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Exercise and exerkine upregulation:Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease

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BIOCELL 2024年第5期48卷 693-706页

作者： VIRAAJ VISHNU PRASAD JENNIFER sally SAMSON VENKATACHALAM DEEPA PARVATHI Department of Biomedical Sciences Sri Ramachandra Institute of Higher Education and ResearchChennai600116India

Physical activity and exercise have several beneficial roles in enhancing both physiological and psychological well-being of an *** addition to aiding the regulation of aerobic and anaerobic metabolism,exercise can stimulate the synthesis of exerkine hormones in the circulatory *** several exerkines that have been investigated for their therapeutic potential,Brain-derived neurotrophic factor(BDNF)is considered the most promising candidate,especially in the management of neurodegenerative *** to the ability of physical activity to enhance BDNF synthesis,several experimental studies conducted so far have validated this hypothesis and produced satisfactory results at the pre-clinical *** review highlights some of the recent animal model studies that have evaluated the efficiency of exercise in enhancing BDNF synthesis and promoting neuroprotective ***,this review focuses on understanding the therapeutic benefits of exercise-induced exerkine synthesis as a non-pharmacological strategy in Parkinson’s disease(PD).Regarding physical activity and exerkine induction,the neuromuscular electrical stimulation(NMES)strategy could be considered as an alternate treatment modality for patients affected with PD.

关键词： Exercise therapy Dopaminergic neurons Parkinson’s disease Brain-derived neurotrophic factor Electrical stimulation

Adaptive Segmentation for Unconstrained Iris Recognition

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Computers, Materials & Continua 2024年第2期78卷 1591-1609页

作者： Mustafa AlRifaee sally Almanasra Adnan Hnaif Ahmad Althunibat Mohammad Abdallah Thamer Alrawashdeh Faculty of Architecture and Design Al-Zaytoonah University of JordanAmman11733Jordan Faculty of Computer Studies Arab Open UniversityRiyadh11681Saudi Arabia Faculty of Science and Information Technology Al-Zaytoonah University of JordanAmman11733Jordan

In standard iris recognition systems,a cooperative imaging framework is employed that includes a light source with a near-infrared wavelength to reveal iris texture,look-and-stare constraints,and a close distance requirement to the capture *** these conditions are relaxed,the system’s performance significantly deteriorates due to segmentation and feature extraction ***,a novel segmentation algorithm is proposed to correctly detect the pupil and limbus boundaries of iris images captured in unconstrained ***,the algorithm scans the whole iris image in the Hue Saturation Value(HSV)color space for local maxima to detect the sclera *** image quality is then assessed by computing global features in red,green and blue(RGB)space,as noisy images have heterogeneous *** iris images are accordingly classified into seven categories based on their global RGB *** the classification process,the images are filtered,and adaptive thresholding is applied to enhance the global contrast and detect the outer iris ***,to characterize the pupil area,the algorithm scans the cropped outer ring region for local minima values to identify the darkest area in the iris *** experimental results show that our method outperforms existing segmentation techniques using the UBIRIS.v1 and v2 databases and achieved a segmentation accuracy of 99.32 on UBIRIS.v1 and an error rate of 1.59 on UBIRIS.v2.

关键词： Image recognition color segmentation image processing localization

A Measurement Study of the Ethereum Underlying P2P Network

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Computers, Materials & Continua 2024年第1期78卷 515-532页

作者： Mohammad ZMasoud Yousef Jaradat Ahmad Manasrah Mohammad Alia Khaled Suwais sally Almanasra Electrical Engineering Department Al-Zaytoonah University of JordanAmman11733Jordan Mechanical Engineering Department Al-Zaytoonah University of JordanAmman11733Jordan Computer Science Department Al-Zaytoonah University of JordanAmman11733Jordan Faculty of Computer Studies Arab Open UniversityRiyadh11681Saudi Arabia

This work carried out a measurement study of the Ethereum Peer-to-Peer(P2P)network to gain a better understanding of the underlying *** was applied because it pioneered distributed applications,smart contracts,and ***,its application layer language“Solidity”is widely used in smart contracts across different public and private *** this end,we wrote a new Ethereum client based on Geth to collect Ethereum node ***,various web scrapers have been written to collect nodes’historical data fromthe Internet Archive and the Wayback Machine *** collected data has been compared with two other services that harvest the number of *** has collectedmore than 30% more than the other *** data trained a neural network model regarding time series to predict the number of online nodes in the *** findings show that there are less than 20% of the same nodes daily,indicating thatmost nodes in the network change *** poses a question of the stability of the ***,historical data shows that the top ten countries with Ethereum clients have not changed since *** popular operating system of the underlying nodes has shifted from Windows to Linux over time,increasing node *** results have also shown that the number of Middle East and North Africa(MENA)Ethereum nodes is neglected compared with nodes recorded from other *** opens the door for developing new mechanisms to encourage users from these regions to contribute to this ***,the model has been trained and demonstrated an accuracy of 92% in predicting the future number of nodes in the Ethereum network.

