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Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus

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World Journal of Diabetes 2024年第3期15卷 331-347页

作者： saleh Fahad Alqifari Omar Alkomi Abdullah Esmail Khadijeh Alkhawami Shahd Yousri Mohamad Ayham Muqresh Nawwarah alharbi Abdullah A Khojah Ahmed Aljabri Abdulrahman Allahham Kousalya Prabahar Hanan Alshareef Mohammed Aldhaeefi Tariq Alrasheed Ali Alrabiah Laila A AlBishi Department of Pharmacy Practice Faculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Clinical Sciences Sulaiman Alrajhi University-College of MedicineAl Bukayriyah 52726Saudi Arabia Department of Family Medicine Dr.Soliman Fakeeh Hospital DSFHJeddah 21461Saudi Arabia Department of Pharmacy Practice Faculty of PharmacyKing Abdulaziz UniversityJeddah 22252Saudi Arabia Clinical and Administrative Pharmacy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Internal Medicine Faculty of MedicineUniversity of TabukTabuk 71491Saudi Arabia Department of Pharmacy Practice Raabe College of PharmacyOhio Northern UniversityOhioOH 45810United States Department of Pediatric Faculty of MedicineUniversity of TabukTabuk 71491Saudi Arabia

Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus common second-line choice after metformin for treating *** considerations can make selecting and switching between different GLP-1 RAs *** study aims to provide a comprehensive guide for the usage of GLP-1 RAs and dual GIP and GLP-1 RAs for the management of T2DM.

关键词： Glucagon-like peptide-1 receptor agonist Diabetes mellitus Metabolic syndrome Dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist Clinical practice Endocrinology

Knowledge and Awareness towards Chronic Kidney Disease Risk Factors in Saudi Arabia

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International Journal of Clinical Medicine 2018年第11期9卷 799-808页

作者： Ibrahim A. Bin Ahmed saleh hadi alharbi Fahad A. Alateeq Abdulmalik M. Aloriney Abdullah Abdulhadi Hammad alharbi Abdul Rahman Ali AlSogair Ali Dawood Mohmmed Almansour Alanoud Mansour Ayed Albalawi Hussain Gadelkarim Ahmed Faculty of Medicine Al Imam Mohammad ibn Saud Islamic University Riyadh Saudi Arabia College of Medicine University of Hail Hail Saudi Arabia

Background: The risk of CKD is high in Saudi Arabia due to increasingly growing prevalence of its risk factors, such as diabetes, hypertension and obesity. Therefore, the objective of this study was to assess the level of awareness of Saudi population towards CKD risk factors in order to generate platform for future planning. Methodology: This study included 940 apparently healthy Saudi volunteers, their ages ranging from 17 to 65 years old with a mean age of 35 years. A purposeful questionnaire was designed and used for obtaining data about the CKD risk factors. Results: Out of 940 participants, 293 (31.2%) were males and 647 (68.8%) were females, giving males “females” ratio of 1.00:2.21. About 62.3% of the participants were found to believe that DM is one of the main risk factors for CKD, of whom, 74% were males and 57% were females. Approximately 60% of the participants were found believing that hypertension is one of the main risk factors for CKD, of whom 79.5% were males and 51.6% were females. Conclusion: There is an increasing in the prevalence of CKD risk factors among Saudi population. Although, the levels of awareness toward some CKD risk factors are relatively increasing, but more health education efforts are deemed importance.

