检索结果-南通市图书馆

Preparation and Spectroscopic of Vanadyl（Ⅱ） Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug

光谱学与光谱分析 2019年第7期39卷 2316-2324页

作者： Enas Aljuhani Amnah M.A.Alsuhaibani A.M.El-Di damony N.Hassan sameh abo taleb Moamen S.Refat Department of Chemistry Faculty of Applied ScienceUmm Al-Qura UniversityMakkahP.O.9168 Zip Code 21955Saudi Arabia Nutrition and Food Sciences Dept. Home Economic CollegePrincess Nourah Bint Abdulrahman UniversityRiyadhSaudi Arabia Department of Chemistry Faculty of ScienceZagazig UniversityEgypt Department of Chemistry Faculty of SciencePort SaidPort Said UniversityEgypt Chemistry Department Faculty of ScienceTaif UniversityP.O.Box 888Al-HawiahTaif 21974Saudi Arabia

A new six intraperitoneal injection insulin-mimetic vanadyl(Ⅱ) compounds [(VD3^-1)(VO^+2)(AAn^-1)](where(n=1~6);AA1=isoleucine, AA2=threonine, AA3=proline, AA4=phenylalanine, AA5=lysine and AA6=glutamine) were synthesized by the chemical reactions between vitamin D3(VD3), VOSO4 and amino acids(AAn) with equal molar ratio 1∶1∶1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl(Ⅳ) ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.

关键词： Insulin alternative Diabetes Drug VO^2+ ion Vitamin D3 Amino acid Spectroscopic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Data–driven decision–making for lost circulation treatments: A machine learning approach

引用

能源与人工智能(英文) 2020年第2期2卷 125-135页

作者： Husam H.Alkinani abo taleb T.Al-Hameedi Shari Dunn-Norman Missouri University of Science and Technology 1201 N State StRollaMO 65409USA

Lost circulation is an expensive and critical problem in the drilling *** of dollars are spent every year to mitigate or stop this *** this work,data from over 3000 wells were collected from multiple *** data went through a processing step where all outliers were removed and decision rules were set *** machine learning methods(support vector machine,decision trees,logistic regression,artificial neural networks,and ensemble trees)were used to create a model that can predict the best lost circulation treatment based on the type of loss and the reason of loss.5-fold cross-validation was conducted to ensure no overfitting in the created *** using all the aforementioned machine learning methods to train models to choose the best lost circulation treatment,overall,the results showed that support vector machine had the highest accuracy among the other ***,it was selected to train the *** created model went through quality control/quality assurance(QC/QA)to limit the results of incorrect *** treatments were suggested to treat partial loss,four to treat severe loss,and seven for complete loss,based on the reason of *** addition,a formalized methodology to respond to lost circulation was provided to help the drilling personnel handling lost circulation in the field.

关键词： Machine learning Lost circulation Data-driven Classification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy Analysis of an Experience on Development of the Combination Therapy Protocol for Endometriosis Management

引用

Open Journal of Obstetrics and Gynecology 2017年第1期7卷 31-40页

作者： abo taleb Saremi Ameneh Lahooti Eshkevari Katayoun Esmaili Pour Arash Pooladi Sarem Fertility & Infertility Research Center (SAFIR) & Sarem Cell Research Center (SCRC) Sarem Women’s Hospital Tehran Iran Infertility Department Sarem Women’s Hospital Tehran Iran

Purpose: Endometriosis can be managed effectively by medication, surgery, or a combination of both. Numerous studies have been conducted on surgical and medication treatment options, but their results are still under discussion. Therefore, we performed a study to develop a combinational treatment for various stages of endometriosis. Methods: Over a 3-year period, 218 documented endometriosis patients were classified in 4 stages. After first laparoscopy (with electrocoagulation and adhesion removal for stages I to III), the patients were treated with GnRH analogs (Gonadotropin Releasing Hormone Agonist-375 mg of Decapeptyl) for 3, 6 & 6 months, respectively. The second and third laparoscopy procedures were performed after 3 and 6 months, with add-back therapy. The treatment was evaluated by direct observation based on laparoscopic view and the pain relief was measured by the VAS (Visual Analogue Scale) after the first step of medication for patients of stages I-III. Results: After 3 months, 70/76 patients (91.9%) with stage-I endometriosis showed complete recovery (six cases after 6 months) while 65/72 and 32/43 cases with stage-II and -III (90.3 and 74.4%), respectively, showed complete recovery after 6 months of treatment. The remaining patients had GnRH treatment for another 3 months, and all showed a complete recovery after 9 months. Furthermore, 12 of the patients with stage-IV symptoms were candidates for laparoscopy or laparotomy, and their treatment response rate was 55.6%. The pain relief was significant after the combinational treatment in patients with stages I-III (P = 0.0001). Conclusion: Our study showed efficacy of the developed protocol for the endometriosis management.

关键词： Endometriosis Combinational Therapy Management Protocol Development Efficacy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：