检索结果-南通市图书馆

Effects of lipids on the activity and structural dynamics of gamma secretase: A study using coarse-grained molecular dynamics simulations

引用

ChemPhysMater 2024年第3期3卷 303-313页

作者： ahmad sajjad Jinfei Mei Chuanbo Wang Hongqi Ai School of Chemistry and Chemical Engineering University of JinanJinan 250022China

Gamma secretase(GS)is an intramembranous enzyme that acts on the amyloid precursor protein and Notch inside lipid *** enzyme is responsible for amyloid-𝛽propagation,one of the well-known causes of Alzheimer’s ***,the effects of lipids on GS activity and structural dynamics are ***,in this study,we performed coarse-grained molecular dynamics simulations to probe the effects of five individual lipids on *** lipids included 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine(POPE),1-palmitoyl2-oleoyl-sn-glycero-3-phosphocholine(POPC),1,2-dipalmitoyl-sn-phosphatidylcholine(DOPC),2-dimyristoyl-snglycero-3-phosphocholine(DMPC),and 1,2-dilauroyl-sn-glycero-3-phosphocholine(DLPC).These lipids are structurally characterized by different heads(i.e.,NH_(3)[PE]for POPE ***_(3)[PC]for POPC),number of double bonds(one for POPC *** for DOPC),and alkyl tail chain lengths(16:1/18:1 for DOPC vs.14:0/14:0 for DMPC vs.12:0/12:0 for DLPC).This indicates distinct microenvironments and adjustable structural elements for catalytic function when GS is *** results revealed that the presence of more unsaturated bonds in DOPC than in POPC resulted in greater GS ***,lipids with short alkyl tail chains or with PC heads instead of PE heads had improved mobility of the sixth transmembrane helix of GS,which is responsible for the considerable active site flexibility and presenilin 1 subunit *** length of the DMPC alkyl tail chain was between that of DOPC and DLPC because the up-down and cross-correlation motions of GS in DMPC was the lowest among the three lipids,and GS mobility in DMPC was the lowest among all five *** may be because the alkyl tail chain length(i.e.,3.8 nm thickness of the DMPC bilayer)was suitable for GS embedding,thereby restraining more GS motions than that of the long(DOPC)or short lipids(DLPC).Collectively,these results indicated that GS activity can be modulated through changes in con

关键词： Five lipids Gamma secretase Presenilin Nicastrin Effect of lipid on GS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular mechanism of different viruses associated with autoimmunity

引用

Life Research 2022年第1期5卷 9-19页

作者： Arslan Habib Zeeshan Ashraf Irfan Ullah Khan Amjad Ali Dominic Kwesi Quainoo sajjad ahmad qamar Umutumwa Eric Principe Dur E Maknoon Razia Laboratory of Molecular Immunology School of Life SciencesFudan UniversityShanghaiChina Department of Fisheries and Aquaculture University of Veterinary&Animal SciencesLahorePakistan Centre of Biotechnology and Microbiology Faculty of Life SciencesUniversity of PeshawarPakistan Department of Biotechnology Faculty of BiosciencesUniversity for Development StudiesGhana Department of Zoology University of OkaraOkaraPakistan School of Biotechnology East China University of Science&TechnologyShanghaiChina Department of Biochemistry Government College University FaisalabadPakistan

Different kinds of human chronic diseases may develop the mechanism of autoimmune *** a group of disorders,in the Western world autoimmunity possess as the third most prevalent morbidity and ***,the mechanism of most autoimmune diseases is still under *** infection is the principal factor involved in the induction of autoimmune diseases other than genetic factors and cytokine *** mechanisms have been proposed by which viral infection might interrupt tolerance to self and induce autoimmune cascade which eventually leads to the destruction of a specific type of cell or a whole-body *** autoimmune attack can be understood through the different immune systems and other possible mechanisms such as molecular mimicry,bystander activation and epitope *** addition to genetic and viral factors,other environmental factors are also involved including bacterial,parasitic and fungal ***,different animal models have been studied which provide strong evidence that viruses induced AIDs as well as accelerated and increased lesions in conditions where self-tolerance is *** the current review,we discussed the virus-induced autoimmunity and the molecular mechanism which is associated with this *** we also discussed the different viruses such as rubella virus,enteroviruses,measles virus,human T-lymphotropic virus type1,human cytomegalovirus,human herpes virus-6,Epstein-Barr virus,rotavirus and some other viruses which modulate the development of AIDs.

