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Retrospective descriptive analysis of the physiological kinetics of prostate-specific antigen in men older than 75 years

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Asian Journal of Andrology 2009年第4期11卷 493-497页

作者： Maria Chiara Sighinolfi salvatore micali Stefano De Stefani Arrigo Cicero Filippo Cianci Marco Giacometti Giampaolo Bianchi Department of Urology University of Modena and Reggio Emilia Modena 41100 Italy Clinical Medicine and Applied Biotechnology Department Alma Mater Studiorum University of Bologna Bologna 40100 Italy

Several studies have compared prostate-specific antigen （PSA） kinetics in men with and without cancer, but there has been no adequate analysis of the longitudinal variation in PSA. The aim of this study was to assess the fluctuations in PSA in a cohort of elderly men in an attempt to define a physiological pattern of PSA kinetics. We searched a specific cohort of patients aged 〉 75 years and with PSA value 〈 2.0 ng mL^-1. A history of all PSA values over the past 10 years was compiled for each patient to create a database of patients fitting the following criteria：（1） minimum of five PSA measurements, （2） over at least 5 years. Exclusion criteria were：（1） PSA 〈 0.2 ng mL^-1 at each measurement and （2） having had more than one PSA test per year. In all, 1 327 patients （mean age： 78.52 years） fit the inclusion criteria. The mean variation from the first to the last PSA test was 0.05 ± 0.43, with a mean follow-up of 6.79 ± 1.71 years. Over the same period, the mean fluctuation from the lowest to the highest PSA value was 0.04 ± 0.55 （P = 0.925）. The mean annual PSA velocity （PSAV） was calculated by dividing the mean variation from the first to the last PSA test by the number of years of observation for each patient and was set at 0.0104 ± 0.1050. Concluding, in a large-scale cohort of elderly individuals considered healthy and evaluated for a considerable follow-up, the average annual PSAV as well as the average fluctuation from the lowest to the highest PSA value are insignificant.

关键词： human sperm nucleus histones protamine telomere

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Does needle calibre affect pain and complication rates in patients undergoing transperineal prostate biopsy？ A prospective, randomized trial

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Asian Journal of Andrology 2009年第6期11卷 678-682页

作者： Saredi Giovanni Maria Chiara Sighinolfi Fidanza Francesco De Stefani Stefano micali salvatore Maurizio Paterlini Roberto D＇Amico Bianchi Giampaolo Department of Urology University of Modena and Reggio Emilia Modena 41100 Italy Department of Oncology University of Modena and Reggio Emilia Modena 41100 Italy

Transperineal prostate biopsy is a procedure that can be used to obtain histological samples from the prostate. To improve both the quality of the biopsy core samples and prostate cancer detection, we are currently performing a prospective, randomized trial comparing prostate biopsy samples obtained using an 18 G-needle to those obtained using a 16 G-needle. The aim of this preliminary study was to evaluate pain and complication rates in both groups in order to assess whether performing a prostate biopsy with a larger calibre needle is a feasible procedure. One hundred and eighty-seven patients undergoing transperineal prostate biopsy were prospectively evaluated and divided into two groups. The first group （94 patients, Group A） received a transperineal prostate biopsy using a 16 G-needle and the second group （93 patients, Group B） underwent transperineal prostate biopsy with an 18 G-needle. Anaesthesia was obtained with a single perineal injection at the prostatic apex in all subjects. A visual analogue scale （VAS） and facial expression scale （FES） were used to assess pain during multiple steps of the procedure in each group. A detailed questionnaire was used to obtain information about drug use because it could potentially influence the pain and complications that patients experienced. Two weeks after the procedure, early and late complications were evaluated. Statistical analysis was carried out using non-parametric tests. Prostate Specific Antigen （PSA） and drug use were similar at baseline between the two groups. Pain during prostate biopsy, which was measured with both the VAS and FES instruments, did not differ significantly between the 18- and 16 G-needle groups, and no significant differences were found in early or late complication rates between the groups. Transperineal prostate biopsy with a 16 G-needle is a feasible Further studies with larger patient populations are required to prostate cancer detection rates. procedure in terms of pain and complicati

关键词： needle calibre prostatic biopsy side effects

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Benign intratesticular schwannoma:a rare finding

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Asian Journal of Andrology 2006年第1期8卷 101-103页

作者： Maria Chiara Sighinolfi Alessandro Mofferdin Stefano S.De Stefani Antonio Celia salvatore micali Giovanni Saredi Giulio Rossi Riccardo Valli Giampaolo Bianchi Division of Urology Department of Pathology Section of Anatomic Pathology University of Modena 41100 ModenaItaly

Schwannoma is a peripheral nerve tumour, occasionally located in the genitourinary tract. We described an extremely rare case of intratesticular neurinoma in a 79-year-old patient. （Asian JAndrol 2006 Jan; 8： 101-103）

关键词： schwannoma Schwann cells testicular neoplasm S 100 protein

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New imaging technologies for robotic kidney cancer surgery

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Asian Journal of Urology 2022年第3期9卷 253-262页

