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Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

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Cellular & Molecular Immunology 2021年第2期18卷 415-426页

作者： Morten Orebo Holmström Rasmus Erik johansson Mortensen Angelos Michail Pavlidis Evelina Martinenaite Stine Emilie Weis-Banke Mia Aaboe-Jørgensen Simone Kloch Bendtsen Özcan Met Ayako Wakatsuki Pedersen Marco Donia Inge Marie Svane Mads Hald Andersen Department of Oncology National Center for Cancer Immune TherapyCopenhagen University HospitalHerlevDenmark IO Biotech ApS CopenhagenDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor-beta(TGFβ)is a highly potent immunosuppressive *** TGFβis a tumor suppressor in early/premalignant cancer lesions,the cytokine has several tumor-promoting effects in advanced cancer;abrogation of the antitumor immune response is one of the most important tumor-promoting *** several immunoregulatory mechanisms have recently been shown to be targets of specific T cells,we hypothesized that TGFβis targeted by naturally occurring specific T cells and thus could be a potential target for immunomodulatory cancer ***,we tested healthy donor and cancer patient T cells for spontaneous T-cell responses specifically targeting 3820-mer epitopes derived from TGFβ*** identified numerous CD4^(+)and CD8^(+)T-cell responses against several epitopes in TGFβ.Additionally,several ex vivo responses were *** enriching specific T cells from different donors,we produced highly specific cultures specific to several TGFβ-derived *** CD8^(+)T-cell clones specific for both a 20-mer epitope and a 9-mer HLA-A2 restricted killed epitope peptide were pulsed in HLA-A2+target cells and killed the HLA-A2+cancer cell lines THP-1 and ***,stimulation of THP-1 cancer cells with cytokines that increased TGFβexpression increased the fraction of killed *** conclusion,we have shown that healthy donors and cancer patients harbor CD4^(+)and CD8^(+)T cells specific for TGFβ-derived epitopes and that cytotoxic T cells with specificity toward TGFβ-derived epitopes are able to recognize and kill cancer cell lines in a TGFβ-dependent manner.

关键词： Immune regulation TGFbeta cancer T cells adaptive immunity

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生活用纸生产的可实施技术和节能实践

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生活用纸 2017年第8期17卷 62-66页

作者： Arvid johansson 维美德(中国)有限公司

可持续发展是当今全民关注的热点，如何减少纤维用量、节能降耗和提高回用减少排放等问题自然是生活用纸生产商关注的焦点。Advantage NTT技术的应用有效减少纤维用量图1显示生活用纸生产成本，其中纤维和能源消耗分别占据总成本的64％... 详细信息

可持续发展是当今全民关注的热点，如何减少纤维用量、节能降耗和提高回用减少排放等问题自然是生活用纸生产商关注的焦点。Advantage NTT技术的应用有效减少纤维用量图1显示生活用纸生产成本，其中纤维和能源消耗分别占据总成本的64％和15％，因此，降低纤维用量对降低总成本有至关重要的作用。

关键词：生活用纸节能降耗生产商技术 Advantage 可持续发展减少排放生产成本

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厨房与客厅的亲密接触

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设计 2010年第7期23卷 39-41页

作者： Pernilla johansson 伊莱克斯亚太区

Eurocucina每两年在意大利北部城市米兰举办一次,是世界上最重要的厨房家居展览。美丽富饶的米兰是阿玛尼、古琦、法拉利以及兰博基尼等著名品牌的故乡,也是举办厨房家居展的理想之地——Eurocucina的英文意思是"欧洲厨房"。展会上,风... 详细信息

Eurocucina每两年在意大利北部城市米兰举办一次,是世界上最重要的厨房家居展览。美丽富饶的米兰是阿玛尼、古琦、法拉利以及兰博基尼等著名品牌的故乡,也是举办厨房家居展的理想之地——Eurocucina的英文意思是"欧洲厨房"。展会上,风格和激情融汇创意与魅力,细致入微。展会历时四天,几百个顶级的厨房展示吸引了30万人参观。我发现今年的Eurocucina展会显露出六大重要的厨房设计动向。

