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Pericyte-like differentiation of human adipose-derived mesenchymal stem cells:An in vitro study

World Journal of Stem Cells 2020年第10期12卷 1152-1170页

作者： Giuliana Mannino Florinda Gennuso Giovanni Giurdanella Federica Conti Filippo Drago salvatore salomone Debora Lo Furno Claudio Bucolo Rosario Giuffrida Physiology Section Department of Biomedical and Biotechnological SciencesUniversity of CataniaCatania 95123Italy Pharmacology Section Department of Biomedical and Biotechnological SciencesSchool of MedicineUniversity of CataniaCatania 95123Italy Biochemistry Section Department of Biomedical and Biotechnological SciencesSchool of MedicineUniversity of CataniaCatania 95123Italy

BACKGROUND Adipose-derived mesenchymal stem cells(ASCs)are characterized by long-term self-renewal and a high proliferation *** adequate conditions,they may differentiate into cells belonging to mesodermal,endodermal or ectodermal *** support endothelial cells and play an important role in stabilizing the vessel wall at the microcirculation *** loss of pericytes,as occurs in diabetic retinopathy,results in a breakdown of the blood-retina barrier(BRB)and infiltration of inflammatory *** this context,the use of pericytelike differentiated ASCs may represent a valuable therapeutic strategy for restoring BRB *** To test in vitro strategies to obtain pericyte-like differentiation of human ASCs(hASCs).METHODS Different culture conditions were tested:hASCs cultured in a basal medium supplemented with transforming growth factorβ1;and hASCs cultured in a specific pericyte medium(PM-hASCs).In a further sample,pericyte growth supplement was omitted from the *** addition,cultures of human retinal pericytes(hRPCs)were used for ***-like differentiation of hASCs was tested by immunocytochemical staining and western blotting to evaluate the expression ofα-smooth muscle actin(α-SMA)and neural/glial antigen 2(NG2).Interactions between human retinal endothelial cells(hRECs)and different groups of hASCs were investigated in co-culture *** these cases,the expression of typical junctional proteins such as vascular endothelial-Cadherin,zonula occludens-1 and Occludin were assessed in *** an in vitro model of the BRB,values of trans-endothelial electrical resistance were measured when hRECs were co-cultured with various groups of pretreated *** values observed were compared with co-cultures of hRECs and hRPCs as well as with cultures of hRECs ***-dimensional co-cultures of hRECs and hRPCs or pericyte-like hASCs in Matrigel were designed to assess their reciprocal *** After 3-6 d of cult

关键词： Adipose-derived mesenchymal stem cells Pericyte-like differentiation Retinal endothelial cells Retinal pericytes Blood-retina barrier Junction proteins

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Work Productivity and Activity Impairment in Breast Cancer Patients Treated with Capecitabine

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Journal of Cancer Therapy 2013年第7期4卷 1224-1227页

作者： Marco Vacante Giulia Malaguarnera Manuela Pennisi Giuseppe Grosso salvatore salomone Filippo Drago Erdogan Ozyalcin Vito Catania Alfredo Consoli Mariano Malaguarnera Department of General Surgery University of Catania Catania Italy Department of Neurosciences University of Catania Catania Italy International PhD Programme in Neuropharmacology University of Catania Catania Italy Research Center “The Great Senescence” Cannizzaro Hospital University of Catania Catania Italy

Background: Although the majority of breast cancer patients are able to work, lower work ability and reduced job retention have been reported. The aim of the present study was to evaluate the effect of chemotherapy with capecitabine in patients with breast cancer on work productivity and daily activity. Methods: 34 patients with metastatic breast cancer were enrolled for our study. Capecitabine was given twice daily at a cumulative dose of 2500 mg/m2 on days 1 - 14 and repeated on day 22. Work productivity was determined using the WPAI questionnaire. Results: We observed an increase in absenteeism, presenteeism, work productivity loss and daily activity impairment after 1 cycle and 6 cycles of therapy, but we could not find statistically different significances. Conclusions: This study provides some data indicating an association between problems in breast cancer and work. Our results confirm that capecitabine may improve quality of life of patients with metastatic breast cancer.

