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Hypoallergenicity of a thickened hydrolyzed formula in children with cow’s milk allergy

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World Journal of Clinical Cases 2019年第16期7卷 2256-2268页

作者： Danilo Rossetti salvatore Cucchiara AlessANDra Morace Beatrice Leter salvatore Oliva Department of Pediatrics Sapienza University of Rome

BACKGROUND Allergy to cow’s milk is the most frequent allergy occurring in infants and young *** dietary management of these patients consists of the elimination of any cow’s milk proteins from the diet,and for formula-fed infants,the substitution of the usual infant formula with an adapted formula that is generally based on extensively hydrolyzed cow’s milk *** American Academy of Pediatrics has established specific criteria to confirm the hypoallergenicity of a formula intended for these *** To assess the hypoallergenicity of a new thickened extensively hydrolyzed casein-based formula (TeHCF) in children with cow’s milk allergy (CMA).METHODS Children diagnosed with CMA through a double-blind placebo-controlled food challenge (DBPCFC) were randomly administered increased doses of a placebo formula or the TeHCF [Allernova,new thickener including fibres (Novalac)] under double-blind conditions and medical surveillance on two separate ***,both of these formulas and a cow’s milk-based formula were randomly introduced to children who were highly suspected of having CMA on three separate *** and late reactions occurring after the introduction of any of these formulas were thoroughly recorded by the physician at the hospital and reported by parents to the physician after hospital discharge,*** the children tolerated the TeHCF during the DBPCFC,they were exclusively fed this formula during a 3-mo period where potential allergic symptoms,anthropometric parameters,as secondary outcomes,and adverse events were *** Cow’s Milk-related Symptoms Score (CoMiSSTM) was assessed and anthropometric parameters were compared to World Health Organization (WHO) reference *** Of the 30 children included in the study,the CMA diagnosis of 29 (mean age: 8.03 ± 7.43 mo) patients was confirmed by a *** children all tolerated the TeHCF during both the challenge and the subsequent 3-mo feeding period,which the

关键词： Cow's milk allergy Hypoallergenicity Tolerance Thickened extensively hydrolyzed formula Digestive comfort Dietary management

Efficacy and tolerability of chitin-glucan combined with simethicone(GASTRAP^(■)DIRECT)in irritable bowel syndrome:A prospective,open-label,multicenter study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第3期15卷 10-22页

作者： Nathalie Talbodec Pauline Le Roy Peggy Fournier Benoit Lesage Elodie Lepoutre François Castex Jean Michel Godchaux Lionel Vandeville Benjamin Bismuth Xavier Lesage Pauline Bayart Michael Genin Christel Rousseaux Veronique Maquet salvatore Modica Pierre Desreumaux Caroline Valibouze Department of Gastroenterology Hôpital privéLe BoisLille 59000France Department of Gastroenterology Hôpital privéde Villeneuve d’AscqVilleneuve d’Ascq 59650France Univ.Lille CHU LilleULR 2694–METRICSÉvaluation des Technologies de Santéet des Pratiques MédicalesLille 59000France Development of Intestinal Biotech 1 Avenue Oscar LambretLille 59045France KitoZyme SA Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium BiOkuris A Parc Industriel des hauts Sarts Zone 2Rue de MilmortHerstal 4040Belgium Department of Hepato-Gastroenterology Lille University HospitalLille 59000France U1286-INFINITE Institute for Translational Research in InflammationUniv.LilleInsermCHU LilleLille 59000France Department of Digestive Surgery and Transplantation Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel ***-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic ***^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of *** To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatment in patients with *** In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 *** primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)*** analysis was performed using the per-protocol *** symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were *** Overall,100 patients were *** W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,P<0.0001).Similar improvements were observed for bloating[8.0±1.7 vs 4.7±2.9,P<0.0001;60%(95%CI:50-70)responders],abdominal distension[7.2±2.1 vs 4.4±3.1,P<0.0001;53%(95%CI:43-63)responders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by *** severe adverse event occurred,and tolerabil

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Flatulence Defecatory disorders Stool consistency Natural non-pharmacological treatment

Three Dimensional Coupling between Elastic and Thermal Fields in the Static Analysis of Multilayered Composite Shells

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Computer Modeling in Engineering & Sciences 2023年第9期136卷 2551-2594页