关键词：厨房设计客厅智能接触潮流亲密隔离未来开放式家居

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金融抑制与经济结构转型

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国民经济管理 2013年第5期 54-67页

作者：王勋 Anders johansson

结构转型是当前世界经济面临的主要问题之一。本文在经济结构转型的模型中，研究了金融抑制对产业结构变化的影响。模型表明经济资源会随着经济增长从工业部门不断流入服务业部门，从而使得服务业的比重不断上升。而政府可以采取金融抑... 详细信息

结构转型是当前世界经济面临的主要问题之一。本文在经济结构转型的模型中，研究了金融抑制对产业结构变化的影响。模型表明经济资源会随着经济增长从工业部门不断流入服务业部门，从而使得服务业的比重不断上升。而政府可以采取金融抑制政策阻碍结构转型过程。通过抑制服务业，保护和促进工业部门的发展，从而造成服务业占比偏低，导致国内产业结构失衡。跨国面板数据的实证结果表明，金融抑制显著阻碍了结构转型。金融抑制程度越高，经济中服务业相对于制造业的比例会越低。基于不同收入水平的国家分组数据、不同的结构变量衡量以及不同的金融抑制指标的稳健性检验支持了这一结论。文章结果表明，在有政府干预和偏好工业部门发展的国家，金融抑制是结构失衡的重要因素。

关键词：金融抑制结构转型经济发展

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Use of a National Clinical Final Examination in a Bachelor’s Programme in Nursing to Assess Clinical Competence—Students’, Lecturers’ and Nurses’ Perceptions

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Open Journal of Nursing 2014年第7期4卷 501-511页

作者： Unn-Britt johansson Petra Lilja Andersson Maria Larsson Kristina Ziegert Marianne Ahlner-Elmqvist Department of Health Sciences Faculty of Medicine Lund University Lund Sweden Department of Health Sciences Karlstad University Karlstad Sweden School of Social and Health Sciences Halmstad University Halmstad Sweden Sophiahemmet University Stockholm Sweden

Objective: The objective of this study was to evaluate the perceptions of students, lecturers, nurses and clinical lecturers regarding the ability of the National Clinical Final Examination (NCFE) to assess clinical competence, and whether the assessment was consistent with the qualifications for a Bachelor of Science in Nursing as outlined by the Swedish Higher Education Authority. The NCFE is divided into two parts (written and bedside) and aims to evaluate third-year nursing students’ clinical competence. Methods: Data were collected at 10 universities using study-specific questionnaires. The total response rate was 84% (n = 1652). Results: The clinical lecturers indicated that there was a need for improvement in the written part of the examination in order to adequately assess clinical competence. Regarding the bedside part the clinical lecturers, nurses and students perceived that the bedside part of the examination assessed whether the student had the clinical competence required by a newly registered nurse. Conclusion: The two-part examination described in this study was perceived as useful for assessing clinical competence and for the qualification requirements for a Bachelor of Science in Nursing as outlined by the Swedish Higher Education Authority. However, especially the written part requires further development. The model and form of assessment ought to be applicable to graduate nursing programme internationally.

关键词： Assessment Clinical Competence Nurse Education Students

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人之生也,为声色尔

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投资有道 2021年第3期 104-106页

作者： [瑞典]Ingela johansson 不详

连载到现在,你看懂了吗?当我们谈论画画的时候,不是真的让你画幅画。某种程度上,绘画需要调动多种感官来激发灵感,感官的发掘是一种正念练习,花点时间去好好感知质地、气味、味道和色彩。森林里,一个蛋型剧场内,一场多感官的艺术疗愈活... 详细信息

连载到现在,你看懂了吗?当我们谈论画画的时候,不是真的让你画幅画。某种程度上,绘画需要调动多种感官来激发灵感,感官的发掘是一种正念练习,花点时间去好好感知质地、气味、味道和色彩。森林里,一个蛋型剧场内,一场多感官的艺术疗愈活动拉开帷幕。

