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评估口服西地那非治疗严重肺动脉高压有效性的一项随机、安慰剂对照、双盲、交叉研究

世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 15-16页

作者： Singh T.P. Rohit M. grover A. 杨海涛 Department of Cardiology Post Graduate Institute of Medical Education and ResearchChandigarhIndia.Dr

Background: Severe pulmonary artery hypertension(PAH) is a disorder with limited treatment options. Recently, several newer drugs have recently been introduced to treat PAH. Sildenafil is one which has shown promise in several uncontrolled studies, but controlled trials have been few. In this randomized placebo-controlled study, we evaluated the efficacy of oral sildenafil in idiopathic PAH and PAH caused by Eisenmenger syndrome. Methods: This was a randomized, double-blind, placebo-controlled crossover study. Twenty patients, 10 of each of idiopathic PAH and Eisenmenger syndrome, were randomized to receive placebo or sildenafil in a double-blind manner for 6 weeks and, after a washout period of 2 weeks, were crossed over. The primary end point of efficacy was the improvement in distance covered in 6-minute walk test. Secondary end points were reduction in pulmonary artery pressure as measured by Doppler echocardiography after 6 weeks of treatment, improvement in clinical condition, New York Heart Association(NYHA) class, and exercise duration and metabolic equivalents(Mets) achieved on modified Bruce exercise protocol. Results: There was significant improvement in primary and secondary end points. The primary end point of distance covered in 6-minute walk test improved from 262±99 to 358.9±96.5 m(P< .0001) after treatment with sildenafil. Pulmonary artery pressure, the secondary end point, improved from the baseline of 98.8±20.5 to 78.3±15.3 mm Hg(P< .0001), NYHA class improved from 2.65±0.59 to 1.55±0.51(P< .0001), exercise duration from 6.4±3.1 to 10.2±2.05 minutes(P< .0001), and Mets achieved from 3.32±1.57 to 6.04±1.87(P< .0001) after treatment with sildenafil. There was no significant fall in blood pressure with placebo and sildenafil, and no serious side effects of drug were observed in the study. Conclusions: Sildenafil significantly improved the symptomatic status, exercise capacity, NYHA class, and hemodynamic parameters of patients with severe PAH and can

关键词：安慰剂对照西地那非治疗方法肺动脉高压随机双盲有效性随机化口服

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Percutaneous endovascular management of atherosclerotic axillary artery stenosis:Report of 2 cases and review of literature

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World Journal of Cardiology 2011年第5期3卷 165-168页

作者： Rajesh Vijayvergiya Mukesh Yadav Anil grover Department of Cardiology Advance Cardiac CentrePostgraduate Institute of Medical Education and ResearchChandigarh 160 012India

With recent advancement in percutaneous endovascular management,most atherosclerotic peripheral arterial diseases are amenable for ***,there is limited published literature about atherosclerotic axillary artery involvement and its endovascular *** report two cases of atherosclerotic axillary artery stenosis,which were successfully managed with stent angioplasty using self expanding nitinol stents. The associated coronary artery disease was treated by percutaneous angioplasty and *** long term follow-up revealed patent axillary stents in both cases.

关键词： Angioplasty Atherosclerosis Axillary artery Coronary artery Endovascular Self expanding stent

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活检及组织学病理学在诊断银屑病甲中的重要性

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 39-40页

作者： grover C. Reddy B.S.N. Chaturvedi K.U. 焦婷 11/15 Nehru Nagar New Delhi- 110065 India

Background: Involvement of the nail is quite common in psoriasis and at times may be the sole diagnostic clue. However, the histopathology of nail psoriasis has not been adequately evaluated. A confirmation of the diagnosis is required in cases suspected to have nail psoriasis in order to plan longterm therapy. Objectives: To assess the diagnostic significance and safety profile of nail biopsy in cases with nail psoriasis. Methods: Clinical and mycological features were studied in 42 patients with nail psoriasis. Of these, 22 patients gave consent for nail biopsies to be taken and the histopathological changes were assessed. Results: Males were affected more commonly (57% ) with a peak incidence in the age group of 10- 20 years (29% ). Distal onycholysis, discoloration of nail plate, subungual hyperkeratosis and fine nail pitting were the predominant clinical features. In the 22 biopsies done, hyperkeratosis with parakeratosis (91% ) was found to be the most common and hypergranulosis was the least common histological finding (36% ). Clinicohistological correlation was possible only in 55% cases. Periodic acid-Schiff (PAS) stainingwas done for all biopsies. Conclusions: Histopathological examination of nails is a valuable diagnostic aid, especially in the absence of skin lesions. Examination of the PAS-stained sections is necessary before making a histological diagnosis of nail psoriasis because onychomycosis and psoriasis may show similar histology.

