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STARD1:a new rising StAR in cholesterol-mediated hepatocarcinogenesis

Hepatobiliary Surgery and Nutrition 2021年第6期10卷 910-912页

作者： salvatore papa Concetta Bubici Wing-Kin Syn Leeds Institute of Medical Research at St.James’ Faculty of Medicine and HealthUniversity of LeedsSt.James’University HospitalLeedsUK Centre for Genome Engineering and Maintenance Department of Life SciencesCollege of HealthMedicine and Life SciencesBrunel University LondonUxbridgeUK Division of Gastroenterology and Hepatology Medical University of South CarolinaCharlestonSCUSA Section of Gastroenterology Ralph H.Johnson Veterans Affairs Medical CenterCharlestonSCUSA Department of Physiology Faculty of Medicine and NursingUniversity of the Basque CountryUniversidad del Pais Vasco/Euskal Herriko Unibertsitatea(UPV/EHU)LeioaSpain

Having cholesterol in our body is essential for living healthy,but too much can lead to serious health problems,including-but not limited to-heart attacks and strokes(1).Indeed,accumulating evidence points to cholesterol as a cancer risk factor especially in colon,rectal,prostatic and testicular cancer(2).Cholesterol is the most abundant sterol in animal tissues with many important functions that spans from simply maintaining cell membrane physical properties to the production of bile acids and biosynthesis of steroid *** the most part,cholesterol is synthetised de novo in the liver,but some is obtained from dietary *** synthesis of cholesterol takes place in the cytoplasm and the endoplasmic reticulum(ER)of hepatocytes(the major liver cell types)and starts with one molecule of acetyl-CoA.

关键词： cholesterol intake cancer

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Peritoneal carcinomatosis

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World Journal of Gastroenterology 2013年第41期19卷 6979-6994页

作者： Federico Coccolini Federico Gheza Marco Lotti salvatore Virzì Domenico Iusco Claudio Ghermandi Rita Melotti Gianluca Baiocchi Stefano Maria Giulini Luca Ansaloni Fausto Catena Department of General Surgery Papa Giovanni ⅩⅩⅢ Hospital24127 BergamoItaly Surgical Clinic University of Brescia25123 BresciaItaly Department of General Surgery Bentivoglio Hospital40010 BentivoglioItaly Department of Anesthesiology Sant’ Orsola-Malpighi Hospital40100 BolognaItaly Regional Health Agency of Emilia Romagna 40100 BolognaItaly Department of Emergency Surgery Ospedale Maggiore43100 ParmaItaly

Several gastrointestinal and gynecological malignancies have the potential to disseminate and grow in the peritoneal *** occurrence of peritoneal carcinomatosis(PC)has been shown to significantly decrease overall survival in patients with liver and/or extraperitoneal metastases from gastrointestinal *** the last three decades,the understanding of the biology and pathways of dissemination of tumors with intraperitoneal spread,and the understanding of the protective function of the peritoneal barrier against tumoral seeding,has prompted the concept that PC is a loco-regional disease:in absence of other systemic metastases,multimodal approaches combining aggressive cytoreductive surgery,intraperitoneal hyperthermic chemotherapy and systemic chemotherapy have been proposed and are actually considered promising methods to improve loco-regional control of the disease,and ultimately to increase *** aim of this review article is to present the evidence on treatment of PC in different tumors,in order to provide patients with a proper surgical and multidisciplinary treatment focused on optimal control of their locoregional disease.

关键词： Carcinosis Peritoneal Ovarian Gastric Colorectal Hipec Intraperitoneal chemotherapy Cytoreductive surgery Cancer Advanced

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