicine National Research CenterGiza 12622DokkiEgypt Department of Child Health National Research CenterGiza 12622DokkiEgypt

Hepatitis C virus(HCV)is a common cause of liver disease and is associated with various extrahepatic manifestations(EHMs).This mini-review outlines the currently available treatments for HCV infection and their prognostic effect on hepatic manifestations and ***-acting antiviral(DAA)regimens are considered pan-genotypic as they achieve a sustained virological response(SVR)>85%after 12 wk through all the major HCV genotypes,with high percentages of SVR even in advanced fibrosis and *** risk factors for DAA failure include old males,cirrhosis,and the presence of resistance-associated substitutions(RAS)in the region targeted by the received *** effectiveness of DAA regimens is reduced in HCV genotype 3 with baseline RAS like A30K,Y93H,and ***,the European Association for the Study of the Liver recommended the identification of baseline RAS for HCV genotype *** higher rate of hepatocellular carcinoma(HCC)after DAA therapy may be related to the fact that DAA regimens are offered to patients with advanced liver fibrosis and cirrhosis,where interferon was contraindicated to those *** change in the growth of pre-existing subclinical,undetectable HCC upon DAA treatment might be also a ***,after DAA therapy,the T cell-dependent immune response is much weaker upon HCV clearance,and the down-regulation of TNF-αor the elevated neutrophil to lymphocyte ratio might increase the risk of *** can result in reactivation of hepatitis B virus(HBV)in HCV coinfected *** are effective in treating HCV-associated mixed cryoglobulinemia,with clinical and immunological responses,and have rapid and high effectiveness in *** improve insulin resistance in 90%of patients,increase glomerular filtration rate,and decrease proteinuria,hematuria and articular *** clearance by DAAs allows a significant improvement in atherosclerosis and metabolic and immunological conditions,with a reduction of m

关键词： Hepatitis C virus Hepatic Extrahepatic Direct-acting antivirals Impact

Impact of intersection type and a vehicular fleet's hybridization level on energy consumption and emissions

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Journal of Traffic and Transportation Engineering(English Edition) 2016年第3期3卷 253-261页

作者： samia Boubaker Ferid Rehimi Adel Kalboussi Institut Superieur de Transport et de la Logistique Uniuersite de SousseSousseTunisia Laboratoire d'Electronique et de Microelectronique Faculte des Sciences de MonastirUniversite de MonastirMonastirTunisia Laboratoire detude des Systemes thermiques et Energetique Ecole Nationale d'Ingenieurs de MonastirUniversite de MonastirMonastirTunisia

A vehicle＇s energy consumption and emissions are two major constraints in sustainable development. Both of them have proportionally raised in recent decades with the exponential growth of world traffic demands. The reduction of road traffic-generated energy consumption and emissions have thus become unprecedentedly challenging and worth examining. This paper investigates energy consumption and environmental problems present at roundabout and signalized intersection to analyze the impact of the hybridization level＇s fleet and intersection type on vehicle consumption and pollution. Instantaneous fuel consumption and emission models coupled with simulation of urban mobility （SUMO） are in this study. The authors started with modeling energy consumption. Then, an emission model emissions from traffic （EMIT） was implemented to quantify vehicle emissions of CO2, CO and NOX. These models help investigate the influence of intersection type on energy consumption and environmental conditions. The authors implemented a signalized intersection and roundabout using SUMO. The input data are collected from the roundabout of Sousse （Tunisia） using video data collection. Since there is a lack of econometric models that emulate hybridized stream behavior near intersections, two energy consumption models for the roundabout and crossroad are developed using traffic flow and hybridization level as the input variables. Compared to crossroads, a roundabout can obtain more environmental improvements and substantial reductions in energy consumption and road traffic emissions.

关键词： Roundabout Signalized intersection Consumption Emission SUMO Hybridization

Observational study to assess pregnant women's knowledge and behaviour related to toxoplasmosis in Essaouira province, Morocco

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Asian Pacific Journal of Tropical Medicine 2019年第2期12卷 87-90页

作者： Nadia Ouzennou samia Boussaa Safa Ben Alla Ali Boumezzough ISPITS-Higher Institute of Nursing and Health Technology Ecology and the Environment Laboratory L2E(URAC 32 CNRST ERACNERS 06) Faculty of Sciences Semlalia Cadi Ayyad University

Objective: To assess knowledge and behaviour related to toxoplasmosis which remains a neglected disease in ***: Observational investigations were conducted among 600 pregnant women from Essaouira *** interview items covered respondents' knowledge of the disease, its preventive practices and risk ***: A total of 22/600 women had already carried out the anti-toxoplasmosis test, while, 96% have never done any screening of anti-Toxoplasma *** 16/600 women have good information about the disease, its mode of transmission and its complications in both the fetus and his *** most women adopt a healthy diet, the consumption of raw or undercooked meat is far to be considered as a risk factor, along with other potential factors that may foster the acquisition of the disease, such as possessing a domestic cat, educational status and knowledge of the ***, in this study, contact with soil was revealed the most important risk factor(P = 0.045), followed by the hygiene conditions after handling raw meat(P = 0.048).Conclusion: The underestimation of the Toxoplasma gondii sero-prevalence in Essaouira Province can be explained by the absence of toxoplasmosis serology in health institutions, as well as the gap of knowledge about the disease by local population.