关键词：多感官激发灵感多种感官正念练习

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Undiagnosed obstructive sleep apnea in hypertensive outpatients in primary care—Associations with sleep complaints, depressive symptoms and global perceived health

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Open Journal of Nursing 2013年第6期3卷 445-452页

作者： Anders Brostrom Ola Sunnergren Kristofer Arestedt Peter johansson Per Nilsen Bengt Fridlund Eva Svanborg Department of Nursing Science School of Health SciencesJonkoping UniversityJonkopingSweden Department of Clinical Neurophysiology Linkoping University HospitalLinkopingSweden Department of Clinical and Experimental Medicine Division of Clinical NeurophysiologyFaculty of Health SciencesLinkoping UniversityLinkopingSweden Department of ENT Ryhov HospitalJonkopingSweden School of Health and Caring Sciences Faculty of HealthSocial Work and Behavioural SciencesLinnaeus UniversityKalmarSweden Department of Medicine and Health Sciences Division of Nursing SciencesFaculty of Health SciencesLinkoping UniversityLinkopingSweden Department of Cardiology Linkoping University HospitalLinkopingSweden. Department of Medicine and Health Sciences Division of Cardiovascular MedicineFaculty of Health SciencesLinköping UniversityLinkopingSweden Division of Health Care Analysis Faculty of Health SciencesDepartment of Health and SocietyLinkoping UniversityLinkopingSweden

Objective: 1) To describe the prevalence of undiagnosed obstructive sleep apnea (OSA) and depressive symptoms in hypertensive men and women below 65 years of age, and 2) to describe the association of OSA to subjective sleep complaints, depressive symptoms and global perceived health. Design: Cross-sectional design focusing on nursing care outcomes of obstructive sleep apnea. Setting: Four primary care health centres in Sweden. PATIENTS: 411 consecutive patients (52% women), mean age 57.9 years (SD 5.9 years), with diagnosed hypertension (BP > 140/90). Main Outcome Measures: Prevalence of OSA and depressive symptoms, and association of OSA to sleep complaints, depressive symptoms and global perceived health. RESULTS: Mild, moderate and severe OSA was seen among 29%, 16% and 14% of patients, respectively. Depressive symptoms were seen in 16% of the total group, with a higher prevalence among men, compared to women, 21% vs. 12%. No differences were found regarding blood pressure, estimated sleep need, sleep sufficiency index, insomnia symptoms, daytime sleepiness or depressive symptoms with respect to different degrees of OSA. Apnea-hypopnea index was significantly associated to perceived health after adjustment for gender and comorbidities, but when depressive symptoms and non-restorative sleep were added to the model, 33% of the variance in global perceived health was explained. Conclusion: OSA is highly prevalent among patients with hypertension in primary care and does together with sleep complaints and depressive symptoms have a negative impact on global perceived health. Hypertensive patients without subjective sleep complaints or depressive symptoms may still have OSA.

关键词： Depression Global Perceived Health Hypertension Nursing Care Obstructive Sleep Apnea Sleep Disordered Breathing Sleep

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饲喂青贮饲料对猪肉脂肪含量与脂肪酸组成的影响

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中国畜牧兽医 2003年第1期30卷 53-54页

作者： L johansson 李琍

本研究结果表明 ,饲喂青贮料 (红三叶青贮 )的生猪腰肉与常规饲养的生猪腰肉相比 ,肌内脂肪 (IMF)、饱和脂肪酸 (SAFA)和单不饱和脂肪酸 (MUFA)含量较低 ,多不饱和脂肪酸 (PUFA,ω6,ω3 )较高。但制熟后 ,ω3 -PUFA相对含量较高 ,ω6/ω... 详细信息