关键词： autoimmunity viruses immune tolerance molecular mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of cerium substitution in Co-Sr based spinel ferrites for high frequency application

引用

Journal of Rare Earths 2024年第9期42卷 1755-1763,I0005页

作者： Laura Khudaysh Inas A.Ahmed Syeda Rabia Ejaz sajjad ahmad Khan Yasir A.Haleem Mohamed M.Ibrahim Mahmood Ali Hafiz Muhammad Tahir Farid Zeinhom M.El-Bahy Department of Physics Faculty of ScienceJazan UniversityJazan45142Saudi Arabia Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha62224Saudi Arabia Department of Physics The Government Sadiq College Women UniversityBahawalpur63100Pakistan Institute of Physics Khwaja Fareed University of Engineering and Information TechnologyRahim Yar Khan64200Pakistan Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Centre of Excellence in Solid State Physics University of the PunjabLahorePakistan Department of Physics Government CollegeTaunsa Sharif32200Pakistan Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City11884CairoEgypt

Spinel ferrites exhibit exceptional magnetic properties,making them a distinctive class of magnetic *** sol-gel technique was utilized for the synthesis of spinel ferrites with the chemical formula Co_(0.6)Sr_(0.4)Ce_(x)Fe_(2-x)O_(4). Following that,a comprehensive X-ray diffraction analysis unveiled the crystalline cubic structure of the synthesized *** the utilization of the M-H loop approach,the ferromagnetic attributes of ferrites were assessed,and the assimilation of rare earth elements led to substantial enhancements in saturation magnetization,remanence,and *** ferrites with a high concentration of rare earth elements have improved direct current resistivity and activation *** logarithm of a material's resistance increased from 5.29 to 8.12 Ω·cm as cerium is *** a change in the amount of cerium,the activation energy goes up from 0.19 to *** changing the frequency from 5.5 to 9.5 GHz,the dielectric characteristics were *** the frequency goes up,the dielectric constant goes *** ferrites that have been made better in every way can be used in high-frequency applications.

关键词： Activation energy DC electrical resistance Remanence magnetization Cobalt strontium spinel ferrites High frequency application Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

M_(4)X_(3) MXenes:Application in Energy Storage Devices

引用

Nano-Micro Letters 2024年第10期16卷 522-542页

作者： Iftikhar Hussain Waqas Ul Arifeen Shahid Ali Khan Sikandar Aftab Muhammad Sufyan Javed sajjad Hussain Muhammad ahmad Xi Chen Jiyun Zhao PRosaiah Khaled Fahmi Fawy Adnan Younis Sumanta Sahoo Kaili Zhang Department of Mechanical Engineering City University of Hong Kong83 Tat Chee AvenueKowloon TongHong KongPeople's Republic of China School of Mechanical Engineering Yeungnam UniversityDaehak-roGyeongsan-siGyeongbuk-do 38541South Korea Department of Semiconductor Systems Engineering and Clean Energy Sejong UniversitySeoul 05006Republic of Korea School of Physical Science and Technology Lanzhou UniversityLanzhou 730000People's Republic of China Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Physics Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)ThandalamChennai 602105India Department of Chemistry Faculty of ScienceKing Khalid UniversityP.O.Box 900461413 AbhaSaudi Arabia Department of Physics College of ScienceUnited Arab Emirates UniversityP.O.Box 15551Al-AinUnited Arab Emirates School of Chemical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541South Korea