关键词：组织病理学改变银屑病甲诊断价值活检术组织学组织病理改变临床特征长期治疗患者安全性

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Percutaneous revascularization in a patient with anomalous origin of left main coronary artery

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World Journal of Cardiology 2011年第9期3卷 311-314页

作者： Rajesh Vijayvergiya Anil grover Manphool Singhal Department of Cardiology Advance Cardiac Centre Post Graduate Institute of Medical Education and Research Department of Radiology Advance Cardiac Centre Post Graduate Institute of Medical Education & Research

Anomalous origin of the coronary artery from opposite coronary sinus is infrequently observed during coronary angiography. Percutaneous coronary intervention (PCI) of anomalous coronary artery is technically difficult and challenging. It requires appropriate selection of guide catheters for adequate stability, coaxial alignment and backup support during the intervention. We hereby report a rare case of anomalous origin of left main coronary artery (LM) from the right coronary sinus, having a retro-aortic course to the left side before its bifurcation into left anterior descending (LAD) and circumflex artery. The 59-year-old man had successful PCI of atherosclerotic LAD lesions. A 64-slice Multi-Detector Computed Tomography (MDCT) performed at 4 years of follow-up demonstrated patency of coronary stents and also delineated the origin and course of the anomalous LM. The case illustrates the rarity of anomalous LM, and describes technical issues during PCI and the role of MDCT in coronary anomaly imaging.

关键词： Anomalous left main coronary artery Atherosclerosis Coronary artery anomalies Drug-eluting stent Multi-detector computed tomography Percutaneous coronary intervention Retro-aortic course

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Acetylsalicylic Acid Administered in Patients with Type 2 Diabetes Mellitus and Its Effect on the Antioxidant Enzyme System

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Journal of Diabetes Mellitus 2022年第4期12卷 252-262页

作者： Sara Pascoe-González Karina Celia Morgado-Castillo Maria Guadalupe Ramos-Zavala Ernesto Germán Cardona-Muñoz Fernando grover-Paez María Claudia Espinel-Bermúdez Sandra Ofelia Hernández-González Instituto de Terapéutica Experimental y Clínica (INTEC) Departamento de Fisiología Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara México Unidad de Investigación Biomédica 02 Unidad Médica de Alta Especialidad Hospital de Especialidades Centro Médico Nacional de Occidente del Instituto Mexicano del Seguro Social Guadalajara México

Type 2 diabetes mellitus and its complications are associated with oxidative stress and the depletion of antioxidant defenses. The influence of acetylsalicylic acid on reversing the decrease in antioxidants, insulin resistance, glucose homeostasis, and inflammatory cascade can help prevent diabetes complications. Purpose: The aim of the study was to evaluate the effect of acetylsalicylic acid on the antioxidant enzymatic system in patients with diabetes. Methods: A randomized, double-blind, placebo-controlled clinical trial was carried out in 21 patients of both sexes with Type 2 diabetes for less than five years at the time of diagnosis, without pharmacological treatment, and randomly selected. Acetylsalicylic acid (300 mg) was administered orally for three months to the study group (n = 11) compared to the placebo control group (n = 10). Before and after the intervention, anthropometric and metabolic measurements were taken, fasting plasma glucose, glycated hemoglobin A1c, lipid profile panel, glutathione peroxidase, superoxide dismutase, catalase, and antioxidant capacity/activity were determined;values are presented as mean ± standard deviation. Intra- and intergroup differences were tested by Wilcoxon signed rank and Mann-Whitney U test, respectively;p-value ≤ 0.05 was considered statistically significant. Results: The acetylsalicylic acid group showed a decrease in weight (85.6 ± 19.3 vs. 84.1 ± 19.0 kg p = 0.01), cholesterol (205.9 ± 16.6 vs. 186.0 ± 23.2 mg/dL p = 0.02), and glycated hemoglobin A1c (7.8% ± 0.9% vs. 7.0% ± 0.7% p = 0.02). The placebo group exhibited reduction in weight (76.1 ± 14.9 vs. 74.9 ± 15.0 kg p = 0.04), glycated hemoglobin A1c (6.9% ± 0.6% vs. 6.2% ± 0.4% p = 0.004), and total antioxidant capacity (4.1 ± 0.5 vs. 4.8 ± 0.3 mmol/L p = 0.002). Conclusion: The administration of acetylsalicylic acid did not modify the antioxidant enzyme system.

