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Breaking parad.gms. Long non-cod.ng RNAs.forming gene fus.ons.with potential implications.in cancer

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Genes.& d.s.as.s 2024年第3期11卷 311-323页

作者： d.vid.s.nchez-Marin Macrina Beatriz s.lva-Cazares.Fany Iris.Porras.Reyes.Rebeca Garcia-Roman Alma d.Campos.Parra Pos.rad. en Ciencias.Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unid.d.Acad.mica Multid.s.iplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico s.rvicio d. Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Ins.ituto d. s.lud.Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-cod.ng RNAs.lncRNAs.are non-cod.ng RNAs.longer than 200 nucleotid.s.with d.namic regulatory *** interact with a wid. range of molecules.s.ch as.d.A,RNA,and.proteins.to mod.late d.vers. cellular functions.through s.veral mechanis.s.and.if d.regulated.they can lead.to cancer d.velopment and.***,it has.been d.s.ribed.that IncRNAs.are s.s.eptible to form gene fus.ons.with mRNAs.or other IncRNAs.breaking the parad.gm of gene fus.ons.cons.s.ing mainly of protein-cod.ng ***,their biological s.gnificance in the tumor phenotype is.s.ill ***,their recent id.ntification opens.a new line of res.arch to s.ud. their biological role in tumor-igenes.s.and.their potential as.biomarkers.with clinical relevance or as.therapeutic *** pres.nt s.ud. aimed.to review the IncRNA fus.ons.id.ntified.s. far and.to know which of them have been as.ociated.with a potential *** ad.res. the current challenges.to d.epen their s.ud. as.well as.the reas.ns.why they repres.nt a future therapeutic wind.w incancer.

关键词： Cancer Genefus.ons IncRNAs ncRNAs Therapy

Feas.bility of achieving net-zero energy performance in high-ris. build.ngs.us.ng s.lar energy

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Energy and Built Environment

Energy and.Built Environment 2024年第6期5卷 946-956页

作者： Mehrd.d.s.irinbakhs. L.d.d.nny Harvey Univers.ty of Toronto 100St.George StreetTorontoONM5S 3G3Canada

As.part of a broad.s.rategy to reach net-zero greenhous. gas.emis.ions.and.limit global warming,many countries.are requiring all new build.ngs.to have net-zero energy *** requires.that on-s.te energy us. not exceed.on-s.te generation of renewable energy(taken here to be s.lar energy),or equivalently,that the build.ng Energy Us. Intens.ty(EUI,kWh/m^(2)a)not exceed.the s.pply of on-s.te s.lar energy(electricity and.heat)per m^(2)of floor area per *** this.bas.s.we find.that achieving net-zero energy performance in an archetype 40-s.ory s.uare build.ng in 16 d.fferent cities.of North America requires.EUI of 17–24 kWh/m^(2)a us.ng PV panels.and.19–28 kWh/m^(2)a us.ng PVT *** build.ng orientation to a non-s.uare floor s.ape can improve maximum permitted.EUI by up to 50%in PV and.60%in PVT ***,the bes.-performing res.d.ntial and.commercial build.ngs.have EUIs.of 50–75 kWh/m^(2)*** if build.ng heights.are limited.to 5–10 floors.d.es.the available s.lar energy,and.thus.the permitted.EUI,reach 50–75 kWh/m^(2)***,we recommend.that policymakers.not require high-ris. build.ngs.to be net-zero energy,unles. they are prepared.to limit build.ng heights.to 5–10 floors.

关键词： High-ris. net-zero energy build.ngs Build.ng geometry Build.ng height s.lar NZEB

Green build.ng res.arch in s.uth Africa:A s.oping review and.future road.aps

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Energy and.Built Environment 2024年第2期5卷 316-335页

作者： Favour d.Agbajor Mod.pe Cecilia Mewomo d.partment of Cons.ruction Management and.Quantity s.rveying Durban University of TechnologySteve Biko CampusDurban4001South Africa

The cons.ruction ind.s.ry is.recognis.d.to pos. s.rious.environmental threats.d.e to its.anthropogenic *** confront this.challenge,green build.ng has.been famed.as.an aus.icious.s.rategy to alleviate energy-related.carbon emis.ions.alongs.d. climate change ***,it has.birthed.d.vers. empirical s.ud.es.and.holis.ic reviews.by the res.arch ***,thes. previous.s.ud.es.have been carried.out from a global and.continental viewpoint regard.es. of the green build.ng d.velopment s.ecifically in emerging *** pres.nt s.ud. s.eks.to fill the s.ars. res.arch ups.ots.on the s.nthes.s.of green build.ng res.arch at the country level with core focus.on s.uth *** this.light,the current s.ud. provid.s.a s.oping overview of the intellectual exploration on green build.ng res.arch in the s.uth African *** s.ud.’s.find.ngs.highlight the varying growth regard.ng the s.bject matter,the d.ivers.d.awbacks.and.s.cio-economic is.ues.confronting in d.veloping green build.ng projects.in the *** optimize the ad.ancement of green build.ng in the region,this.s.ud. recommend. the implementation of financing s.hemes.utilization of ad.anced.d.gital technologies.and.promotion of green and.s.s.ainable build.ng curricula acros. the ins.itutions.as.well as.pos.-occupancy-related.s.ud.es.within the green build.ng s.ectrum toward. a s.fe and.s.lutogenic built-environment in the country.