MXene has garnered widespread recognition in the scientific com-munity due to its remarkable properties,including excellent thermal stability,high conductivity,good hydrophilicity and dispersibility,easy processability,tunable surface properties,and admirable *** have been categorized into different families based on the number of M and X layers in M_(n+1)X_(n),such as M_(2)X,M_(3)X_(2),M_(4)X_(3),and,recently,M_(5)X_(4).Among these families,M_(2)X and M_(3)X_(2),par-ticularly Ti_(3)C_(2),have been greatly explored while limited studies have been given to M_(5)X_(4)MXene ***,studies on the M_(4)X_(3)MXene family have developed recently,hence,demanding a compilation of evaluated ***,this review provides a systematic overview of the latest advancements in M_(4)X_(3)MXenes,focusing on their properties and applications in energy storage *** objective of this review is to provide guidance to researchers on fostering M_(4)X_(3)MXene-based nanomaterials,not only for energy storage devices but also for broader applications.

关键词： MXene M_(4)X_(3)MXenes 2D materials Energy storage Properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rapid development in two-dimensional layered perovskite materials and their application in solar cells

引用

Chinese Chemical Letters 2018年第5期29卷 657-663页

作者： sajjad ahmad Xin Guo State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian National Laboratory for Clean Energy Dalian 116023 China University of Chinese Academy of Sciences Beijing 100049 China

Two-dimensional （2D） layered organic-inorganic hybrid perovskite （2D PVK） materials have beenrecently developed as a novel candidate for photovoltaic application with high stability and a maximumpower conversion efficiency of 12.5%. This article summarized these newly emerging 2D PVK materialsand their uses in solar cells. The structural, physical, and chemical properties as well as the classificationof 2D PVK materials are discussed. The photovoltaic performance parameters of various 2D perovsldtesolar cells （2D PSCs） are summarized and their device stability is compared with conventional 3Dperovskite solar cells （3D PSCs）. It has been concluded that 2D PVKs show greater stability upon humidity,heat stress, and light intensity as compared to 3D analogues and act as a class of promising materials forapplication in solar cells.

关键词： Perovskite solar cells2D Perovskite materials2D Perovskite solar cellsStabilityPower conversion efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Competitive role of nitrogen functionalities of N doped GO and sensitizing effect of Bi_(2)O_(3)QDs on TiO_(2)for water remediation

引用

Journal of Environmental Sciences 2021年第10期33卷 107-119页

作者： Saima Noor Shamaila sajjad sajjad Ahmed Khan Leghari Cristina Flox Saeed ahmad International Islamic University Islamabad 44000Pakistan Department of Chemistry and Materials Science Aalto UniversityEspoo 16100Fl-00076Finland Pakistan Institute of Engineering and Applied Sciences Islamabad 44000Pakistan Department of Applied Physics Aalto UniversityEspoo 15100Fl-00076Finland

The promising solar irradiated photocatalyst by pairing of bismuth oxide quantum dots(BQDs)doped TiO_(2)with nitrogen doped graphene oxide(NGO)nanocomposite(NGO/BQDs-TiO_(2))was *** was used for degradation of organic pollutants like 2,4-dichlorophenol(2,4-DCP)and stable dyes,*** B and Congo Red.X-ray diffraction(XRD)profile of NGO showed reduction in oxygenic functional groups and restoring of graphitic crystal *** characteristic diffraction peaks of TiO_(2)and its composites showed crystalline anatase TiO_(2).Morphological images represent spherical shaped TiO_(2)evenly covered with BQDs spread on NGO *** surface linkages of NO-O-Ti,C-O-Ti,Bi-O-Ti and vibrational modes are observed by Fourier transform infrared spectroscopy(FTIR)and Raman *** and NGO modified TiO_(2)results into red shifting in visible region as studied in diffused reflectance spectroscopy(DRS).NGO and BQDs in TiO_(2)are linked with defect centers which reduced the recombination of free charge carriers by quenching of photoluminescence(PL)intensities.X-ray photoelectron spectroscopy(XPS)shows that no peak related to C-O in NGO/BQDs-TiO_(2)is *** indicated that doping of nitrogen into GO has reduced some oxygen functional *** functionalities in NGO and photosensitizing effect of BQDs in ternary composite have improved photocatalytic activity against organic *** byproducts during photo degradation process of 2,4-DCP were studied through high performance liquid chromatography(HPLC).Study of radical scavengers indicated that O_(2)^(·-) has significant role for degradation of 2,*** investigations propose that fabricated nanohybrid architecture has potential for degradation of environmental pollutions.