关键词： Type 2 Diabetes Mellitus Acetylsalicylic Acid Oxidative Stress Glucose Glycated Hemoglobin A1c

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Successful Management of a Complicated Ulcer Caused by Autoimmune Vasculitis, with Sildenafil Citrate in a Patient with Primary Antiphospholipid Syndrome and Transient Steroid-Induced Diabetes Mellitus: A Case Report and Literature Review

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Journal of Diabetes Mellitus 2014年第3期4卷 189-193页

作者： Fernando grover-Paez Leonel Garcia-Benavides Ernesto German Cardona-Munoz Carlos Gerardo Ramos-Becerra Jesus Ricardo Garcia-Corral Carlos Enrique Medina-Garcia Guillermo Adrian Alanis-Sanchez Sylvia Elena Totsuka-Sutto Institute of Experimental and Clinical Therapeutics Department of PhysiologyUniversity Center of Health SciencesUniversity of GuadalajaraGuadalajaraMexico

Antiphospholipid syndrome (APS) is a prothrombotic condition that can affect both the venous circulation and the arterial system. The deep veins of the lower extremities and cerebral blood flow are the most common sites of venous and arterial thrombosis, respectively. Skin ulceration and gangrene may be associated with an active vasculitis in patients with APS. These kinds of ulcers are considered intractable because healing is difficult to achieve. Using steroids as immunesuppressant therapy is still a basic part of managing APS and vasculitis. Nevertheless, in the presence of steroid-induced diabetes mellitus, the priority is to achieve faster wound healing, because of the potential complications that can develop due to metabolic dysfunction and augmented vulnerability to infection. Until recently, there were few reports demonstrating the benefits of the use of adjuvant phosphodiesterase-5 inhibitors like sildenafil citrate in different clinical entities with courses like Raynaud’s phenomenon, scleroderma, and resistance to vasodilator therapy. We present the first report demonstrating the additional benefit of sildenafil citrate for the integration of grafts in a patient with steroid-induced diabetes and APS who had ulcers due to vasculitis resistant to the usual vasodilator therapy.

关键词： Autoimmune Vasculitis Sildenafil Citrate Steroid-Induced Diabetes Mellitus Primary Antiphospholipid Syndrome

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Allosteric inhibitors of plasma membrane Ca^(2+) pumps: Invention and applications of caloxins

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World Journal of Biological Chemistry 2011年第3期2卷 39-47页

作者： Jyoti Pande M Szewczyk Ashok K grover Department of Medicine HSC 4N41McMaster University1200 Main Street WestHamilton Ontario L8N 3Z5Canada Magdalena Ashok K grover Department of BiologyHSC 4N41McMaster University1200 Main Street WestHamiltonOntario L8N 3Z5Canada

Plasma membrane Ca2+pumps(PMCA)play a major role in Ca2+homeostasis and signaling by extruding cellular Ca2+with high *** isoforms are encoded by four genes which are expressed differentially in various cell types in normal and disease ***, PMCA isoform selective inhibitors would aid in delineating their role in physiology and *** are testing the hypothesis that extracellular domains of PMCA can be used as allosteric targets to obtain a novel class of PMCA-specific inhibitors termed caloxins. This review presents the concepts behind the invention of caloxins and our progress in this area.A section is also devoted to the applications of caloxins in literature. We anticipate that isoform-selective caloxins will aid in understanding PMCA physiology in health and disease. With strategies to develop therapeutics from bioactive peptides,caloxins may become clinically useful in car diovascular diseases,neurological disorders,retinopathy,cancer and contraception.