作者： Stefano Puliatti Ahmed Eissa Enrico Checcucci Pietro Piazza Marco Amato Stefania Ferretti Simone Scarcella Juan Gomez Rivas Mark Taratkin Jose Marenco Ines Belenchon Rivero Karl-Friedrich Kowalewski Giovanni Cacciamani Ahmed El-Sherbiny Ahmed Zoeir Abdelhamid MEl-Bahnasy Ruben De Groote Alexandre Mottrie salvatore micali Urology Department University of Modena&Reggio EmiliaModenaItaly ORSI Academy MelleBelgium Urology Department Faculty of MedicineTanta UniversityTantaEgypt Department of Surgery Candiolo Cancer InstituteFPO-IRCCSCandioloTurinItaly Division of Urology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Department of Urology Polytechnic University of Marche RegionUmberto I Hospital“Ospedali Riuniti”AnconaItaly Uro-technology and SoMe Working Group of the Young Academic Urologists Working Party European Association of UrologyArnhemthe Netherlands Department of Urology Hospital Clinico San CarlosMadridSpain Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Department of Urology Fundacio´n Instituto Valenciano de Oncologı´aValenciaSpain Urology and Nephrology Department Virgen del Rocı´o University HospitalManuel Siurot Sin NumeroSevilleSpain Department of Urology and Urological Surgery University Medical Centre MannheimMannheimGermany USC Institute of Urology University of Southern CaliforniaLos AngelesCAUSA Department of Urology Onze-Lieve-VrouwziekenhuisAalstBelgium

Objective:Kidney cancers account for approximately 2%of all newly diagnosed cancer in *** the primary treatment options for kidney cancer,urologist may choose between radical or partial nephrectomy,or ablative ***,robotic-assisted partial nephrectomy(RAPN)for the management of renal cancers has gained popularity,up to being considered the gold ***,RAPN is a challenging procedure with a steep learning ***:In this narrative review,different imaging technologies used to guide and aid RAPN are ***:Three-dimensional visualization technology has been extensively discussed in RAPN,showing its value in enhancing robotic-surgery training,patient counseling,surgical planning,and intraoperative *** imaging technologies such as intracorporeal ultrasound,near-infrared fluorescent imaging,and intraoperative pathological examination can also be used to improve the outcomes following ***,artificial intelligence may play a role in the field of RAPN ***:RAPN is a complex surgery;however,many imaging technologies may play an important role in facilitating it.

关键词： Kidney cancer Imaging Technology Robotic

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COVID-19 outbreak impact on urolithiasis treatments:A multicenter retrospective study across 9 urological centers in Italy

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Current Urology 2024年第4期18卷 301-306页

作者： Giorgio Mazzon Stefania Ferretti Emanuele Serafin Francesco Claps Pietro Acquati Davide Brusa Federico Germinale Giuseppe Celentano Andrea Pescuma Andrea Vismara Fugini Davide Campobasso Umberto Maestroni Giovanni Costa Tonino Morena Flavia Di Marco Andrea Baudo Massimiliano Creta Nicola Pavan Marco Ticonosco Angelo Peroni Devis Collura Maria Angela Cerruto Alessandro Antonelli Luca Carmignani salvatore micali Carlo Trombetta Giovanni Muto Antonio Celia Department of Urology AULSS7 PedemontanaSan Bassiano HospitalBassano del GrappaItaly Department of Urology University Hospital of PamaParmaItaly Department of Urology University of VeronaAzienda Ospedaliera Universitaria Integrata VeronaVeronaItaly Urological Clinic Department of MedicineSurgery and Health SciencesUniversity of TriesteTriesteItaly Department of Urology IRCCS Policlinico San DonatoMilanItaly Department of Urology Humanitas Gradenigo HospitalTurinItaly Department of Neurosciences Reproductive and Oral SciencesUniversity of Naples Federico IINaplesItaly Urology Department University ofModena&Reggio EmiliaModenaItaly Department of Urology Poliambulanza Foundation HospitalBresciaItaly Urology Section Department of SurgicalOncological and Oral SciencesUniversity of PalermoPalermoItaly

Background The coronavirus disease(COVID-19)pandemic has posed challenges to the global health care community,affecting the management of upper urinary tract *** and methods This retrospective study involved 9 Italian *** compared the 12-month period prior to COVID-19(March 1,2019,to February 28,2020;Period A)with the COVID-19 period(March 1,2020,to February 28,2021,Period B).This study aimed to compare outcomes during Periods A and B,specifically focusing on the overall number of treatments,rate of urgent/elective cases,and operational *** A total of 4018 procedures were collected,comprising 2176 procedures during Period A and 1842 during Period B,indicating a loss of 15.35%(p<0.001).In the elective cases,1622 procedures were conducted in Period A,compared with 1280 in Period B,representing a 21.09%reduction in cases(p=0.001).All types of stone treatments were affected:extracorporeal shock wave lithotripsy(−29.37%,p=0.001),percutaneous nephrolithotomy(−26.47%,p=0.008),retrograde surgeries for renal stones(−10.63%,p=0.008),and semirigid ureterolithotripsy(−24.86%,p=0.008).Waiting lists experienced significant delays during Period *** waiting time(WT)for elective procedures increased during Period B(p<0.001).For ureteral stones,the mean WT in Period A was 61.44 days compared with 86.56 days in Period B(p=0.008).The WT for renal stones increased from 64.96 days in Period A to 85.66 days in Period B for retrograde intrarenal surgery(p=0.008)and from 96.9 days to 1103.9 days(p=0.035)for percutaneous nephrolithotomy *** Our study demonstrates that COVID-19 significantly disrupted endourological services across the *** data underline how patients received treatment over a prolonged period,potentially increasing the risk of stone-related complications and patient discomfort.

关键词： COVID-19 Urolithiasis Percutaneous nephrolithotomy Retrograde intrarenal surgery Extracorporeal shock wave lithotripsy

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