关键词： Bi_(2)O_(3)quantum dots Nitrogen doped graphene oxide Nitrogen defects TiO_(2) 2,4-Dichlorophenol Water treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

One-dimensional quantum walks with a position-dependent coin

引用

Communications in Theoretical Physics 2020年第6期72卷 18-28页

作者： Rashid ahmad Uzma sajjad Muhammad Sajid Department of Physics Kohat University of Science and TechnologyKohat 26000Khyber-PakhtunkhwaPakistan

We investigate the evolution of a discrete-time one-dimensional quantum walk driven by a position-dependent *** rotation angle,which depends upon the position of a quantum particle,parameterizes the coin *** different values of the rotation angle,we observe that such a coin leads to a variety of probability distributions,***,periodic,classicallike,semi-classical-like,and ***,we study the Shannon entropy associated with position and the coin space of a quantum particle,and compare them with the case of the position-independent *** results show that the entropy is smaller for most values of the rotation angle as compared to the case of the position-independent *** also study the effect of entanglement on the behavior of probability distribution and Shannon entropy by considering a quantum walk with two identical position-dependent entangled *** observe that in general,a wave function becomes more localized as compared to the case of the positionindependent coin and hence the corresponding Shannon entropy is *** results show that a position-dependent coin can be used as a controlling tool of quantum walks.

关键词： quantum walk position-dependent coin Shannon entropy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A system dynamics model for billion trees tsunami afforestation project of Khyber Pakhtunkhwa in Pakistan:Model application to afforestation activities

引用

Journal of Mountain Science 2019年第11期16卷 2640-2653页

作者： Naila NAZIR Aqsa FAROOQ sajjad ahmad JAN Aftab ahmad Department of Economics University of PeshawarKhyber Pakhtunkhwa 25000Pakistan Department of Economics Edwardes CollegePeshawar Saddar 25000Pakistan Global Change Impact Study Center Ministry of Climate Change10-Mauve AreaG-8/1IslamabadPakistan

As part of the global effort to plant billion trees,an afforestation project is launched in Pakistan in Khyber Pakhtunkhwa(KP)province to conserve existing forests and to increase area under forest *** present study is designed to build a Systems'model by incorporating major activities of the Billion Tree Tsunami Afforestation Project(BTTAP)with special focus on afforestation activities to estimate the growth in forest area of *** of complete dataset was a *** fix the model,the raw data taken from the project office has been *** Commission Form 1-Phase I&II helped us with additional *** relied on the data available for one and half period of the project as rest of the data is subject to the completion of the *** results show that the project target to enhance area under forest differs from the target to afforest area under the *** system dynamics'model projection shows that the forest area of KP would be 23.59 million hectares at the end of the BTTA project,thus having an increase of 3.29%instead of 2%that has been initially ***,the results show that the progress to meet the target in some afforestation classes is slow as compared to other *** forestry,plantation on communal lands and owners'plantation need special focus of the *** would affect 0.02 million hectares area of the *** model under study may be used as a reference model that can be replicated to other areas where billion tree campaigns are going on.