作者： salvatore Brischetto Roberto Torre Domenico Cesare Department of Mechanical and Aerospace Engineering.Politecnico di Torino Torino10129Italy

This new work aims to develop a full coupled thermomechanical method including both the temperature profile and displacements as primary unknowns of the *** generic full coupled 3D exact shell model permits the thermal stress investigation of laminated isotropic,composite and sandwich *** and spherical panels,cylinders and plates are analyzed in orthogonal mixed curved reference *** 3D equilibrium relations and the 3D Fourier heat conduction equation for spherical shells are coupled and they trivially can be simplified in those for plates and cylindrical *** exponential matrix methodology is used to find the solutions of a full coupled model based on coupled differential relations with respect to the thickness *** analytical solution is based on theories of simply supported edges and harmonic relations for displacement components and *** sovra-temperature magnitudes are directly applied at the outer faces through static state *** a consequence,the sovra-temperature description is assumed to be an unknown variable of themodel and it is calculated in the sameway as the three *** final systemis based on a set of coupled homogeneous differential relations of second order in the thickness *** system is reduced in a first order differential relation system by redoubling the number of ***,the exponential matrix methodology is applied to calculate the *** temperature field effects are evaluated in the static investigation of shells and plates in terms of displacement and stress *** an appropriate preliminary validation,new benchmarks are discussed for several thickness ratios,geometrical data,lamination sequences,materials and sovra-temperature values imposed at the outer *** make evident the accordance between the uncoupled thermo-mechanical model and this new full coupled thermo-mechanical model without the need to se

关键词： Three-dimensional exact thermo-elastic shellmodel full coupled thermoelasticity three-dimensional fourier heat conduction relation plate and shell geometries laminated and sandwich configurations

Structure and functions of the translation initiation factor eIF4E and its role in cancer development and treatment

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Journal of Genetics and Genomics 2018年第1期45卷 13-24页

作者： Arianna Pisera Adele Campo salvatore Campo Department of Biomedical and Dental Sciences and Morphofunctional Images Policlinico Universitario University of Messina Messina 98125 Italy

In eukaryotic cells, protein synthesis is a complex and multi-step process that has several mechanisms to start the translation including cap-dependent and cap-independent initiation. The translation control of eukaryotic gene expression occurs principally at the initiation step. In this context, it is critical that the eukaryotic translation initiation factor eIF4E bind to the 7-methylguanosine （m7G） cap present at the 5＇- UTRs of most eukaryotic mRNAs. Combined with other initiation factors, elF4E mediates the mRNA recruitment on ribosomes to start the translation. Moreover, the eIF4E nuclear bodies are involved in the export of specific mRNAs from the nucleus to the cytoplasm. In this review, we focus on the elF4E structure and its physiological functions, and describe the role of eIF4E in cancer development and progression and the current therapeutic strategies to target eIF4E.

关键词： elF4E factor Translation initiation mRNA exportCancer

Structural health monitoring of asphalt pavements using smart sensor networks: A comprehensive review

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 639-651页

作者： Alessandro Di Graziano Vincenzo Marchetta salvatore Cafiso Department of Civil Engineering and Architecture University of CataniaCatania 95225Italy

Early, effective and continuous monitoring allows to reduce costs and to extend life of road infrastructure. For this reason, over the years, more and more efforts have been made to implement more advanced and effective monitoring systems at ever more contained costs,going from impractical manual and destructive methods through automated in vehicle equipment to the most recent wireless sensor network(WSN) embedded into the pavement. The purpose of this paper is to provide a comprehensive, up-to-date critical literature review of wireless sensor networks for pavement health monitoring, considering, also,the experience gained for wired sensor as fundamental point of reference. This work presents both the methodology used to collect and analyse the current bibliography and provides a description and comments fundamental characteristics of wireless sensor networks for pavement monitoring for damage detection purposes, among which energy supply, the detection method, the hardware and network architecture and the performance validation procedures. A brief analysis of other possible complementary applications of smart sensor networks, such as traffic and surface condition monitoring, is provided. Finally, a comment is provided on the gaps and possible directions that future research could follow to allow the extensive use of wireless sensor networks for pavement health condition monitoring.