关键词： CKD Saudi Arabia Hypertension Diabetes Obesity Awareness Risk Factors

Knowledge towards Chronic Kidney Disease Manifestations in Saudi Arabia

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Open Journal of Preventive Medicine 2018年第11期8卷 315-323页

作者： Fahad A. Alateeq Abdulmalik M. Aloriney saleh hadi alharbi Ibrahim A. Bin Ahmed Abdullah Abdulhadi Hammad alharbi Abdul Rahman Ali AlSogair Ali Dawood Mohmmed Almansour Alanoud Mansour Ayed Albalawi Hussain Gadelkarim Ahmed Faculty of Medicine Al Imam Mohammad Ibn Saud Islamic University Riyadh KSA College of Medicine University of Hail Hail KSA

Background: Increasing awareness level and health education can reduce the burden of Chronic Kidney Disease (CKD) at community base. Therefore, the aim of the present study was to assess the level of knowledge towards CKD manifestations in Saudi Arabia. Methodology: This is a descriptive prospective study including 900 apparently health Saudi volunteers, their ages ranging from 18 to 65 years old with a mean age of 34 years. A purposeful questionnaire was deliberated and used for obtaining data about the CKD. Results: Out of 900 contributors, 268 (29.8%) were males and 632 (70.2%) were females, giving males:females ratio of 1.00:2.36. About 102/900 (11.3%) of the participants (all of them were females) were found to believe that CKD has no specific symptoms. Conclusion: The awareness towards CKD manifestation is relatively low, which necessitates the important of community based intervention including health educational programs.

关键词： CKD Saudi Arabia Awareness Manifestations

The Patterns of Blood Groups and Its Association with Blood Donation in Saudi Arabia

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Open Journal of Preventive Medicine 2018年第9期8卷 291-300页

作者： Fahad A. Alateeq Thamer Z. Aldugieman Yousef Duhaim A. Al-Rashdi Abdul Rahman Ali A. Alsogair saleh hadi alharbi Ibrahim Bin Ahmed Hussain Gadelkarim Ahmed Faculty of Medicine Al Imam Mohammad Ibn Saud Islamic University Riyadh Kingdom of Saudi Arabia (KSA) College of Medicine University of Hail Hail Kingdom of Saudi Arabia (KSA)

Background: Blood groups system has key importance for transfusion safety and clinical practice. Therefore, the objective of the present study was to evaluate the distribution of ABO blood groups and its association with blood donation in Saudi Arabia. Methodology: In this study, we collected information regarding blood donation from 715 Saudi volunteers living in the city of Hail, Northern Saudi Arabia. Data about blood donation were obtained from 715 Saudi volunteers living in the city of Hail. Results: The majority of the study population was found with group B+ representing 174 participants, followed by A+, O+, AB+, B-ve, A-ve, AB-ve and O-ve, representing 165, 153, 47, 29, 20, 9, and 7 participants, in this order. Conclusion: The major blood group among Saudi population is group B+ followed by group A+ and O+. Individuals with rare blood groups were less likely to participate in blood donation programs, which necessitate the need for educational programs using motivating factors.

关键词： Blood Donation Donors Saudi Arabia Voluntary Donation ABO Group

Irritable Bowel Syndrome and Dietary Habits in Northern Saudi Arabia

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Health 2019年第3期11卷 289-297页

作者： saleh hadi alharbi Fahad A. Alateeq Khalil Ibrahim Alshammari Abdulaziz Saad Sharea Alshammri Naif Abdulmohsen Naif Alabdali Motab Ali Saud Alsulaiman Sami Mamdouh Ibrahim Algothi Abdulrahman Sulaiman Altoraifi Maha Qasem Almutairi Hussain Gadelkarim Ahmed Faculty of Medicine Al-Imam Mohammad Ibn Saud Islamic University Riyadh KSA College of Medicine University of Hail Hail KSA Department of Histopathology and Cytology FMLS University of Khartoum Khartoum Sudan

Background: dietary habit is one of the most universally recounted initiators of irritable bowel syndrome (IBS). The objective of the present study was to determine the role of some dietary habits in the etiology of IBS in Northern Saudi Arabia. Methodology: In this community based cross-sectional survey, data about IBS were obtained from 930 Saudi volunteers living in the city of Hail, Northern Saudi Arabia. IBS was diagnosed using Rome IV criteria. Results: The prevalence of IBS was 11% among males vs. 12.5% among females. The prevalence of IBS symptoms among males was 30% vs. 36.5% females. IBS was significantly associated with reduced water intake, the RR (95% CI) = 1.1800 (1.0146 to 1.3722), P = 0.0316. In the present study, the majority of the study population 904/929 (97.3%) didn’t accustom to vegetables/fruits intake. Conclusion: IBS is prevalent in Northern Saudi Arabia, both among males and females with relatively increasing among females. Low water intake and insufficient fibers intake (particularly, in vegetables and fruits) might be behind the growing prevalence of IBS in Saudi Arabia.