关键词： Billion trees project Afforestation System dynamic model Forest area Deforestation Pakistan

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Long-range precipitation forecasts using paleoclimate reconstructions in the western United States

引用

Journal of Mountain Science 2016年第4期13卷 614-632页

作者： Christopher Allen CARRIER Ajay KALRA sajjad ahmad Department of Civil and Environmental Engineering University of NevadaLas Vegas4505 S.Maryland ParkwayLas VegasIVV89154-4015USA Development Review Division Clark County Public Works500 S.Grand Central ParkwayLas VegasNV 89155USA Department of Civil and Environmental Engineering Southern Illinois University1230 Lincoln DriveCarbondaleIL 62901-6603USA

Long-range precipitation forecasts are useful when managing water *** oscillations have been shown to influence *** to a longer cycle of some of the oscillations,a short instrumental record is a limitation in using them for long-range precipitation *** influence of oscillations over precipitation is observable within paleoclimate reconstructions;however,there have been no attempts to utilize these reconstructions in precipitation forecasting.A data-driven model,KStar,is used for obtaining long-range precipitation forecasts by extending the period of record through the use of reconstructions of *** is a nearest neighbor algorithm with an entropy-based distance ***-atmospheric oscillation reconstructions include the El Nino-Southern Oscillation(ENSO),the Pacific Decadal Oscillation(PDO),the North Atlantic Oscillation(NAO),and the Atlantic Multi-decadal Oscillation(AMO).Precipitation is forecasted for 20 climate divisions in the western United States.A 10-year moving average is applied to aid in the identification of oscillation phases.A lead time approach is used to simulate a one-year forecast,with a 10-fold cross-validation technique to test the *** are used from 1658-1899,while the observed record is used from *** model is evaluated using mean absolute error(MAE),root mean squared error(RMSE),RMSE-observations standard deviation ratio(RSR),Pearson's correlation coefficient(R),NashSutcliffe coefficient of efficiency(NSE),and linear error in probability space(LEPS) skill score(SK).The role of individual and coupled oscillations is evaluated by dropping oscillations in the *** results indicate 'good' precipitation estimates using the KStar *** modeling technique is expected to be useful for long-term water resources planning and management.

关键词： Precipitation Oscillations Paleoclimate reconstruction Forecast KStar

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Potential of rooftop rainwater harvesting to meet outdoor water demand in arid regions

引用

Journal of Arid Land 2018年第1期10卷 68-83页

作者： Kazi TAMADDUN Ajay KALRA sajjad ahmad Department of Civil and Environmental Engineering and Construction University of NevadaLas VegasNV 89154-4015USA Department of Civil and Environmental Engineering Southern Illinois UniversityCarbondaleIL 62901USA

The feasibility of rooftop rainwater harvesting （RRWH） as an alternative source of water to meet the outdoor water demand in nine states of the U.S. was evaluated using a system dynamics model developed in Systems Thinking, Experimental Learning Laboratory with Animation. The state of Arizona was selected to evaluate the effects of the selected model parameters on the efficacy of RRWH since among the nine states the arid region of Arizona showed the least potential of meeting the outdoor water demand with rain harvested water. The analyses were conducted on a monthly basis across a 10-year projected period from 2015 to 2024. The results showed that RRWH as a potential source of water was highly sensitive to certain model parameters such as the outdoor water demand, the use of desert landscaping, and the percentage of existing houses with RRWH. A significant difference （as high as 37.5%） in rainwater potential was observed between the projected wet and dry climate conditions in Arizona. The analysis of the dynamics of the storage tanks suggested that a 1.0-2.0 m3 rainwater barrel, on an average, can store approximately 80% of the monthly rainwater generated from the rooftops in Arizona, even across the high seasonal variation. This interactive model can be used as a quick estimator of the amount of water that could be generated, stored, and utilized through RRWH systems in the U.S. under different climate conditions. The findings of such comprehensive analyses may help regional policymakers, especially in arid regions, to develop a sustainable water management infrastructure.

关键词： rooftop rainwater harvesting rainwater storage tank dynamics sustainability of outdoor water usage sustainability of water in arid regions best management practices in arid regions variation of rainfall under variousclimate conditions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：