关键词： Breast Cancer Capecitabine Work Productivity Absenteeism Presenteeism

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MIS 5e sea surface temperature estimation;a multi-proxy approach using a marine macrofossil assemblage(Mar Piccolo,Gulf of Taranto,Southern Italy)

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Journal of Palaeogeography 2024年第2期13卷 327-350页

作者： Pierluigi Santagati Edoardo Perri Maria Pia Bernasconi Mario Borrelli salvatore Guerrieri salvatore Critelli Dipartimento di Biologia Ecologia e Scienze della TerraUniversita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly Dipartimento di Ingegneria Ambientale Universita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly

It is reported a multi-proxy palaeoclimatic study conducted on a MIS 5e calcarenite from the Mar Piccolo Basin(MP),Gulf of Taranto(GT)(Central Mediterranean).The calcarenite returned a rich malacofauna consisting of 120 extant species,including four of the tropical Senegalese Fauna,today absent in the *** biogeographic-climatic affinity of the assemblage shows,compared to today,a double percentage of warm affinity species,while the cold affinity species are nearly equally represented,indicating a warmer but not strictly tropical *** is confirmed by the most recurring preferred SST ranges of the assemblage,indicating an average of 20℃.The skeletal compositions of five well-preserved molluscan and coral specimens were analyzed for trace elements and stable isotopes for further mean SST *** the comparison of the results of several equations available in literature,it appears that only some SST estimations are realistic,converging into similar values of,on average,20.8±0.9℃.Considering all the used proxies,the MIS 5e SST difference compared to today falls in the range 1.2—2.0℃for the GT(being a more reasonable scenario)and 2.0—2.8℃for the *** is not a firmly tropical-like SST setting as suggested by the sole Senegalese fauna,indicating at least 2.7℃—3.5℃more than today’s GT and MP,*** approximations and assumptions made for obtaining SST values with any single proxy indicate the need of a multi-proxy approach to define the best SST estimation.

关键词： MiS 5e Sea surface temperature Palaeoclimate proxy Fossil fauna Gulf of Taranto

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Work Productivity and Activity Impairment in Colorectal Cancer Patients Treated with Capecitabine

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Journal of Cancer Therapy 2013年第7期4卷 1198-1202页

作者： Giulia Malaguarnera Manuela Pennisi Giuseppe Grosso Marco Vacante salvatore salomone Filippo Drago Michele Malaguarnera Erdogan Ozyalcin Massimo Motta Valentina Raciti Mariano Malaguarnera Department of Neurosciences University of Catania Catania Italy International PhD Programme in Neuropharmacology University of Catania Catania Italy Research Center “The Great Senescence” Cannizzaro Hospital University of Catania Catania Italy

Background: The employment status of workers with cancer has important implications for impairment of intimate and family relationships and for economic, social and psychological health. The aim of the present study was to evaluate the effect of chemotherapy with capecitabine in patients with colorectal cancer on work productivity and daily activity. Methods: 30 patients with primary diagnosis of stage III colorectal cancer were enrolled for our study. All patients received capecitabine twice daily at a cumulative dose of 2500 mg/m2 on days 1 -14 and repeated on day 22. Work productivity was determined using the WPAI questionnaire. Results: We observed a significant increase in absenteeism after 1 cycle, after 6 cycles of therapy and at follow-up (p 0.001). On the other hand, presenteeism, work productivity loss and daily activity impairment, increased after 1 cycle and 6 cycles of therapy, but we could not find statistically different significances. Conclusions: Colorectal cancer diagnosis and treatment are associated with frailty and vulnerability. Chemotherapy with capecitabine may result in negative consequences for job performance.

关键词： Capecitabine Colorectal Cancer Work Productivity Activity Impairment Absenteeism Presenteeism

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Reconstructing hourly residential electrical load profiles for Renewable Energy Communities using non-intrusive machine learning techniques

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Energy and AI 2024年第1期15卷 217-235页

作者： Lorenzo Giannuzzo Francesco Demetrio Minuto Daniele salvatore Schiera Andrea Lanzini Energy Center Lab Polytechnic of Turinvia Paolo Borsellino 38/1610152TurinItaly Department of Energy(DENERG) Polytechnic of TurinCorso Duca degli Abruzzi 2410129TurinItaly

The successful implementation of Renewable Energy Communities(RECs)involves maximizing the self-consumption within a community,particularly in regulatory contexts in which shared energy is *** many countries,the absence of a metering infrastructure that provides data at an hourly or sub-hourly resolution level for low-voltage users(e.g.,residential and commercial users)makes the design of a new energy community a challenging *** study proposes a non-intrusive machine learning methodology that can be used to generate residential electrical consumption profiles at an hourly resolution level using only monthly consumption data(i.e.,billed energy),with the aim of estimating the energy shared by *** proposed methodology involves three phases:first,identifying the typical load patterns of residential users through k-Means clustering,then implementing a Random Forest algorithm,based on monthly energy bills,to identify typical load patterns and,finally,reconstructing the hourly electrical load profile through a data-driven rescaling *** effectiveness of the proposed methodology has been evaluated through an REC case study composed by 37 residential users powered by a 70 kWp photovoltaic *** Normalized Mean Absolute Error(NMAE)and the Normalized Root Mean Squared Error(NRMSE)were evaluated over an entire year and whenever the energy was shared within the *** Relative Absolute Error was also measured when estimating the shared energy at both a monthly(MRAE)and at an annual basis.(RAE).A comparison between the REC load profile reconstructed using the proposed methodology and the real load profile yielded an overall NMAE of 20.04%,an NRMSE of 26.17%,and errors of 18.34%and 23.87%during shared energy timeframes,***,our model delivered relative absolute errors for the estimation of the shared energy at a monthly and annual scale of 8.31%and 0.12%,respectively.