关键词： Irritable Bowel Syndrome Dietary Habits Saudi Arabia

Clinical characteristics and outcomes of COVID-19 in patients with autoimmune hepatitis:A population-based matched cohort study

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World Journal of Hepatology 2023年第1期15卷 68-78页

作者： Arunkumar Krishnan Ruhee A Patel Yousaf Bashir hadi Diptasree Mukherjee Sarah Shabih Shyam Thakkar Shailendra Singh Tinsay A Woreta saleh A Alqahtani Section of Gastroenterology and Hepatology West Virginia University School of MedicineMorgantownWV 26505United States Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMD 21287United States Department of Medicine Apex Institute of Medical ScienceKolkata 700075West BengalIndia Liver Transplant Center King Faisal Specialist Hospital and Research CenterRiyadh 12713Saudi Arabia

BACKGROUND Patients with autoimmune hepatitis(AIH)require life-long immunosuppressive agents that may increase the risk of poor coronavirus disease 2019(COVID-19)*** is a paucity of large data at the population level to assess whether patients with AIH have an increased risk of severe *** To evaluate the impact of pre-existing AIH on the clinical outcomes of patients with *** We conducted a population-based,multicenter,propensity score-matched cohort study with consecutive adult patients(≥18 years)diagnosed with COVID-19 using the TriNeTx research network *** outcomes of patients with AIH(main group)were compared to a propensity score-matched cohort of patients:(1)Without chronic liver disease(CLD);and(2)Patients with CLD except AIH(non-AIH CLD)control *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** primary outcome was all-cause mortality,and secondary outcomes were hospitalization rate,need for critical care,severe disease,mechanical ventilation,and acute kidney injury(AKI).For each outcome,the risk ratio(RR)and confidence intervals(CI)were calculated to compare the association of AIH with the *** We identified 375 patients with AIH,1647915 patients with non-CLD,and 15790 patients with non-AIH CLD with COVID-19 *** to non-CLD patients,the AIH cohort had an increased risk of all-cause mortality(RR=2.22;95%CI:1.07-4.61),hospitalization rate(RR=1.78;95%CI:1.17-2.69),and severe disease(RR=1.98;95%CI:1.19-3.26).The AIH cohort had a lower risk of hospitalization rate(RR=0.72;95%CI:0.56-0.92),critical care(RR=0.50;95%CI:0.32-0.79),and AKI(RR=0.56;95%CI:0.35-0.88)compared to the non-AIH CLD *** Patients with AIH are associated with increased hospitalization risk,severe disease,and all-cause mortality compared to patients without pre-existing CLD from the diagnosis of ***,p

关键词： Autoimmune hepatitis SARS-CoV-2 COVID-19 Mortality Outcomes Liver disease Severe

Photoneutron dose and flux determination of a typical LINAC by MCNP simulation

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Radiation Detection Technology and Methods 2021年第4期5卷 627-632页

作者： Aydin Ghalehasadi Eren Sahiner saleh Ashrafi Sasan Geranmayeh hadi kasani Niyazi Meriç University of Tabriz TabrizIran Institute of Nuclear Sciences Ankara University06100 Be¸sevlerAnkaraTurkey