本研究结果表明 ,饲喂青贮料 (红三叶青贮 )的生猪腰肉与常规饲养的生猪腰肉相比 ,肌内脂肪 (IMF)、饱和脂肪酸 (SAFA)和单不饱和脂肪酸 (MUFA)含量较低 ,多不饱和脂肪酸 (PUFA,ω6,ω3 )较高。但制熟后 ,ω3 -PUFA相对含量较高 ,ω6/ω3较小。 IMF和烹调都影响猪肉脂肪酸 (FA)浓度。饲喂青贮料的生猪腰肉与常规饲养的生猪腰肉相比 ,SAFA、MUFA和 PUFA浓度有差异烹熟后 ,这些差异就消失了 ,但 ω6/ ω3较小这种差异仍存在 ,所以 ,饲喂青贮料的猪腰肉烹熟后肉品有所改善。

关键词：饲喂青贮饲料猪肉脂肪含量脂肪酸组成

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Photoemission and NEXAFS Studies of PTCDA on Sn/Si（111）-2√3×2√3

Photoemission and NEXAFS Studies of PTCDA on Sn/Si（111）-2...

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第18届国际真空大会

作者： L.K.E. Ericsson L.S.O. johansson Department of Physics Karlstad University

Interface interactions between organic molecules and semiconductor substrates are especially important since they affect the electronic structure and modify its growth mode of molecular films. The planar perylene derivative 3,4,9,10-tetracarboxylic dianhydride （PTCDA） has been widely used as a model compound for organic thin films since it has promising electronic and optical properties for organic electronic applications. In this context, a detailed understanding of the interface interactions between PTCDA molecules and semiconductor surfaces may therefore be used to optimize organic-inorganic devices. A series of coverages （0.3-10 monolayer （ML）） of PTCDA were deposited on the Sn/Si（111）-2√3×2√3 surface at room temperature. As shown by O 1s core-level spectra, at low coverage there are two major peaks located at binding energies of 530.3 and 532.6 eV. According to the previous studies [1,2], these two O 1s components should be O atoms in the carboxylic and anhydride groups. At 10 ML, the O 1s spectrum shows a line shape similar with the ones from PTCDA thick films on the H-terminated Si（111） and Ag/Si（111）-√3×√3 surfaces [1,2]. But at low coverages （0.3-1.0 ML） the O 1s spectra also resemble the bulk one, which is very different from other cases. This is a clear evidence of non-chemical interaction between PTCDA O atoms and the Sn/Si（111）-2√3×2√3 substrate. High-resolution C 1s core-level spectra have also been recorded from the same surfaces. At 10 ML the C 1s spectrum looks like a bulk one in a similar way as the O 1s spectrum. There is a strong peak at 284 eV, which originates from the perylene core of the PTCDA molecule. The second peak is located at 288.1 eV, which has previously been assigned to the carboxylic C. The other two small features at 286 eV and 289 eV in the 10 ML spectrum are mainly due to shake-up effects. Interestingly, at 0.3 ML there is an extra peak located at a binding energy of 286.8 eV. The extra peak is well-defined and becomes saturated

关键词： PTCDA Sn/Si(111)-2√3×2√3 photoemission NEXAFS

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地下油库的地质勘察

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地下空间与工程学报 1981年第1期 50-55页

作者： Stigr johansson 胡振瀛芬兰赫尔辛基Geotekoy公司地质工程师哲学硕士

前言自古以来,人类就利用岩洞。古时候地下建筑主要用于人类的居住,因为整体岩石为防卸野兽提供条件,并使洞室保持冬暖夏凉。今天,进行地下建筑,人们具有远为优良的机具。实际上,我们能够使地下建筑工程比地面建筑更快更便宜。关于地下... 详细信息

前言自古以来,人类就利用岩洞。古时候地下建筑主要用于人类的居住,因为整体岩石为防卸野兽提供条件,并使洞室保持冬暖夏凉。今天,进行地下建筑,人们具有远为优良的机具。实际上,我们能够使地下建筑工程比地面建筑更快更便宜。关于地下空间的利用,芬兰是很幸运的,以前寒武系结晶岩为主的基岩为建造地下岩石

关键词：地下油库工程地质测绘工程地质勘察岩石力学岩土力学地下洞库实验室试验室内试验岩体质量现场勘察

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