关键词： Renewable Energy Community Load profiling Non-intrusive machine learning Data-driven models Data analytics Shared energy estimation

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Current status of magnetic resonance imaging radiomics in hepatocellular carcinoma:A quantitative review with Radiomics Quality Score

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World Journal of Gastroenterology 2024年第4期30卷 381-417页

作者： Valentina Brancato Marco Cerrone Nunzia Garbino Marco salvatore Carlo Cavaliere Department of Information Technology IRCCS SYNLAB SDNNaples 80143Italy Department of Radiology IRCCS SYNLAB SDNNaples 80143Italy

BACKGROUND Radiomics is a promising tool that may increase the value of magnetic resonance imaging(MRI)for different tasks related to the management of patients with hepatocellular carcinoma(HCC).However,its implementation in clinical practice is still far,with many issues related to the methodological quality of radiomic *** To systematically review the current status of MRI radiomic studies concerning HCC using the Radiomics Quality Score(RQS).METHODS A systematic literature search of PubMed,Google Scholar,and Web of Science databases was performed to identify original articles focusing on the use of MRI radiomics for HCC management published between 2017 and *** methodological quality of radiomic studies was assessed using the RQS ***’s correlation(ρ)analysis was performed to explore if RQS was correlated with journal metrics and characteristics of the *** level of statistical significance was set at P<*** One hundred and twenty-seven articles were included,of which 43 focused on HCC prognosis,39 on prediction of pathological findings,16 on prediction of the expression of molecular markers outcomes,18 had a diagnostic purpose,and 11 had multiple *** mean RQS was 8±6.22,and the corresponding percentage was 24.15%±15.25%(ranging from 0.0% to 58.33%).RQS was positively correlated with journal impact factor(IF;ρ=0.36,P=2.98×10^(-5)),5-years IF(ρ=0.33,P=1.56×10^(-4)),number of patients included in the study(ρ=0.51,P<9.37×10^(-10))and number of radiomics features extracted in the study(ρ=0.59,P<4.59×10^(-13)),and time of publication(ρ=-0.23,P<0.0072).CONCLUSION Although MRI radiomics in HCC represents a promising tool to develop adequate personalized treatment as a noninvasive approach in HCC patients,our study revealed that studies in this field still lack the quality required to allow its introduction into clinical practice.

关键词： Hepatocellular carcinoma Systematic review Magnetic resonance imaging Radiomics Radiomics quality score

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Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions:theoretical basis

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 951-962页

作者： Ciro Caruso Luca D’Andrea Mario Troisi Michele Rinaldi Raffaele Piscopo salvatore Troisi Ciro Costagliola Corneal Transplant Center Pellegrini HospitalVia Portamedina alla Pignasecca 41Napoli 80127Italy Eye Clinic Department of NeurosciencesReproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples 80131Italy Public Health Department University of Naples Federico IINaples 80131Italy Salerno Hospital University Ophthalmologic UnitBaronissiCampania 84131Italy

Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual *** therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced *** keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe *** consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks *** aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original Dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment ***,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

关键词： corneal collagen cross linking keratoconus custom fast protocol Dresden protocol lambert-beer law Bunsen-roscoe law

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Chitin-glucan improves important pathophysiological features of irritable bowel syndrome

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World Journal of Gastroenterology 2024年第16期30卷 2258-2271页