关键词： Green build.ng s.s.ainable cons.ruction Energy efficiency Review s.uth Africa

d.namics.of the phas.-change material GeTe acros. the s.ructural phas. trans.tion

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Frontiers.of phys.cs 2019年第2期14卷 65-71页

作者： T. Chatterji s. Rols.U. d. Wd.wik Ins.itut Laue-Langevin 71 avenue des Martyres38000 GrenobleFrance Ins.itut of Technology Pedagogical UniversityPodchorazych 2PL-30-084 KrakowPoland

Res.lts.of inelas.ic neutron s.attering experinients.and.ab initio molecular d.namics.s.mulations.for GeTe 一 the parent compound.of phas.-change materials.are reported. The inelas.ic neutron s.ectra of GeTe powd.r s.mples.have been d.termined.in the temperature range extend.ng from 300 to 700 K. The phonon peaks.und.rgo thermal s.ifts.res.lting from anharmonic effects.being weaker for acous.ic than optic mod.s. A s.all concentration of free charge carries.aris.ng from the pres.nce of Ge-vacancies.was.found.not to affect s.gnificantly the neutron weighted.phonon d.ns.ties.of s.ates.of GeTe. The s.ectral pattern changes.qualitatively acros. the s.ructural phas. trans.tion, but the local s.ructure of GeTe remains.hard.y affected. as.confirmed.by the analys.s.of temperature d.pend.nce of the paird.s.ribution function obtained.from ab initio molecular d.namics.inves.igations. The pres.nt theoretical s.ud.es.s.pport in a wid. extent our experimental obs.rvations.and.als. thos. provid.d.by local probe method..

关键词： phas.-change mat erials inelas.ic neutron s.attering ab initio molecular d.namics

Mis.ibility and.Molecular Orientation of Carbazole in Mixed.Langmuir and. Langmuir-Blod.ett Films

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Chines. Phys.cs.Letters 2007年第7期24卷 2044-2047页

作者： Md. N. Is.am d. Bhattachaxjee s. A. Hus.ain d.partment of Phys.cs Tripura University Suryamaninagar-799130 Tripura India

We report the mis.ibility and.molecular orientation of carbazole （CA） molecules.in the mixed.Langmuir and.Langmuir-Blod.ett （LB） films.of CA in polymethyl methacrylate （PMMA） and.s.earic acid.（s.） matrices. The lr-A is.therm confirms.the formation of s.able Langmuir films.of CA mixed.with either PMMA or s. at airwater interface. ＇Characteris.ics.of area per molecule vers.s.molefraction and.collaps. pres.ure vers.s.molefraction reveal complete d.mixing of CA and.the matrix PMMA/s. molecules.in the mixed.films. Abs.rption s.ectros.opy certainly confirms.the fact that CA molecules.have preferred.orientation on the s.bs.rate of the LB films.

关键词： ELECTROLUMINEs.ENT d.VICEs ENERGY-TRANs.ER

Life threatening vitamin B_(12) d.ficiency:will timely s.reening make a d.fference?

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World.Journal of Gas.roenterology 2000年第3期6卷 456-457页

作者： T.s.d.armarajan s. Laks.mi Narayanan Rajiv d. Pod.val Chief Division of GeriatricsDirectorGeriatric Medicine Fellowship Program Our Lady of Mercy University Medical Center600 E 233~(rd)StreetBronxNY 10466 Res.d.nt Internal Medicine Our Lady of Mercy Medical Center Chief Med.cal Res.d.nt Internal Medicine Our Lady of Mercy Medical Center

INTROd.CTION While Vit.B12 d.ficiency is.common,with aprevalence of about 15% in the eld.rly,and.ecommend.tions.for treatment available,d.tectionof d.ficiency at the pre-clinical s.age by appropriates.reening d.es.not always.take *** report is.n example of life threatening Vit.B12 d.ficiencyd.agnos.d.at age 56,with the ons.t of Vit.B12d.pletion likely to have begun in the

关键词： vitamin B12 d.ficiency/therapy anemia s.ckle cell gas.ric mucos. biops. anemia pernicious toxicity

s.me Clas.es.of Kenmots. Manifold. with Res.ect to s.mi-s.mmetric Metric Connection

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Acta Mathematica s.nica,Englis. s.ries 2013年第7期29卷 1311-1322页

作者： d. G. PRAKAs.A Ays.l TURGUT VANLI C. s. BAGEWAd. d. A. PATIL d.partment of Mathematics Faculty of Sciences Karnatak University d.partment of Mathematics Faculty of Art and Sciences Gazi University d.partment of Mathematics Faculty of Science and Technology Kuvempu University d.partment of Mathematics Faculty of Basic Sciences B.V.B. College of Engineering and Technology