关键词： Toxoplasmosis Knowledge Risk behaviour Pregnant women Morocco

Kallimni ’Arabi - An Intermediate Course in Spoken Egyptian Arabic

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Structural effects on the magnetic hyperthermia properties of iron oxide nanoparticles

2007年

作者： Soliman Iman A. Louis samia

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Progress in Natural Science:Materials International 2016年第5期26卷 440-448页

作者： Eric C.Abenojar Sameera Wickramasinghe Jesbaniris Bas-Concepcion Anna Cristina S.samia Department of Chemistry Case Western Reserve University Chemistry Department University of Puerto Rico Rio Piedras Campus

Magnetic iron oxide nanoparticles(IONPs) are heavily explored as diagnostic and therapeutic agents due to their low cost, tunable properties, and biocompatibility. In particular, upon excitation with an alternating current(AC) magnetic field, the NPs generate localized heat that can be exploited for therapeutic hyperthermia treatment of diseased cells or pathogenic microbes. In this review, we focus on how structural changes and inter-particle interactions affect the heating efficiency of iron oxide-based magnetic NPs. Moreover, we present an overview of the different approaches to evaluate the heating performance of IONPs and introduce a new theranostic modality based on magnetic imaging guided–hyperthermia.

关键词： Iron oxide nanoparticles Magnetic hyperthermia Magneto-structural effects Magnetic dipolar interactions Magnetic imaging guided–hyperthermia

Mitochondrial dysfunction,oxidative stress and apoptotic induction in microglial BV-2 cells treated with sodium arsenate

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Journal of Environmental Sciences 2017年第1期29卷 44-51页

作者： Wafa Kharroubi samia Hai Ahmed Thomas Nury Pierre Andreoletti Rachid Sakly Mohamed Hammami Gerard Lizard Univ.Bourgogne Franche-Comte Laboratory Bio-PeroxIL Biochemistry of the PeroxisomeInflammation and Lipid Metabolism EA7270/INSERMFaculty of Sciences GabrielDijon 21000France Laboratory of Nutrition-Functional Foods and Vascular Diseases Faculty of MedicineUniversity of MonastirMonastir 5019Tunisia

The treatment of microglial BV-2 cells with sodium arsenate（As（V）：0.1-400 μmol/L — 48 hr）induces a dose-dependent *** neurotoxic effects of high concentrations of As（V）（100,200 and 400 μmol/L） are characterized by increased levels of mitochondrial complexesⅠ,Ⅱ,and Ⅳ followed by increased superoxide anion ***,As（V） triggers an apoptotic mode of cell death,demonstrated by an apoptotic SubG1 peak,associated with an alteration of plasma membrane *** is also a decrease in transmembrane mitochondrial potential and mitochondrial adenosine triphosphate *** is therefore tempting to speculate that As（V） triggers mitochondrial dysfunction,which may lead to defective oxidative phosphorylation subsequently causing mitochondrial oxidative damage,which in turn induces an apoptotic mode of cell death.

关键词： Sodium arsenate Microglial BV-2 cells Mitochondrial dysfunction Oxidative phosphorylation complexes Superoxide anions Apoptosis

Florid Autonomic Features Associated with Medullary Lacunar Stroke

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International Journal of Clinical Medicine 2022年第12期13卷 679-690页

作者： Muaz Elsayed Akram Harazeen Asma Shams Pournamy Sarathchandran Feras Alrawi Tayseer Zain samia Noor Department of Neurology Al Qassemi Hospital (EHS) Emirates Health Services Sharjah UAE Faculty of Medicine and Health Sciences Omdurman Islamic University Omdurman Sudan

Introduction: Autonomic nuclei affection results in variations in hemodynamics, temperature, sweating and ECG. Medullary strokes are challenging in their presentation, bizarre clinical signs, work and neurological outcome. The commonest cause is infarction of the posterior inferior cerebellar artery (PICA). Anatomical areas affected include the inferior cerebellar peduncle, dorsolateral medulla, nuclei of the Trigeminal, vestibular nuclei, Ninth and Vagus nerves. The descending sympathetic tracts and spin thalamic tracts. Serious cardiopulmonary events can complicate 11% of cases. Case Presentation: A middle-aged female developed sub-acute dizziness associated with vomiting and right head pains. She was unable to walk but remained cognitively clear. Her gastrointestinal symptoms were disabling and this was the main factor for presenting to the emergency room. The risk factors included hypertension and diabetes mellitus. Imaging studies were essential for posterior circulation stroke diagnosis and follow-up. She manifested remarkable autonomic features regarding the skin and hemodynamics. Nevertheless, the hospital course was controllable. Discussion: This case report was consistent with relevant literature in the contra lateral vaso motor changes and drop in body temperature during the acute phase. Moreover, our patient developed clinical and radiological extension through double antiplatelets. Superiority of the magnetic resonance imaging (MRI) scans in this patient enabled better diagnostic accuracy in a brainstem stroke. Conclusion: The autonomic features, in this case, represent major symptomatology and clinical signs. The variation in the hemodynamics and persistence of symptoms is thought provoking. This increases the awareness of emergency doctors for acute stroke presenting with autonomic features will enable early detection and helps outcome.

关键词： Autonomic Medullary Infarction Wallenberg’s Syndrome Brainstem Stroke

A New Full-NT-Step Infeasible Interior-Point Algorithm for SDP Based on a Specific Kernel Function

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Applied Mathematics 2012年第9期3卷 1014-1022页

作者： Samir bouali Samir Kabbaj Department of Mathematics and Informatics Faculty of Sciences University Ibn Tofail Kenitra Morocco

In this paper, we propose a new infeasible interior-point algorithm with full NesterovTodd (NT) steps for semidefinite programming (SDP). The main iteration consists of a feasibility step and several centrality steps. We used a specific kernel function to induce the feasibility step. The analysis is more simplified. The iteration bound coincides with the currently best known bound for infeasible interior-point methods.

关键词： Semidefinite Programming Full Nesterov-Todd Steps Infeasible Interior-Point Methods Polynomial Complexity Kernel Functions