作者： Caroline Valibouze Caroline Dubuquoy Philippe Chavatte Michaël Genin Veronique Maquet salvatore Modica Pierre Desreumaux Christel Rousseaux Department of Digestive Surgery and Transplantation Lille UniversityLille 59037France Intestinal Biotech Development Facultéde MédicineLille 59045France U1286-INFINITE-Institute for Translational Research in Inflammation Universitéde LilleLille 59000France ULR 2694-METRICS Évaluation des Technologies de santéet des Pratiques MédicalesUniversity of LilleLille 59000France KitoZyme SA Institution SociétéAnonymeZone 2Parc des Hauts SartsRue de MilmortHerstal 4040Belgium Hepato-Gastroenterology Department Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological ***,recommended treatments remain limited,yielding only limited therapeutic ***-glucan(CG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety *** provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in *** To evaluate the roles of CG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular *** Visceral pain was recorded through colorectal distension(CRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley *** pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving CG(n=14)at a human equivalent dose(HED)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)*** anti-inflammatory effect of CG was evaluated using clinical and histological scores in 30 C57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 ***-29 cells under basal conditions and after stimulation with lipopolysaccharide(LPS)were treated with CG to evaluate changes in pathways related to analgesia μ-opioid receptor(MOR),cannabinoid receptor 2(CB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(IL)-10,IL-1b,and IL-8]and barrier function[mucin 2-5AC,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PCR *** modelling of CG,LPS,lipoteichoic acid(LTA),and phospholipomannan(PLM)was developed,and the abili

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Inflammation Intestinal barrier Molecular modelling Microbial cell walls chelation

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The formation and growth mechanisms of young back-arc spreading ridges from high-resolution bathymetry:The Marsili Seamount(Tyrrhenian Sea,Italy)

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Geoscience Frontiers 2024年第1期15卷 325-338页

作者： Eugenio Nicotra salvatore Passaro Guido Ventura Dipartimento di Biologia Ecologia e Scienze della Terra Universitàdella Calabria87036 Arcavacata di RendeCosenzaItaly Istituto di Scienze Marine CNR 80133 NapoliItaly Istituto Nazionale di Geofisica e Vulcanologia 00143 RomaItaly Istituto per lo Studio degli impatti Antropici e Sostenibilitáin ambiente marino CNR 91026 Capo GranitolaTrapaniItaly

The formation and growth mechanisms of Mid-Ocean Ridges(MOR)are relatively well known,whereas those of back-arc spreading ridges are comparatively less known because geophysical,geochemical,and morphological data are scarce and of low *** we present a high-resolution bathymetry of the Marsili Seamount(MS;1 Ma-3 ka),which represents the inflated spreading ridge of the 2 Ma old Marsili back-arc basin associated to the subduction of the Ionian Sea below the Calabrian Arc and Tyrrhenian *** is 70 km long,30 km wide,and its height reaches about 3000 m from surrounding *** new digital bathymetric model has a 5 m grid cell size resolution and covers the MS bathymetry from-1670 mbsl to the top at-491 *** conduct morphometric and morphological analyses of the bathymetry and recognize landforms due to volcanic,tectonic,hydrothermal and gravity *** consists of volcanoes related to fissural and central-type activity,this latter located at the northern and southern tips of the main dike *** swarms represent the surface expression of different ridge segments whose strikes are controlled by the larger scale back-arc spreading processes and by the local occurrence of an active hydrothermal *** latter develops in a flat area between two partly overlapping ridge segments where historical volcanism and extensional processes *** ridges represent the embryonic stage of the formation of transform-like *** volcanoes,the northern of which is characterized by a caldera,form at the tips of MS because the decrease in width of the major volcanic fissures promotes vent localization associated with the formation of sill-like reservoirs from which central-type vents may *** processes affecting the MS flanks are due to shallow seafloor *** collapses affecting the northernmost central-type polygenic volcano must be included in the evaluation of the hazard related to potential *** dipping faul

关键词： Back-arc spreading ridge Morphology Tectonics Volcanism Marsili seamount

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Mechanism of Universal Quantum Computation in the Brain

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Journal of Applied Mathematics and Physics 2024年第2期12卷 468-474页

作者： Aman Chawla salvatore Domenic Morgera Department of Computer Science and Engineering Indian Institute of Technology Delhi India Department of Electrical Engineering University of South Florida Tampa USA

In this paper, the authors extend [1] and provide more details of how the brain may act like a quantum computer. In particular, positing the difference between voltages on two axons as the environment for ions undergoing spatial superposition, we argue that evolution in the presence of metric perturbations will differ from that in the absence of these waves. This differential state evolution will then encode the information being processed by the tract due to the interaction of the quantum state of the ions at the nodes with the “controlling’ potential. Upon decoherence, which is equal to a measurement, the final spatial state of the ions is decided and it also gets reset by the next impulse initiation time. Under synchronization, several tracts undergo such processes in synchrony and therefore the picture of a quantum computing circuit is complete. Under this model, based on the number of axons in the corpus callosum alone, we estimate that upwards of 50 million quantum states might be prepared and evolved every second in this white matter tract, far greater processing than any present quantum computer can accomplish.

关键词： Axons Quantum computation Metric perturbation Decoherence Time-coded information

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