关键词： Phage display Calcium signaling Plasma membrane Ca2+pumps Hypertension Neuronal disorders Contraception Cancer Thrombosis Lipid rafts

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用色谱分析氯碱厂电解槽气

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氯碱工业 1980年第2期 44-46页

作者： S.K.DANG P.D.grover S.L.CHAWLA 曹喜生印度技术研究所

为了保持阳极室氢气的浓度低于爆炸极限(3％)和测定电解槽的电流效率,对氯碱厂电解槽气必须进行分析。体积计量法既不精确又费时间,而用色谱进行在线分析比较合适。过去有人介绍过用热导气体分析仪估算氯或氢百分数的方法(见参考文献1... 详细信息

为了保持阳极室氢气的浓度低于爆炸极限(3％)和测定电解槽的电流效率,对氯碱厂电解槽气必须进行分析。体积计量法既不精确又费时间,而用色谱进行在线分析比较合适。过去有人介绍过用热导气体分析仪估算氯或氢百分数的方法(见参考文献1—5)。1960年以来,人们对用色谱分析电解槽气进行了各种尝试。 Neelay(见参考文献6)用两台色谱仪。在载气管路上有一个多通管和这两台仪器相连接。由于没有一种吸附剂能分离所有的组分,所以两台色谱仪的柱子串联。第一台色谱的柱子充填涂在Chromosorb上的氟碳润滑脂,用来分离永久性气体,二氧化碳和氯气。第二台色谱的柱子

关键词：电解槽氯气二氧化碳载气电解池 CO2 氯碱厂色谱分析硅胶柱热导检测工业气体氢气

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下一代DVD标准之争：索尼略占上风

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商业周刊（中文版） 2008年第1期 18-19页

作者：罗纳德·格罗弗（Ronald grover）克利夫·爱德华兹（Cliff Edwards）夏芳（译者）

以索尼为首的蓝光技术阵营似乎在单一高清DVD标准的竞争中略胜出竞争对手一筹

关键词： DVD标准索尼竞争对手技术

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Comparative effectiveness of quetiapine and haloperidol in delirium:A single blind randomized controlled study

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World Journal of Psychiatry 2016年第3期6卷 365-371页

作者： Sandeep grover Sudhir Mahajan Subho Chakrabarti Ajit Avasthi Department of Psychiatry Postgraduate Institute of Medical Education and Research

AIM To evaluate the effectiveness of quetiapine and haloperidol in patients of delirium referred to psychiatry consultation liaison *** The study followed a single blind randomised controlled trial ***-two patients in the haloperidol group and 31 patients in the quetiapine group were assessed at the baseline and 6 consecutive *** dosing regimen(haloperidol:0.25-1.25 mg;quetiapine 12.5-75 mg/d) was *** Rating Scale-Revised-98(DRS-R-98) and mini mental status examination(MMSE) were the primary and secondary efficacy measures *** Baseline DRS-R-98 severity score and MMSE scores did not differ between the 2 study *** baseline to day 6,there was significant reduction in the total DRS-R-98 scores,DRS-R-98 cognitive domain scores,DRS-R-98 non-cognitive domain scores and significant increase in the MMSE scores in both the *** the groups did not differ on any of the assessments in terms of DRS-R98 and MMSE *** effectiveness of both the medications was similar in adult and elderly(≥ 60 years) *** the end of the trial,68.75% and 67.74% of subjects in the haloperidol and quetiapine group respectively had mean DRS-R-98 scores below *** 6th day,12(37.5%) patients in haloperidol group and 9(29.03%) patients in the quetiapine group hadDRS-R98 score of "0" with no significant difference between the two groups(P = 0.47).CONCLUSION Quetiapine is as effective as haloperidol in the management of delirium.

关键词： Delirium Quetiapine Effectiveness Atypical antipsychotics

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