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Colorectal cancer: Parametric evaluation of morphological,functional and molecular tomographic imaging

World Journal of Gastroenterology 2019年第35期25卷 5233-5256页

作者： Pier Paolo Mainenti Arnaldo Stanzione salvatore guarino Valeria Romeo Lorenzo Ugga Federica Romano Giovanni Storto Simone Maurea Arturo Brunetti Institute of Biostructures and Bioimaging of the National Council of Research (CNR) Naples 80145 Italy University of Naples "Federico II" Department of Advanced Biomedical Sciences Naples 80131 Italy IRCCS-CROB Referral Cancer Center of Basilicata Rionero in Vulture 85028 Italy

Colorectal cancer (CRC) represents one of the leading causes of tumor-related deaths worldwide. Among the various tools at physicians’ disposal for the diagnostic management of the disease, tomographic imaging (e.g., CT, MRI, and hybrid PET imaging) is considered essential. The qualitative and subjective evaluation of tomographic images is the main approach used to obtain valuable clinical information, although this strategy suffers from both intrinsic and operator-dependent limitations. More recently, advanced imaging techniques have been developed with the aim of overcoming these issues. Such techniques, such as diffusion-weighted MRI and perfusion imaging, were designed for the “in vivo” evaluation of specific biological tissue features in order to describe them in terms of quantitative parameters, which could answer questions difficult to address with conventional imaging alone (e.g., questions related to tissue characterization and prognosis). Furthermore, it has been observed that a large amount of numerical and statistical information is buried inside tomographic images, resulting in their invisibility during conventional assessment. This information can be extracted and represented in terms of quantitative parameters through different processes (e.g., texture analysis). Numerous researchers have focused their work on the significance of these quantitative imaging parameters for the management of CRC patients. In this review, we aimed to focus on evidence reported in the academic literature regarding the application of parametric imaging to the diagnosis, staging and prognosis of CRC while discussing future perspectives and present limitations. While the transition from purely anatomical to quantitative tomographic imaging appears achievable for CRC diagnostics, some essential milestones, such as scanning and analysis standardization and the definition of robust cut-off values, must be achieved before quantitative tomographic imaging can be incorporated into

关键词： Colorectal cancer Computed tomography Magnetic resonance imaging Positron emission tomography Parametric imaging Perfusion imaging Diffusion imaging Texture analysis

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Laparoscopic reversal of Hartmann’s procedure:safety and feasibility

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Gastroenterology Report 2013年第2期1卷 149-152页

作者： Daniel C.K.Ng salvatore guarino Steven L.C.Yau Benny K.L.Fok Hester Y.S.Cheung Michael K.W.Li C.N.Tang Department of Surgery Pamela Youde Nethersole Eastern HospitalHong Kong Department of Surgery Hong Kong Sanitorium Hospital

Aims:The present study aimed to compare the surgical outcomes of patients receiving laparoscopic reversal of Hartmann’s procedure(RHP)with those receiving open ***:Records of all patients with RHP performed in our unit(including laparoscopic and open surgery)between 2000 and 2012 were *** were retrospectively reviewed and ***:Eighty-two RHPs were performed between 2000 and ***-five were performed with an open approach and 47 with a laparoscopic *** rate was 28%in the laparoscopic *** was no difference,between the two groups,in operation time or blood *** median length of stay was significantly shorter in the laparoscopic group(12 vs 14 days,P=0.002)and fewer patients in the laparoscopic group had complications with post-operative paralytic ileus(2 vs 17%,P=0.038).None of the patients in the laparoscopic group developed incisional hernia at the conclusion of follow-up,as opposed to five in the open group(0 vs 14%,P=0.012).Conclusion:Laparoscopic RHP is safe and feasible,with more favorable surgical outcomes,when compared with open *** rate is *** should be the technique of choice for patients undergoing RHP.

关键词： Hartmann’s procedure reversal laparoscopy

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