Purpose High-energy electron linear accelerators(LINACs)have a wide use in *** photoneutron production in medical linear accelerators,when operating at energies greater than 10 MeV,is an important subject to consider in patient’s treatment *** this work,we simulate a typical LINAC to calculate photoneutron dose and flux in radiotherapy *** The latest version of MCNPX Monte Carlo code along with MCNP visual editor has been used to simulate the LINAC and its *** production has been successfully simulated by selecting appropriate physics card and *** and flux of produced photoneutrons have been calculated by using mesh tally *** Production of photoneutrons in LINAC head and its components have been successfully simulated by using MCNPX *** visual editor has been used to track the *** dose and flux have been calculated using mesh tally function,with good results of statistical *** The photoneutron production has been successfully simulated and *** proposed simulation code is able to calculate photoneutron dose and *** to photoneutron production cross sections,the appropriate parameters have been selected to reduce the run-time of simulation code.

关键词： LINAC Photoneutron Dose Flux MCNPX code

Detection of Clinically Significant Warm Reactive Anti-A1 in a Post Red Blood Cells Transfusion Patient with Acute Lymphoblastic Leukemia

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Case Reports in Clinical Medicine 2023年第6期12卷 180-188页

作者： Ahmed alharbi Alenazi Abdullah Mahal Al Saqri Faisal Wasel Haya Alotaibi Abdulmohsen Hassan Jalal Shareefi Ahmed Almutairi saleh alharbi Abrar Almutairi Eiman Alzabaidi Waleed Almutariy Hiyam Alotaibi Rayyan Alfraidi Rawan Alahmadi Omar Alghamdi Abdullah Alotaibi Sarah Department of Laboratory and Pathology King Abdulaziz Medical City of National Guard Riyadh Saudi Arabia

The purpose of this article is to report that some anti-A1 that react at 37°C are IgG antibodies and are clinically significant, as they can cause the destruction of a proportion of A1 cells in vivo following the transfusion of red blood cells. Therefore, when a serum of an individual contains anti-A1, further testing of the plasma against group A1, A2, and O by referencing red blood cells and individual cells against anti-A1 lectin (Dolichos biflorus lectin) must be performed. Confirming the specificity of anti-A1 by referencing red blood cells is also important in selecting the appropriate blood for transfusion. ABO antibodies are naturally occurring and activate the complement cascade, making them more likely to cause severe transfusion reactions compared to antibodies to other RBC antigens.

关键词： Anti-A1 Clinical Significant Direct Antiglobulin Testing Anti-A1 Lectine Compatibility

The Effect of Ketogenic-Diet on Health

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Food and Nutrition Sciences 2020年第4期11卷 301-313页

作者： Amal alharbi Noorah saleh Al-Sowayan Master Student in Biology Department College of Science Qassim University Buraydah KSA Department of Biology Faculty of Science Qassim University Buraydah KSA

In recent years, the ketogenic diet is the most popular diet around the world. Therefore, keto diet, short for ketogenic, involves eating a high amount of fat, a moderate amount of protein and very few carbs. This research paper aims to know about the effect of a ketogenic diet on our body, to know about the mechanism of the ketogenic diet in treating neurodegenerative disorders and to know about the mechanism of the ketogenic diet in reducing the weight of our body. Also, the objective was to investigate the ketogenic diet stimulates ketogenesis which treats certain neurodegenerative disorders. Although this is high fats containing food it is beneficial for our body in certain conditions. It is also useful in the conditions in which the brain requires a low level of glucose so the brain starts utilizing ketone bodies. As the intake of carbohydrates is lowered so it is also used to reduce the weight of the body. In this research, the qualitative methodology has been adopted which refers to secondary sources of data. In this project, I used a variety of research that has also been undertaken by numerous researchers including dietitians who tend to support the positive benefits of using ketogenic diets to manage losing weight as well as other health problems that could result from overweight. Also, we used a table to show the difference between studies. Finally, it is important to note that the ketogenic-diet has created debate, partially although traditional dietary education has, for years, illustrated the adverse effects of high overall including trans-fat intake.

关键词： The Keto Diet Fats Carbohydrates Ketosis