关键词： Ethereum measurement ethereum client neural network time series forecasting web-scarping wayback machine blockchain

Literature,Medicine,and Public Health:An Interview with sally Shuttleworth

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外国文学研究 2024年第4期46卷 1-14页

作者： Kong Derong sally Shuttleworth the School of Foreign Studies Nanjing UniversityNanjing 210023China English Literature at the University of Oxford

sally Shuttleworth is Professor of English and former Head of the Humanities Division at the University of Oxford and a Fellow of the British Academy(FBA). In 2021, she was included in The Queens' s Birthday Honours List and became a Commander of the Order of the British Empire(CBE). She has published extensively on the interrelated study of Victorian literature and science, especially medicine and public health, including The Mind of the Child: Child Development in Literature, Science and Medicine, 1840-1900(2020) and Anxious Times: Medicine and Modernity in Nineteenth-Century Britain(2019). In this interview, which was conducted during the interviewer's visit at the University of Oxford in early 2023, Prof. Shuttleworth discusses several major issues concerning the interdisciplinary study of “literature-medicine”: the borders of this field, the rise of Health Humanities, women's writings and healthcare, and the mission of humanists in the post-epidemic period.

关键词： Shuttleworth interdisciplinary studies medicine public health

Irregular dietary habits as a predictor of stunting occurrence among children under 5 years of age:a literature review

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Frontiers of Nursing 2024年第1期11卷 17-22页

作者： Risnah Huriati Eka Hadrayani Arbianingsih Muthahharah Nurhidayah sally Purwanti Nursing Department Faculty of Health and MedicineUniversitas Islam Negeri AlauddinSouth Sulawesi 92118Indonesia

Objective:To identify the illustration of feeding patterns of stunting children using literature review ***:This study was a descriptive narrative research using literature review approach to explore dietary habits of children with stunting *** the literature review processes employed Guideline Review measurement of Joanna Briggs *** ar ticles in literature were obtained from journal databases,such as Pub Med,Science Direct,Google Scholar,and Dimensions through structured research question with Patient,Exposure an interest,Outcome or response(PEO)***:This study found 2246 published ar ticles from 2018 to 2021 about children with *** process was conducted fur ther to eliminate ar ticles with irrelevant titles and abstracts,and also the unsuitable ar ticles with the research question;hence,about 9 ar ticles were eligible to be reviewed *** these ar ticles mentioned that children with irregular dietary habits would likely experience *** low intake of nutritional food became the major predictor of ***:Inappropriate feeding patterns and the variety of food were being the factors of stunting emergence among children<5 years of *** consumption of carbohydrates,less animal-based protein,and misunderstanding about intake of sweetenedcondensed milk predisposed children to suffer stunting.

关键词： children dietary habit feeding pattern stunting literature review

A single-nucleotide substitution in the leucinerich-repeat-only gene CsLRR1 confers powdery mildew resistance in cucumber

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Plant Communications 2024年第3期5卷 9-12页

作者： Xuewen Xu Wei Wang Yujiao Du Ziyi Wang Xueli Liu Ming Tan Xiaojian Lin Jun Xu Congxi Cai Xiaohua Qi Qiang Xu Aimin Wei Haipeng Fu Shengli Du sally A.Mackenzie Yuhui Wang Xuehao Chen Xiaodong Yang School of Horticulture and Landscape Architecture Yangzhou UniversityYangzhouJiangsu 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety the Ministry of Education of ChinaYangzhou UniversityYangzhouJiangsu 225009China Xuzhou Institute of Agricultural Sciences in Jiangsu Xuhuai District XuzhouJiangsu 221131China Tianjin Vegetable Research Center Vegetable Research Institute of Tianjin Kernel Agricultural Science&Technology Co.Ltd.Jinjing RoadTianjin 300384China State Key Laboratory of Vegetable Germplasm Innovation Tianjin 300381China Department of Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization College of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China

Dear Editor,A variant with single substitution in the LRR-only protein CsLRR1,which regulates cucumber resistance to powdery mildew through a salicylic-acid-mediated pathway,provides a major source of resistance for cucumber *** powdery mildew(PM),mainly caused by the biotrophic pathogen Podosphaera xanthii(synonym Podosphaera fusca),poses a serious threat to cucumber crops globally,leading to substantial reductions in fruit yield and quality(Martinez-Cruz et al.,2017).

关键词： cucumber breeding powdery mildew resistance LRR-only protein salicylic acid