关键词： Pavement engineering Wireless sensor network Literature analysis Structural health monitoring Asphalt pavement

Homeopathic potencies of Arnica montana L. change gene expression in a Tamm-Horsfall protein-1 cell line in vitro model: the role of ethanol as a possible confounder and statistical bias

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Journal of Integrative Medicine 2017年第4期15卷 255-264页

作者： salvatore Chirumbolo Geir Bj?rklund Department of Neurological and Movement Sciences University of Verona Council for Nutritional and Environmental Medicine

Marzotto et al. showed that homeopathic preparations of Amica montana L. acted directly on gene expression of Tamm-Horsfall protein- 1 （THP-1） monocyte/macrophage cell lines activated with phorbol 12-mydstate 13- acetate and interleukin-4 （IL-4）. A. montana homeopathic dilutions are used in complementary and alternative medicine to treat inflammation disorders and post-traumatic events as well as for wound repair. The French Pharmacopoeia of these remedies uses 0.3% ethanol in each centesimal dilution. In this paper, we discuss how ethanol-containing A. montana homeopathic centesimal dilutions can change gene expression in IL-4- treated monocyte/macrophage THP-I. We assessed the role of ethanol in the Arnica homeopathic dilutions containing this alcohol by investigating its action on gene expression of THP-1 cell. Evidence would strongly suggest that the presence of ethanol in these remedies might play a fundamental role in the dilutions ability to affect gene expression, particularly for doses from 5c to 15c. Where, rather than playing a major role in the mesoscopic structure of water, the ethanol might have a chemical-physical role in the induction of THP-1 gene expression, apoptosis, and deoxyribonucleic acid function. This evidence generates a debate about the suggestion that the use of a binary-mixed solvent in homeopathic chemistry, used by Hahnemann since 1810, may be fundamental to explain the activity of homeopathy on cell models.

关键词： Arnica homeopathy bias statistics gene expression Tamm-Horsfall protein cell line

Downwash modelling for three-lifting-surface aircraft configuration design

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Chinese Journal of Aeronautics 2023年第6期36卷 161-173页

作者： salvatore CORCIONE Giordana BONAVOLONTÃ Agostino DE MARCO Fabrizio NICOLOSI Department of Industrial Engineering University of Naples“FedericoⅡ”Naples 8125Italy School of Aerospace Transport&Manufacturing Cranfield UniversityBedford MK43 OALUnited Kingdom

This paper introduces a semi-empirical model to predict the downwash gradient at the horizontal tail of a three-lifting-surface *** superposition principle applied to well established formulations valid for two lifting surfaces is not a reasonable approach to calculate the downwash of a canard-wing-tail layout,and this paper demonstrates that such a basic technique leads to incorrect ***,an ad hoc prediction model is proposed that considers the combined nonlinear effects of canard and main wing inductions on tail downwash,being based on a full factorial design sweep of CFD simulations obtained by varying the main geometrical parameters of the three lifting surfaces.A suitable analytical formula for the downwash gradient is established through a process of data analysis and factor *** presented model extends the validity of the available models for traditional two-lifting-surface designs by means of a correction *** engineering estimation method introduced here exhibits an acceptable accuracy,as well as relatively small prediction errors,and it is suitable for conceptual and preliminary studies of threesurface *** value of this methodology is confirmed by the validation with the results of numerical and experimental investigations on a case study aircraft.

关键词： Aerodynamic modelling Aircraft design Design of experiments Downwash Three-lifting-surface

Energy-related catalysis

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National Science Review 2015年第2期2卷 143-145页

作者： salvatore Abate Gabriele Centi Siglinda Perathoner Department DIECII Section Industrial ChemistryUniversity of Messina

Availability of energy is a vital element of our current society,but energy must be converted to usable forms,either when stemming from fossil fuel sources or from renewable(perennial)*** plays a central role to enabl... 详细信息

关键词： Energy-related catalysis GTL

Blue carbon on the rise:challenges and opportunities

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National Science Review 2018年第4期5卷 464-468页

作者： Nianzhi Jiao Hong Wang Guanhua Xu salvatore Aricò State Key Laboratory of Marine Environmental Science Xiamen University State Ocean Administration Ministry of Science and Technology China Intergovernmental Oceanographic Commission of United Nations Educational Scientific and Cultural Organization (UNESCO)

BLUE CARBON ON THE RISE Climate change is a global concern that requires urgent *** a signatory to the Paris Agreement,China has committed to have its greenhouse gas emission reach a peak by the year 2030,which means ... 详细信息

关键词： Blue carbon on the rise:challenges and opportunities