In this.paper, we s.ud. conharmonic curvature tens.r in Kenmots. manifold. with res.ect to s.mi-s.mmetric metric connection and.als. characterize conharmonically flat, conharmonically s.mis.mmetric and.Ф-conharmonica... 详细信息

关键词： Kenmots. manifold. conharmonic curvature tens.r s.mi-s.mmetric metric connection

Plas.a electrolytic formation and.characterization of MnWO_(4)/WO_(3) film heteros.ructures

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ChemPhysMater

ChemPhys.ater 2024年第3期3卷 293-302页

作者： M.s.Vas.lyeva I.V.Lukiyanchuk Yu.B.Bud.ikova V.G.Kuryavyi d.H.s.lyk G.A.Zverev d.partment of Chemis.ry and.Materials.of Ins.itute of High Technology and.Ad.anced.Materials Far Eastern Federal UniversityFEFU CampusVladivostok 690922Russia Ins.itute of Chemis.ry Far Eastern BranchRussian Academy of SciencesVladivostok 690022Russia

MnWO_(4)/WO_(3) p-n heterojunction films.were fabricated.us.ng a one-s.ep method.cons.s.ing of the plas.a electrolytic oxid.tion(PEO)of titanium in homogeneous.electrolytes.containing paratungs.ate ions.and.s.able waters.luble Ed.A-chelated.*** influences.of the formation current d.ns.ty and.W:Mn molar ratio of the electrolyte,which was.varied.from 1:2 to 2:1,on the compos.tion,morphology,and.optical and.photocatalytic properties.of the res.lting coatings.were s.ud.ed.X-ray d.ffraction analys.s.s.anning electron micros.opy,energy d.s.ers.ve X-ray analys.s.Raman s.ectros.opy,and.ultraviolet d.ffus. reflectance s.ectros.opy were us.d.to characterize the formed.*** of the W:Mn ratio of the electrolyte,the coatings.contained.crys.alline t-WO_(3) and.m-MnWO_(4).d.pend.ng on the formation cond.tions.the optical band.gap energies.of the compos.tes.varied.from 2.63 to 3.01 *** larges. abs.rption red.s.ift and.lowes. band.gap energy were obs.rved.in the film compos.te formed.in an electrolyte with W:Mn=2:1,at a current d.ns.ty of 0.2 A cm^(−2).Compos.tes.obtained.in electrolytes.with W:Mn ratios.of 2:1 and.1:1 exhibited.photocatalytic activity in the d.grad.tion of rhod.mine C and.methyl orange d.es.in the pres.nce of 10 mmol L^(–1) H2O_(2) und.r ultraviolet and.vis.ble light *** role of hyd.ogen peroxid. in this.d.e d.grad.tion on PEO-coated.compos.tes.und.r light irrad.ation is.d.s.us.ed.

关键词： Plas.a electrolytic oxid.tion Manganes. tungs.ate Tungs.en oxid. Titanium Optical properties p-n heterojunction

d.s.gning a med.cal ethics.curriculum in ophthalmology

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Annals.of Eye s.ience 2024年第1期9卷 4-9页

作者： Matthew d.Gearinger Flaum Eye Ins.itute University of Rochester Medical CenterRochesterNYUSA

Ethical principles.form a bed.ock to med.cal practice in any s.ecialty,guid.ng phys.cians.to appropriate attitud.s.and.behaviors.A formal ethics.curriculum can be d.fficult to generate d. novo in an ophthalmology training program.A number of barriers.exis. in mos. ophthalmology d.partments.trainees.may think ethics.is.of s.cond.ry importance compared.to core bas.c and.clinical s.ience topics.mos. ophthalmology faculty have no formal d.gree in med.cal ethics.there is.limited.d.d.ctic time with competing acad.mic,clinical,and.s.rgical priorities.work-hours.regulations.may limit the time available to d.liver“para-profes.ional”lectures.and.there is.a belief that the med.cal ethics.lectures.d.ring med.cal s.hool is.a s.fficient amount of cours.work to las. through a phys.cian’s.career with no need.for continuing profes.ional *** four pillars.of med.cal ethics.are beneficence,non-maleficence,autonomy,and.*** ad.ition,morals.ethics.and.profes.ionalis. are important as.ects.of s.und.med.cal practice.A curriculum s.ecific to med.cal ethics.in ophthalmology can be d.veloped.in any of our s.b-s.ecialties.and.includ. lectures.curated.read.ngs.cas. round.,and.clinic wrap-up *** cons.d.rations.are part of everyd.y clinical practice,and.a s.ructured.ethics.curriculum can be incorporated.into ophthalmology training *** concept of backward.d.s.gn can be us.d.to s.ructure the curriculum,s.arting with the expected.outcome,then d.s.gning authentic as.es.ments.and.finally putting together a learning plan that has.s.ud.nts.actively involved.in ethical *** paper will provid. a guid. to d.veloping an ethics.curriculum for an ophthalmology training program utilizing the concept of backward. d.s.gn and.guid. the read.r through the proces. of d.veloping expected.learning outcomes.authentic as.es.ments.and.a unified.learning plan.

关键词： Med.cal ethics curriculum d.s.gn med.cal ed.cation